High molecular weight adiponectin. Medical search. Frequent questions

This study in Egypt investigated the association between serum adiponectin levels and pre-eclampsia and between adiponectin levels and some clinical and hormonal parameters. (who.int)
Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was more marked in cases of severe pre-eclampsia. (who.int)
However, there was no correlation between serum adiponectin and proteinuria or estradiol and progesterone levels. (who.int)
Serum adiponectin levels are independently associated with PCOS and are only partly explained by IR. (biomedcentral.com)
This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes. (biochemia-medica.com)
In the diabetes group, the serum adiponectin level in patients with renal dysfunction (22.3 (21.5-23.1) ng/mL) was higher than in patients with no complications (12.1 (11.45-12.75) ng/mL) and than in patients with coronary artery disease (11.2 (10.25-12.15) ng/mL) (P = 0.009). (biochemia-medica.com)
We conclude that patients with type 2 diabetes have lower serum adiponectin concentration than healthy individuals, and that there is a weak inverse correlation between adiponectin and testosterone serum concentrations in male diabetics. (biochemia-medica.com)
Data from large cross-sectional and cohort studies showed a positive correlation between serum adiponectin and mortality in chronic kidney disease. (encyclopedia.pub)
It has been reported that in patients with obesity, diabetes, hypertension, stroke, coronary disease serum adiponectin concentrations were decreased. (czytelniamedyczna.pl)

In the development and progression of lung cancer, a pathogenic role of adiponectin was defined by both in vivo and in vitro studies [ 15 , 16 ]. (hindawi.com)
However, reports of the role of adiponectin in pre-eclampsia are conflicting. (who.int)
However, studies on the role of adiponectin in younger and lean patients are limited. (biomedcentral.com)
However, the role of adiponectin in younger and lean patients has been examined only in few studies. (biomedcentral.com)

Adiponectin is an abundant adipocytokine secreted by adipocytes . (bvsalud.org)
After its secretion by adipocytes, adiponectin oligomerizes in three forms: trimers of low molecular weight (LMW), hexamers of medium molecular weight (MMW), and multimers of high molecular weight (HMW) [ 8 ]. (hindawi.com)
In addition to their main functions, adipocytes have endocrine functions and can secrete a variety of adipokines such as leptin, adiponectin, and resistin ( 2 - 4 ). (frontiersin.org)
In our recent research, we observed that adipocytes express MHC class II molecules and co-stimulatory molecules CD80/CD86, and that their expression significantly increases in response to high fat diet (HFD) challenges ( 8 ). (frontiersin.org)
Adiponectin is a protein exclusivelysecreted by mature adipocytes, which circulates in high concentrationsin the blood (1,2). (biochemia-medica.com)
Adiponectin is a peptide secreted by adipocytes. (czytelniamedyczna.pl)

Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. (frontiersin.org)

Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. (hindawi.com)
If adiponectin levels in younger and lean women provide similar association with PCOS as in obese patients, the level of adiponectin may be a useful proxy measure of an ongoing ovarian disease in women with atypical presentation of PCOS. (biomedcentral.com)
Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. (biochemia-medica.com)

There was a significant negative correlation between adiponectin levels and arterial blood pressure in all groups. (who.int)
Univariate correlation analysis showed an inverse weak correlation between adiponectin and testosterone concentrations in male diabetic patients (r = -0.27, P = 0.009). (biochemia-medica.com)
There was no significant correlation between adiponectin and testosterone in female patients (r = -0.05,P = 0.167). (biochemia-medica.com)
The recent prospective studies concerning correlation between adiponectin and cardiovascular disease (CVD) mortality have demonstrated controversial results. (czytelniamedyczna.pl)

Adiponectin is secreted from adipose tissue (and also from the placenta in pregnancy) into the bloodstream and is very abundant in plasma relative to many hormones. (wikipedia.org)
Furthermore, a recent study suggests that adipose tissue within bone marrow, which increases during caloric restriction, contributes to elevated circulating adiponectin in this context. (wikipedia.org)
Adipose tissue, through adiponectin and leptin, exerts several effects on energy metabolism and inflammatory processes. (hindawi.com)
Adiponectin is a hormone exclusively expressed from adipose tissue. (prospecbio.com)
Adiponectin and leptin are both adipose cytokines that can have pro- or anti-inflammatory properties. (medscape.com)
Adipokines such as adiponectin, leptin, resistin, visfatin, and plasminogen activator inhibitor type-1 (PAI-1) are secreted from adipose tissues. (biomedcentral.com)
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. (ximbio.com)
Total adiponectin levels increased by approximately twofold in P+ in association with increased adipose tissue gene expression. (elsevierpure.com)

Adiponectin in an adipokine that is inversely associated with the fat mass, and has been linked to cardiometabolic risk stratification in the general population. (bepress.com)
Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in regulating glucose levels and fatty acid breakdown. (wikipedia.org)
Adiponectin is an abundant serum adipokine composing up to 0.05% of total circulating protein [ 7 ]. (hindawi.com)
Conclusions: Our findings suggest that molybdenum was associated with favorable profiles of HMW-adiponectin, leptin, and sOB-R. Exposures to cadmium, cesium, and lead were associated with adverse adipokine profiles. (cdc.gov)
It would thus be interesting to determine whether distinctive dietary patterns for Japanese influence circulating adipokine levels, but to our knowledge only one study has examined the relationship between dietary pattern and blood adiponectin level among Japanese [ 27 ]. (biomedcentral.com)
Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. (encyclopedia.pub)
Despite the pro-inflammatory factors secreted by VAT, adiponectin is the most abundant anti-inflammatory and atheroprotective adipokine secreted by fatty tissues. (healthvoice360.com)

The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)
Dietary calorie restriction and exercise promote weight loss and may have additive effects for improving insulin sensitivity, independent of weight loss. (wustl.edu)
We evaluated the hypothesis that modest, matched weight loss induced by calorie restriction and exercise have additive effects on circulating cytokines and these changes correlate with improvements in insulin sensitivity. (wustl.edu)
Modest weight loss in overweight adults decreases serum leptin and high molecular weight adiponectin, and increases pentraxin-3 concentrations in a manner that correlates with increased insulin sensitivity. (wustl.edu)
HMW adiponectin has a better association with insulin sensitivity than total adiponectin levels. (healthvoice360.com)
Besides, adiponectin has proven to suppress the expression of TNF-a and IL-6, therefore enhancing insulin sensitivity by reducing inflammation. (healthvoice360.com)

Decreased plasma adiponectin is associated with impaired endothelial function and, thereby, increased risk for cardiovascular events. (elsevierpure.com)
GC pulse therapy impaired endothelial function while increasing plasma adiponectin levels, which may in turn restore the endothelial function in patients with IgA nephropathy. (elsevierpure.com)
Clone 399R is used to detect plasma adiponectin concentrations. (ximbio.com)
Moreover, decreased levels of plasma adiponectin result in higher insulin resistance. (healthvoice360.com)

Adiponectin is a 244-amino-acid-long polypeptide (protein). (wikipedia.org)
Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid oxidation. (wikipedia.org)
Adiponectin is secreted into the bloodstream, where it accounts for about 0.01% of all plasma protein at around 5-10 μg/mL. (wikipedia.org)
So far, two receptors have been identified with homology to G protein-coupled receptors, and one receptor similar to the cadherin family: Adiponectin receptor 1 (AdipoR1) Adiponectin receptor 2 (AdipoR2) T-cadherin - CDH13 These have distinct tissue specificities within the body and have different affinities to the various forms of adiponectin. (wikipedia.org)
Further, HMW adiponectin pretreatment decreases glycogen synthase kinase -3ß ( GSK-3 ß) inactivation by abrogating LPS-induced Akt (Ser473) phosphorylation , which subsequently suppresses LPS-induced CCAAT/enhancer binding protein ß (C/EBPß) protein translation and nuclear translocation. (bvsalud.org)
These improvements in patients' conditions are associated with immunometabolic processes involving adiponectin, leptin, and C-reactive protein. (hindawi.com)
Other adipokines, such as leptin and adiponectin and, to a lesser extent, resistin and retinol binding protein-4 are also involved. (wjgnet.com)
Levels of adiponectin are higher in older people with migraine, a new study suggests, although after adjustment, higher levels of this protein were associated with greater odds of migraine only in men. (medscape.com)
Fourteen young patients with IgA nephropathy were evaluated for flow-mediated vasodilation (FMD), plasma levels of adiponectin both in high molecular weight (HMW adiponectin) form and in single molecular form (total adiponectin), hepatocyte growth factor (HGF), asymmetric dimethylarginine (ADMA), and high-sensitive C-reactive protein, before and after a course of GC pulse therapy. (elsevierpure.com)
Activated protein C resistance and low molecular weight lipoprotein (a): dual pathogens for atherothrombosis? (mcmaster.ca)
In multiple linear regression analysis, log adiponectin was positively associated with high-density lipoprotein cholesterol levels (β = 0.006), whereas it was negatively associated with serum albumin (β = −0.284), triglyceride (log β = −0.288), high sensitivity C-reactive protein (log β = −0.058) levels and estimated glomerular filtration rate (β = −0.005). (biomedcentral.com)
Serum levels of retinol-binding protein 4 and adiponectin in women with polycystic ovary syndrome: associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this condition. (ximbio.com)
The last few years have brought a rising body of evidence that adiponectin is a multipotential protein with anti-inflammatory, metabolic, anti-atherogenic, and reactive oxygen species (ROS) protective actions. (encyclopedia.pub)
Human adiponectin protein has 244 amino acids (30 kDa), as well as the complex primary structure of a signal peptide, a hyper-variable region, a collagenous domain of 22 G-X-Y repeats, and a globular domain. (encyclopedia.pub)
T-cadherin, lacking a transmembrane structure, is considered a binding protein for the high molecular weight (HMW) form. (encyclopedia.pub)
There are several factors regulating the expression of adiponectin gene ( AdipoQ ), such as: forkhead box O1 (FOXO1), peroxisome proliferator-activated receptor γ (PPAR-γ), CCAAAT-enhancer binding protein α, and sterol regulatory element binding protein 1c (SREBP-1c) [ 9 ] . (encyclopedia.pub)
The food hourglass is an alternative to a low fat or low carb/high protein diet for diabetes patients. (clessidraalimentare.com)
SPIOMET also produced greater reductions in insulin production, C-reactive protein , and high-molecular-weight adiponectin and normalized visceral and hepatic fat to a greater degree. (medscape.com)

Adiponectin may serve as a biomarker of cardiometabolic risk and response to interventions to prevent and manage obesity and its comorbidities in SCBT. (bepress.com)
In non-obesity-related inflammatory disorders, adiponectin levels are increased [ 9 - 11 ]. (hindawi.com)
The mediators of the specific weight effect on the kidney appear to be an obesity-related inflammation, aggravated by a lowered anti-inflammatory adiponectin level, an increased oxidative stress and advanced glycation, and an enhanced TGF-beta expression, all of which might constitute promising therapeutic targets. (hindawi.com)
Previous research showed that in people of reproductive age, there is a substantial association between migraine and obesity and a suggestion that adiponectin levels are higher in those with migraine than in those without migraine. (medscape.com)
Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. (biomedcentral.com)
Although low adiponectin levels have been associated with PCOS which is mainly attributed to obesity among these patients, studies have also suggested that low adiponectin in PCOS may be related to IR in these women. (biomedcentral.com)
Weight increase and obesity in menopausal females have been identified as the most important prognostic risk factors for breast cancer in postmenopausal women [ 3 ]. (biomedcentral.com)
Adiponectin plays an important role in pathogenesis and amplification of insulin-resistant states in humans, where levels are reduced in patients with type-2 diabetes and obesity. (ximbio.com)
Besides, descriptive studies show that patients with visceral obesity have lower adiponectin plasma levels. (healthvoice360.com)
While abdominal obesity is strongly associated with pro-inflammatory cytokines and hormones that result in insulin resistance, and now high levels of visceral fat add to these conditions. (healthvoice360.com)
Like adiponectin, both receptors are inversely associated with obesity and insulin resistance, as shown by mouse modelsâ€"consequently, the reduction of visceral obesity associates with an increased expression of both receptors. (healthvoice360.com)
Study of the association between polymorphism of persistent obesity, human leptin gene/leptin receptor gene and molecular subtypes of breast cancer]. (cdc.gov)
People with low levels of this hormone usually have a higher risk of developing type 2 diabetes, obesity, heart disease, and fatty liver disease. (diet-food.pl)

Testosterone is another factor that influences concentration of circulating adiponectin. (biochemia-medica.com)

Ethnicity-specific alterations of plasma and hepatic lipidomic profiles are related to high NAFLD rate and severity in Hispanic Americans, a pilot study. (ucdavis.edu)
Increased abundance of the HMW adiponectin multimer may contribute to the hepatic insulin-sensitizing effects of these agents. (elsevierpure.com)

The circulating concentrations of adiponectin are inversely proportional to adiposity, and low adiponectin concentrations predict the development of type 2 diabetes and cardiovascular disease (2). (biochemia-medica.com)

In addition, testosterone therapy in combination with diet and exercise in type 2 diabetic men resulted in an increase of adiponectin (10). (biochemia-medica.com)
Interestingly, many factors may be involved in the mechanism of an increase of adiponectin levels, eg. (czytelniamedyczna.pl)

In school-aged girls with type 1 diabetes, the decrease in adiponectin concentrations was correlated with increasing levels of testosterone (8). (biochemia-medica.com)

Systematic evaluation was performed for diagnostic accuracy and predictivity of adiponectin variation for metabolic syndrome in enrolled studies including 1,248 and 6,020 subjects, respectively. (frontiersin.org)
Adiponectin can identify metabolic syndrome with moderate accuracy (area under the curve = 0.81, 95% CI: 0.77-0.84). (frontiersin.org)
Heterogeneity analysis revealed that an increasing index of insulin resistance was independently associated with improving the performance of adiponectin upon metabolic syndrome diagnosis (ratio of diagnostic odds ratio = 3.89, 95% CI: 1.13-13.9). (frontiersin.org)
In addition, reductions in adiponectin were associated with increasing metabolic syndrome incidence in a linear dose-response manner. (frontiersin.org)
In conclusion, adiponectin measurement might have potential benefits in the detection of metabolic syndrome. (frontiersin.org)
This suggests that patients with recently diagnosed breast cancer have biochemical changes consistent with an activated stress response and/or that patients with metabolic syndrome manifestations have a higher risk of developing this disease. (biomedcentral.com)
Meanwhile, the relationship between adiponectin and metabolic syndrome in patients with chronic kidney disease has not been clarified. (biomedcentral.com)
The aim of this study was to elucidate the relationship between adiponectin level and metabolic syndrome in patients with chronic kidney disease. (biomedcentral.com)
The median adiponectin level was 10.7 μg/mL and 585 (44.3%) patients had metabolic syndrome. (biomedcentral.com)
Regarding the important impact on clinical outcomes of metabolic syndrome in patients with chronic kidney disease, clarification of the relationship between metabolic syndrome and adiponectin level is mandatory. (biomedcentral.com)
In middle-aged patients with metabolic syndrome, blood concentrations of testosterone were positively correlated witj adiponectin (9). (biochemia-medica.com)

Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002-2003). (cdc.gov)
This rat strain has the same hypertensive background as SHR but also a genetic mutation in the leptin receptor gene, which leads to hyperphagia with an attendant wide range of metabolic abnormalities, that is, high body weight, hyperglycemia, hyperlipidemia, and hyperinsulinemia. (hindawi.com)

Adiponectin binds to a number of receptors. (wikipedia.org)
There are three known receptors for adiponectin: adiponectin receptor 1 (AdipoR1), adiponectin receptor 2 (AdipoR2), and T-cadherin. (encyclopedia.pub)
The adiponectin's glucose metabolism effect is mediated through its receptors, adiponectin receptor 1 (adipoR1) and adiponectin receptor 2 (adipoR2). (healthvoice360.com)
Genetic polymorphisms in leptin, adiponectin and their receptors affect risk and aggressiveness of prostate cancer: evidence from a meta-analysis and pooled-review. (cdc.gov)

Adiponectin (ADPQ), which is encoded by the AdipoQ gene located on chromosome 3q27.3, is a 244-amino acid pleiotropic hormone with a molecular weight of approximately 30 kDa for its basic subunit. (frontiersin.org)

Although pairwise biomarker correlations tended to have similar directions comparing diabetes case subjects to noncase subjects, most correlations were stronger in noncase than in case subjects, with the largest differences observed for the insulin/HbA 1c and leptin/adiponectin correlations. (diabetesjournals.org)
Adiponectin level may serve as a potential independent biomarker for diagnosis of PCOS in young and lean women with fewer symptoms, or women with a family history of PCOS. (biomedcentral.com)

Females with a family history of PCOS were significantly more likely to have lower adiponectin (OR = 3.32, 95% CI 1.27-8.67, p-value 0.014) compared to those who did not have a family history of PCOS. (biomedcentral.com)

In the circulation, Adiponectin is present as three different oligomeric complexes, including the high molecular weight (HMW), the middle molecular weight (MMW, also called hexamer) and low molecular weigh (MMW, also called trimer) forms 8. (prospecbio.com)
It is present in human serum in relatively high concentrations, in three different structural forms: trimer (low molecular weight, LMW), hexamer (middle molecular weight, MMW), and 12-18-mer (high molecular weight, HMW). (encyclopedia.pub)
Adiponectin circulates in plasma in three isoforms with different biological activities, a low-molecular-weight trimer, a middle-molecular weight hexamer, and a high-molecular-weight 12-to18- mer. (healthvoice360.com)
Adiponektyna - peptyd wydzielany przez komórki tłuszczowe, występuje we krwi w postaci trzech frakcji - izomerów różniących się masą cząsteczkową jako: frakcja niskocząsteczkowa (trimer) - LMW (low molecular weight), średniocząsteczkowa - heksamer MMW (middle molecular weight) oraz wysokocząsteczkowa - 12, 14 merów HMW (high molecular weight). (czytelniamedyczna.pl)
Adiponectin circulates in three isoforms: a trimer (low molecular weight - LMW), a hexamer (middle molecular weight - MMW) and a multimeric high molecular weight (HMW). (czytelniamedyczna.pl)

A Cochrane meta-review showed that ad libitum low glycemic index diets are superior to caloric restricted low-fat diets in terms of lipid profiles and weight loss (8). (clessidraalimentare.com)
The aim of the present study was to compare the effects of low and moderate intensity circuit resistance trainings on the levels of adiponectin and lipid profiles in overweight women. (ac.ir)
Before and after the exercise training program, the levels of adiponectin and lipid profiles were measured. (ac.ir)

Adiponectin exerts some of its weight-reduction effects via the brain. (wikipedia.org)
Different oligomeric complex of Adiponectin activates different signaling pathways and exerts distinct functions. (prospecbio.com)

It exists in the plasma in its trimeric, hexameric, high-molecular-weight (HMW), and globular (a proteolytic product) isoforms . (bvsalud.org)
It could be suggested that in CVD patients alterations in the process of adiponectin multimerization may lead to the deficiency of cardioprotective isoforms of adiponectin. (czytelniamedyczna.pl)

Furthermore, low adiponectin levels and high levels of visceral fat mass were associated with B-cell dysfunction leading to insulin resistance. (healthvoice360.com)
However, animal or mainly attributed to the accumulation ing prevalence of uncontrolled weight genetic studies, studies not relevant of intra-abdominal (visceral) fat ( 13 ). (who.int)

High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors. (bepress.com)
We tested the hypothesis that high molecular weight (HMW) adiponectin levels, the more biologically active form of adiponectin, were associated with adiposity in SCBT similarly to non-cancer controls. (bepress.com)
Partial correlations and multivariable regression analyses assessed the relationship between HMW adiponectin and adiposity. (bepress.com)
In conclusion, HMW adiponectin is inversely correlated with adiposity in SCBT. (bepress.com)

Weight reduction significantly increases circulating concentrations. (wikipedia.org)
Adiponectin levels were significantly higher while leptin levels were lower in patients with CF than in healthy controls. (hindawi.com)
A few days in the diagnosis, breast cancer subjects had significantly higher systolic blood pressure ( p = 0.03), glucose ( p = 0.01), triglycerides ( p = 0.001), leptin ( p = 0.044), resistin ( p = 0.04), ANG II ( p = 0.02), TNF-α ( p = 0.045), and CRP ( p = 0.04) than the controls. (biomedcentral.com)
On the other hand, HDL ( p = 0.01) and adiponectin ( p = 0.02) were significantly lower in cancer subjects than controls. (biomedcentral.com)
The significantly lower increase in HMWA in the first 6 months in [non-Hispanic black patients] may explain the higher therapeutic failure rates in [non-Hispanic black patients] compared with the other 2 racial/ethnic groups," the researchers concluded. (endocrinologyadvisor.com)

Globular adiponectin has the highest affinity to AdipoR1, therefore in animal studies it acts mainly in muscle cells [ 1 ] . (encyclopedia.pub)

Some authors reported that adiponectin was not independently associated with future development of CVD, whereas others showed that high adiponectin levels were correlated with an increased risk of CVD and/or mortality. (czytelniamedyczna.pl)

Recent studies showed that the high-molecular-weight form may be the most biologically active form regarding glucose homeostasis. (wikipedia.org)

However, coronary artery disease has been found to be positively associated with high molecular weight adiponectin, but not with low molecular weight adiponectin. (wikipedia.org)
Background It has been reported previously that the measurement of plasma total adiponectin level is clinically useful to estimate the risk of coronary artery disease (CAD). (go.jp)
A prospective study following a cohort of 75 521 women for 10 years showed that the risk of coronary heart disease for the highest glycemic load quintile was 98% higher (6). (clessidraalimentare.com)
High adiponectin levels in this group correlated with lower incidence of hypertension, diabetes, coronary disease and dyslipidemia. (czytelniamedyczna.pl)

Plasma levels of adiponectin are lower in obese subjects than in lean subjects. (wikipedia.org)
Acute effects of acylated and unacylated ghrelin on total and high molecular weight adiponectin inmorbidly obese subjects. (ximbio.com)

Nevertheless, a significant positive interaction effect between added sugar intake and CRP on the risk of T2D was observed ( p = 0.01), where increased T2D risk from high added sugar intake could only be observed at higher CRP levels. (lu.se)

Similarly, adiponectin has shown many positive and direct actions in kidney diseases, and among many kidney cells. (encyclopedia.pub)

Raspberry ketones help your body burn fat faster and more efficiently as it increases levels of adiponectin - a hormone that regulates metabolism and blood sugar levels. (diet-food.pl)

OBJECTIVES: To examine associations of serum PFAS concentrations with longitudinal trajectories of blood total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides in midlife women undergoing menopausal transition. (cdc.gov)

CONCLUSION: The AINS modulated adiponectin biology, an early predictor of type 2 diabetes risk, was associated with bidirectional modulation of adipogenic gene methylation in weight-stable overweight adolescents. (asoi.info)

High-molecular-weight adiponectin was further found to be associated with a lower risk of diabetes with similar magnitude of association as total adiponectin. (wikipedia.org)
The researchers had access to total adiponectin levels and high molecular weight (HMW) adiponectin, but levels of low molecular weight (LMW) adiponectin were not available. (medscape.com)
The researchers found that compared with control participants, crude total adiponectin levels were increased in participants with migraine. (medscape.com)
P = .011) for each standard deviation (SD) increase in total adiponectin. (medscape.com)
On multivariable analysis, PCOS cases were 3.2 times more likely to have low adiponectin level (OR = 3.2, 95% CI 1.49-6.90, p-value 0.003) compared to the controls after adjustment for age, BMI, family history, marital status, total cholesterol, HDL level and IR. (biomedcentral.com)
In obese men, serum and interstitial total adiponectin levels are lower than in lean subjects (7). (biochemia-medica.com)
After hyperinsulinemia, serum and interstitial total adiponectin is reduced in both obese and lean men. (biochemia-medica.com)
The circulating concentration and ratio of total and high molecular weight adiponectin in post-menopausal women with and without osteoporosis and its association with body mass index and biochemical markers of bone metabolism. (ximbio.com)
Responders' pretreatment phenotype was characterized by higher HOMA-IR, total and LDL cholesterol, but similar BMI in comparison to nonresponders. (asoi.info)
0.05) at physiologic hyperinsulinemia (∼50 μU/ml), which was highly correlated with an increased ratio of HMW adiponectin/total levels (r 2 = 0.90). (elsevierpure.com)
0.05), which did not correlate with HMW of total adiponectin levels. (elsevierpure.com)
Adiponektyna wysokocząsteczkowa (HMW - high molecular weight) wywiera silniejsze działanie metaboliczne, kardioprotekcyjne i antymiażdżycowe niż całkowita adiponektyna (total adiponectin). (czytelniamedyczna.pl)
It has been reported that isomer of adiponectin, HMW, has more potent metabolic, insulin sensitizing and cardioprotective effects than LMW, MMW and total adiponectin. (czytelniamedyczna.pl)
RESULTS: Three distinct trajectories (low, middle, high) of total, LDL, and HDL cholesterol and two distinct trajectories (low and high) of triglycerides were identified. (cdc.gov)

Another circulating, active form is globular adiponectin. (encyclopedia.pub)

adiponectin oligomeric profiles were analysed by western blot. (hindawi.com)

We investigated the association between major dietary patterns and circulating levels of adiponectin, leptin, resistin, visfatin, and plasminogen activator inhibitor-1 (PAI-1) in a working population. (biomedcentral.com)

ABSTRACT Adiponectin has profound insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. (who.int)

Suppression of Lipopolysaccharide-Induced IL-1ß Gene Expression by High-Molecular-Weight Adiponectin in RAW264.7 Macrophages. (bvsalud.org)
Pretreatment with human native HMW adiponectin inhibited lipopolysaccharide (LPS)-induced interleukin-1 ß ( IL-1 ß) gene expression , but not tumor necrosis factor (TNF)-α expression. (bvsalud.org)
These results suggest that HMW adiponectin mediates potent anti-inflammatory activities in macrophages by inhibiting its Akt-C/EBPß signaling pathway, thereby suppressing IL-1 ß gene expression . (bvsalud.org)
HMW adiponectin response to the AINS was associated with bidirectional modulation of adipogenic gene methylation. (asoi.info)
Two founder mutations in the SEC23B gene account for the relatively high frequency of CDA II in the Italian population. (unina.it)

Previous studies revealed that adiponectin played a causal role in maintaining energy homeostasis via regulation of glucose and lipid metabolism. (frontiersin.org)
Since its discovery, adiponectin has been identified as one of the key regulators involved in glucose and lipid metabolism. (encyclopedia.pub)
Also, the molecular structure of raspberry ketones resembles molecules believed to accelerate metabolism What are BHB Ketones? (diet-food.pl)
In addition to the metabolic influence on metabolism of glucose and lipids, adiponectin reveals direct vasoprotective and antiatherogenic effects on endothelial cells. (czytelniamedyczna.pl)
enhanced secretion of adiponectin by cardiomyocytes that is stimulated by BNP (brain natriuretic peptide), disturbed metabolism of adiponectin in older patients with CVD as well as changes in multimerization of adiponectin. (czytelniamedyczna.pl)

Many studies demonstrate that Adiponectin has direct anti-diabetic, anti-atherogenic and anti-inflammatory functions. (prospecbio.com)

Testosterone was determined by the radio-immunoassay , whereas adiponectin levels weredetermined by enzyme-linked immunosorbent assay (ELISA). (biochemia-medica.com)

Adiponectin connects energy balance regulation in the central nervous system and peripheral tissues [ 10 ] . (encyclopedia.pub)

Adiponectin 's anti-inflammatory effects on macrophages remain controversial. (bvsalud.org)
Here, we investigated whether native HMW adiponectin from human plasma has anti-inflammatory effects on macrophages . (bvsalud.org)
In addition, data from in vitro studies on lung cells were consistent with an anti-inflammatory function of adiponectin [ 11 , 12 ], and adiponectin-deficient mouse models develop lung function impairment and systemic inflammation [ 13 , 14 ]. (hindawi.com)
As LMW adiponectin was not evaluated, a potential piece of the inflammatory role it plays in older migraineurs may be missing, said the authors. (medscape.com)
The effect of an anti-inflammatory nutrition supplement (AINS) on IR and adiponectin biology in overweight adolescents was investigated. (asoi.info)

Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). (hindawi.com)

It is generated by proteolytic cleavage of full-length adiponectin and has biological activity in humans [ 1 ] . (encyclopedia.pub)

High adiponectin levels correlate with a lower risk of diabetes mellitus type 2. (wikipedia.org)
The average serum testosterone did not differ between the diabetes and the control group, but the average adiponectin in the diabetes group was lower (14.6 (14.2-15.0) vs . 24.3 (24.05-24.55) ng/mL, P = 0.001). (biochemia-medica.com)
However, whether testosterone is also associated with circulating adiponectin in patients with diabetes is not very well understood. (biochemia-medica.com)
Therefore, we performed this prospective study to investigate the relationship between plasma testosterone and adiponectin in a group of adult patients with type 2 diabetes. (biochemia-medica.com)
We developed the food hourglass, a nutrition model to help type 2 diabetes patients to make healthier food choices, in order to improve their metabolic and cardiovascular health and lose weight. (clessidraalimentare.com)
We therefore hypothesized that the higher glycemic failure rates in [non-Hispanic black patients] could stem from these differences in the pathophysiological components of type 2 diabetes and/or differences in adiponectin levels. (endocrinologyadvisor.com)
Therapeutic modalities that more effectively increase adiponectin levels may yet prove beneficial in [non-Hispanic black patients] as well as all youth with type 2 diabetes. (endocrinologyadvisor.com)
High-contact structured diabetes prevention programs are effective in lowering weight and HbA1cs, yet their intensity level can create barriers to participation. (kaiserpermanente.org)

Diseases4

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes4

Serum adiponectin9

Role of adiponectin4

Adipocytes6

Circulating adiponectin levels1

Level of adiponectin3

Correlation between adiponectin4

Adipose8

Adipokine7

Insulin sensitivity6

Plasma adiponectin4

Protein18

Obesity13

Concentration of circulating1

Hepatic2

Concentrations of adiponectin1

Increase of adiponectin2

Decrease in adiponectin1

Metabolic syndrome11

Leptin receptor2

Receptors4

AdipoQ1

Biomarker2

Lower adiponectin1

Trimer5

Lipid profiles3

Exerts2

Isoforms2

Visceral2

Adiposity4

Significantly5

AdipoR11

Independently associated1

Biologically active1

Coronary4

Obese subjects2

0.011

Similarly1

Increases1

Lipoprotein1

Conclusion1

Total14

Globular1

Oligomeric1

Resistin1

ABSTRACT1

Gene5

Metabolism5

Anti-diabetic1

ELISA1

Tissues1

Inflammatory5

Type 2 diabetic1

Proteolytic1

Diabetes8