• They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [ PMID: 25281808 ]. (ebi.ac.uk)
  • When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol. (wikipedia.org)
  • The protein is highly conserved in all metazoans, plants, and yeasts and in the parasites Trypanosoma cruzi ( 49 ), Schistosoma mansoni ( 29 ), and Plasmodium falciparum ( 13 ). (pubmedcentralcanada.ca)
  • Homologous proteins with highly conserved sequences are found in other mammalian species, including lab mice (Mus musculus). (wikipedia.org)
  • It is now well established that protein phosphorylation-dephosphorylation is a major general mechanism by which external stimuli controls the intracellular activity. (springer.com)
  • Therefore, in this study, we have examined the effects of triiodothyronine (T 3 ) on protein phosphorylation in different subcellular fractions of cultured astrocytes. (springer.com)
  • The proteins bind to the inner side of the nucleosomal DNA, altering the interaction between the DNA and the histone octamer. (wikipedia.org)
  • The domain is most commonly found in the high mobility group (HMG) proteins, HMG14 and HMG17, however, it is also found in other proteins which bind to nucleosomes, e.g. (wikipedia.org)
  • Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. (wikipedia.org)
  • HMGA2 contains three basic DNA-binding domains (AT-hooks) that cause the protein to bind to adenine-thymine (AT)-rich regions of nuclear DNA. (wikipedia.org)
  • TFIID is the first protein to bind to DNA during the formation of the pre-initiation transcription complex of RNA polymerase II (RNA Pol II). (wikipedia.org)
  • In a collaborative study the content of the acetylated histone species associated with the highly transcriptionally active chromatin of yeast was found to contain very high levels of the acetylated species for histones H3, H4 and possibly the H2B variants, H2B-1 and H2B-2. (oregonstate.edu)
  • Genomic DNA is packaged into nucleosomes by association with core histones, which are among the most highly evolutionarily conserved proteins. (biomedcentral.com)
  • High mobility group box 1 protein inhibits the proliferation of human mesenchymal stem cells and promotes their migration and differentiation along osteoblastic pathway," Stem Cells and Development , vol. 17, no. 4, pp. 805-813, 2008. (hindawi.com)
  • Let-7 inhibits production of specific proteins by complementary binding to their mRNA transcripts. (wikipedia.org)
  • The SMART signature describes a nucleosomal binding domain, which facilitates binding of proteins to nucleosomes in chromatin. (wikipedia.org)
  • These findings led to the suggestion that this domain, common to NBP-45, HMG14 and HMG17 is responsible for binding of the proteins to nucleosomes in chromatin. (wikipedia.org)
  • Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes," Surgery , vol. 126, no. 2, pp. 389-392, 1999. (hindawi.com)
  • Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function. (wikipedia.org)
  • Many of these cancers express the normal HMGA2 protein, but the mature mRNA transcript is truncated, missing a portion of the 3'UTR that contains the critical let-7 complementary regions. (wikipedia.org)
  • Gel retardation assays using sequences derived from the pea plastocyanin and oat phytochrome A3 gene promoters have suggested that rice shoot HMG protein extracts contain a DNA-binding protein factor resembling PCF1 from pea in its binding characteristics, and that this factor is closely related to the HMG-I/Y-like PFI protein from rice. (nus.edu.sg)
  • binding domain present within the protein. (uniprot.org)
  • p>This subsection of the 'Function' section specifies the position and type of each DNA-binding domain present within the protein. (uniprot.org)
  • The high mobility group protein 1 enhances binding of the estrogen receptor DNA binding domain to the estrogen response element. (semanticscholar.org)
  • H1 proteins typically contain a short N-terminus, a central globular domain, and a basic C-terminal domain, and mammalian cells encode multiple somatic isoforms. (biomedcentral.com)
  • HMG-1 belongs to high mobility group and contains HMG-box domain. (wikipedia.org)
  • POU domain, class 3, transcription factor 1 (also known as Oct-6) is a protein that in humans is encoded by the POU3F1 gene. (wikipedia.org)
  • POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene. (wikipedia.org)
  • Isoforms of the RAGE protein, which lack the transmembrane and the signaling domain (commonly referred to as soluble RAGE or sRAGE) are hypothesized to counteract the detrimental action of the full-length receptor and are hoped to provide a means to develop a cure against RAGE-associated diseases. (wikipedia.org)
  • Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. (wikipedia.org)
  • These proteins share a similar structure, in which the extracellular region consists of membrane distal single variable immunoglobulin domain (IgV) and a glycosylated mucin domain of variable length located closer to the membrane. (wikipedia.org)