High levels of cyclin cyclin g. Medical search. Frequent questions

Inhibitors of the cyclin-dependent kinases CDK4 and CDK6 induce cell-cycle arrest in RB1-proficient tumors and have had promising results in several tumor types. (aacrjournals.org)
Cyclins and cyclin dependent kinases, or CDK. (jove.com)
Positive regulators include two protein groups that allow cells to pass through regulatory checkpoints: cyclins and cyclin-dependent kinases (CDKs). (jove.com)
High impact information on E2f Negative regulation of d E 2 F 1 by cyclin- dependent kinases controls cell cycle timing. (wikigenes.org)
Concomitantly, p27 Kip1 levels rose and the inhibitor accumulated in both Cdk4 and Cdk2 complexes, as these kinases were inactivated. (ku.dk)
Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
Similarly, depletion in the STRIPAK component STRIP1 affects activation of GCKIII kinases and cell cycle disruption through elevated expression of cyclin dependent kinase inhibitors p21 and p27, enhanced levels of which lead to a protective effect from therapeutic treatments and increased proliferation. (lu.se)
As a biologically important example we have studied the complex formed by cyclins and cyclin-dependent kinases (CDKs), which play an essential role in the control of the eukaryotic cell cycle. (lu.se)

p27 is a cyclin dependent kinase inhibitor that blocks the activity of Cyclin E-CDK2, which phosphorylates pRb, thereby ushering the cell from G1 into S phase through the Restriction point (Figure 2). (shu.edu)
P15 INK4 is a cyclin dependent kinase inhibitor that blocks the activity of Cyclind-CDK4,6, inhibiting it from hypophosphorylating Rb, thereby, rendering the cell cycle unresponsive to external proliferation signals. (shu.edu)
Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma. (ox.ac.uk)

THZ1 was tested on HER2-positive breast cancer cells and exhibited high potency for the cells regardless of their sensitivity to HER2 inhibitors. (wikipedia.org)
High levels of cyclin D3 and CDK6 may predict response to CDK4/6 inhibitors in multiple tumor types. (aacrjournals.org)
Together, these findings elucidate a prosurvival role for cyclin D3-CDK6 in metabolism, in addition to its role in cell-cycle progression, and suggest that high levels of cyclin D3 and CDK6 may predict response to CDK4/6 inhibitors. (aacrjournals.org)
Unlike iPS cells, undifferentiated FReP cells proliferate slowly and express low proto-oncogene c-MYC and unexpectedly high levels of cyclin-dependent kinase inhibitors p15(Ink4B) and p21(WAF1/Cip1). (ca.gov)
Together, the results indicate that presence of high SKP2 plus high pSer10p27 levels in triple-negative breast cancers is associated with aggressive growth, and highlight the validity of using SKP2 inhibitors as a therapeutic approach for treating this subset of breast cancers. (umass.edu)

Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. (wikipedia.org)
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. (wikipedia.org)
This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). (wikipedia.org)
information on E 2 f 1 Levels of E 2 F 1 protein were greater in the nucleus of neurons in brains of HIV- infected. (wikigenes.org)
They would be specified as the reduction of neuroinflammation, the elimination of amyloid-β, neurofibrillary tangles, and abnormal protein degradation, the promotion of autophagy-associated and blood-brain barrier recoveries, the upregulation of acetylcholine levels, improved cognition, and the recovery of mitochondrial transport. (j-alz.com)
In the current study, Lu and her colleagues show that a protein complex named cyclin B1/cdk1, which is expressed at high levels in the cytoplasm of advanced melanomas, induces a pair of precise chemical modifications on iASPP to activate the protein. (medindia.net)
Cell cycle ratio and apoptosis in the two groups were determined using flow cytometry, while Pi3k/Akt signal route-linked protein levels were assayed by immunoblot method. (ajol.info)
With the advances of high-throughput experimental technologies, large amounts of Protein-Protein Interaction (PPI) data are uncovered, which make it possible to study proteins on a systematic level [ 7 , 8 ]. (hindawi.com)
But it has been noticed that PPI data are often associated with high false positive and false negative rates due to the limitations of the associated experimental techniques and the dynamic nature of protein interaction maps, which may have a negative impact on the performance of complex discovery algorithms [ 11 ]. (hindawi.com)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
It can be mixed with pre-workout to aid with energy levels during exercise and can be used with post-workout drinks such as protein or BCAAs. (peaksupps.co.uk)
S-phase kinase-associated protein 2 (SKP2) is an important cell cycle regulator, targeting the cyclin-dependent kinase (CDK) inhibitor p27 for degradation, and is frequently overexpressed in breast cancer. (umass.edu)
Cyclin E1 appeared to be the most significant predictive indicator of how a patient will respond to palbociclib, and they identified possible others including associated protein CDK2. (reachmd.com)
The cyclin D1-Cdk4 complex phosphorylates the pRB protein leading to sequential phosphorylation by cyclin E-Cdk2 and release of free E2F. (shu.edu)
p27, cyclin D1, and retinoblastoma (Rb) protein have been demonstrated using immunohistochemistry in 189 cases of primary breast carcinoma with long-term follow-up. (ox.ac.uk)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)
Ashok B. Kulkarni, Ph.D., has spent years studying a protein called cyclin-dependent kinase 5 (Cdk5). (medlineplus.gov)
Protein drugs are increasingly important in drug development worldwide due their high specificity, potency, and low toxicity. (lu.se)

Thus, the CDK4/6 inhibitor palbociclib reduced NADPH and GSH levels in T-ALL cells, thereby increasing ROS levels to induce apoptosis, which could be rescued by the antioxidant N -acetyl-cysteine. (aacrjournals.org)
Moreover, in breast cancer cells, which express CDK4 instead of CDK6, palbociclib induced cell-cycle arrest instead of apoptosis, further indicating that expression of cyclin D3 and CDK6 in T-ALL cells promotes apoptosis in response to palbociclib. (aacrjournals.org)
Additionally, 16 of 18 nonleukemic cancer cell lines exhibiting high expression of cyclin D3 and CDK6 underwent apoptosis in response to palbociclib, and, in melanoma patient-derived xenografts, high cyclin D3 and CDK6 expression was associated with tumor regression after CDK4/6 inhibition. (aacrjournals.org)
The Cyclin D-Cdk4,6/INK4/Rb/E2F pathway plays a key role in controlling cell growth by integrating multiple mitogenic and antimitogenic stimuli. (nih.gov)
This pathway is deregulated in the vast majority of human tumors by genetic and epigenetic alterations that target at least some of its key members such as Cyclin D1, Cdk4, INK4a and INK4b, pRb etc. (nih.gov)
As normal cells entered density-dependent arrest, cyclin D1 decreased while cyclin D2 was induced and replaced D1 in Cdk4 complexes. (ku.dk)
We believe this activity level reflects in part zotatifin's mechanism of down-regulating cyclins D and E, and the synergy this provides with CDK4/6 inhibition. (financialcontent.com)
Consistent with these results, PMFs and ATST combinations decreased expression levels of phospho Rb, cyclin D1, and CDK4. (umass.edu)
Full holoenzyme activity of the cyclin D1-Cdk4 complex is induced by mitogen recruitment of CAK. (shu.edu)

Thus, levels of the four different cyclins vary in predictable patterns and combine with consistent CDKs at specific points to achieve forward momentum. (jove.com)
The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)

the endogenous cyclin E gene is activated following expression of the E 2 F 1 product encoded by a recombinant. (wikigenes.org)

1983 Subsequently cyclin A genes have been found in all multicellular organisms including humans (Pines and Hunter 1990 While only a single cyclin A gene is present in the genomes of and cultured fibroblasts XI-006 or other cell types blocked DNA synthesis consistent with the essential function for cyclin A in DNA replication (Girard et al. (immune-source.com)
We found that 4HPR impairs DU145 and PC3 prostate cancer cells migration and invasion by down-regulating FAK and AKT activation and by enhancing β-catenin degradation, causing the downregulation of target genes like cyclin D1, survivin and VEGF. (biomedcentral.com)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)

In renal cell carcinoma (RCC), the expression of CDK7 was significantly higher in the advanced stage tumors. (wikipedia.org)
Besides, the overall survival was significantly shorter in patients with higher CDK7 expression in the tumors. (wikipedia.org)
Tumors from the BB group had higher expression of PTEN and E-cadherin and lower cyclin D1 and Bcl2 levels. (usda.gov)
by the coinjection of SV40 T- antigen, adenovirus E1A, or a high level of E 2 F - 1 expression plasmids. (wikigenes.org)
ACT‑3 significantly reduced the expression levels of cyclin D1 and cyclin‑dependent kinase 4, and upregulated the expression levels of p21 and p53. (iasp-pain.org)
Expression of CCND1 mRNA level was significantly higher in carcinomas than in adenomas (p = 0.003). (nih.gov)
Western blot and immunohistochemical analysis also demonstrated higher expression of CCND1 in carcinoma specimens than in adenoma samples. (nih.gov)
Functionally, miR-193b induces a G1 cell cycle arrest and cell death in neuroblastoma cell lines by reducing the expression of MYCN , Cyclin D1 and MCL-1 , three important oncogenes in neuroblastoma of which inhibition has shown promising results in preclinical testing. (oncotarget.com)
Fibroblasts were isolated from cyclin A1-/-A2f/f embryos cultured and transduced with Cre-expressing viruses thereby ablating all cyclin A expression (Figures 1D and S1A). (immune-source.com)
Our data suggest that G0 marker mice can be a useful tool for identifying senescent proximal tubular cells both in vivo and in vitro, in combination with cyclin D1 expression. (asn-online.org)
IHC showed SKP2 to be more highly expressed in estrogen receptor α (ERα)-negative breast cancers and demonstrated that triple-negative tumors were more likely to have high expression of SKP2 than were non-triple negative, ERα-negative tumors. (umass.edu)
There was a statistically significant association between the expression of p27 and both cyclin D1 and the retinoblastoma gene product (pRb), corresponding to their close interactions in regulating the G1/S transition in the cell cycle. (ox.ac.uk)
When the combined expression of p27 and cyclin D1 was related to survival, patients with high levels of p27, regardless of their cyclin D1 status, did well, whilst those with low p27 had a poor outcome. (ox.ac.uk)
In univariate analysis high expression (strong staining) of EphrinA-1 was associated with poor disease-free ( P = 0.033) and disease-specific ( P = 0.039) survival. (medsci.org)
Adiponectin treatment also suppressed angiogenesis assessed by CD31 staining and VEGFb and VEGFd mRNA expression in tumours obtained from mice fed a high-fat diet and from adiponectin-deficient mice. (nuthealth.org)
In our recent research, we observed that adipocytes express MHC class II molecules and co-stimulatory molecules CD80/CD86, and that their expression significantly increases in response to high fat diet (HFD) challenges ( 8 ). (frontiersin.org)
In addition, we found that BMP-2, a 4HPR target with antiangiogenic activity, decreased prostate cancer cell proliferation, migration and invasion by down-regulating the pathway described involving AKT phosphorylation, β-catenin stability and cyclin D1 expression. (biomedcentral.com)
Epigenetic Downregulation of Hsa-miR-193b-3p Increases Cyclin D1 Expression Level and Cell Proliferation in Human Meningiomas. (cdc.gov)

It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)

Cyclin E1 is also involved in the checkpoints that dictate when a cell can multiply, and the researchers hypothesize that high levels of cyclin E1 allow cells to bypass other checks and keep multiplying, uncontrolled. (reachmd.com)

Cells from breast cancer tumors were found to have elevated levels of CDK7 and Cyclin H when compared to normal breast cells. (wikipedia.org)
Transcript levels for DNA methylation enzymes DNMT1 and EZH2 were also higher in BB tumors. (usda.gov)
The study by the team at the Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, showed that women with low levels of cyclin E1 in their tumors responded to palbociclib given in combination with hormone treatment for nearly twice as long as women with high levels. (reachmd.com)
But the researchers suggest that women with higher levels of cyclin E1 in their tumors should be monitored especially closely, since they can be expected to stop responding much more quickly than others. (reachmd.com)
Doses as high as of 60 Gy (1 Gy=100 rad) were needed in stage 3 or 4 tumors that have invaded bone, nerves, or lymph nodes. (medscape.com)

The components of this pathway are gene families with a high level of structural and functional redundancy and are expressed in an overlapping fashion in most tissues and cell types. (nih.gov)
It was shown that amplification of CCND1, a gene encoding cyclin D1, was more prevalent in parathyroid carcinomas than in adenomas (71 vs. 21 %, p = 0.056). (nih.gov)
RESULTS Generation and Characterization of Conditional Cyclin A2 Knockout Mice To obtain a conditional cyclin A2 allele we inserted sites into the first and seventh intron of the murine cyclin A2 gene (Physique 1A). (immune-source.com)
The gene-targeting construct was launched into embryonal stem (ES) cells and heterozygous cyclin A2f/+ (Af denotes XI-006 the "floxed" allele) ES were obtained through homologous recombination (Figures 1A and 1B). (immune-source.com)
Correlation of CYP2R1 gene promoter methylation with circulating vitamin D levels among healthy adults. (cdc.gov)

The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
In addition, Cyclin and CKI proteins are controlled at the level of their destruction. (intechopen.com)
The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers. (medsci.org)

This generated low ROS levels, which were not sufficient to inactivate a key cell cycle regulator, thus leading to an active Cyclin B-Cdk1 complex to allow entry into mitosis. (manchester.ac.uk)
The down regulation of OXPHOS allowed higher levels of ROS to be produced, which indirectly inactivated the Cyclin B-Cdk1 complex allowing the cell cycle transition. (manchester.ac.uk)
This is in contrast to control cells where cyclin B 1 appears at the centrosomes in early prophase based on cell cycle-specific localization of CENP-F. Furthermore, cyclin B/Cdk1 kinase activity in early G 2 is aberrantly high in BubR1-depleted cells. (ewha.ac.kr)

embryos were observed (Physique 1C) consisted with the early embryonic lethality associated with a cyclin A-null phenotype. (immune-source.com)

CDK12 and CDK13 could also be inhibited using THZ1 (but at higher concentrations) because they have similar structures in the region surrounding C312. (wikipedia.org)
E is then degraded by cytoplasmic enzymes and cyclin A concentrations increase throughout the S phase and remain high into G2 to promote entry into the M phase when in an active complex. (jove.com)
After A is degraded, concentrations of cyclin B peak in M phase and the complex will activate the different stages of mitosis. (jove.com)
ACT‑3 significantly decreased the cell viability in a concentration‑dependent manner and induced different morphological changes at high concentrations. (iasp-pain.org)
HSV-1 and APOE ε4 increase the risk of AD and relate to abnormal autophagy, higher concentrations of HSV-1 DNA in AD, and formation of Aβ plaques and neurofibrillary tangles. (j-alz.com)
Gallic acid is also present at high concentrations in gallnuts (name), which are proliferations of plant leaves that become elicited by gall wasp exudates to build up a hatchery for their larvae. (nature.com)

In these compartments cyclin A-Cdk complexes are expressed at particularly high levels which may render stem cells dependent on cyclin A. INTRODUCTION Replication of genetic material during cell division in Metazoan organisms is thought to be driven by cyclin A. Cyclin A was the first cyclin cloned in any organism (Swenson et al. (immune-source.com)
p27 regulates G1 /S transition by abrogating the activity of cyclin/CDK complexes. (umass.edu)

As expected, BubR1 depletion leads to degradation of cyclin B 1 in the G 2 phase. (ewha.ac.kr)

The growth suppressor p53 has been shown to interact with cyclin H both in vitro and in vivo. (wikipedia.org)
In vitro, it was found that adiponectin directly controls malignant potential (cell proliferation, adhesion, invasion and colony formation) and regulates metabolic (AMPK/S6), inflammatory (STAT3/VEGF) and cell cycle (p21/p27/p53/cyclins) signalling pathways in both mouse MCA38 and human HT29, HCT116 and LoVo colon cancer cell lines in a LKB1-dependent way. (nuthealth.org)

Surprisingly, this delayed arrest was molecularly distinct from contact inhibition of normal cells, as it occurred in the absence of p27 Kip1 induction and cyclin D1 levels remained high. (ku.dk)

Serum levels of insulin but not adiponectin, leptin and IGF-1, differed between tumor-bearing BB and CAS offspring at sac. (usda.gov)
Adiponectin treatment decreased serum insulin levels in mice on a high-fat-diet and increased serum-interleukin (IL)-12 levels in adiponectin-deficient mice. (nuthealth.org)
Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
On the univariable logistic regression model, male sex, age, serum uric acid, creatinine, concomitant drugs, and cisplatin schedule were significantly associated with a higher rate of AKI. (bvsalud.org)
We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 µg/mL is essential. (who.int)
Serum levels of these factors in non-pregnant women were similar to those in healthy pregnant women. (who.int)
However, serum levels were significantly higher with mild or severe pre-eclampsia compared with normal pregnancies and significantly higher with severe rather than with mild pre-eclampsia. (who.int)
The levels of serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were inversely associated with BMD in both pre- and post-menopausal women. (who.int)
Our data indicate a relationship between BMD values and serum lipid levels and suggest differences between pre- and post-menopausal women in terms of the effects of serum lipids on BMD at various skeletal sites. (who.int)

When B levels drop, the cell exits mitosis and divides. (jove.com)
1992 In addition cyclin A2 was postulated to play a role in access of cells into mitosis (Swenson et al. (immune-source.com)

These results suggest that cyclin E, cdk2, cdk5 and E 2 F - 1 play. (wikigenes.org)
Under the microscope, the team saw that mice who had high levels of Cdk5 showed larger calcium surges, indicating that their pain responses were intensified. (medlineplus.gov)

However, in T-cell acute lymphoblastic leukemia (T-ALL), which predominately expresses CDK6 and the activating cyclin, cyclin D3, inhibition of CDK6 or cyclin D3 induces apoptosis. (aacrjournals.org)

In this system very high levels of E 2 F 1 overexpression cause. (wikigenes.org)
101. Pathologically confirmed MCL, with documentation of either overexpression of cyclin D1 or presence of t(11;14) 102. (who.int)

Cyclin D3-CDK6 inhibits the glycolytic enzymes PFK1 and PKM2 to prevent T-ALL cell apoptosis. (aacrjournals.org)
6-phosphofructokinase (PFK1) and pyruvate kinase M2 (PKM2), enzymes that catalyze irreversible, rate-limiting steps in glycolysis, were directly phosphorylated and inhibited by cyclin D3-CDK6, suggesting that cyclin D3-CDK6 may have a unique role in glucose metabolism. (aacrjournals.org)

These high levels of proliferation may be achieved via regulation of cellular metabolism in a manner similar to the Warburg effect observed in cancer cells. (manchester.ac.uk)

Researchers found that testing for cyclin E1 could predict the chances of a year or more of successful treatment with a drug called palbociclib-a drug hailed by doctors as the biggest advance in breast cancer treatment for 20 years. (reachmd.com)
In the POP trial, palbociclib treatment stopped the tumor growing in 80 percent of women if low levels of cyclin E1 were present, whereas palbociclib only stopped the tumor growing in 36 percent of women it high levels of cyclin E1 were present. (reachmd.com)

Cyclins can be categorized as G 1 , G 1 /S, S, or M cyclins based on the cell cycle phase or transition they are most involved in. (jove.com)

Chromatin immunoprecipitation (ChIP) showed that pS2 and another active form of Pol II, phosphorylated on serine 5 (pS5), were enriched across rDNA, with the highest levels-at IGS28 and IGS38-being comparable to those at known Pol-II-transcribed loci (Fig. 1b and Extended Data Fig. 1a, d-f ). (nature.com)

Low levels of p27 were seen in high-grade, rapidly proliferating, oestrogen receptor-negative tumours. (ox.ac.uk)
The only exception, in the latter group, was patients with tumours expressing high levels of cyclin D1, who did as well as the high p27 group. (ox.ac.uk)
Results: Mice fed a high-fat-diet gained more weight and had larger tumours than mice fed a low-fat-diet. (nuthealth.org)

Anticancer effects of the HDAC inhibitor, 3β,6β‑dihydroxyurs‑12‑en‑27‑oic acid, in MCF‑7 breast cancer cells via the inhibition of Akt/mTOR pathways. (iasp-pain.org)
In the present study, the effects of ACT‑3 on anticancer effects of MCF‑7 cells were determined by measuring the level of apoptotic cell death and cell cycle regulator using flow cytometry analysis and western blot analysis, respectively. (iasp-pain.org)
ACT‑3 and SAHA increased the levels of acetylated histone H3 and reduced the levels of HDAC1 and HDAC3 in MCF‑7 cells. (iasp-pain.org)
The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
cyclin A function was essential for proliferation of hematopoietic and embryonal stem cells. (immune-source.com)
Cyclin A2f/+ ES cells were then injected into mouse blastocysts and homozygous cyclin A2f/f animals were generated using standard procedures (Geng et al. (immune-source.com)
However analyses of cell cycle progression using propidium iodide and anti-BrdU staining revealed that ablation of cyclin A2 increased the portion of cells in S and G2/M phases with concomitant decrease in the G1 populace (Figures 2C and 2D). (immune-source.com)
We found that cells lacking all A-type cyclins proliferated normally in culture (Physique XI-006 2A) and joined the S phase from G0. (immune-source.com)
Surprisingly, immunohistochemical analysis revealed the G0 marker-positive cells with nuclear abnormalities expressed high levels of cyclin D1 along with the G0 marker (G0 + CycD1 high ), which was inconsistent with normal cell cycle. (asn-online.org)
The PIC-based RNAseq study showed that G0 + CycD1 high cells exhibited the characteristic features of "Injured PTC" and "Senescence" compared with G0 + cells in the vehicle group. (asn-online.org)
Furthermore, most of the senescent cells with G0 marker expressed Cyclin D1 and had enlarged nuclei. (asn-online.org)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
Intriguingly, cyclin B 1 is prematurely targeted to centrosomes appearing at early G 2 phase in BubR1-depleted cells despite its low levels. (ewha.ac.kr)

The mechanisms underlying the prosurvival function of cyclin D3-CDK6 have not been elucidated, prompting Wang and colleagues to search for substrates that may promote cancer cell survival. (aacrjournals.org)
The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. (aacrjournals.org)
The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. (oncotarget.com)

There was a significantly higher apoptosis in si-Prok1 group. (ajol.info)

We determined VEGF and endostatin levels in the sera of 20 healthy, non-pregnant women and 64 pregnant women: 20 healthy, 20 with mild pre-eclampsia and 24 with severe pre-eclampsia. (who.int)

1986 and injection of anti-cyclin A2 antibodies into cultured fibroblasts or inhibiting cyclin A2 function by p21Cip1 during the G2 phase blocked G2?M phase progression (Furuno et al. (immune-source.com)
Use of the triple-negative TMX2-28 breast cancer cell line to address the role of SKP2 in cell cycle progression confirmed that SKP2 contributes to a more rapid cell cycle progression and may regulates pSer10p27 levels. (umass.edu)
Analysing levels of a molecule called cyclin E1 in tumor biopsies could be used to guide breast cancer treatment-helping delay chemotherapy for some women and ensuring others are closely monitored for any signs of progression. (reachmd.com)
Background: Obesity and a high-fat diet are associated with the risk and progression of colon cancer. (nuthealth.org)

1997 In the work explained below we decided to revisit the requirement for cyclin A function in cell proliferation using conditional cyclin A knockout mice. (immune-source.com)
2003 Cyclin A2f/f mice were viable and phenotypically normal (data not shown) consistent with our expectation that this "floxed" cyclin A2 allele is usually functionally wild-type. (immune-source.com)
Physique 1 Generation of Cyclin A2f/f Mice In order to verify that deletion of the "floxed" cyclin A2 sequences resulted in a functionally null allele we crossed cyclin A2f/f mice with a "deleter" Meox2-Cre strain (Tallquist and Soriano 2000 and generated cyclin A2? (immune-source.com)
Fibroblasts To rule out the possible contribution from cyclin A1 we crossed cyclin A2f/f mice with cyclin A1-null animals (Liu et al. (immune-source.com)
2005 and generated cyclin A1-/-A2f/f mice. (immune-source.com)
Objective: To investigate the effects of adiponectin on the growth of colorectal cancer in adiponectin-deficient or wild-type-C57BL/6 mice fed a low-fat or high-fat diet. (nuthealth.org)
DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. (researchgate.net)

For instance, during G1, when one type of cyclin, named D, is synthesized and binds to a CDK, the cell transitions into S phase, as another cyclin, E, peaks and forms a complex with CDK to promote DNA replication. (jove.com)

The partial response observed at a higher dose of zotatifin in combination with only fulvestrant is encouraging and we look forward to reporting data from the completed dose escalation in the second half of 2023. (financialcontent.com)

The anticancer activity of 3β,6β‑dihydroxyurs‑12‑en‑27‑oic acid (ACT‑3), a major component isolated from , has not yet been investigated in detail. (iasp-pain.org)
The activity observed with the ZFA triplet, with partial responses seen in 26% of patients, is substantially higher than we would expect for treating such heavily pretreated patients with just fulvestrant and abemaciclib," said Steve Worland, Ph.D., president and chief executive officer of eFFECTOR. (financialcontent.com)

It is a glucose polymer and is considered to be a complex carbohydrate although it has an extremely high glycemic index (GI) rating of 110. (peaksupps.co.uk)

It is unclear whether nucleolar Pol II exists in higher organisms or directly promotes ribosome biogenesis in any species. (nature.com)
APOE-ε4 reduces the levels of neuronal cholesterol, interferes with the transportation of cholesterol, impairs repair of synapses, decreases the clearance of neurotoxic peptide amyloid-β (Aβ), and promotes the deposition of amyloid plaque, and eventually may cause development of AD. (j-alz.com)

In most cases, when a cyclin is degraded, the CDK is inactivated, signaling the end of a particular phase. (jove.com)
It also blocks Cyclin A-CDK2 from further phosphorylating pRb to maintain S phase. (shu.edu)
In the model I have generated from these data, during the non-Warburg phase of the cell cycle both glycolysis and OXPHOS are active which lead to high ATP levels. (manchester.ac.uk)
Here, we demonstrate that reducing BubR1 levels during the G 2 phase causes accelerated mitotic entry. (ewha.ac.kr)

This demonstrates that although oncogenic Ras efficiently disabled the normal response to contact inhibition, a separate back-up mechanism enforced cell cycle arrest at higher cell density. (ku.dk)

Through high specificity, targeted treatment can overcome the unfortunate side effects to normal tissue. (lu.se)

All the cyclin A binding E2F family members can interact. (wikigenes.org)

Ninety (44 %) suffered from any grade AKI (grade I 51.1 %): out of them, 84.4 % received high-dose cisplatin (100 mg/m2 q21). (bvsalud.org)
These include gamma-knife stereotactic radiosurgery and brachytherapy (radioactive seeds or sources are placed in or near the tumor itself, giving a high radiation dose to the tumor while reducing the radiation exposure in the surrounding healthy tissues). (medscape.com)
Cohort 1 and Cohort 2: Prior therapy must have included: - Anthracycline or bendamustine-containing chemotherapy and - Anti-CD20 monoclonal antibody therapy and - Ibrutinib or acalabrutinib Cohort 3: Prior therapy must have included anthracycline, bendamustine-, or high dose cytarabine-containing chemotherapy and anti-CD20 monoclonal antibody therapy. (who.int)

by contrast, subjects in a higher quartile of TG levels show lower lumbar BMD values in the pre-menopausal women. (who.int)

It was also found that the higher levels were generally found in ER-positive breast cancer. (wikipedia.org)
Generally, levels of a given cyclin are low during most of the cell cycle but abruptly increase at the checkpoint they most contribute to (G 1 cyclins are an exception, as they are required throughout the cell cycle). (jove.com)

Both NBT/ATST and TAN/ATST combinations at low doses produced much stronger inhibitory effect on cancer cell viability in comparison to those produced by NBT, TAN, or ATST alone at much higher doses. (umass.edu)
Results: Our study revealed that RAI therapy at all doses significantly increased ALP level in comparison with baseline amounts (P≤0.05). (bvsalud.org)
If the tumor is completely unresectable, doses as high as 66 Gy are needed. (medscape.com)

As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. (intechopen.com)
ATP and ROS levels were found to rise and fall once per cell cycle in an inverse manner. (manchester.ac.uk)

Anatomy11

Organisms4

Diseases4

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes37

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Kinases8

Dependent kinase inhibitor3

Inhibitors5

Protein20

CDK49

CDKs2

Endogenous cyclin1

Genes4

Expression18

Downregulation1

Checkpoints1

Tumors5

Gene5

Proteins3

Cdk13

Phenotype1

Concentrations6

Complexes2

Degradation1

Vitro2

Kip11

Serum9

Mitosis2

Cdk52

Induces1

Overexpression2

Enzymes2

Metabolism1

Palbociclib2

Transition1

Serine1

Tumours3

Cells13

Survival3

Apoptosis1

VEGF1

Progression4

Mice7

Replication1

20231

Activity2

Complex1

Promotes2

Phase4

Cell-cycle arrest1

Specificity1

Interact1

Dose3

Contrast1

Generally2

Doses3

Found2