High grade prostatic. Medical search. Frequent questions

High-grade prostatic intraepithelial neoplasia (HGPIN) is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer). (wikipedia.org)
It may be referred to simply as prostatic intraepithelial neoplasia (PIN). (wikipedia.org)
High grade prostatic intraepithelial neoplasia is the most likely precursor of invasive prostate cancer. (nih.gov)
The identification of prostatic intraepithelial neoplasia in needle biopsy specimens warrants repeat biopsy because of its high predictive value for cancer. (nih.gov)
The incidence of prostatic intraepithelial neoplasia in contemporary needle biopsies is unknown. (nih.gov)
To determine the incidence of patients requiring repeat needle biopsy because of abnormal findings in needle aspirations (high grade prostatic intraepithelial neoplasia and microscopic foci suspicious for but not diagnostic of malignancy), we compared the pathological findings in 400 prostatic needle biopsies, including 200 consecutive cases from an academic medical center (Mayo Clinic) and an equal number from a private practice laboratory (Glendale Memorial Hospital and Health Center). (nih.gov)
The biopsies revealed similar findings from the 2 medical centers: benign prostatic tissue in 41.5 to 50% of the cases, prostatic intraepithelial neoplasia in 16.5 to 9.5%, foci suspicious for but not diagnostic of malignancy in 1.5 to 2.5% and cancer in 40.5 to 38% (Mayo Clinic versus Glendale Memorial, respectively). (nih.gov)
Clinical information was available from the 200 Mayo Clinic patients who underwent biopsy, and there was no difference in the distribution of findings by digital rectal examination or transrectal ultrasound, although the median serum prostate specific antigen concentration was higher in patients with prostatic intraepithelial neoplasia and cancer than in those with benign biopsies. (nih.gov)
High grade prostatic intraepithelial neoplasia is a frequent finding in needle biopsies and is present in up to 16.5% of the cases. (nih.gov)
There was no apparent difference in the incidence of prostatic intraepithelial neoplasia and cancer between 2 geographically diverse medical centers. (nih.gov)
Up to 18% of patients are candidates for another biopsy based on needle biopsy findings of prostatic intraepithelial neoplasia or foci suspicious for but not diagnostic of malignancy. (nih.gov)
An abnormality called "high-grade prostatic intraepithelial neoplasia" is a major precursor for prostate cancer. (rxwiki.com)
For this study, Dr. Roberts and his team worked with a mouse model of high-grade prostatic intraepithelial neoplasia and used various types of ADT to treat it. (rxwiki.com)
For men, a condition known as high-grade prostatic intraepithelial neoplasia (HGPIN), which is a kind of precursor to cancer, is often mistreated as if it was actually cancer. (davidwolfe.com)
We showed that there was an increase in angiogenesis (an angiogenic switch), structurally patterned by adrenergic nerves, during progression from the pre-neoplastic low-grade prostatic intraepithelial neoplasia (PIN) to the cancer-committed high-grade PIN," Ali said. (taconic.com)
Researchers at the Harvard Medical School investigated the effect of androgen deprivation in a preclinical mouse model of stable high grade prostatic intraepithelial neoplasia induced by the loss of the PTEN tumor suppressor. (malecare.org)
We investigated the cellular localization of CART in normal human prostate, benign prostatic hyperplasia, prostatic intraepithelial neoplasia and acinar adenocarcinoma. (bvsalud.org)
CART expression was markedly diminished and, in some cases, entirely absent in tissues of prostatic intraepithelial neoplasia and adenocarcinoma. (bvsalud.org)
In addition to benign prostatic hyperplasia, prostatic intraepithelial neoplasia, and angiogenesis have a critical role in the initiation and progression of prostate cancer. (bvsalud.org)
GSTP1 becomes silenced in prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma (CaP) via cytosine-phospho-guanine (CpG) island promoter hypermethylation. (bvsalud.org)

Its cytologic features are that of prostatic adenocarcinoma: presence of nucleoli, increased nuclear-to-cytoplasmic ratio and, increased nuclear size. (wikipedia.org)
Characteristic morphologic features of prostatic adenocarcinoma, 10x. (bosnianpathology.org)
Two patients had known metastatic adenocarcinoma of the prostate, and 1 had recently presented with prostatic SCC. (karger.com)
Prostate xanthomas may mimic high-grade prostatic acinar adenocarcinoma with foamy cytoplasm, as well as adenocarcinoma with posthormonal therapy effect, particularly androgen deprivation therapy. (medscape.com)
If prostate biopsies are performed following hormonal therapy for prostatic adenocarcinoma, the appearance of residual tumor cells can mimic xanthoma cells. (medscape.com)
Fibromixoma and low grade mucinous adenocarcinoma (pseudomixoma peritonei) of the appendix and ovary (closed to accrual 03/20/2018) 8. (sncrf.org)
This retrospective study aimed to assess the concordance and interobserver variation between histopathologists in reporting prostatic adenocarcinoma using material obtained from prostatic core biopsy specimens. (who.int)
A total of 810 prostatic needle core biopsy specimens obtained from 100 patients with suspected prostatic adenocarcinoma were retrieved from the archival material at King Khalid University Hospital, Riyadh, and classified independently by 3 experienced histopathologists who were blinded to the original diagnosis. (who.int)
of prostatic adenocarcinoma among 3 Analysis histopathology consultants. (who.int)
Owing to loss of CART expression in adenocarcinoma and its increase in benign prostatic hyperplasia, CART may prove to be an important prostate marker. (bvsalud.org)

Stromal sarcoma may arise de novo or coexist with either preexistent or concurrent prostatic stromal tumors of uncertain malignant potential (STUMP), suggesting a potential for STUMP in dedifferentiate into stromal sarcoma. (medscape.com)
The World Health Organization (WHO) histologically classifies tumors into three grades: benign (I), atypical (II) and anaplastic (III) 2 . (nature.com)
Radiation is used as adjuvant to treat progressive tumors since there are no efficient chemotherapies for the management of high-grade tumors that fail treatments. (nature.com)
Two previous trials have shown that ADT used to ward off prostate cancer does decrease the risk of low-grade prostate cancers, but increases the risks for high-grade tumors. (rxwiki.com)
This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
The announcement follows the FDA's Oncologic Drugs Advisory Committee's vote of 17-0 in December that GlaxoSmithKline's dutasteride and Merck's finasteride should not be used to prevent prostate cancer because the drugs are linked to a higher incidence of high-grade tumors . (medpagetoday.com)
In the REDUCE trial, 29 high-grade tumors were found among patients being treated with dutasteride compared with 19 in the placebo group. (medpagetoday.com)
In the PCPT, there was a 26% decrease in all prostate cancers but an absolute increase of 1.3% in the incidence of high-grade tumors. (medpagetoday.com)
How to handle low-grade prostate cancer is controversial in the urology community, in part because it is unknown if the low-grade tumors would ever develop into high-grade tumors, and also because the method used to originally detect prostate cancer -- the PSA test -- is inexact. (medpagetoday.com)
NKX3.1 as a marker of prostatic origin in metastatic tumors. (roche.com)
However, this increase in the diagnosis of high-grade tumors did not translate into an increased risk of prostate cancer death among these men. (renalandurologynews.com)

In this retrospective study, we validate a deep learning-based classifier for prostate cancer (PCA) detection and Gleason grading (AI tool) in biopsy samples. (nature.com)
Two tumor-bearing datasets (core n = 227 and 159) were graded by an international group of pathologists including expert urologic pathologists ( n = 11) to validate the Gleason grading classifier. (nature.com)
The quadratically weighted kappa levels for Gleason grading agreement for single pathologists was 0.62-0.80 (0.77 for AI tool) and 0.64-0.76 (0.72 for AI tool) for the two grading datasets, respectively. (nature.com)
High levels of agreement for Gleason grading were indistinguishable between experienced genitourinary pathologists and the AI tool. (nature.com)
The aim of the current study is the validation of a clinical grade AI tool for prostate cancer detection and Gleason grading from prostate biopsy cases. (nature.com)
The validation of the Gleason grading algorithm was performed using biopsy samples from two pathology departments analyzed by 11 board-certified pathologists representing 8 different countries. (nature.com)
We show that the performance of the AI tool for both tumor detection and Gleason grading is indistinguishable from experienced genitourinary pathologists. (nature.com)
Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). (biomedcentral.com)
Adenocarcinomas of the prostate are categorized according to the Gleason grading system, which consists of five histological patterns based on microscopic tumor architecture [ 1 ]. (biomedcentral.com)
Numerous studies have shown a correlation between Gleason grade and disease outcome [ 2 ]. (biomedcentral.com)
The PCPT (Prostate Cancer Prevention Trial) and REDUCE (Reduction by Dutasteride of Prostate Cancer Events) had found increases in Gleason 7 to 10 PCa among men treated with 5-ARIs for benign prostatic hyperplasia (BPH), investigators noted. (renalandurologynews.com)
The Gleason score (grade rate of prostate cancer in Saudi Arabia 810 prostatic needle biopsies obtained of malignant cases) was not, however, ranked sixth among male patients with from 100 patients from 2005 until the recorded as this parameter was outside a crude annual incidence of 5.7 per end of 2011 were retrieved from the the scope of this retrospective study. (who.int)
To meet enrollment criteria, participants had to have two of the three following high-risk characteristics: a Gleason score of 8 or above, at least three bone metastases , or at least three visceral metastases. (medscape.com)

No information on the molecular and genetic features of prostatic xanthoma is currently available. (medscape.com)

The risk for men with high grade PIN of being diagnosed with prostate cancer after repeat biopsy has decreased since the introduction of biopsies at more than six locations (traditional sextant biopsies). (wikipedia.org)
Because low grade PIN has no significance and does not require repeat biopsies or treatment, it is not mentioned in pathology reports. (wikipedia.org)
However, first biopsies often miss higher grade cancers, so an MRI and a targeted confirmatory biopsy within six months is recommended to help assure that you are correctly diagnosed. (cancer.org)
We examined the association between obesity and risk of low- and high-grade prostate cancer in REDUCE, in which biopsies were largely independent of PSA. (aacrjournals.org)

A 2009 study of more than 300 prostate tissue samples collected from American men reported XMRV in 27 percent of the tumor samples from men who had been diagnosed with prostate cancer and 6 percent of the noncancerous prostate samples in men who had been diagnosed with benign prostatic disease. (meassociation.org.uk)

HGPIN is diagnosed from tissue by a pathologist, which may come from:[citation needed] a needle biopsy taken via the rectum and, surgical removal of prostate tissue: transurethral resection of the prostate - removal of extra prostate tissue to improve urination (a treatment for benign prostatic hyperplasia), radical prostatectomy - complete removal of prostate and seminal vesicles (a treatment for prostate cancer). (wikipedia.org)
however, cases have been discovered mostly in prostate core biopsy specimens, which suggests that prostatic xanthomas occur in men in the same age range as those with prostate cancer. (medscape.com)
No specific clinical findings have been reported for xanthoma of the prostate other than an elevation in the serum level of prostate-specific antigen (PSA), which prompts the prostatic biopsy. (medscape.com)
Five external cohorts of patients with multifocal prostate biopsy were analyzed from high-volume pathology institutes. (nature.com)
The PCA detection classifier showed high accuracy for PCA detection in biopsy cases during external validation, independent of the institute and scanner used. (nature.com)
In the dutasteride trial, men were at somewhat higher risk, with a PSA of 2.5 to 10.0 ng/mL and a prior negative biopsy. (cigna.com)
3 ] Subsequent studies showed that diagnostic tests (PSA, prostate digital rectal exam, and prostate biopsy) had improved performance for detection of cancer and of high-grade cancer in men who received finasteride. (cigna.com)
Grade and aggressiveness of prostatic inflammation were assessed by Irani G and A scores, respectively, in prostate biopsy specimens of men having undergone this procedure because of increased serum PSA and/or digital rectal examination. (jgerontology-geriatrics.com)
A Four-kallikrein Panel Predicts High-grade Cancer on Biopsy: Independent Validation in a Community Cohort. (lu.se)

MAO-A is also highly expressed in basal cells of the normal prostatic epithelium. (biomedcentral.com)
Real-time PCR and western blot were used to detect ENDOD1 mRNA and protein expression in normal prostatic epithelial and PCa cell lines. (biomedcentral.com)
We found cellular expression of CART in both normal prostatic luminal secretory epithelial cells neuroendocrine cells (NEC) of both ducts and acini. (bvsalud.org)

We examined the effects of clorgyline on the transcriptional program of epithelial cells cultured from high grade PCa (E-CA). (biomedcentral.com)

Abrahamsson PA: Neuroendocrine differentiation in prostatic carcinoma. (karger.com)
The prostate has a complex stromal-epithelial interaction that responds to hormonal stimulation that is responsible for prostatic epithelial morphogenesis, differentiation, proliferation, and expression of prostate-specific proteins. (medscape.com)
Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma. (roche.com)

Patients with recurrent/multifocal low-grade Ta lesions who require intravesical therapy should receive intravesical chemotherapy such as mitomycin, gemcitabine, epirubicin, or docetaxel instead of BCG. (auanet.org)
Human papillomavirus genotyping using next generation sequencing (NGS) in cervical lesions: Genotypes by histologic grade and their relative proportion in multiple infections. (who.int)

But both trials also found an unexpected increase in the incidence of high-grade prostate cancers among men receiving the 5-alpha reductase inhibitors. (medpagetoday.com)

Medium magnification showing spindle cell sarcoma replacing and distorting prostatic tissue. (medscape.com)
In the discovery set of fresh-frozen tissue specimens (14), the A-kinase anchor protein 12 (AKAP12) protein was found downregulated across the grades. (nature.com)
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Moreover, quantitative real-time polymerase-chain-reaction (RT-PCR) analysis revealed a decreased mRNA expression of ENDOD1 in high-grade and lymphnode-metastatic PCa [ 17 ]. (biomedcentral.com)
We identified 26 cases of metastatic prostatic carcinoma in supradiaphragmatic lymph nodes from 1972-1987. (citationimpact.com)

CART expression also was increased in both neuroendocrine and glandular epithelial cell populations from samples of benign prostatic hyperplasia as validated by IHC, ISH and RTqPCR. (bvsalud.org)

High grade PIN can be found in 85 to 100% of radical prostatectomy specimens, nearby or even in connection with prostate cancer. (wikipedia.org)
A retrospective review was performed at a tertiary-care hospital, and 3 patients with prostatic SCC in voided urinary specimens were identified. (karger.com)

It is considered to be a pre-malignancy, or carcinoma in situ, of the prostatic glands. (wikipedia.org)
Other patterns include arrangement of the histiocytes in cords or single cells that percolate between benign prostatic glands. (medscape.com)

As mentioned in both trials, there was a slight increase in high grade cancers. (rxwiki.com)
Although the 5-alpha reductase inhibitors were shown to prevent low-risk cancers better than placebo, two large clinical trials painted a disturbing link between both drugs and an increased incidence of higher-risk prostate cancers. (medpagetoday.com)
Despite the accumulating knowledge about the biology of PCa, the molecular machineries that differ between grade 3 and 4/5 cancers and mark a critical change from curable to lethal are largely unknown. (biomedcentral.com)
Similar to prior studies, we found an increased prevalence of high-grade prostate cancers diagnosed among men who were exposed 5-ARIs for the treatment of lower urinary tract symptoms related to BPH," lead investigator Lauren P. Wallner, PhD, MPH, of the University of Michigan in Ann Arbor, told Renal & Urology News . (renalandurologynews.com)

The residual prostatic gland in the center shows no anaplasia. (medscape.com)
Indeed, patients with high-grade inflammation had greater PSA, prostate volume, post-void residual and international prostate symptoms score, suggesting high-grade inflammation to correlate with benign prostatic obstruction. (jgerontology-geriatrics.com)

This image demonstrates a malignant spindle cell tumor replacing the prostatic stroma and invading vascular structures. (medscape.com)
Sarcomas arising in the prostatic stroma in children are virtually always rhabdomyosarcomas . (medscape.com)

Molecular analysis has shown that high grade PIN and prostate cancer share many genetic abnormalities. (wikipedia.org)
Only high grade PIN has been shown to be a risk factor for prostate cancer. (wikipedia.org)
Ask for feedback from people with prostate cancer and their partners or carers to identify the highest quality information resources. (nice.org.uk)
Clinicians should inform patients with intermediate-risk prostate cancer considering whole gland or focal ablation that there are a lack of high-quality data comparing ablation outcomes to radiation therapy, surgery, and active surveillance. (cancer.org)
Obesity is associated with decreased risk of low-grade and increased risk of high-grade prostate cancer. (aacrjournals.org)
Avoiding obesity may prevent the risk of developing high-grade prostate cancer. (aacrjournals.org)
Other topics include methods for diagnosing and monitoring prostate cancer, such as biomarker (e.g., serum PSA) testing, histopathological grading, and anatomical and molecular imaging techniques, as well as treatment options that are currently available and under development. (cshlpress.com)
2 Also, the PSA rate of rise (PSA velocity), although not a more specific marker, may have value in prostate cancer prognosis-because men with prostate cancer whose PSA level increased by more than 2.0 ng/mL during the year before their diagnosis showed a higher risk of death from prostate cancer. (lifeextension.com)
Note that when the percentage of free PSA is high (over 20% ), this means the risk of prostate cancer is low, whereas a low percentage of free PSA (under 11% indicates high risk). (lifeextension.com)
Disease recurrence and progression is a major issue in high risk non-muscle-invasive bladder cancer (NMIBC). (bcan.org)
The relationship between prostatic inflammation, benign prostatic hyperplasia and prostate cancer is controversial. (jgerontology-geriatrics.com)
The present study aimed to determine the relationship between grade and aggressiveness of prostatic inflammation and the risk of being diagnosed with prostate cancer. (jgerontology-geriatrics.com)
Prostatic inflammation seems to be associated with benign prostatic hyperplasia rather than prostate cancer, with benign prostatic obstruction being strictly linked to the degree of inflammation. (jgerontology-geriatrics.com)
WASHINGTON -- The FDA has issued a warning of an increased risk of high-grade prostate cancer with the 5-alpha reductase inhibitors finasteride (Proscar) and dutasteride (Avodart), currently approved to treat benign prostatic hypertrophy. (medpagetoday.com)
In contrast, each increase of 10% in the percent of the tumor classified as grade 4/5 at the time of surgery leads to a 10% increase in the failure rate as measured by detectable and rising serum prostate specific antigen (PSA), a biomarker of prostate cancer (PCa). (biomedcentral.com)
Therefore, understanding the molecular basis of the aggressive behavior of grade 4/5 cancer is of considerable clinical relevance. (biomedcentral.com)
The AUA recommends several management approaches to maintain high quality care for patients with Non-Muscle-Invasive Bladder Cancer (NMIBC). (auanet.org)
5α-reductase inhibitors may increase the risk of high-grade prostate cancer ( 5.3 , 6.1 ). (nih.gov)
Increased risk of high-grade prostate cancer among testicular cancer survivors. (endourology.ph)
Ali next measured prostate cancer progression in the transgenic HI-myc prostate cancer model after conditional beta-2 adrenergic receptor (Adrb2) deletion in stromal populations. (taconic.com)
Investigators have found that estrogen levels measured through blood tests may be predictive of which individuals at high risk of breast cancer will benefit from aromatase inhibitors, according to a recent study presented by Cuzick et al at the 2023 San Antonio Breast Cancer Symposium (Abstract. (ascopost.com)
Adstiladrin is currently in clinical development for the treatment of patients with high-grade non-muscle-invasive bladder cancer (NMIBC). (nihr.ac.uk)
High-grade NMIBC means the cancer is more likely to grow and spread quickly and also more likely to come back after initial treatment. (nihr.ac.uk)
This gene then stimulates the cells of the bladder to produce high quantities of a protein that the body uses to fight cancer. (nihr.ac.uk)
Previous studies have raised concerns that 5-alpha reductase inhibitors (5-ARIs) might increase the risk of high-grade prostate cancer (PCa), but new research confirms that 5-ARIs are associated with no greater risks compared with alpha-adrenergic blockers (ABs). (renalandurologynews.com)
5-Alpha Reductase Inhibitors and the Risk of Prostate Cancer Mortality in Men Treated for Benign Prostatic Hyperplasia. (renalandurologynews.com)
Patients with platinum-resistant, high-grade serous ovarian cancer are being enrolled in the UPLIFT segment of this study. (uci.edu)
Lycopene is used for high blood pressure, high cholesterol, cancer, and many other conditions, but there is no good scientific evidence to support most of these uses. (medlineplus.gov)
Prognostic and Predictive Value of Fibroblast Growth Factor Receptor Alterations in High-grade Non-muscle-invasive Bladder Cancer Treated with and Without Bacillus Calmette-Guérin Immunotherapy. (cdc.gov)
The immunohistochemical molecular risk classification in endometrial cancer: A pragmatic and high-reproducibility method. (cdc.gov)
Cervical cancer prevention in countries with the highest HIV prevalence: a review of policies. (who.int)

Common clinical presentations in men with prostatic stromal sarcoma are urinary retention, abnormal digital rectal examination (DRE), hematuria or hematospermia, and a palpable rectal mass. (medscape.com)
Bio-Techne, a leading supplier of high-quality and innovative tools for life science research, therapeutic manufacturing and clinical diagnostics and Carterra Inc., the world leader in high-throughput antibody screening and characterization, announced a clinical research collaboration studying COVID-19 variants. (biospace.com)
We also assessed the correlation between Irani G and A scores and clinical variables related to benign prostatic obstruction. (jgerontology-geriatrics.com)
Patients with low-risk ductal carcinoma in situ (DCIS) who skipped adjuvant radiotherapy after breast-conserving surgery had comparable 5-year outcomes to those with high-risk DCIS who received adjuvant radiotherapy, according to results from the E4112 clinical trial presented at the 2023 San. (ascopost.com)
A strong recommendation supported by high to moderate quality evidence suggesting net clinical benefits or harms. (cdc.gov)

The diagnosis of prostatic SCC in urine has to date not been described. (karger.com)
Understanding pathways of oncogenesis that drive high-grade meningiomas is important to improve current diagnosis and treatment. (nature.com)

The treatment of high risk NMIBC includes a transurethral resection of the tumour(s), which is followed by an adjuvant instillation therapy, aiming to reduce the risk of recurrence and progression. (bcan.org)
The aim of the study is to compare effectiveness and tolerability of the two treatment regimens in preventing recurrence and progression of high risk NMIBC. (bcan.org)
The remaining trials were either underpowered, at high or unclear risk of bias, inadequately reported, of short duration or measured surrogate outcomes of unproven relationship to mortality or disease progression, which precluded any benefits reported being reliable. (springer.com)

To map the mechanisms of aggressiveness we aimed to investigate changes in protein phosphorylation across WHO grades of human meningiomas. (nature.com)

The current study is a prospective, open label, phase III randomized study allocating patients with high risk NMIBC to receive adjuvant instillation therapy either as traditional BCG treatment, or sequential BCG- and EMDA-MMC treatment. (bcan.org)
For patients with high-risk NMIBC, high-grade T1 and CIS patients receiving induction therapy, they should be prioritized for use of full-strength BCG. (auanet.org)
If not available, these patients and other high-risk patients may be given a reduced 1/2 to 1/3 dose, if feasible. (auanet.org)
For health care providers, this broad spectrum of cultural diversity in its patients introduces higher incidences of certain conditions, while also posing challenges relating to care and communications. (minoritynurse.com)
Safety and feasibility of thullium laser transurethral resection of prostate for the treatment of benign prostatic enlargement in overweight patients. (endourology.ph)
We aimed to determine safety and feasibility of thulium laser transurethral vapoenucleation of prostate (ThuVEP) for treatment of obese patients affected by benign prostatic hyperplasia (BPH). (endourology.ph)
If licensed, Adstiladrin will offer an advanced (gene) therapy treatment option for patients with high-grade NMIBC that are BCG unresponsive. (nihr.ac.uk)
Minimize urinary catheter use and duration of use in all patients, particularly those at higher risk for CAUTI or mortality from catheterization such as women, the elderly, and patients with impaired immunity. (cdc.gov)

The current study compares two adjuvant instillation therapies in the treatment of high risk NMIBC. (bcan.org)
Intravesical bacillus Calmette-Guérin (BCG) treatment is been the most effective single agent against NMIBC, and it is referred to as the gold standard in the treatment of high risk disease. (bcan.org)
MMC provides a better tolerated side effect profile, but is less effective against high risk NMIBC than BCG, when MMC is used as a single agent. (bcan.org)

Tumor cells usually retain prostatic epithelial antigenicity, and immunohistochemical stains can be used for their identification. (medscape.com)
RTqPCR analysis also validated the immunohistochemical data and gene expression, which both indicated low to moderate expression in prostatic tissues. (bvsalud.org)

Benign Prostatic Hyperplasia (BPH) Benign prostatic hyperplasia (BPH) is nonmalignant adenomatous overgrowth of the periurethral prostate gland. (msdmanuals.com)

In the present work, we introduce a combination of mass spectrometry-based phosphoproteomics and peptide array kinomics to profile atypical and anaplastic (high-grade) meningiomas. (nature.com)

This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called H3 K27M mutation. (ucbraid.org)

Prostatic stromal sarcoma is a rare malignant neoplasm of mesenchymal origin that is believed to originate from specialized stromal prostatic cells. (medscape.com)

These trials were also assessed as having low risk of bias and high methodological quality (as were seven other trials with no evidence of benefit). (springer.com)
Glioma is considered high risk (or high-grade) when it is growing and spreading quickly. (ucbraid.org)

The higher rate of detection of XMRV and other microbes in immunosuppressed individuals is not unexpected. (virology.ws)

A December 2019 PubMed search using the terms "prostate xanthoma," "prostatic xanthoma," and "xanthoma of the prostate" returned only a maximum of 16 results, the majority of which were peripherally related. (medscape.com)

Radiation therapy uses high-energy x-rays to kill tumor cells. (ucbraid.org)

Grade PIN all malignancy. (cancer.org)

Anatomy1

Diseases10

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Disciplines and Occupations1

Intraepithelial20

Adenocarcinoma10

Tumors11

Gleason13

Features of prostatic1

Biopsies4

Diagnosed with benign1

Biopsy9

Normal prostatic3

Epithelial cells1

Differentiation3

Lesions2

Incidence of high grade1

Tissue4

Metastatic2

Neuroendocrine1

Specimens2

Glands2

Cancers4

Residual2

Stroma2

Cancer31

Clinical5

Diagnosis2

Progression3

Aggressiveness1

Patients8

NMIBC3

Immunohistochemical2

Gland1

Atypical1

Genetic1

Malignant1

Risk2

Detection1

20191

Tumor cells1

Malignancy1