High grade endometrioid carcinomas. Medical search. Frequent questions

Participant must have histologically documented, platinum resistant, advanced (metastatic and/or unresectable) high-grade serous/endometrioid ovarian, primary peritoneal, or fallopian tube cancer. (uclahealth.org)
These cells ultimately undergo additional genetic changes to emerge as primary peritoneal high-grade serous cancer years later. (ascopost.com)
One report with longer follow-up has estimated the 5- and 10-year risks of a follow-up "primary peritoneal" high-grade serous cancer to be higher, at 10% and 27%, respectively. (ascopost.com)
To be eligible for enrollment, patients had to have a histologically confirmed diagnosis of epithelial ovarian, fallopian tube, or primary peritoneal carcinoma with an epithelial cell type of either high-grade serous adenocarcinoma, endometrioid adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, or mixed epithelial carcinoma. (onclive.com)
I. Determine whether treatment with ruxolitinib phosphate (ruxolitinib) in combination with conventional neoadjuvant and post-surgical chemotherapy is safe and tolerable in the primary therapy for epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. (uchicagomedicine.org)
Demonstrate whether treatment with ruxolitinib in combination with conventional neoadjuvant and post-surgical chemotherapy results in a prolonged progression-free survival when compared to chemotherapy alone, in primary therapy for epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. (uchicagomedicine.org)
Demonstrate whether treatment with ruxolitinib in combination with conventional chemotherapy results in an improvement in overall survival in primary management of epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. (uchicagomedicine.org)
It appears that the vast majority of what seem to be primary epithelial ovarian and primary peritoneal carcinomas is, in fact, secondary from the fimbria, the most distal part of the fallopian tube. (biomedcentral.com)

The diagnosis of endometrioid adenocarcinoma can also be made if there is extensive papillary pattern or infiltrative glands with desmoplastic response . (webpathology.com)
This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status. (uclahealth.org)
Endometrial cancer is usually endometrioid adenocarcinoma. (msdmanuals.com)
Загальні джерела літератури Endometrial cancer is usually endometrioid adenocarcinoma. (msdmanuals.com)
Endometrioid adenocarcinoma (grades 1 and 2) is the most common histology. (msdmanuals.com)
In this cross-sectional study, we performed HER2/neu immunohistochemical (IHC) staining in 37 high-grade EC cases with histological diagnostic categories of PSC (n=23), clear cell carcinoma (CCC) (n=9), and carcinosarcoma with high-grade carcinomatous component (PSC, CCC, grade 3 endometrioid carcinoma, or unclassified high-grade adenocarcinoma) (n=5). (iranpath.org)
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes. (nih.gov)
Low grade endometrial endometrioid adenocarcinoma: A review and update with emphasis on morphologic variants, mimics, immunohistochemical and molecular features. (nih.gov)
Serous endometrial intraepithelial carcinoma (serous EIC) is the in situ correlate of invasive papillary serous-type (type 2) endometrial adenocarcinoma. (surgpath4u.com)

The category of ovarian borderline tumor or tumor of low-malignant potential, which historically had been considered in the context of ovarian cancer, is now generally considered a nonmalignant entity, although it has a postulated relationship with the development of some histological subtypes of low-grade ovarian carcinomas. (uofmhealth.org)
The association of endometriosis with ovarian cancer is stronger for nonserous subtypes, especially clear cell carcinoma and endometrioid subtypes. (uofmhealth.org)
A number of subtypes exist, including high-grade and low-grade serous carcinomas, clear cell, endometrioid carcinoma and mucinous carcinoma. (johnshopkins.edu)
Recently, however, differences in epidemiology, tumor biology, tumor marker expression and treatment responses have been elucidated among the histologic subtypes, with a clear distinction emerging between the Type I, lower grade tumors and Type 2, higher grade epithelial malignancies. (johnshopkins.edu)
Indeed, with the exception of high-grade serous carcinoma, most other epithelial subtypes exhibit some degree of chemotherapy resistance, rendering treatment problematic, especially in the setting of advanced disease. (johnshopkins.edu)
According to molecular, histologic, and clinical factors, epithelial ovarian cancer (EOC) can be divided into five main subtypes: ovarian clear cell carcinoma (OCCC), endometrioid ovarian cancer (EnOC), mucinous, low-grade serous ovarian carcinoma (LGSOC), and high-grade serous ovarian carcinoma (HGSOC). (mrnabased-drug.com)

The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along with fallopian tube and peritoneal cancers because of shared clinical features. (merckmanuals.com)
The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along. (merckmanuals.com)
Type II tumors are usually high-grade and include grade 3 endometrioid carcinomas and tumors with nonendometrioid histology (eg, serous, clear cell, mixed cell, undifferentiated, carcinosarcoma). (msdmanuals.com)
Histology, grade, stage, and age were prospectively reported to the regional clinical and national cancer registers. (bmj.com)
High-risk features such as stage IC, higher grade, or clear-cell histology should prompt consideration of adjuvant chemotherapy. (medscape.com)
Preoperative endometrial sampling was performed by hysteroscopic directed biopsy, aspiration biopsy, or dilatation and curettage (D&C). Biopsy results (histology and grading) were compared with the pathologic findings of the hysterectomy specimens. (medscape.com)
Patients with endometrioid cancer and grade 1 or 2 histology localized to the uterus may undergo hysterectomy only and require no extensive dissection of lymph nodes. (medscape.com)
Therefore, the advanced knowledge of histology and grading could determine the extent of surgery. (medscape.com)

They are characterized by a high frequency of mutations in TP53 , a tumor suppressor gene, and a high proliferative index. (hindawi.com)
Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene. (biomedcentral.com)
However, it is not known whether the precursor cells from the serous tubal intraepithelial carcinoma implant on the peritoneal surface or float freely in the peritoneal fluid prior to undergoing a pivotal genomic change, resulting in tumor development. (ascopost.com)
If the cancer looks similar to healthy tissue and has different cell groupings, it is called "well differentiated" or a "low-grade tumor. (cancer.net)
If the cancerous tissue looks very different from healthy tissue, it is called "poorly differentiated" or a "high-grade tumor. (cancer.net)
Compared to endometrial endometrioid carcinoma, MLA showed larger tumor size, deeper myometrial invasion, increasingly advanced-stage disease, and more frequent lymphovascular space invasion. (iiarjournals.org)
An endometrioid tumor exhibiting squamous differentiation. (nih.gov)

In general, the lower the tumor's grade, the better the prognosis. (cancer.net)
Fig. 1: Complete gross tumour resection is associated with improved prognosis in advanced stage high-grade serous ovarian cancer patients. (nature.com)
TNBC carry the worst prognosis mainly because of their high proliferation index and the absence of efficient targeted therapies due to their molecular heterogeneity, even. (researchgate.net)
This type of EC mainly occurs in background of endometrial hyperplasia and it usually responds to hormone therapy, whereas type II EC is not related to hyperestrogenic state and usually occurs in older age groups in the setting of atrophic endometrium or sometimes endometrial polyp, and typically presents as high-grade tumors with poor prognosis (1-6). (iranpath.org)
Due to differed biological characteristics, very aggressive behavior, high recurrence rate, poor prognosis, as well as difficulty in histopathological diagnosis of such tumors, the immunohistochemical (IHC) assessment may be useful (3, 4, 8, 9). (iranpath.org)
The larger expectation for improved prognosis in ovarian carcinoma is related to the use of the new biological agents. (biomedcentral.com)
Uterine serous carcinoma (USC) represents a rare and aggressive histologic subtype of endometrial cancer, associated with a poor prognosis. (gcigtrials.org)
Type 2 presents as a high-grade aggressive lesion, with a significantly poorer prognosis than type 1 carcinomas. (surgpath4u.com)

These are for the most part low-grade tumors that are characterized by a high frequency of mutations of KRAS , BRAF, ERBB2, CTNNB1 (the gene encoding beta catenin), and PIK3CA , low proliferation, and a 5-year survival of approximately 55% [ 2 ]. (hindawi.com)
Although the National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines ® ) indicate that either of these screening methods can be used in high-risk mutations carriers, there are currently no effective screening tests that have altered survival in screened populations (high risk or other). (ascopost.com)
Although ovarian cancer affects about 1 in 70 women, certain mutations are associated with increased risk, especially for high-grade serous ovarian cancer. (ascopost.com)
Risk factors for ovarian cancer include a family history of breast and/or ovarian cancer and inheritance of deleterious mutations in BRCA1, BRCA2, and selected other high-penetrance genes. (uofmhealth.org)
10 ] Further, among carriers of deleterious mutations in BRCA1 or BRCA2, increasing evidence suggests that many tumors previously classified as ovarian high-grade serous carcinoma may develop from malignant cells arising in the tubal epithelium (serous tubal intraepithelial carcinoma [STIC]), although these tumors continue to be referred to as ovarian cancers in most writings. (uofmhealth.org)
It is hypothesized that high-grade serous carcinomas among individuals who are not carriers of mutations in BRCA1 or BRCA2 may also develop in the fallopian tube, but few STICs have been identified among these women in the absence of concurrent high-stage disease. (uofmhealth.org)
Incidence of these mutations is higher in people with Ashkenazi Jewish ancestry than in the general population. (merckmanuals.com)
Type II tumors which show greater morphologic and molecular homogeneity are genetically unstable and have a very high frequency of TP53 mutations. (biomedcentral.com)
Both USC and approximately 25% of high-grade endometrioid tumors represent extensive copy number alterations, few DNA methylation changes, low estrogen and progesterone levels, and frequent P53 mutations. (gcigtrials.org)

Several investigations have demonstrated HER2/neu expression and amplification in type II EC, especially papillary serous carcinoma (PSC). (iranpath.org)
High-grade ECs are composed of grade 3 endometrioid endometrial carcinoma (EEC3) and mainly non-endometrioid endometrial carcinomas including papillary serous carcinoma (PSC), clear cell carcinoma (CCC), undifferentiated carcinomas, and malignant mixed mullerian tumors (MMMT) (7). (iranpath.org)
Serous EIC is characterized by marked nuclear atypia, similar to that found in invasive papillary serous endometrial carcinoma. (surgpath4u.com)
An enlarged ovary with a papillary serous carcinoma on the surface. (medscape.com)

Based on the model of development of serous tubal intraepithelial carcinomas, there are several theories or pathways by which serous cancers metastasize. (ascopost.com)
Doctors also describe ovarian/fallopian tube cancers by their grade. (cancer.net)
They are very different from high-grade cancers and represent about 10% to 15% of epithelial ovarian/fallopian tube neoplasms, which are abnormal growths of cells. (cancer.net)
Epithelial carcinoma makes up 85% to 90% of ovarian/fallopian tube cancers. (cancer.net)
Endometrioid adenocarcinomas account for about 75 to 80% of endometrial cancers. (msdmanuals.com)
Amplification and overexpression of HER2/neu have been shown to have a significant role in the pathogenesis of cancers in various organs, including carcinomas of breast, ovary, stomach, and esophagus (10). (iranpath.org)
We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). (biomedcentral.com)
[ 1 ] Most endometrial cancers are of endometrioid type and are associated with exposure to unopposed estrogen . (medscape.com)
Typically, these cancers are well differentiated and are diagnosed at an early stage when treatments can result in high survival rates. (medscape.com)

Reported rates of mucinous carcinoma diagnoses have declined dramatically, but expert pathology reviews suggest that this reflects increased recognition of metastases from occult gastrointestinal primary tumors to the ovary, rather than a true decline in rates of ovarian primary tumors. (uofmhealth.org)

Type II tumors include high-grade serous carcinoma, malignant mixed mesodermal tumors, and undifferentiated carcinomas. (hindawi.com)
Type I tumors include low-grade serous, low-grade endometrioid, clear cell and mucinous carcinomas and type II include high-grade serous, high-grade endometrioid and undifferentiated carcinomas. (biomedcentral.com)

Malignant mixed mesodermal tumors (carcinosarcomas) are included in the type II category because their epithelial components are identical to the pure type II carcinomas. (biomedcentral.com)

The intraepithelial carcinomas have been referred to as serous intraepithelial carcinomas (STICs) but our own findings (unpublished data) and recent reports have drawn attention to a spectrum of changes that fall short of STICs that we have designated serous tubal intraepithelial lesions (STILs). (hindawi.com)
Early investigators reported on serous tubal intraepithelial carcinomas, which developed in the distal fallopian tubes. (ascopost.com)
Findings revealed that 59% to 71% were associated with serous tubal intraepithelial carcinomas after careful inspection of the fallopian tubes. (ascopost.com)

Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. (nih.gov)
An agreement was found in 75% of preoperative grade 1 diagnosis (95% CI, 69%-81%) and in 75% (95% CI, 65%-86%) of preoperative grade 3 diagnosis. (medscape.com)
Performing a hysterectomy and salpingo- oophorectomy alone, however, may prove to be suboptimal if the final diagnosis indicates grade 3 disease. (medscape.com)
if the final diagnosis is stage I, grade 1 or 2 disease, she may expose herself to unnecessary postoperative morbidity ( lymphedema ) due to the extensive surgery. (medscape.com)

Glandular involvement by serous intraepithelial carcinoma. (surgpath4u.com)

The first (Type I) pathway leads to borderline tumors, which can develop into low-grade serous, mucinous, endometrioid, and clear cell carcinomas. (hindawi.com)
The carcinoma component is usually high-grade endometrioid, serous, clear cell, or undifferentiated carcinoma. (medscape.com)

Gender-specific counselling of patients with upper tract urothelial carcinoma and Lynch syndrome. (cdc.gov)

Although there has been some progress in improving the 5-year survival of those with high-grade serous ovarian cancer with poly (ADP-ribose) polymerase inhibitors, most patients' disease is frequently found at an advanced stage, making cure rare. (ascopost.com)
Patients and Methods: We reviewed 237 endometrial carcinoma cases and investigated the clinicopathological and molecular characteristics of uterine MLA. (iiarjournals.org)
In view of the ever-fewer numbers of high-care/intensive care beds and the introduction of fast-track treatment concepts, it is increasingly being suggested that these patients should be cared for postoperatively in 24-h Post Anesthesia Care Units (PACU24). (bvsalud.org)
This ancillary test is supportive in follow-up of patients with high-grade ECs. (iranpath.org)
Conclusion We can conclude that S-phase fraction, DNA ploidy, and p53 overexpression did not improve identification of high-risk patients by stage, grade, and age in stage I-III endometrioid endometrial carcinoma. (bmj.com)
Although overall initial response rates are high, resistance to chemotherapy often develops, and only 10-15% of EOC patients achieve and maintain complete response to therapy [ 1 ]. (biomedcentral.com)
This small percentage includes patients with stage IA or IB (grade 1) serous, mucinous, endometrioid, and Brenner tumors. (medscape.com)
All patients with stage II or higher cancer should be considered for front-line chemotherapy based on burden of disease and ability to achieve optimal primary resection. (medscape.com)
Are High Levels of Microsatellite Instability and Microsatellite Stability Identical in DNA Mismatch Repair-Deficient Colorectal Cancer Patients? (cdc.gov)
Information needs on nutrition in link to cancer prevention among cancer patients, high-risk individuals and general population - A national cross-sectional study. (cdc.gov)
Early-onset grade 2-3 diffuse gliomas and schwannomas increase the risk of central nervous system tumors among the patients' relatives. (cdc.gov)

HGSC is much more invasive than LGSC with a higher fatality rate - although it is more sensitive to platinum-based chemotherapy, possibly due to its rapid growth rate. (wikipedia.org)
Consider chemotherapy for stages 1A and 1B grades 2 and 3, and stage 1C. (medscape.com)
The combination of radiation and chemotherapy appears to be associated with the highest survival rates. (gcigtrials.org)
This is because of a lack of effective detection strategies in the early stage and high relapse rate after treatment (such as cytoreductive surgery and chemotherapy). (mrnabased-drug.com)

High-grade serous carcinoma (HGSC) is a type of tumour that arises from the serous epithelial layer in the abdominopelvic cavity and is mainly found in the ovary. (wikipedia.org)
HGSC is distinct from low-grade serous carcinoma (LGSC) which arises from ovarian tissue, is less aggressive and is present in stage I ovarian cancer where tumours are localised to the ovary. (wikipedia.org)

Ovulation is accepted as the cause of ovarian cortical inclusion cysts, the precursor lesions of serous carcinomas, and lower numbers of these cortical inclusion cysts are thought to be the mechanism by which reducing lifetime ovulations can lower the risk of developing HGSC. (wikipedia.org)
The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. (hindawi.com)
A lack of effective screening tools for early detection of ovarian cancer in high-risk and general populations has led to increased interest in the identification of precursor lesions defined by both morphological and molecular changes that could be the target of not only early detection but prevention efforts. (hindawi.com)
Although the pathway of oncogenesis has not yet been clearly established for type 2 endometrial carcinomas, 'precursor' lesions have been identified that exhibit the cytogenetic aberrations characteristic of type 2 carcinomas such as p53 mutation, increase in Ki-67 and LOH at multiple chromosomal loci such as 17p and 1p. (surgpath4u.com)
These precursor lesions include serous endometrial intraepithelial carcinoma and serous endometrial gland dysplasia (serous EmGD), which exhibits a morphology and IHC pattern that lies at the midpoint between normal glands and serous EIC. (surgpath4u.com)

High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations. (nih.gov)
However, as explained below, recent morphologic findings and molecular analyses have demonstrated that each morphologic subtype of ovarian carcinoma might be derived from a Müllerian-type epithelium. (biomedcentral.com)

Uterine serous carcinoma shares molecular characteristics with ovarian serous and basal-like breast carcinomas. (gcigtrials.org)

Maximal effort cytoreductive surgery is associated with improved outcomes in advanced high-grade serous ovarian cancer (HGSOC). (nature.com)

Both epithelial and mesenchymal components of carcinosarcoma show high-grade malignant cells. (medscape.com)
Carcinosarcoma with both a high-grade carcinomatous and sarcomatous component. (medscape.com)
A higher power view of carcinosarcoma. (medscape.com)
Diverse growth patterns make it difficult to distinguish uterine MLA from more commonly encountered histological types of endometrial carcinoma, including endometrial endometrioid carcinoma (EC) ( 10 ), serous carcinoma (SC), and carcinosarcoma (CS). (iiarjournals.org)

Among these, high-grade serous ovarian carcinoma (HGSOC) represents the most frequent type, comprising about 70% of all advanced EOCs [ 4 ]. (biomedcentral.com)

A tubal origin for high-grade serous ovarian cancer is supported by gene expression profiles of OSC that reveal that they are more similar to normal müllerian epithelium than the ovarian surface epithelium [ 7 ]. (hindawi.com)
In a second pathway, the serous tubal intraepithelial carcinoma metastasizes directly into the peritoneal cavity, seeding it and resulting in early dissemination of metastases. (ascopost.com)
The discovery of a serous tubal intraepithelial carcinoma imposes a later risk of high-grade serous cancer. (ascopost.com)
Serous carcinomas are thought to be derived from the fallopian tubes through foci of endosalpingiosis, which are inclusion cysts from the tubal epithelium at the ovarian and peritoneal surface. (biomedcentral.com)

There is some difficult in the concept of 'intraepithelial' in type 2 endometrial carcinoma, as this lesion is notorious for extensive metastasis without evidence of myometrial invasion. (surgpath4u.com)

This study found a moderate agreement on histologic grading between biopsy and final pathology results. (medscape.com)

MLA had the lowest progression-free survival rate among different histological types of endometrial carcinoma. (iiarjournals.org)
This type of cancer is most likely to show up in young women ranging in age from 16 to 29 and has a high survival rate. (thefashionablehousewife.com)
When this cancer is caught early, survival rates are very high. (thefashionablehousewife.com)
Objectives To assess the effects on relative survival of established and new prognostic factors in stage I-III grade 1-3 endometrioid endometrial carcinoma and in the subgroup of stage I grade 1-2. (bmj.com)
Results Based on univariable statistical analyses we found that 5-year relative survival was significantly associated with S-phase fraction, DNA ploidy, p53, stage, grade, and age. (bmj.com)
In a subgroup analysis of stage I grade 1-2, aneuploidy identified a subgroup with impaired 5-year relative survival. (bmj.com)
In stage I, aneuploidy and grade 2 predicted lower relative survival rates than other variables. (bmj.com)
However, recent landmark phase III randomized controlled trials (RCTs) proved survival benefit from maintenance therapy with poly(ADP-ribose) polymerase inhibitors (PARPis), both olaparib (OLA) and niraparib (NIRA), which significantly improved the progression-free survival (PFS) in PSR EOC, especially for BRCA mutated, high-grade serous or endometrioid carcinoma [ 7 - 9 ]. (e-crt.org)

Gynecologic Cancer InterGroup (GCIG) consensus review for uterine serous carcinoma. (gcigtrials.org)
Uterine serous carcinoma is a unique and biologically aggressive subtype of endometrial cancer and should be studied as a distinct entity. (gcigtrials.org)

Introduction: Hepatitis B virus (HBV) is a major public health problem affecting 400 million people worldwide, and is a common cause of chronic liver failure (cirrhosis) and hepatocellular carcinoma. (bvsalud.org)

Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). (samatashkhis.com)

Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies). (medscape.com)

The finding of occult invasive and intraepithelial fallopian tube carcinomas in prophylactically removed specimens from asymptomatic high-risk BRCA 1/2-mutation carriers supports the notion of an origin for OSC in the fallopian tube. (hindawi.com)
It is estimated that 60% of sporadic ovarian carcinomas and the majority of those diagnosed in BRCA1 mutation carriers are of the high-grade serous type [ 4 , 5 ]. (hindawi.com)

In contrast, type 2 serous endometrial carcinoma is estrogen-independent, associated with atrophic endometrium and does not follow the hyperplasia-dysplasia-carcinoma sequence. (surgpath4u.com)

Ovarian carcinomas consist of several histopathological types, with high-grade serous being both the most common and most lethal. (uofmhealth.org)
This study assessed HER2/neu expression in high-grade EC as well as its association with other clinical and histopathological prognostic factors. (iranpath.org)

Rarely, mucinous differentiation or squamous cell carcinoma is seen. (medscape.com)

Indeed, it has been postulated that the possible mechanisms by which repetitive ovulation could influence the development of ovarian carcinomas include an increased formation of inclusion cysts, repeated bathing of the surface epithelium by an estrogen-rich follicular fluid, excessive production of growth factors or cytokines, and an aberration of the repetitive repair process that follows the trauma to the surface epithelium as a consequence of ovulation. (biomedcentral.com)

TP53-/- mice (in which the TP53 gene has been deleted) do not develop ovarian carcinomas. (wikipedia.org)

Ovarian cancer is a rare disease, with carcinomas comprising approximately 90% of tumors and germ cell and stromal tumors accounting for the remainder. (uofmhealth.org)
An estimated 16% of carcinosarcomas have a low-grade stromal component. (medscape.com)
Carcinomas are characterized by cell proliferation, nuclear atypia, and stromal invasion. (biomedcentral.com)

Anatomy1

Diseases24

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes3

Disciplines and Occupations1

Health Care1

Primary peritoneal8

Adenocarcinoma9

Subtypes6

Histology8

Tumor7

Prognosis8

Mutations9

Papillary4

Cancers9

Mucinous carcinoma1

Tumors include2

Mesodermal tumors1

Intraepithelial carcinomas3

Diagnosis4

Serous intraepithelial1

Clear2

Urothelial Carcinoma1

Patients11

Chemotherapy4

Ovary2

Precursor lesions5

Morphologic2

Ovarian serous1

Advanced high-grade serous1

Carcinosarcoma4

HGSOC1

Tubal4

Myometrial invasion1

Pathology1

Survival8

Uterine2

Hepatocellular1

Adenocarcinomas1

Lesions include1

Mutation2

Endometrium1

Histopathological2

Squamous1

Epithelium1

TP531

Stromal3