High doses. Medical search. Frequent questions

This page provides information on the high-dose seasonal flu vaccine, Fluzone High-Dose Quadrivalent . (cdc.gov)
What is Fluzone High-Dose Quadrivalent vaccine? (cdc.gov)
Fluzone High-Dose Quadrivalent vaccine contains four times the antigen as standard dose flu vaccines. (cdc.gov)
It is manufactured by Sanofi Pasteur Inc. Fluzone High-Dose Quadrivalent is a four-component flu vaccine. (cdc.gov)
In the United States, Fluzone High-Dose Quadrivalent vaccine is approved only for people 65 years and older. (cdc.gov)
Fluzone High-Dose Quadrivalent is not approved for people younger than 65 years or for people of any age with a history of severe allergic reaction to any influenza vaccine or to vaccine components other than eggs. (cdc.gov)
These are Fluzone High-Dose Quadrivalent vaccine , Flublok Quadrivalent recombinant flu vaccine and Fluad Quadrivalent adjuvanted flu vaccine . (cdc.gov)
Fluzone High-Dose Quadrivalent contains four times the antigen, the part of the vaccine that helps your body build up protection against flu viruses, than Fluzone Quadrivalent and other standard-dose inactivated flu vaccines. (cdc.gov)
The higher dose of antigen in the vaccine is intended to give people 65 years and older a better immune response to vaccination, and therefore, better protection against flu. (cdc.gov)
Data from immunogenicity studies comparing Fluzone (a trivalent standard dose vaccine) to Fluzone High-Dose (a previously available trivalent high-dose vaccine) among people 65 years and older indicated that a stronger immune response (i.e., higher antibody levels) occurred after vaccination with Fluzone High-Dose. (cdc.gov)
A randomized efficacy study published in the New England Journal of Medicine indicated that the trivalent high-dose vaccine was 24% more effective in preventing flu in adults 65 years and older relative to a standard-dose vaccine. (cdc.gov)
Does Fluzone High-Dose Quadrivalent offer better protection than the adjuvanted flu vaccine? (cdc.gov)
Observational studies comparing each of these vaccines suggest that each is potentially more effective in preventing influenza-associated hospitalizations (with the most data being available for the high-dose vaccine). (cdc.gov)
Should I Get the High-Dose Flu Vaccine? (wral.com)
Q. If the high-dose flu vaccine is more potent, why do I have to wait until I'm 65 to get it? (wral.com)
A. People younger than 65 can receive the high-dose vaccine, but there are caveats. (wral.com)
Because older people have a weaker immune response to influenza vaccine than younger people do and are at increased risk for hospitalization and death from flu, the Food and Drug Administration approved a high-dose flu vaccine, called Fluzone High-Dose, in 2009, but only for those 65 and older. (wral.com)
Fluzone High-Dose contains four times as much immune-stimulating antigen as the standard-dose vaccine does. (wral.com)
In a rigorous post-licensure safety and efficacy study mandated by the FDA, Fluzone High-Dose was about 24 percent more effective than standard-dose vaccine in preventing influenza among older recipients. (wral.com)
A few small trials have studied the effect of high-dose vaccine in younger patients. (wral.com)
In a study of 300 adults who were 50 to 64 years old, Fluzone High-Dose produced higher levels of antibodies than the standard-dose vaccine did. (wral.com)
Since the evidence suggests that younger people would also benefit from the high-dose vaccine, why is it restricted to older people? (wral.com)
Methods: A cohort study of 805,741 residents in Skåne county, Southern Sweden, aged 18-64 years, of whom 26,587 received at least one dose of the BNT162b2 vaccine. (lu.se)
Results: The estimated vaccine effectiveness in preventing infection ≥7 days after second dose was 86% (95% CI 72-94%) but only 42% (95% CI 14-63%) ≥14 days after a single dose. (lu.se)
Fluzone High-Dose Quadrivalent Southern Hemisphere is a vaccine indicated for active immunization for the prevention of influenza disease caused by influenza A subtype viruses and type B viruses contained in the vaccine. (cdc.gov)
A high-dose formulation outperformed a standard influenza vaccine among older people, the CDC's Advisory Committee on Immunization Practices was told. (medpagetoday.com)
A high-dose formulation outperformed a standard influenza vaccine among older people, a CDC committee was told. (medpagetoday.com)
The efficacy study, a post-licensing commitment for the high-dose formulation, "proves once and for all" that the higher dose protects seniors better than the standard vaccine, said David Greenberg, MD , vice president, U.S. Scientific and Medical Affairs for Sanofi Pasteur. (medpagetoday.com)
An NHS Trust has apologised after one of its clinics accidentally gave children a higher dose of the Covid vaccine. (itv.com)
World Health Organization (WHO) vaccine advisers met last week to discuss and weigh in on several vaccine issues, including a recommendation that people who are moderately or severely immunocompromised receive a third COVID-19 vaccine dose. (umn.edu)
The group, called the Strategic Advisory Group of Experts (SAGE) , said people in the immunocompromised groups should be offered an additional dose in the vaccine series, since they are less likely to respond adequately to vaccination with the standard series and are at high risk for severe disease. (umn.edu)
WHO leaders have previously urged countries to postpone broader use of booster doses to free up more vaccine for countries that had much less access to supplies. (umn.edu)
It added that a third dose of a different vaccine could be considered, based on vaccine supply and access. (umn.edu)
In a large-scale trial, Sanofi's Fluzone High-Dose vaccine demonstrated efficacy in preventing influenza specifically in adults aged 65 years or older. (pharmacytimes.com)
Fluzone High-Dose vaccine is the only influenza vaccine in the (United States) that is designed specifically to address the age-related decline of the immune system in older adults," said David Greenberg, MD, Vice President of Scientific & Medical Affairs and Chief Medical Officer at Sanofi Pasteur US. (pharmacytimes.com)
We are thrilled that the results of this trial have shown that Fluzone High-Dose vaccine is significantly more effective than standard-dose Fluzone vaccine in providing protection against influenza in the 65 and over population. (pharmacytimes.com)
At the conclusion of the study, Fluzone High-Dose was shown to be 24.2% more effective in keeping influenza at bay than the standard-dose vaccine. (pharmacytimes.com)
Considering the burden of influenza in older adults, it is encouraging to see that this trial demonstrated the ability of Fluzone High-Dose vaccine to provide better protection in this high-risk population," said Keipp Talbot, MD, a coordinating investigator of the trial. (pharmacytimes.com)
A new high-dose vaccine against the flu shows evidence of significantly enhanced efficacy for older people. (acsh.org)
Symptomatic COVID-19 course and outcomes after three mRNA vaccine doses in multiple sclerosis patients treated with high-efficacy DMTs. (bvsalud.org)
Little is known about COVID-19 course and outcomes after a third booster dose of mRNA vaccine against SARS-CoV-2 ( mRNA -Vax) in patients with multiple sclerosis (pwMS) treated with ocrelizumab (OCR) and fingolimod (FNG), which showed a weakened immune response to mRNA -vax. (bvsalud.org)

There are currently no randomized studies comparing the efficacy of high-dose and adjuvanted influenza vaccines against laboratory-confirmed influenza. (cdc.gov)
Of note, there are not yet studies comparing the efficacy or effectiveness of the currently available quadrivalent formulations of the high-dose and adjuvanted inactivated vaccines with standard-dose unadjuvanted vaccines. (cdc.gov)
The idea behind this approach is that when using single-agent chemotherapy, the doctor can easily escalate the dose of the drug to the maximum tolerable dose by the patient, avoiding additive hematological toxicity from chemotherapeutic combinations, and thus improving efficacy. (wikipedia.org)
AALL0232 was a phase 3 randomized trial for patients 1 to 30 years of age with newly diagnosed National Cancer Institute high-risk B-precursor ALL that evaluated the safety and efficacy of interventions targeted to enhance CNS control. (medscape.com)
In a large randomized trial, over two flu seasons, Fluzone High-Dose had a relative efficacy of 24.2% compared with standard Fluzone, the Advisory Committee on Immunization Practices (ACIP) was told. (medpagetoday.com)
During recent years, numerous trials to analyze the efficacy and tolerability of high doses of statins have been published. (nih.gov)
Following the trial, the full results were submitted to the FDA to modify the prescribing instructions for Fluzone High-Dose to reflect the vaccine's improved efficacy compared to the standard-dose version. (pharmacytimes.com)
Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial. (medindia.net)
These findings build upon accumulating evidence of the safety and efficacy of higher doses of buprenorphine. (medicalxpress.com)

Cadmium Toxicity: What Health Effects Are Associated With Acute High-Dose Cadmium Exposure? (cdc.gov)
Dr. Larsen noted that adverse events were closely monitored, and high-dose methotrexate appeared to be safe with no increase in toxicity. (medscape.com)
We studied the feasibility and toxicity of escalating the doses of fractionated TBI above our previous prescription of 13.5 Gy. (nature.com)
The aim of this study is to evaluate the dosemetric parameters and acute toxicity of dose-escalated whole pelvis (WP) Intensity Modulated Radiation Therapy (IMRT) and volumetric modulated arc therapy (VMAT) prostate boost following neoadjuvant and concomitant with androgen deprivation therapy in high-risk prostate cancer patients. (scirp.org)
Dose escalation in two phases utilizing Simultaneous integrated boost (SIB) combined with ADT in high risk prostate cancer patient is feasible and associated with acceptable acute GI and GU toxicity. (scirp.org)
Daily doses of calcium folinate should be adjusted depending on the hematological toxicity of trimetrexate. (janusinfo.se)

Who can receive Fluzone High-Dose Quadrivalent? (cdc.gov)
What is the difference between Fluzone High-Dose Quadrivalent and Fluzone Quadrivalent? (cdc.gov)
Both Fluzone High-Dose and Fluzone Quadrivalent (standard dose) are produced by the same manufacturer and are quadrivalent vaccines. (cdc.gov)
Are there benefits of Fluzone High-Dose Quadrivalent compared to standard dose seasonal flu vaccines for adults 65 years and older? (cdc.gov)
How safe is Fluzone High-Dose Quadrivalent? (cdc.gov)
To include the use of a 0.5 mL single dose presentation of Fluzone Quadrivalent formulation in children 6 to ‹36 months of age. (cdc.gov)

the difference is that it has four times the antigen dose of the standard Fluzone. (medpagetoday.com)
Due to limited amounts of reagent antibodies in the coated wells and extremely high concentrations of analyte in the sample leads to decrease in the formation of antigen-antibody complex and ultimately resulting in false low values of the analyte. (lww.com)
According to a statement from Sanofi Pasteur , the vaccines division of Sanofi, the High-Dose version of the shot contains 4 times the amount of antigen than its standard-dose predecessor. (pharmacytimes.com)
High-dose flu shots contain four times the amount of antigen (the active ingredient that stimulates the immune response) compared to standard flu shots. (total-health-care.com)

Some side effects were reported more frequently after vaccination with trivalent Fluzone High-Dose than after standard-dose inactivated flu vaccines. (cdc.gov)
Though vaccination levels in Africa remain far below the rest of the world, deliveries are picking up, with 12 million doses received in the last week. (umn.edu)
Before diving into the specifics of high-dose and standard flu shots, let's briefly discuss the importance of influenza vaccination. (total-health-care.com)

Sequential high-dose chemotherapy is a chemotherapy regimen consisting of several (2 to 4) sequential monochemotherapies with only one chemotherapeutic agent per course. (wikipedia.org)
Depending on the patient's performance status, his/her ability to tolerate chemotherapy, the type of lymphoma, the stage of disease and different prognostic factors, one or more courses of the full sequence can be omitted or dose reduced. (wikipedia.org)
More than 60 years ago, British physician Denis Parsons Burkitt and his associates achieved one of the signal successes in cancer medicine when they cured children in sub-Saharan Africa with a form of lymphoma by treating them with high doses of the chemotherapy drug cyclophosphamide. (dana-farber.org)
Our results show that, at high doses, cyclophosphamide and other alkylating agents blur the line between chemotherapy and immunotherapy," said Dana-Farber's David Weinstock, MD, the senior author of the study. (dana-farber.org)
They have conducted clinical research showing High dose vitamin C, delivered by the use of Intravenous vitamin C injections, significantly slows the rate of growth of cancer - either on its own, or in conjunction with chemotherapy and radiotherapy. (canceractive.com)

The study found that high doses of vitamin D administered to hospital patients with moderate or severe COVID-19 did not affect the course of the disease. (medicalnewstoday.com)
The scientists gave participants in the first group a single 200,000-unit dose of vitamin D3 dissolved in peanut oil. (medicalnewstoday.com)
The design of the study was to discover whether a high dose of vitamin D was associated with a shorter hospitalization - the researchers found that it was not. (medicalnewstoday.com)
Having suggested that a single high dose of vitamin D is not a solution to severe COVID-19, Pereira is now leading a new study to determine whether a vitamin D deficiency has any effect on a person's ability to overcome SARS-CoV-2. (medicalnewstoday.com)
She said current recommendations of vitamin D supplementation for preterm infants span a wide range of doses, even among major medical groups such as the American Academy of Pediatrics, the Institute of Medicine, and the Endocrine Society. (sciencedaily.com)
Researchers studied 32 infants at doses of 400 or 800 IU/day of vitamin D. (sciencedaily.com)
We know that even with standard vitamin D dosing, we were still seeing a fair number of pre- term infants who suffered from impaired bone health. (sciencedaily.com)
She said the study is one of the first to look at higher dosing of vitamin D in premature infants. (sciencedaily.com)
A recently published study sheds new light on the importance of DHA during pregnancy, highlighting that doses higher than what is found in many prenatal vitamin supplements can significantly decrease the rate of early preterm birth (EPB). (dsm.com)
Taking high-dose vitamin D-with or without calcium-helps prevent hip and nonvertebral fractures in adults aged 65 and older, according to findings from an international study. (contemporaryobgyn.net)
The reductions were independent of assigned treatment dose of vitamin D, age, sex, additional calcium intake, whether the subjects lived at home or in an institution, and baseline levels of vitamin D. (contemporaryobgyn.net)
High dose vitamin C involves intravenous injections of vitamin C of up to 85 gm (depending upon body weight), every 5 days, for 8 rounds to increase 'Hydrogen Peroxide' levels in cells. (canceractive.com)
More correctly, High Dose vitamin C uses injections of ascorbate, and this acts as a pro-drug to increase H 2 O 2 in cancer cells and kill them. (canceractive.com)
High dose intravenous vitamin C is one of these treatments, and we use it extensively in our clinic. (canceractive.com)
Vitamin C accumulates in solid tumours at concentrations higher than those in surrounding normal tissue. (canceractive.com)

Results from the PULSAR randomized clinical trial that compared 2- and 8-mg doses of the drug showed that 89% of the patients who received the higher dose achieved at least every-3-month dosing and 78% achieved every-4-month dosing at the 96-month mark, Paolo Lanzetta, MD, of the University of Udine in Udine, Italy, reported at EURETINA 2023. (medscape.com)
Mar. 22, 2023 People who have low bone density may have an increased risk of developing dementia compared to people who have higher bone density. (sciencedaily.com)
Retrieved on Oct 04, 2023 from https://www.medindia.net/news/healthwatch/prescribing-a-high-dose-of-baclofen-may-not-be-effective-in-treating-alcoholism-165761-1.htm. (medindia.net)

June 3, 2011 (Chicago, Illinois) - A regimen of high-dose methotrexate appears to be superior to the standard protocol of escalating methotrexate in children and young adults with high-risk B-precursor acute lymphoblastic leukemia (ALL). (medscape.com)
In a planned interim analysis, 5-year event-free survival for patients who received the high-dose regimen was 82%, compared with 75% for those receiving the escalation protocol. (medscape.com)
Outcomes were better for patients who received the high-dose regimen than for those who received the dose-escalating Capizzi regimen, he explained. (medscape.com)
High-dose methotrexate was actually less toxic than the Capizzi regimen," he said. (medscape.com)
The authors note that there were fewer marrow (42 vs 68) and central nervous system (CNS) relapses (22 vs 32) with the high-dose regimen than with the standard protocol. (medscape.com)
Even though methotrexate has been used for more than 5 decades and is an essential part of the treatment regimen for children with ALL, the optimal dose and schedule have not been fully established. (medscape.com)
The Capizzi regimen, which involves the administration of escalating-dose methotrexate and L-asparaginase, has been the standard treatment for ALL for the past 20 years. (medscape.com)
Enrollment was stopped early because the survival difference crossed a predefined boundary, explained Dr. Larsen, and patients receiving the escalating-dose regimen were permitted to cross over to the high-dose regimen when feasible. (medscape.com)
The new formulation will allow for a less frequent dosing regimen compared with the daily subcutaneous injection which was approved in 1996 but is coming off-patent. (pharmatimes.com)
He added that US patients "can now benefit from an improved dosing regimen without compromising the known benefits" of the drug. (pharmatimes.com)
Since the calcium folinate rescue dosage regimen depends heavily on the posology and method of the intermediate- or high-dose methotrexate administration, the methotrexate protocol will dictate the dosage regimen of calcium folinate rescue. (janusinfo.se)

It's a daily dose of potassium conveniently! (recombu.com)
Among patients newly initiating buprenorphine treatment for opioid use disorder , 59% of those prescribed the target daily dose of 16 milligrams recommended by the U.S. Food and Drug Administration and 53% of those prescribed the higher 24 mg daily dose discontinued treatment within 180 days. (medicalxpress.com)
Calcium folinate can be administered either by the intravenous route at a dose of 20 mg/m2 for 5 to 10 minutes every 6 hours for a total daily dose of 80 mg/m2 or by oral route with four doses of 20 mg/m2 administered at equal time intervals. (janusinfo.se)

Our results support the effectiveness of the third booster dose of mRNA -Vax against severe forms of COVID-19 in pwMS treated with OCR and FNG. (bvsalud.org)

This recommendation was based on a review of available studies which suggests that, in this age group, these vaccines are potentially more effective than standard dose unadjuvanted flu vaccines. (cdc.gov)
SAGE said its third-dose recommendation applies to all vaccines that the WHO has approved for emergency use. (umn.edu)
For Sinopharm and Sinovac, two inactivated vaccines from China, SAGE said a third dose should be offered to people ages 60 and older as part of an extended primary series. (umn.edu)

In a paper in today's issue of the journal Cancer Discovery , the researchers demonstrate that large doses of cyclophosphamide not only kill cancer cells directly, as has been known, but also spur an immune system attack on the cells. (dana-farber.org)
Cyclophosphamide and other alkylating agents are now used at lower doses to treat many types of cancer, including breast, ovarian, and pediatric cancers. (dana-farber.org)
In the new study, investigators focused on the effect of high doses of cyclophosphamide on macrophages - cells that, under the right conditions, eat infected cells or cells in the process of dying. (dana-farber.org)
Although high doses of cyclophosphamide and other alkylating agents may be too toxic for patients with diseases other than Burkitt lymphoma, researchers are investigating agents that mimic their ability to stress cancer cells, but with milder side effects. (dana-farber.org)

describe the health effects of acute high-dose cadmium exposure. (cdc.gov)
We decided to investigate whether a high dose of the substance could have a protective effect in the context of an acute viral infection, reducing either the inflammation or the viral load. (medicalnewstoday.com)
Background In the 1980s, randomized-controlled trials showed that high-dose corticosteroid treatment did not improve the mortality of acute respiratory distress syndrome (ARDS). (medscape.com)

Each arm started therapy with three monthly doses of the assigned treatment. (medscape.com)
What side effects can Amoxicillin or Co-amoxiclav/Amoxicillin-Clavulanate (High Dose Therapy) cause? (cgh.com.sg)
Before taking Amoxicillin or Co-amoxiclav/Amoxicillin-Clavulanate (High Dose Therapy) , what precautions must I follow? (cgh.com.sg)
In a Phase III trial, The Radiation Therapy Oncology Group (RTOG) showed improved progression-free survival (PFS) for high-risk prostate cancer patients treated with Whole Pelvis Radiation Therapy (WPRT) compared with prostate-only radiation therapy (PORT) [4]. (scirp.org)
Dose escalation can be achieved with either 3-Dimensional Conformal Radiation Therapy (3-DCRT) or with intensity-modulated Radiation Therapy (IMRT). (scirp.org)
Does barium impaction therapy using high-dose barium enemas prevent recurrent diverticular bleeding? (the-hospitalist.org)
This small study demonstrates that barium impaction therapy using high-dose barium enemas is safe and effective at reducing the rate of recurrent diverticular bleeding. (the-hospitalist.org)
High-dose barium impaction therapy for the recurrence of colonic diverticular bleeding. (the-hospitalist.org)
THURSDAY, Oct. 21, 2021 (HealthDay News) -- For children with hemiparetic cerebral palsy, high-dose constraint-induced movement therapy (CIMT) produces more consistent gains than usual customary treatment (UCT), according to a study published online Oct. 14 in Pediatrics . (healthday.com)
With recent technological advances, modalities such as Intensity Modulated Radiotherapy (IMRT), Stereotactic Body Radiotherapy (SBRT) or Volumetric Modulated Arc Therapy (VMAT) can conform doses to tumours more precisely than possible a few decades ago sparing the normal tissue to a larger extent. (frontiersin.org)
Due to this higher normal tissue sparing effect relative to any of the photon based modalities, proton therapy has drawn an increasing interest with globally over 150 proton therapy centres being operational and under construction or at the planning stage [ 8 ]. (frontiersin.org)

The high-dose 8-mg formulation of aflibercept, approved by the US Food and Drug Administration in August, has been shown to sustain improvement in visual acuity as well as retinal anatomy out to 22 months on par with every-other-month treatment with the original 2-mg dose, but with up to 36% fewer injections. (medscape.com)
But, Greenberg told the committee, in the past three flu seasons only one vaccinated senior in five used the high-dose formulation. (medpagetoday.com)

In childhood idiopathic thrombocytopenic purpura (ITP), both intravenous high-dose steroids and immunoglobulin treatments have been demonstrated to raise platelet counts reliably and in most cases within 72 h, when used as separate therapeutic modalities. (karger.com)
Treatment consisted of intravenous high-dose methylprednisolone (20 mg/kg in 30 min) followed by intravenous gamma globulin (Gamimune-N, 1 g/kg over 5 h). (karger.com)

Prevention: Calcium folinate should be administered every day during treatment with trimetrexate and for 72 hours after the last dose of trimetrexate. (janusinfo.se)

The killing of leukemia cells is proportional to the radiation absorbed dose. (nature.com)
Water-powered proportional dosing pumps manufacturer since 1974. (dosatron.com)
We employed propensity score weighting with a Cox proportional hazards model in order to minimize the bias associated with the retrospective collection of data on baseline characteristics and compared the mortality between the high-dose and non-high-dose corticosteroid groups. (medscape.com)

But for those taking doses of 50 milligrams, the fifth day "was a disaster, suddenly," he says. (npr.org)

In their study, Dr. Larsen and colleagues randomized 2426 patients to receive dexamethasone or prednisone during induction, and then to receive high-dose methotrexate (5 g/m 2 biweekly for 4 weeks) or escalating-dose methotrexate plus PEG-L-asparaginase during interim maintenance. (medscape.com)
Study participants were given a drug dose that was too high, the companies delayed alerting authorities, and Biotrial did not react quickly enough after the first participant got sick, the report said. (npr.org)
Despite the fact that he was experiencing stroke-like symptoms, five other healthy volunteers received a sixth dose of the experimental medicine at the highest dose used in the study the next morning. (npr.org)
Healthy volunteers were recruited to test preliminary doses for the drug and its safety in a so-called phase 1 study . (npr.org)
To help fill that gap, the post-licensing study enrolled 31,803 people 65 and older at 126 sites in the U.S. and Canada and -- over the 2011-2012 and 2012-2013 flu seasons -- randomly assigned them to Fluzone High-Dose or standard Fluzone. (medpagetoday.com)
Over the entire study period, the proportion of participants who suffered a serious adverse event was similar between the arms -- 8.27% in the high-dose arm and 9.02% in the standard arm. (medpagetoday.com)
There were three adverse events, all in the high-dose arm, that were thought to be related to the study drug, Greenberg reported. (medpagetoday.com)
A prospective bronchoscopic study evaluated 14 severe, high-dose oral glucocorticoid dependent asthmatics. (nih.gov)
Those with more severe disease had a higher level of virus replication, although we have no evidence to relay the initial exposure dose to disease outcome," says Leo Poon at Hong Kong University, who was involved in the study. (newscientist.com)
A study that found high doses of the polyphenol, resveratrol, could inhibit exercise benefits in older people, has been attacked in the same journal that published the original work back in June for methodology and statistical errors. (nutraingredients-usa.com)
To this end, we initiated a study using high doses of the MAO inhibitor tranylcypromine, at a range of 90 mg to 170 mg daily, in seven refractory depressed patients who had failed to respond to at least three prior treatments regimens. (biopsychiatry.com)
This prospective study was designed to look at the possible effects of radiation on cerebral, frontal lobe, and temporal lobe volumes and their associations with higher cognitive functioning. (cancernetwork.com)
Both study patients and control patients had significant increases in cerebral volume over time, but overall growth was higher in control patients. (cancernetwork.com)
Note that this study was conducted in Japan, where the rate of rebleeding for patients with diverticulosis is much higher than in Western populations. (the-hospitalist.org)
Individuals with opioid use disorder who were prescribed a lower buprenorphine dose were 20% more likely to discontinue treatment than those on a higher dose, according to a study of patients prescribed buprenorphine in Rhode Island from 2016 to 2020, as fentanyl became widely available. (medicalxpress.com)
Those prescribed more than 24 mg were unable to be analyzed due to the small number (0.2%, or 15 patients) prescribed such doses during the study period. (medicalxpress.com)
Now, we're seeing people with higher levels of tolerance to and dependence on opioids, and our findings suggest that a higher buprenorphine dose-up to 24 mg-may help improve treatment retention for these individuals," said Rachel Wightman, M.D., Associate Professor of Emergency Medicine and Epidemiology at Alpert Medical School of Brown University and one of the principal investigators of the study. (medicalxpress.com)
We evaluated the effect of high-dose corticosteroid treatment in patients with ARDS using a nationwide administrative database in Japan in a retrospective and observational study. (medscape.com)
The aim of this study was to evaluate COVID-19 course and outcomes in pwMS on OCR and FNG after receiving the third dose of mRNA -Vax and to compare it with pwMS on natalizumab (NTZ). (bvsalud.org)
Conclusions This study offers evidence of a dose-response relation between the number of CPIs owned by adolescents and higher likelihood of experimental and established smoking. (who.int)

As a result, it produces significantly higher antibody levels in those who receive it. (wral.com)
Similar results were obtained in the endobronchial and transbronchial biopsy specimens, which consistently showed significantly higher numbers of neutrophils in the severe asthmatics than in the control groups. (nih.gov)
The number of CPIs owned by students was not associated with grade in school but was significantly higher in males, those with poorer school performance, those who perceived high prevalence of peer smoking, and those with higher exposure to peer and family smoking. (who.int)

A high-dose continuous infusion of IV dexmedetomidine was administered, and his violent behavior and delirium significantly improved. (hindawi.com)

Prescribing a high-dose of baclofen for alcohol dependence should be reconsidered as the drug was found to have only little effect. (medindia.net)
Doctors should rethink before prescribing a high-dose of baclofen to treat alcoholism. (medindia.net)
The French authorities in 2014 were asked to allow doctors to prescribe high doses of baclofen for alcohol-dependent patients. (medindia.net)
Baclofen use for alcohol dependence actually originated from 'The end of my addiction', written by the French physician Olivier Ameisen, who asserted to have cured alcohol dependence by administering a high dose of baclofen. (medindia.net)
Out of which 58 patients received high-dose baclofen (starting with a low dose to 150mg/day), 31 patients low dose baclofen and 62 received placebo. (medindia.net)
In August 2015 a small German RCT** had indicated that high dose baclofen showed good results, but their control group did not receive any treatment, whereas all our patients, including the placebo group, received psychosocial treatment. (medindia.net)
We are planning a new RCT, where we will test high dose Baclofen, up to 330 mg per day, in alcohol-dependent patients who have not responded to regular psychological treatment. (medindia.net)
For comparison, the maximum recommended adult dose of baclofen for its normal (spasticity) use is 80 mg/day. (medindia.net)

The agency is also reviewing data from other clinical trials, observational studies, adverse event reports, and data on prescription use of simvastatin to better understand the relationship between high-dose simvastatin use and muscle injury (see Data Summary below). (fda.gov)

In this photo, the U.S. Preventive Services Task Force recommended a low-dose aspirin daily can help prevent both heart disease and cancer in adults ages 50 to 69. (ibtimes.com)

We conclude that TBI dose escalation above the previously used 13.5 Gy dose is feasible using a high-energy source and high-dose etoposide. (nature.com)

Re: documention of *high dose* Parnate? (dr-bob.org)

The concentration of eosinophils in bronchoalveolar lavage fluid was highest in the moderate asthmatics not on glucocorticoids, with very little difference between normal controls and severe asthmatics (significant difference among the groups, p = 0.007). (nih.gov)
Although low and moderate doses show a favourable profile, there is concern about the tolerability of higher doses. (nih.gov)
High-dose CIMT produced significantly greater improvement than a moderate dose or UCT in O'Brien's rank-order analyses. (healthday.com)

These findings suggest that inflammation remains in severe symptomatic asthmatics despite treatment with high dose glucocorticoids which may be due to the severity of disease, glucocorticoid treatment, or other as yet undefined factors. (nih.gov)
The learning that a significant relationship exists between maternal DHA status and DHA dosing agrees with exploratory findings from another recent trial on DHA during pregnancy, the "Australian Omega-3 to Reduce the Incidence of Preterm Birth" (ORIP). (dsm.com)
In addition to the findings around DHA dosing and EPB, the research team also found an impact of the higher DHA dose on premature birth overall. (dsm.com)
High doses of CIMT delivered in three-hour sessions five days per week for four weeks produced a consistent pattern of gains more than that of UCT on almost all blinded and parent-reported functional outcomes, although the findings are complex," the authors write. (healthday.com)

We feel that it is the standard of care to receive high-dose methotrexate in this population," said lead author Eric C. Larsen, MD, director of the Maine Children's Cancer Program and the division of pediatric hematology/oncology at the Barbara Bush Children's Hospital at Maine Medical Center in Portland, adding that he hopes to see it incorporated into practice guidelines. (medscape.com)

Given a sufficient dose however, hemorrhagic gastroenteritis, liver and kidney necrosis, cardiomyopathy, and metabolic acidosis can occur (Newman-Taylor 1998). (cdc.gov)
The researchers say that such high doses can cause liver damage, may stop the heart, and be fatal. (eurekalert.org)

[3-19-2010] Based on review of data from a large clinical trial and data from other sources, the U.S. Food and Drug Administration (FDA) is informing the public about an increased risk of muscle injury in patients taking the highest approved dose of the cholesterol-lowering medication, Zocor* (simvastatin) 80 mg, compared to patients taking lower doses of simvastatin and possibly other drugs in the "statin" class. (fda.gov)
The higher the dose of statin used, the greater the risk of developing myopathy. (fda.gov)
Be aware of the potential increased risk of muscle injury with the 80 mg dose of simvastatin compared to lower doses of simvastatin and possibly other statin drugs. (fda.gov)

Initially, the same response was seen as with a lower dose. (eurekalert.org)
At lower doses ketamine has a pain-relieving effect, and its use in adult humans is mainly restricted to field situations such as frontline pain-relief for injured soldiers or victims of road traffic accidents. (eurekalert.org)
The lower rates of CNS and marrow relapses in the high-dose group reached statistical significance," said Dr. Larsen. (medscape.com)
Conclusion: A satisfactory effectiveness of BNT162b2 after the second dose was suggested, but with possibly substantially lower effect before the second dose. (lu.se)
None of the other 90 volunteers exposed to the drug at lower doses experienced any problems. (npr.org)
Although the numbers were small, he added, point estimates of hospital admissions, pneumonia, and cardiorespiratory disease within 30 days of any form of respiratory illness were lower for Fluzone High-Dose. (medpagetoday.com)
The researchers also found that higher radiation doses were associated with lower vocabulary scores in patients, suggesting that "radiation dose affects performance on vocabulary measures in a dose-dependent manner. (cancernetwork.com)
Women with low DHA status at enrollment and who were randomized to the high dose of DHA had half the incidence of EPB compared to those on the lower dose, 2% vs. 4.1%," explains Dr. Carlson. (dsm.com)

The committee decided it can be used for high-risk infants 2 through 23 months. (medpagetoday.com)
3, 2021 Extremely premature infants are at a high risk for brain damage. (sciencedaily.com)
These infants carry the highest risks of mortality, requiring costly in-hospital medical care, and experiencing long-term developmental challenges. (dsm.com)

thus, the effect of high-dose corticosteroid treatment may be different in this era. (medscape.com)

The role of inflammation in the pathogenesis of severe asthma chronically treated with high doses of glucocorticoids is poorly understood. (nih.gov)
The eicosanoid mediators, thromboxane and leukotriene B4, were also highest in the severe asthma group (differences among the groups, p = 0.019 and p = 0.023, respectively). (nih.gov)
However, in the case of covid-19, it doesn't necessarily follow that a higher viral load will lead to more severe symptoms. (newscientist.com)
However, its rapid metabolism within the body means it has a short serum half-life, so it needs to be given in high doses, which can trigger severe side effects. (bioworld.com)
High-dose flu shots, on the other hand, are specifically designed for individuals who are more susceptible to severe influenza illness, such as older adults aged 65 and above. (total-health-care.com)
They have demonstrated a higher antibody response and a reduced risk of developing severe flu-related complications. (total-health-care.com)

High-dose hook effect has important medical implications, and simple methods of sample dilution helps in preventing false low concentrations. (lww.com)
But, in all sandwich assays, the signal begins to plateau with high concentrations of analyte due to limiting amounts of reagent antibodies and rare samples with extremely high concentrations of analyte can even lead to the hook effect in assays with a wash step. (lww.com)
In general, plants that are grown in fields with a high concentration of ground water calcium have higher concentrations of oxalate. (medscape.com)

Does a high viral load or infectious dose make covid-19 worse? (newscientist.com)
PwMS who had COVID-19 on OCR and FNG compared with those on NTZ were slightly more symptomatic with higher hospitalization rates (11.1% vs 7.1% vs 1.3%, respectively). (bvsalud.org)

When the drug wore off and the sheep regained consciousness, the researchers were surprised to see the brain activity start switching between high and low frequency oscillations. (eurekalert.org)
Interestingly, the right frontal and right temporal lobe volumes differed significantly between patients and controls, and this persisted over time, with controls having higher volumes than patients," the researchers wrote. (cancernetwork.com)
Researchers discovered, for example, that while high doses are much more effective against certain cancers than low doses, they inflict about the same amount of DNA damage, suggesting that something else comes into play at high doses. (dana-farber.org)
In mouse models implanted with human lymphoma tissue, the researchers showed that high doses of the drug, but not normal doses, damaged tumor cells in a way that severely stressed the lymphoma cells. (dana-farber.org)

IMRT permits the use of different total doses and different doses/fraction to different volumes within the irradiation field, utilizing the "simultaneous integrated boost" (SIB) technique. (scirp.org)

As a result, there is a higher antibody response within the recipient of Fluzone High-Dose, the manufacturer noted. (pharmacytimes.com)

However, SAGE urged countries to prioritize 2-dose coverage in that age group, then administer third doses, starting with the oldest age groups. (umn.edu)

High-dose methotrexate will be incorporated in current and future Children's Oncology Group trials for children and young adults. (medscape.com)
Although event-free survival continues to improve for children and young adults with high-risk ALL, CNS disease has become an increasing site of treatment failure, the authors note. (medscape.com)
This higher dosage aims to provide a stronger immune response in older adults and enhance their protection against the flu. (total-health-care.com)
Studies have shown that high-dose flu shots can be more effective in preventing influenza illness in older adults compared to standard flu shots. (total-health-care.com)

For high risk prostate cancer, the treatment volumes and even dose levels are still a controversial issue. (scirp.org)
Hence, there is increased interest in radiation dose escalation combined with androgen deprivation in high risk prostate cancer patients [6] [7]. (scirp.org)
An ongoing GETUG-AFU-18 phase III trial is evaluating the impact of dose escalation in combination with 3-year androgen deprivation treatment on 5-year biochemical or clinical control in high-risk prostate cancer patients [8]. (scirp.org)

If you are an older adult aged 65 or above, high-dose flu shots may be a suitable option for you. (total-health-care.com)

Prosecutors said during Mashali's change-of-plea hearing that he had been prescribing oxycodone and other strong opioid painkillers in extremely high numbers to his patients, even though most of his patients did not require it medically. (ibtimes.com)
Effective treatment can save lives, but our proven treatments for opioid use disorders must evolve to match the challenges posed by the fentanyl crisis," said NIDA Director, Nora Volkow, M.D. "If science continues to demonstrate that a higher dosage of buprenorphine increases treatment retention, we must re-evaluate clinical guidelines to optimize treatment and help people achieve recovery. (medicalxpress.com)
The ubiquity of fentanyl in the drug supply and resulting overdose death rate increase have raised questions about whether existing dosing guidelines for buprenorphine should be modified to better address the unique challenges posed by such a potent opioid. (medicalxpress.com)
The goal was to estimate the association between patients' daily buprenorphine dose and retention in treatment over 180 days, a time frame which aligns with the minimum treatment period considered by the U.S. Centers for Medicare and Medicaid Services to measure treatment continuity for opioid use disorder. (medicalxpress.com)
Background: Construction workers have high rates of work-related musculoskeletal disorders, which lead to frequent opioid use and opioid use disorder (OUD). (cdc.gov)
Results: There were high rates (42.8% per year) of chronic musculoskeletal disorders among workers, of whom 24.1% received new opioid prescriptions and 6.3% received long-term opioid prescriptions per year. (cdc.gov)

In children with primary brain tumors who were treated with cranial radiation, cerebral volume and radiation dose may affect the rate of vocabulary development. (cancernetwork.com)
If DOL determines that the energy worker (1) had the potential for workplace radiation exposure and (2) had developed cancer, then the claim is forwarded to NIOSH for a dose reconstruction before DOL makes its final compensation decision. (cdc.gov)
Under the Act, dose reconstruction is an accepted scientific method used by NIOSH to determine the amount of radiation a worker likely received while employed at a DOE facility or an Atomic Weapons Employer (AWE) facility. (cdc.gov)
DOL uses the results of the dose reconstruction to assist in determining the Probability of Causation (POC)-that is, the likelihood that the worker's cancer was caused by his/her workplace exposure to radiation. (cdc.gov)
When conducting a dose reconstruction, NIOSH may use personal radiation exposure data such as film badge readings, urine sample data, incident reports, medical x-rays, and employment history, as well as other information such as co-worker data, environmental exposure records, and process records. (cdc.gov)

There have been studies showing that the higher dose does a better job of inducing antibodies to the flu, including one recently presented at the 2013 IDWeek in San Francisco showing superiority for seniors. (medpagetoday.com)

For influenza, a higher amount of virus at infection has been associated with worse symptoms . (newscientist.com)
For example, ingestion of a vesicant leads to gastrointestinal symptoms more prominent than those that would result from inhalation exposure to the same dose and type of vesicant. (cdc.gov)

Most accidental paediatric drug ingestions involve doses that fall well below what would be considered a toxic ingestion. (rch.org.au)
There are a handful of drugs and chemicals that are dangerous after relatively small paediatric ingestions involving 1 or 2 dose units of an available preparation or a mouthful. (rch.org.au)

The higher dose of DHA reduced premature birth regardless of baseline DHA status (pp=0.95). (dsm.com)

However, in the context of dose escalation to the prostate, dosimetric and clinical results from the literature comparing WP IMRT with PO IMRT are still limited. (scirp.org)

At 8 mg for injection, it's the higher-dose version of the Tarrytown, N.Y.-based firm's VEGF inhibitor, first approved in November 2011. (bioworld.com)

Anatomy14

Organisms16

Diseases19

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment80

Psychiatry and Psychology2

Phenomena and Processes37

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care25

Vaccine41

Efficacy9

Toxicity6

Quadrivalent6

Antigen4

Vaccination3

Chemotherapy5

Vitamin15

20233

Regimen11

Daily dose3

Booster1

Vaccines3

Cyclophosphamide4

Acute3

Therapy11

Formulation2

Intravenous2

Last dose1

Proportional3

Milligrams1

Study20

Significantly higher3

Infusion1

Baclofen8

Adverse1

Aspirin1

Feasible1

Parnate1

Moderate3

Findings4

Pediatric1

Liver2

Statin3

Lower8

Infants3

Effect of high-dose1

Severe6

Concentrations3

Covid2

Researchers4

Irradiation1

Antibody response1

Administer1

Adults4

Prostate cancer3

Adult1

Opioid6

Radiation5

Antibodies1

Symptoms2

Paediatric2

Premature1

Escalation1

Inhibitor1