• Radiosensitizers are chemical agents that have the potential to increase the lethal effect of radicals induced during irradiation [1-6].The extent of radiation damage to cells is dependent on the amount of oxygen available to the cell [1,2,7,8]. (who.int)
  • However, the accumulation of evidence suggests that immunotherapy also induces severe and complex neurologic immune-related adverse events (ir-AEs) and even leads to immunotherapy-related death, which arouses the concern of clinicians. (hindawi.com)
  • It is a dose-limited factor of cancer immunotherapy and affects the prognosis and quality of life [ 15 ]. (hindawi.com)
  • As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
  • The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
  • One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
  • The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • In this study, it was found that oxidative stress inhibited apoptosis by depleting cells of their energy source, which is called adenosine triphosphate (ATP). (pinestreetfoundation.org)
  • RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
  • The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
  • Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
  • Compared with low-dose chidamide or bortezomib alone, the low-dose drug combination significantly inhibited the proliferation, migration, and invasion of MGC-803 and BGC-823 cells and induced apoptosis of the cells. (dovepress.com)
  • Previous studies have shown that Dermal Papilla Cells (DPC) from balding hair follicles were more susceptible to go into senescence after exposure to oxidative stress and growth inhibition by androgens than DPC from non-balding hair follicles. (imedpub.com)
  • Experimental Approach: Inhibition of oxaliplatin-induced mechanical hypersensitivity was measured following intraperitoneal administration of MG. Both male and female C57BL/6J mice were used to characterize potential sex-differences in MG's therapeutic efficacy. (authorea.com)
  • In mice injected with human breast and ovarian cancer cells, fasting cycles promoted survival extension by protecting the mice from chemotherapy while causing a strong inhibition of tumor progression. (kingdomfasting.com)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • At therapeutic doses of metronidazole (4.98-24.86 μg/mL) significant inhibition of the production of reactive oxygen species was noted in both methods. (who.int)
  • À des doses thérapeutiques de métronidazole (4,98-24,86 μg/mL), on a observé une inhibition significative de la production d'espèces réactives de l'oxygène avec les deux méthodes. (who.int)
  • It is not yet clear whether the doses required to produce inhibition of tubulin polymerization are higher than those achievable via dietary intakes," wrote Jackson and Singletary. (illinois.edu)
  • Metformin suppresses cells in a time-dependent manner, but the inhibition does not change with the dose of metformin. (oncotarget.com)
  • Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
  • Taurine has been shown to be depleted in people taking chemotherapy. (peacehealth.org)
  • It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. (peacehealth.org)
  • Though cancer cells use glutamine as a fuel source, studies in humans have not found that glutamine stimulates growth of cancers in people taking chemotherapy. (peacehealth.org)
  • Efficacy was demonstrated in patients who had experienced severe thrombocytopenia following the previous chemotherapy cycle. (wikipedia.org)
  • The purpose of the present study was to characterize the effects of MG in a mouse model of CIPN, and to investigate the potential impact of sex on MG's therapeutic efficacy. (authorea.com)
  • MG was more potent in males vs females, and the highest dose of MG (10 mg/kg) exhibited greater anti-allodynic efficacy in males. (authorea.com)
  • Conclusions and Implications: Repeated MG exposure significantly attenuated oxaliplatin-induced mechanical hypersensitivity with greater potency and efficacy in males, which has crucial implications in the context of individualized pain management. (authorea.com)
  • Although clinical trials testing the effect of fasting in cancer treatment are still in the early stages, they suggest that fasting cycles may boost the efficacy of chemotherapeutic agents and could be as effective as chemotherapy drugs in the killing of specific tumor cells. (kingdomfasting.com)
  • These studies suggest that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers. (kingdomfasting.com)
  • Based on a controlled clinical trial, the efficacy of two doses of vaccine (360 enzyme-linked immunosorbent assay units) administered 1 month apart in preventing hepatitis A in children was estimated to be 94% (95% confidence interval=79%-99%) (3). (cdc.gov)
  • Most previous observational studies have been limited by a small number of cases, short follow-up period, unverified self-reports on use and consistency of statins therapy, and no assessment of statins efficacy. (cdc.gov)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
  • People receiving cisplatin chemotherapy should ask their prescribing doctor to closely monitor magnesium and potassium status. (peacehealth.org)
  • The chemotherapy drug cisplatin may cause kidney damage, resulting in depletion of calcium and phosphate. (peacehealth.org)
  • The chemotherapy drug cisplatin may cause depletion of sodium due to kidney damage which sometimes occurs in people treated with cisplatin. (peacehealth.org)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
  • Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
  • For instance, the phase III trial conducted by Scagliotti et al 1 compared cisplatin plus gemcitabine with cisplatin with pemetrexed in chemotherapy-naive patients with advanced-stage NSCLC. (jnccn.org)
  • The highest dose of onion extract slowed the growth of colon tumors by 67% compared to the controls after three weeks. (naturalnews.com)
  • Design and Methods OPM2 and high-risk primary myeloma tumors were grown in human fetal bone implanted into non-obese diabetic severe combined immunodeficiency mice with a deficient interleukin-2 receptor gamma chain. (haematologica.org)
  • Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
  • However, the combination of fasting and chemotherapy was much more effective than either alone and delayed the progression of a variety of tumors, including breast cancer and glioma, reduced the number of organs affected by melanoma metastases, and promoted long-term cancer-free survival in up to 40% of mice with neuroblastomas. (kingdomfasting.com)
  • Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
  • Taking niacinamide by mouth while undergoing chemotherapy doesn't seem to benefit people with brain tumors. (medlineplus.gov)
  • Clinical trials to date have benefited only limited subsets of patients, accentuating the fact that pediatric high-grade gliomas (HGGs) constitute an extremely heterogeneous group of highly aggressive brain tumors. (frontiersin.org)
  • This most recent study points to the potential of specialized T-cells to fight even more types of immune-evading tumors. (childrensnational.org)
  • The study team writes that their findings underscore the potential utility of expressing DNRII when battling other tumors that have learned to evade the immune system. (childrensnational.org)
  • Ovarian cancer is one of the female genital tumors that has recently been found to have a high prevalence rate, which has no early symptoms and lacks an early diagnosis approach [ 1 , 2 ]. (oncotarget.com)
  • We conducted a retrospective study of 326 patients with solid tumors treated with anti-cancer medications to determine the proportion of cancer patients with immunogenicity against SARS-CoV2, following two doses of the BNT162b2 vaccine. (cdc.gov)
  • In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
  • However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
  • Mechanistically, activity at µ-opioid, α1- and α2-adrenergic receptors, but not β-adrenergic receptors contributed to the effects of MG against oxaliplatin-induced mechanical hypersensitivity. (authorea.com)
  • Surgery to the extent that this is feasible in terms of safety, followed by involved-field radiation therapy and concomitant and maintenance chemotherapy with temozolomide, has set the standard of care since 2005. (frontiersin.org)
  • Newer immunotherapies under investigation were among the featured topics during Dr. Horn's presentation at the NCCN 19th Annual Conference, joining maintenance chemotherapy and treatment of patients with acquired resistance to tyrosine kinase therapy with newer generation inhibitors. (jnccn.org)
  • Second, in switch maintenance chemotherapy, platinum-based doublet therapy is given and then a different regimen is used until disease progression. (jnccn.org)
  • One example is a human study in which researchers discovered that higher levels of the antioxidant selenium in the blood of patients with aggressive B-cell non-Hodgkin's lymphoma correlated with increased achievable doses of anthracycline based chemotherapy, better treatment response, achievement of long term remission, and longer overall survival. (pinestreetfoundation.org)
  • The absence of a methoxy group at position 4 of the anthracycline structure gives the compound a high lipophilicity which results in an increased rate of cellular uptake compared with other anthracyclines. (nih.gov)
  • Epirubicin is an anthracycline drug used for chemotherapy. (centerwatch.com)
  • A relationship between increased blood-brain barrier permeability and radiation therapy has been posited to contribute to this leukoencephalopathy and to methotrexate-induced vasculopathy. (medscape.com)
  • A definitive recommendation is still lacking as to whether or when antiox- idants should at all be used in the course of chemotherapy or radiation therapy (17-20). (vdocuments.net)
  • The programmed cell death 1 (PD-1) receptor is an immune checkpoint molecule that induces immune tolerance and mediates the immune escape of tumor cells. (jcancer.org)
  • It is mainly expressed on mature cytotoxic T lymphocytes [ 7 , 8 ], and it can inhibit T cell function by binding with PD-L1 or PD-L2 ligand, which is mainly expressed on the surface of tumor cells, to induce immune tolerance and limit autoimmunity [ 9 ]. (jcancer.org)
  • Thus, between fractionation doses, healthy cells have a greater probability than tumor cells of repairing themselves. (medscape.com)
  • In a variety of clinical studies upon which FDA approval is based, Neumega showed effectivity in reducing thrombocytopenia in oncologic patients treated with myelosuppressant chemotherapeutic drugs as measured by significantly decreased need of platelet transfusions. (wikipedia.org)
  • In a human clinical trial, he had a group of cancer patients go on short fasts before and then soon after undergoing chemotherapy. (coconutresearchcenter.org)
  • The three clinical forms of anthrax are cutaneous, gas- response in approximately 10% of vaccines, and the percent- trointestinal, and inhalational, caused by inoculation, inges- age of nonresponders is substantially higher in immunocom- tion, or inhalation of spores of Bacillus anthracis , respectively promised persons (1). (cdc.gov)
  • However, clinical trials have used dosages as high as 3,000 mg per day. (medicalnewstoday.com)
  • Advances in medicine emerge from prospective clinical trials, which allow patients with a given disease and meeting specific eligibility criteria to access studies that provide a controlled assessment of a therapy. (abta.org)
  • In recent years, thanks to the study of genetic variants, significant information associated with the prognosis and clinical course of glioma has been acquired. (frontiersin.org)
  • In a study of 4 children, 3 children showed significant clinical improvement with bevacizumab and were able to discontinue steroid use, which, according to the authors, can have numerous side effects that significantly compromise a patient's quality of life. (medscape.com)
  • Results of the small study at Baylor College of Medicine were published online Jan. 9, 2018, in the Journal of Clinical Oncology . (childrensnational.org)
  • Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. (mdpi.com)
  • Several studies indicate CBD may be useful for treating neuropathy pain, although more clinical research is needed to confirm the preliminary findings. (cfah.org)
  • In clinical practice, the use of an assessment tool can aid in the assessment of a patient's skin reaction, for example, the eviQ radiation-induced dermatitis assessment tool . (eviq.org.au)
  • According to the 2014 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for NSCLC, many chemotherapy drugs are useful for treating patients with advanced-stage NSCLC. (jnccn.org)
  • According to the latest data released by the International Cancer Research Center in 2018, gastrointestinal cancer has the highest incidence and mortality rates among all cancers worldwide. (dovepress.com)
  • While there, he ran into an animal study showing that melatonin had an extremely curious effect on active cancers. (innovativemedicine.org)
  • In a study of the US Medicare population, the treatment of nonmelanoma skin cancers ranked fifth among the most expensive cancers to treat in the head-and-neck region. (medscape.com)
  • During the study period, 8,662 incident cancers were reported. (cdc.gov)
  • Statins have been associated with a significantly lower risk of breast (8), colorectal (9), and lymph cancers (10-12) in several observational studies (10,13). (cdc.gov)
  • Recent promising studies demonstrate that immune checkpoint inhibitors (ICI) can induce objective intracranial response. (abta.org)
  • Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each of the treatment strategies has several serious side effects. (frontiersin.org)
  • There is no significant difference in overall survival between several different chemotherapy regimens," noted Dr. Horn. (jnccn.org)
  • In recent years, studies have shown that tumor cell-intrinsic PD-1 plays different roles in the development of melanoma, Liver cancer and lung cancer. (jcancer.org)
  • We also demonstrated that high concentrations of C. tropicalis can down-regulate tumor cell-intrinsic PD-1 expression in colon cancer cells. (jcancer.org)
  • Colorectal cancer (CRC) is the most common gastrointestinal malignancy which is always accompanied by high metastasis in the United States and the CRC prognosis biomarker is still poor currently [ 1 , 2 ]. (jcancer.org)
  • It has long been known that oxidative stress is an essential mechanism by which chemotherapy works to treat cancer. (pinestreetfoundation.org)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
  • In a study in which multiple, subcutaneous doses of both 25 and 50 µg/kg were administered to cancer patients receiving chemotherapy, Neumega did not accumulate and clearance of Neumega was not altered following multiple doses. (wikipedia.org)
  • Pediatric cancer patients treated with aggressive chemotherapy showed similar pharmakinetic characteristics. (wikipedia.org)
  • NaturalNews) Researchers have just discovered that flavonoids extracted from common onions slow the rate of colon cancer growth in mice just as effectively as a chemotherapy drug. (naturalnews.com)
  • The fatty diet was used to induce high blood fats and cholesterol (hyperlipidemia), since that is a major risk factor for colon cancer, and many human colon cancer patients have this condition. (naturalnews.com)
  • The mice on chemo had their cancer growth slowed slightly more, but there was no statistically significant difference compared to high-dose onion extract. (naturalnews.com)
  • However, a recent study out of Europe gives some clues as to what dosage of onions might have a meaningful anti-cancer effect. (naturalnews.com)
  • Ethan Evers is author of the award-winning medical thriller "The Eden Prescription," in which cutting-edge researchers perfect an effective, all-natural treatment for cancer, only to be hunted down by pharmaceutical interests which will stop at nothing to protect their $80 billion cancer drug cash machine. (naturalnews.com)
  • The immune system involves a host of cells, biological structures, and processes that protect us from disease and ill health caused by microorganisms, parasites, toxic chemicals, and diseased cells (cancer). (coconutresearchcenter.org)
  • In animal research, he found that fasting for 48 hours or longer protects normal, healthy mammalian cells, but not cancer cells from chemotherapy. (coconutresearchcenter.org)
  • In fact, animal studies show that glutamine may actually decrease tumor growth while increasing susceptibility of cancer cells to radiation and chemotherapy, though such effects have not yet been studied in humans. (peacehealth.org)
  • In mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs-but not either treatment alone-resulted in long-term cancer-free survival. (kingdomfasting.com)
  • However, DR is not feasible for patients already prone to weight loss from the cancer itself or from the chemotherapy, because, based on animal studies, several months may be necessary for patients undergoing DR to reach a protected state. (kingdomfasting.com)
  • Finally, it is not known whether DR would also protect cancer cells from chemotherapy. (kingdomfasting.com)
  • RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
  • Between 2004 and 2010, the survival rate in the United States in children up to 14 years of age with all types of cancer was 83%- significantly higher than the 58% reported in the mid-1970s. (ajmc.com)
  • 7 While several cardiovascular toxicity studies have been conducted in adult cancer patients, far fewer have been conducted in pediatric cancer patients. (ajmc.com)
  • The aim of this study was to investigate the antitumor effect of chidamide in combination with bortezomib on gastric cancer cell lines. (dovepress.com)
  • The effects of the low-dose chidamide and bortezomib combination reduced the growth on gastric cancer in vivo were investigated by using a subcutaneous tumor mouse model. (dovepress.com)
  • To date, combinational chemotherapy forms the main part of the treatment strategy for advanced gastric cancer with less than 10% of 5-year survival rate. (dovepress.com)
  • Progress in our studies will establish a model approach for future studies that take into account sex as a biological variable in cancer care. (abta.org)
  • Understanding how brain cancer starts requires studying the brains of normal people, and trying to figure out where and how the earliest mutations arise that might lead to cancer years later. (abta.org)
  • By studying the occurrence of early cancer mutations in normal brains, we will establish a roadmap of early-occurring processes that precedes cancer initiation. (abta.org)
  • Metronidazole (Flagyl) is a drug used to treat infections and has been studied in the treatment of cancer [10,11] as a radiosensitizer drug, especially for hypoxic cells [9]. (who.int)
  • What the paper showed was that melatonin could stop cancer from growing-provided the amount consumed was high enough and provided it was taken before sleep under light-restricted conditions. (innovativemedicine.org)
  • While our study is small, its findings are incredibly encouraging for our families and for the cancer field," says Dr. Bollard, who now directs the Children's Research Institute's Center for Cancer & Immunology Research and was lead study author. (childrensnational.org)
  • T-cells seek out and destroy cancer cells or virus-infected cells, protecting the body from infection and malignancy. (childrensnational.org)
  • In this study, the local and systemic side effects, tumor recurrens and progression rates of single or continuous epirubicin instillation during the early postoperative period were investigated in low and intermediate risk non-muscle-invasive bladder cancer. (centerwatch.com)
  • NMIBC are divided into four groups as low-medium-high and very high risk according to EORTC (European Organization for Research and Treatment of Cancer). (centerwatch.com)
  • Immediate single instillation of epirubicin has been shown to act by destroying circulating tumour cells after TURB(Transurethral Resection of a Bladder Tumor), and by an ablative effect on residual tumour cells at the resection site and on small overlooked tumours.European Association of Urology Guidelines on Bladder Cancer advocates single immediate postoperative intravesical chemotherapy. (centerwatch.com)
  • Despite this, surgical oncologists must maintain focus on providing high-quality, empathetic care for the almost 2 million patients nationally who will be diagnosed with operable cancer this year. (springer.com)
  • SUL is studied extensively for its effects against cancer. (illinois.edu)
  • Previous reports have shown that SUL induces defensive mechanisms that are effective in protecting normal cells from the initiation of cancer. (illinois.edu)
  • This study aims to investigate the association of p53 and D-loop gene with drug resistance and sensitization induced by metformin in ovarian cancer. (oncotarget.com)
  • Metformin enhances the sensitivity of drug-resistant ovarian cancer cells to chemotherapy. (oncotarget.com)
  • Then, the inhibitory rate on cells in the experimental group was observed by CCK8 assay, in order to study the sensitization effect of metformin in different chemotherapies of ovarian cancer. (oncotarget.com)
  • However, there are few studies on the relationship between gene mutations in these two and the sensitization of ovarian cancer. (oncotarget.com)
  • This study was designed to investigate the association of gene polymorphisms in the p53 gene and mitochondrial genome D-loop region with metformin-induced sensitization and prognosis of ovarian cancer. (oncotarget.com)
  • In this study, we examined the effects of quercetin on cell cycle, viability, and proliferation of cancer cells, either singly or in combination with the microtubule-targeting drugs taxol and nocodazole. (vdocuments.net)
  • Dietary com- pounds are being intensively studied for their chemopreventive, chemotherapeutic, or adjuvant potential in cancer management. (vdocuments.net)
  • Prolia was later approved to treat men with osteoporosis, glucocorticoid induced osteoporosis, bone loss in men receiving androgen deprivation therapy for prostate cancer and in women receiving aromatase inhibitor therapy for breast cancer. (medlineplus.gov)
  • The objective of this study was to investigate the association between persistent statin use and the risk of primary cancer in adults. (cdc.gov)
  • In a multivariable model, the highest cancer risk was calculated among nonpersistent statin users. (cdc.gov)
  • Our study demonstrated that persistent use of statins is associated with a lower overall cancer risk and particularly the risk of incident hematopoietic malignancies. (cdc.gov)
  • The objective of this study was to investigate the association between persistent use of statins and the risk of overall and site-specific cancer in adults, to assess dose-response relationship, and to examine the effects of varying types of statins. (cdc.gov)
  • autopsy studies show prostate cancer in 15 to 60% of men aged 60 to 90 years old, with incidence increasing with age. (msdmanuals.com)
  • However, when one looks more closely at the existing published science on how antioxidants and chemotherapy combine, the true answer is not so definitive. (pinestreetfoundation.org)
  • Many research studies, encompassing cell culture tests in the laboratory and also animal and some human studies, are coming to a conclusion often very different from the conventional perspective that chemotherapy and antioxidants should never be combined. (pinestreetfoundation.org)
  • 2003) As seen in this study, higher levels of natural antioxidants can help treatment outcomes. (pinestreetfoundation.org)
  • On the other hand, the decreased levels of antioxidants (or oxidative stress) that are caused by many chemotherapy treatments correlates with increased side effects. (pinestreetfoundation.org)
  • Using antioxidants during chemotherapy is an important and controversial question among health care providers, patients, and their support teams. (pinestreetfoundation.org)
  • In this article, we turn our focus to lymphoma, conducting a systematic search for published research that would support or discourage the use of antioxidants in combination with chemotherapy. (pinestreetfoundation.org)
  • The overwhelming majority of studies find a favorable interaction between antioxidants and chemotherapy, providing evidence that antioxidants can decrease chemotherapy side effects, increase treatment effectiveness, and decrease resistance to chemotherapy. (pinestreetfoundation.org)
  • In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
  • A comprehensive review of antioxidants and chemotherapy leaves open the question of whether supplemental antioxidants definitely help people with chemotherapy side effects, but it clearly shows that antioxidants need not be avoided for fear that the actions of chemotherapy are interfered with. (peacehealth.org)
  • Moreover, gingerol found in the ginger root is said to be filled with healthy antioxidants that protect our body from diseases and facilitate better immunity. (skincell.org)
  • This has especially been true for therapeutic agents that induce oxidative stress as the mechanism of action, as antioxidants may also re- duce the side effects of chemotherapeutic agents. (vdocuments.net)
  • Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)
  • Neumega is indicated for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusions following myelosuppressive chemotherapy in adult patients with nonmyeloid malignancies who are at high risk of severe thrombocytopenia. (wikipedia.org)
  • Neumega is not indicated following myeloablative chemotherapy (increased likelihood of severe side-effects) and in pediatric patients. (wikipedia.org)
  • 3. As is usual with antileukemic agents, severe myelosuppression occurs when idarubicin hydrochloride is used at effective therapeutic doses. (nih.gov)
  • The rates of both documented SARS-CoV-2 infections and severe COVID-19 exhibit a statistically significant increase as time from second vaccine dose elapsed. (cdc.gov)
  • Elderly individuals (60+) who received their second dose in March 2021 were 1.6 (CI: [1.3, 2]) times more protected against infection and 1.7 (CI: [1.0, 2.7]) times more protected against severe COVID-19 compared to those who received their second dose in January 2021. (cdc.gov)
  • Preliminary results from a separate internal FDA study investigating the risk of hypocalcemia suggest that patients on dialysis treated with Prolia are at substantial risk for severe and symptomatic hypocalcemia, including hospitalization and death. (medlineplus.gov)
  • For example, fasting for 48 to 60 hours protected mice of three different genetic backgrounds from the chemotherapy drug etoposide (12). (kingdomfasting.com)
  • In mice and nonhuman primate studies Neumega has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. (wikipedia.org)
  • In this study, researchers fed three different doses of flavonoids extracted from onion, an oral chemo drug, or saline (as control) to mice, along with a high-fat diet. (naturalnews.com)
  • It is also known that the chemo drug may induce hyperlipidemia (high cholesterol and/or triglycerides) in humans and that is exactly what happened with the mice -- their average LDL cholesterol levels went up significantly. (naturalnews.com)
  • More impressively, the mice getting onion extract had total cholesterol and apolipoprotein B levels that were markedly lower (as much as 60% lower for each) than controls on the high fat diet. (naturalnews.com)
  • Unfortunately, the authors of the mice study did not disclose what quantity of extract was used. (naturalnews.com)
  • He showed that short-term fasting provided complete protection to mice against the side effects of high-dose chemotherapy. (coconutresearchcenter.org)
  • Here, cycles of fasting for 2 days in the absence of other treatments are shown to delay the progression of several tumor types in mice and, in some cases, to be as effective as toxic chemotherapy drugs. (kingdomfasting.com)
  • Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. (kingdomfasting.com)
  • By contrast, a limited exposure to a severely restricted diet (short-term starvation or fasting) can protect yeast, mammalian cells, mice, and possibly patients from the toxic effects of oxidative and chemotherapeutic agents without causing chronic weight loss (10-14). (kingdomfasting.com)
  • Studies on mice show that even at astronomical doses of 300 mg per day for two years, there were no side effects. (innovativemedicine.org)
  • The new Illinois study confirms a previous study in mice. (illinois.edu)
  • The influence of apple (poly)phenols on energy metabolism in high-fat (HF) diet-induced obese mice remains controversial. (bvsalud.org)
  • PD-like behavior was induced in the mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (30 mg·kg-1) for five days, followed by BBP (50, 100, and 200 mg·kg-1) treatment daily for ten days. (bvsalud.org)
  • Our preliminary and published studies uncovered a remarkably better response to standard care in female glioblastoma patients than in male patients as well as sex-specific differences in signaling networks and interactions in the tumor microenvironment. (abta.org)
  • Often, people who undergo chemotherapy develop aversions to certain foods, sometimes making it permanently difficult to eat those foods. (peacehealth.org)
  • In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy. (peacehealth.org)
  • At weeks 12 and 24 of treatment, the children had significantly higher CoQ10 plasma levels and improved heart function. (medicalnewstoday.com)
  • This study demonstrated a significantly higher humoral immunogenicity of the SARS-CoV-2 mRNA-1273 vaccine (Moderna) compared with the BNT162b2 vaccine (Pfizer-BioNTech), in infected as well as uninfected participants, and across age categories. (cdc.gov)
  • A 2018 randomized trial compared the effects of 200 mg daily doses of ubiquinone and ubiquinol supplements on CoQ10 levels in older men. (medicalnewstoday.com)
  • In one 2018 pilot study , ten children with cardiac muscle dysfunction received 110-700 mg of liquid ubiquinol per day. (medicalnewstoday.com)
  • Passive antibody therapy has substantial advantages over antimicrobial agents and other measures for postexposure prophylaxis, including low toxicity and high specific activity. (cdc.gov)
  • 4. It is recommended that idarubicin hydrochloride be administered only under the supervision of a physician who is experienced in leukemia chemotherapy and in facilities with laboratory and supportive resources adequate to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity. (nih.gov)
  • Therefore, this study has the objective of assessing the toxicity of varying concentrations of MTBE (0, 2.5, 5.0 µL L-1) and RP (0, 5.0, 10.0 mg L-1 RP), both individually and in combination, over a period of 28 days on Nile tilapia (Oreochromis niloticus). (bvsalud.org)
  • Improvements in treatments such as chemotherapy have led to an 88 percent survival rate in Caucasian women and a 74 percent survival rate in African-American women, according to the most recent ACS survey in 2003. (illinois.edu)
  • However, some current chemotherapy drugs have side effects that have the ACS and other organizations seeking new strategies that combine chemotherapy drugs with other treatments to potentially lessen the toxic effects. (illinois.edu)
  • Our previous studies have found that Candida tropicalis ( C. tropicalis ) can promote CRC tumor growth and chemotherapy resistance to oxaliplatin by regulating mismatch repair system. (jcancer.org)
  • Because of this broad ability to promote stress resistance, DR could in theory be applied in the clinic to protect patients from toxic side effects of chemotherapy. (kingdomfasting.com)
  • high tensile strength · flexibility, and · resistance to break down by acid, alkali, water, heat, and flame. (cdc.gov)
  • The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. (who.int)
  • 17 ] or by luminol induced CL [ 18 ]. (who.int)
  • 20% of pediatric gliomas are high grade gliomas (HGGs) and include anaplastic astrocytoma (AA), diffuse intrinsic pontine glioma (DIPG), and glioblastoma multiforme (GBM). (frontiersin.org)
  • 2005) In children with acute lymphoblastic leukemia who received high-dose methotrexate, oxidative damage to proteins as well as other factors was related to toxic side effects. (pinestreetfoundation.org)
  • Chemo drugs are known to carry some serious side effects, and the drug used in this study was no exception -- over 100 possible side effects are known, including coma, temporary blindness, loss of ability to speak, convulsions, paralysis and collapse. (naturalnews.com)
  • Longo found that short-term fasting before and just after undergoing chemotherapy could greatly reduce the side effects associated with the therapy. (coconutresearchcenter.org)
  • Two to 4 days of fasting before chemotherapy treatment is safe and protect animals, and possibly humans, against the side effects of chemotherapy. (kingdomfasting.com)
  • In this study, continuous infusion of epirubicin into the bladder and instillation of a single dose epirubicin will be evaluated in terms of side effects, tumor recurrence and progression rates. (centerwatch.com)
  • Laboratory studies suggest that ginger can protect brain cells from the plaques that cause Alzheimer's disease, but this effect has not been studied in humans. (mskcc.org)
  • Conclusions These studies provide the rationale for testing expanded natural killer cells in humans. (haematologica.org)
  • Many of the genes analyzed in this study are conserved in both humans and sea urchins," said Bodnar, who is GMGI's Donald G. Comb Science Director. (drugdiscoverynews.com)
  • Patients receiving chemotherapy are instructed to increase protein and calorie intake. (coconutresearchcenter.org)
  • A 20 to 40% reduction in calorie intake or dietary restriction (DR) protects a wide variety of organisms against oxidative stress and aging (1-6). (kingdomfasting.com)
  • Pharmacokinetic studies have been performed in adult leukemia patients with normal renal and hepatic function following intravenous administration of 10 to 12 mg/m 2 of idarubicin daily for 3 to 4 days as a single agent or combined with cytarabine. (nih.gov)
  • Rates are far higher in unvaccinated persons in all adult age groups, including during a period when the Delta variant was the predominant strain of the SARS-CoV-2 virus. (cdc.gov)
  • Oprelvekin is recombinant interleukin eleven (IL-11), a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. (wikipedia.org)
  • 1 According to Longo, fasting causes cells to rapidly switch to a protected mode with changes in levels of glucose, IGF-1, protein kinase A (PKA), and many other proteins and molecules, protecting the cells from various toxins, including chemotherapy drugs. (coconutresearchcenter.org)
  • In this assay, over 40 actives were screened for their ability to stimulate the proliferation of hair follicle dermal papilla cells and protect against induced cellular senescence. (imedpub.com)
  • Related studies have reported that the complete response rate of CD19-CAR-T cells in hematological malignancies is approximately 88-90% [ 13 , 14 ]. (hindawi.com)
  • We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)
  • The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)
  • Studies of cellular (nucleated blood and bone marrow cells) drug concentrations in leukemia patients have shown that peak cellular idarubicin concentrations are reached a few minutes after injection. (nih.gov)
  • In this way, CoQ10 helps protect cells from the harmful effects of DNA damage. (medicalnewstoday.com)
  • CoQ10 protects cells against oxidative damage. (medicalnewstoday.com)
  • We developed a method that, for the first time, is able to study the complete genome of glial cells and see how they accumulate somatic mutations, starting from fetal life and through older stages. (abta.org)
  • What's more, they infused patients with the tumor-directed T-cells without requiring "pretreatment" chemotherapy. (childrensnational.org)
  • In the dose-escalation study, eight patients with Epstein Barr virus-positive Hodgkin lymphoma received as few as 2 and as many as 12 doses of between 2 × 107 and 1.5 × 108 cells/m2 of specially engineered T-cells. (childrensnational.org)
  • Quercetin also partially restored drug-induced loss in viability of treated cells for up to 72 h. (vdocuments.net)
  • We hypothesized an additive or a synergistic effect with this drug-flavonoid com- bination, but unexpectedly, quercetin protected cells from the activity of these antimicrotubule drugs and sustained the via- bility of the cells. (vdocuments.net)
  • However, prolonged exposure of the cells to the highest protective dose of quercetin was still able to pre- vent cell proliferation. (vdocuments.net)
  • Rates of new infection and acute disease are highest among adults, but chronic infection is more likely to occur in persons infected as infants or young children. (cdc.gov)
  • In a multicenter, single-arm, open-label phase 2 study on patients with relapsed or refractory B-precursor acute lymphoblastic leukemia, the distribution of any grade neurologic ir-AEs frequency was 52% among patients receiving blinatumomab, and grade 3 or 4 neurologic ir-AEs occurred in 11% and 2% patients, respectively [ 19 ]. (hindawi.com)
  • However, evidence in children with high-risk acute lymphoblastic leukemia (ALL) indicates that a continuous infusion is not more cardioprotective than a bolus infusion. (ajmc.com)
  • Some studies have found ginger may help nausea caused by chemotherapy, but larger studies are needed to confirm these effects. (mskcc.org)
  • Eating fresh ginger in high doses can have blood-thinning effects by preventing platelets from sticking together. (mskcc.org)
  • Ginger (Zingiber officinale) can be helpful in alleviating nausea and vomiting caused by chemotherapy. (peacehealth.org)
  • It's high time that we made ginger a part of our daily cooking like any other herb available on the market. (skincell.org)
  • Several studies in modern medical science also show that ginger does have a positive effect on our digestion. (skincell.org)
  • Chemotherapy itself is very harsh on the body and causes significant collateral damage, including immune suppression by inducing DNA damage and cell death in both peripheral blood and bone marrow (disrupting stem cell development), which often results in long-term impairment to the immune system. (coconutresearchcenter.org)
  • Preliminary results from the DHEAge study in France suggest that the hormone may slow bone loss, improve skin health, and enhance sexual drive in aging adults, particularly women older than 70 years of age. (healthyplace.com)
  • Studies have shown that DHEA cream applied to the inner thigh may boost bone density in older women. (healthyplace.com)
  • Some studies suggest that DHEA may help protect against bone loss in people who are anorexic. (healthyplace.com)
  • BACKGROUND: Prolia is a prescription medicine approved in June 2010 to treat postmenopausal women with osteoporosis at high risk for bone fracture. (medlineplus.gov)
  • People taking it also experienced stabilized body weight and a reduction in the fatigue and inertia that usually accompany this combination of chemotherapy agents. (peacehealth.org)
  • It may be seen in greater than 90% of patients older than 60 years who have been successfully treated with combination chemotherapy and whole-brain radiation. (medscape.com)
  • Preliminary studies suggest andrographis alone or in combination with other herbs may reduce duration and severity of upper respiratory infections associated with the common cold or flu. (mskcc.org)
  • In one study, patients who took 1,200 mg/day of NAC in combination with weekly intravenous NAC, had better neurological health and improvement in midbrain dopamine neurons. (traceminerals.com)
  • Some studies have confirmed that [ 9 - 12 ] metformin could increase chemosensitivity, especially in combination with paclitaxel. (oncotarget.com)
  • Numerous in vitro and animal model studies using quercetin alone or quercetin in combination with other bioactive com- pounds have shown the anticancer activities of the compound (8-15). (vdocuments.net)
  • In settings in which a high proportion of adults have risks for HBV infection (e.g., sexually transmitted disease/human immunodeficiency virus testing and treatment facilities, drug-abuse treatment and prevention settings, health-care settings targeting services to IDUs, health-care settings targeting services to MSM, and correctional facilities), ACIP recommends universal hepatitis B vaccination for all unvaccinated adults. (cdc.gov)
  • Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification. (cancerindex.org)
  • STZ-based chemotherapy is an effective and well-tolerated treatment option in patients with well differentiated neuroendocrine neoplasms. (cancerindex.org)
  • Exposing people to what researchers have called a "scapegoat stimulus" just before the administration of chemotherapy can direct the food aversion to the "scapegoat" food instead of more important parts of the diet. (peacehealth.org)
  • 12 In another study, researchers found that high oral doses of NAC safely raised levels of NAC in the cerebrospinal fluid without any adverseeffects. (traceminerals.com)
  • Hence, this study was designed to explore the effect and mechanism of BBP on suppressing astrocyte-mediated neuroinflammation in a mouse model of PD. (bvsalud.org)
  • No dose adjustment in patients with renal impairment is generally recommended. (who.int)
  • The aim of the present study was to determine the status of STZ usage in Japan and to evaluate the effectiveness and safety of STZ chemotherapy in Japanese NET patients. (cancerindex.org)
  • In this study, we first found that high concentrations of C. tropicalis promote tumor growth in cell cultures and xenografts. (jcancer.org)
  • When immune globulin (IG) is given concurrently with the first dose of vaccine, the proportion of persons who develop protective levels of anti-HAV is not affected, but antibody concentrations are lower. (cdc.gov)
  • Because the final concentrations of anti-HAV are substantially higher than that considered to be protective, this reduced immunogenicity is not expected to be clinically important (7). (cdc.gov)
  • The heart contains some of the highest concentrations of CoQ10 in the body. (medicalnewstoday.com)
  • 3] When urate is filtered at exceedingly high concentrations from the plasma and is further concentrated through the course of the tubular system, with the pH becoming progressively more acidic, uric acid precipitation and obstruction in the tubules, collecting ducts, and even pelves and ureters may result. (medscape.com)
  • HN-2 has a fruity odor at high concentrations and a soapy odor at low concentrations. (cdc.gov)
  • Al- though quercetin induced cell death in a dose-dependent manner, 12.5-50 µ M quercetin inhibited the activity of both taxol and noco- dazole to induce G2/M arrest in various cell lines. (vdocuments.net)
  • In women, NAC protects ovarian follicles and ovarian tissue 16 and triggers ovulation in women with polycystic ovary syndrome (when used together a fertility drug). (traceminerals.com)
  • Instead of using a water fast, they generally use a very low-calorie, high-fat diet that mimics the effects of fasting, but still allows some calories and nutrients. (coconutresearchcenter.org)
  • If use is unavoidable, closely monitor for adverse reactions and consider dose reduction of BCRP substrate drug (refer BCRP substrate prescribing information). (medscape.com)
  • Preliminary results from a separate internal FDA study further investigating hypocalcemia in dialysis patients treated with Prolia show a substantial risk with serious outcomes, including hospitalization and death. (medlineplus.gov)
  • Radiation-induced dermatitis (RID) is a cutaneous reaction that occurs because of damage by ionising radiation. (eviq.org.au)
  • Two recent studies show that this class of pharmaceutical, which is commonly used to treat osteoarthritis in the knees, actually contributes to the progression of the disease. (naturalnews.com)
  • No difference was seen in terms of overall and progression-free survival between these study arms. (jnccn.org)
  • Herein we report the development of a high-throughput screening assay, using low, repeat dosing of to induce senescence. (imedpub.com)
  • Persons who are allergic to a vaccine component or otherwise elect not to receive vaccine should receive a single dose of IG (0.02 mL per kg of body weight), which provides effective protection against hepatitis A for up to 3 months. (cdc.gov)
  • Early single-dose instillation of epirubicin immediately after transurethral resection was shown to improve recurrence rates in low and intermediate risk groups. (centerwatch.com)
  • High dietary niacin intake is associated with decreased. (cambridge.org)
  • We observed a significant inverse association between translocation frequency and dietary intake of niacin ( P = 0·02): adjusted rate ratio for subjects in the highest tertile compared with the lowest tertile was 0·58 (95 % CI 0·40, 0·83). (cambridge.org)