High dose mucositis. Medical search. Frequent questions

We studied the feasibility and toxicity of escalating the doses of fractionated TBI above our previous prescription of 13.5 Gy. (nature.com)
The 2 most commonly used are the World Health Organization (WHO) Oral Toxicity score and the National Cancer Institute (NCI) Common Common Terminology Criteria for Adverse Events (CTCAE) for oral mucositis. (medscape.com)
BIND-014 was generally safe and well-tolerated with transient and manageable neutropenia as the dose limiting toxicity. (tgen.org)
Chemotherapy induced mucositis is a common side effect of drug toxicity with up to 80% of patients having symptoms during their treatment (Dodd et al 2000, Lalla and Patterson 2006). (ukessays.com)
It is generally accepted that mucositis is underreported when measured as a toxicity compared with studies in which mucositis is the endpoint being evaluated. (medscape.com)
Acute Radiation Syndrome (ARS) (sometimes known as radiation toxicity or radiation sickness) is an acute illness caused by irradiation of the entire body (or most of the body) by a high dose of penetrating radiation in a very short period of time (usually a matter of minutes). (cdc.gov)
Treatment continued until treatment-limiting toxicity (TLT) developed, such as mucositis, diarrhea, or fatigue. (elsevierpure.com)
Conclusion: IFN-α substantially enhanced the gastrointestinal toxicity of low-dose PCI 5-FU without affecting 5-FU pharmacokinetics, contrary to previous reports using alternative 5-FU schedules in which IFN- α-related enhancement of 5-FU toxicity was attributable to reduced 5-FU clearance. (elsevierpure.com)
Optimizing the therapeutic ratio for radiation therapy (RT) in head and neck squamous cell carcinoma (HNSCC) is uniquely challenging owing to high rates of early and late toxicity involving nearby organs at risk. (biomedcentral.com)
Genetic alterations in BRCA2, ERBB3, NOTCH1 and CCND1 were all associated with higher mean grade of toxicity with BRCA2 alteration implicated in all toxicity parameters evaluated including mucositis, early dysphagia, xerostomia and to a lesser extent, late dysphagia. (biomedcentral.com)
Dose limitations are uniquely challenging in HNSCC due to the proximity of critical OARs with early and late toxicity resulting in mucositis, dysphagia, xerostomia, tooth decay, vocal dysfunction and loss of taste [ 11 ]. (biomedcentral.com)
The main grade = 3 toxicity was mucositis in 6 (6/29, 21%) patients. (baycitycapital.com)
Dose adjustments and dose delays of one or both agents were allowed based on toxicity. (baycitycapital.com)
Daily doses of calcium folinate should be adjusted depending on the hematological toxicity of trimetrexate. (janusinfo.se)

Chemotherapy-induced oral mucositis causes the mucosal lining of the mouth to atrophy and break down, forming ulcers. (medscape.com)
Results: The results showed that the treatment did not induce clinical signs of mucositis in the ventral mucosal tongue region. (bvsalud.org)
Oral mucositis (OM) is defined as oral mucosal changes secondary to cancer therapies. (ukessays.com)
Because hypothermia can reduce oral temperature, constrict blood vessels, and reduce the dose of drugs in contact with mucosal tissues. (ecbasis.org)
Chemotherapeutic agents can cause direct mucosal injury (mucositis) or predispose to distension and necrosis, thereby altering intestinal motility, the authors write. (medscape.com)

The Oral Mucositis Daily Questionnaire (OMDQ), which evaluates mouth and throat soreness and its impact on daily activities, is a validated instrument that correlates with oral mucositis severity based on the WHO score. (medscape.com)
Depending on the severity and extent of discomfort, oral mucositis is treated symptomatically and usually involves targeting the infection while managing symptoms. (outsourcestrategies.com)
With increasing severity of mucositis, and especially when involving the esophagus, systemic opioids may be indicated. (medscape.com)
Low-level laser therapy (LLLT) also called Photobiomodulation therapy (PBMT) could reduce oral mucositis (OM) incidence and severity in head and neck cancer patients treated by chemoradiotherapy, however randomised data about efficacy and safety are missing with curative dose 4 J/cm 2 . (biomedcentral.com)
It is common (40-100% incidence) in patients undergoing high dose chemotherapy and hematopoietic cell transplantation, where the incidence and severity of oral mucositis depends greatly on the nature of the conditioning regimen used for myeloablation. (soligenix.com)
Severe mucositis was defined as either grades 2 to 4 or grades 3 and 4, depending on the studies' definition of severity. (elsevierpure.com)
Emerging evidence suggests that RT dose alone cannot fully account for the variable severity of RT-related adverse events (rtAEs) observed in HNSCC patients. (biomedcentral.com)
secondary end points included severity and duration of grade 3 or higher oral/GI toxicities, and time to neutrophil and platelet engraftment. (targetedonc.com)

They may help to prevent oral mucositis or mouth sores associated with high-dose chemotherapy. (wikipedia.org)
Mucositis (mouth sores) is a severe adverse complication of chemotherapy & radiation treatments. (soothiefrost.com)

This study proved that low temperature can effectively prevent oral mucositis. (ecbasis.org)

Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)
To our knowledge, this is the first analysis on OM in allogeneic HSCT patients with respect to conditioning regimens, and we observed that RIC regimens led to a high incidence of OM similar to that of MA regimens. (elsevierpure.com)

However, locally in practice no interventions on minimizing the risk of mucositis exists despite the impact it can have on cancer patients. (ukessays.com)

Fluorouracil can cause severe mucositis. (nih.gov)
[ 4 ] They found that the incidence of severe mucositis (WHO grades 3 and 4) was no higher than 10% (and in most cases much lower) in any of the disease groups. (medscape.com)
Severe mucositis (grade 3 or 4) occurred in 23% of cycles but tended to be short-lived and was reversible. (tau.ac.il)

however, Lalla et al, while reviewing published trials for the 2014 Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) guidelines, found that mucositis occurs in approximately 20-40% of patients receiving conventional chemotherapy and in 80% of patients receiving high-dose chemotherapy. (medscape.com)
Oral mucositis is estimated to occur in 20% - 40% of patients receiving conventional chemotherapy & up to 80% of patients receiving high-dose chemotherapy. (soothiefrost.com)

Oral mucositis, pharynx mucositis and salivary gland inflammation were positively correlated with swallowing functional outcomes, and the pharynx mucositis presented the highest absolute value of β. (bmj.com)
for example, intense oral and pharyngeal pain induced by a combination of oral mucositis, oropharyngeal candidiasis, salivary gland hypofunction, and xerostomia frequently lead to dysphagia in cancer patients compromising nutritional intake. (pocketdentistry.com)

It is estimated, based upon review of historic published studies and reports and an interpolation of data on the incidence of mucositis, that mucositis affects approximately 500,000 people in the US per year and occurs in 40% of patients receiving chemotherapy. (soligenix.com)
It is estimated, based upon review of historic published studies and reports and an interpolation of data on the incidence of oral mucositis, that oral mucositis in head and neck cancer is a subpopulation of approximately 90,000 patients in the US, with a comparable number in Europe. (soligenix.com)

Doxepin hydrochloride in treating oral mucositis pain in patients with head and neck cancer undergoing radiation therapy with or without chemotherapy. (medscape.com)

Neutropenia enhances the degree of oral mucositis. (touchoncology.com)
The more serious the neutropenia, the more serious the oral mucositis. (touchoncology.com)
Safety profile of docetaxel regimens includes toxicities, particularly a high risk of neutropenia and febrile neutropenia. (hindawi.com)
Two (0.5%) patients and 32 (8.1%) patients had dose delayed due to febrile neutropenia and neutropenia, respectively. (hindawi.com)
Four (1.0%) patients and 32 (8.1%) patients had a dose changed due to febrile neutropenia and neutropenia, respectively. (hindawi.com)
These improvements in outcome are very welcome, yet they do have associated substantial toxicities, especially a moderate-to-high risk of neutropenia or febrile neutropenia (FN) [ 8 ]. (hindawi.com)
There is strong and consistent clinical evidence to show that granulocyte-colony stimulating factors (G-CSFs) reduce the risk of chemotherapy-induced neutropenia and therefore complicated neutropenia and can be used to maintain chemotherapy at the desired dose intensity or density and minimize delays in treatment [ 11 ]. (hindawi.com)
People exposed to radiation may be divided into "low-risk" and "high-risk" susceptibility groups, based on degree of neutropenia and the presence of comorbidities. (msdmanuals.com)
The incidence of febrile neutropenia/neutropenia with sepsis may also be higher in patients treated with trastuzumab in combination with docetaxel than in those treated with docetaxel alone. (medscape.com)
Patients with febrile neutropenia and/or neutropenic infection should have their docetaxel dose reduced to 60 mg/m 2 for all subsequent cycles. (medscape.com)

Patients should be informed about their risk for developing oral mucositis, as well as potential signs and symptoms, and should alert their provider at the earliest onset of oral discomfort. (medscape.com)
In today's podcast, Amber Darst, Solutions Manager from Managed Outsource Solutions discusses the causes, symptoms and treatment for mucositis . (outsourcestrategies.com)
Today, I'll be discussing the causes, symptoms and treatment for mucositis. (outsourcestrategies.com)
Mucositis can cause a range of symptoms, many of which affect the mouth. (outsourcestrategies.com)
o Mild symptoms may be observed with doses as low as 0.3 Gy or 30 rads. (cdc.gov)
the full syndrome will usually occur with a dose greater than approximately 0.7 Gy (70 rads) although mild symptoms may occur as low as 0.3 Gy or 30 rads. (cdc.gov)
The classic symptoms for this stage are nausea, vomiting, as well as anorexia and possibly diarrhea (depending on dose), which occur from minutes to days following exposure. (cdc.gov)
8 Patients often do not report oral mucositis if the symptoms are mild or if they are not queried about it. (touchoncology.com)
These symptoms can limit the doses and duration of cancer treatment, leading to sub-optimal treatment outcomes. (soligenix.com)

One study has reported that on repeat dosing of 0.5 mg/kg every 6 weeks, the clearance of melphalan decreased from 8.1 mL/min/kg after the first course, to 5.5 mL/min/kg after the third course, but did not decrease appreciably after the third course. (nih.gov)
Mean (±SD) peak melphalan plasma concentrations in myeloma patients given intravenous melphalan at doses of 10 or 20 mg/m 2 were 1.2 ± 0.4 and 2.8 ± 1.9 mcg/mL, respectively. (nih.gov)
Arm 2: Intravenous melphalan 16 mg/m 2 q 2 weeks x 4 (over 6 weeks) followed by the same dose every 4 weeks. (nih.gov)
4 Patients receiving chemotherapy treatments using certain drugs such as 5-fluorouracil (5-FU) 5 and melphalan 6 have a higher incidence of oral mucositis than those receving other chemotherapy drugs. (touchoncology.com)
The LoE for prevention of OM with oral cryotherapy in patients undergoing autologous hematopoietic stem cell transplant using high-dose melphalan conditioning protocols was upgraded, and the guideline changed to recommendation. (elsevierpure.com)
Conclusions: The evidence supports recommendations for the use of oral cryotherapy for the prevention of OM for either (i) patients undergoing autologous hematopoietic stem cell transplant with high-dose melphalan conditioning protocols or (ii) patients receiving bolus 5-fluorouracil chemotherapy. (elsevierpure.com)

Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy. (medscape.com)
Individualize the dose and dosing schedule of fluorouracil based on tumor type, the specific regimen administered, disease state, response to treatment, and patient risk factors. (nih.gov)

Efficacy of curcumin for amelioration of radiotherapy-induced oral mucositis: a preliminary randomized controlled clinical trial. (bvsalud.org)
Mechanism-based management for mucositis: option for treating side effects without compromising the efficacy of cancer therapy. (viho.es)
Purpose: To determine the safety and efficacy of multiple cycles of dose-intensive, nonablative chemotherapy in women with poor-prognosis breast cancer. (tau.ac.il)
It is a potent, selective and long half-life inhibitor of all three VEGF receptors and is designed to optimize VEGF blockade while minimizing off-target toxicities, potentially resulting in improved efficacy and minimal dose modifications. (ewhealthcare.com)
Furthermore, they can lead to delays and dose reductions in chemotherapy treatment, thereby potentially compromising the efficacy of chemotherapy and, consequently, patient outcome [ 10 ]. (hindawi.com)

Conclusion: This study showed that, in the mouse model, methotrexate-induced mucositis histological result in manifestations in the ventral tongue region. (bvsalud.org)
RE, P =06) than that found among patients who received methotrexate (83.4%), either standard or reduced dose. (elsevierpure.com)
The higher doses of methotrexate often used in cancer chemotherapy can cause toxic effects to the rapidly-dividing cells of bone marrow and gastrointestinal mucosa. (the-medical-dictionary.com)
The resulting myelosuppression and mucositis are often prevented (termed methotrexate "rescue") by using folinic acid supplements (not to be confused with folic acid). (the-medical-dictionary.com)
Trial participants were randomized to 15 mg of methotrexate once weekly given in three divided doses with a 12-hour interval between doses, or cyclosporine in a dosage of 3 mg per kg given in two daily doses. (the-medical-dictionary.com)
Since the calcium folinate rescue dosage regimen depends heavily on the posology and method of the intermediate- or high-dose methotrexate administration, the methotrexate protocol will dictate the dosage regimen of calcium folinate rescue. (janusinfo.se)
refer to the applied intermediate or high dose methotrexate protocol for posology and method of administration of calcium folinate. (janusinfo.se)
Calcium folinate rescue is necessary when methotrexate is given at doses exceeding 500 mg/m2 body surface and should be considered with doses of 100 mg - 500 mg/m2 body surface. (janusinfo.se)
In addition to calcium folinate administration, measures to ensure the prompt excretion of methotrexate (maintenance of high urine output and alkalinisation of urine) are integral parts of the calcium folinate rescue treatment. (janusinfo.se)

All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
Oral mucositis (OM) is a debilitating early adverse effect of allogeneic hematopoietic stem cell transplantation (HSCT). (elsevierpure.com)
AB-205 demonstrated robust effects and an encouraging safety profile in patients with systemic lymphoma undergoing high-dose therapy and autologous hematopoietic stem cell transplantation. (targetedonc.com)
The engineered cord endothelial cell (E-CEL) product AB-205 demonstrated robust effects and an encouraging safety profile in patients with systemic lymphoma undergoing high-dose therapy and autologous hematopoietic stem cell transplantation (HDT-ASCT). (targetedonc.com)
Figure 8‐2 ) may be treated by moderate or high‐dose chemotherapy, with or without hematopoietic stem cell transplantation (HSCT). (pocketdentistry.com)

Studies have shown higher survival rates for people with head and neck cancers that test positive for HPV when they are treated with systemic chemotherapy and radiation therapy. (sciencedaily.com)
Reactivation of such infections occurs in 70-90% of patients who have antibodies to these agents and can aggravate preexisting oral mucositis and result in systemic infection. (medscape.com)
Systemic adjuvant chemotherapy with anthracycline- and taxane-containing regimens has become the standard first line treatment for early and metastatic breast cancer [ 5 ], with large phase III randomized trials showing extremely high long-term disease-free survival and overall survival rates (resp. (hindawi.com)
In fact, reducing the planned dose intensity of systemic adjuvant chemotherapy regimens by as little as 15% has been shown to significantly reduce time to progression and overall survival rates in women with metastatic breast cancer [ 5 ]. (hindawi.com)

Oral mucositis leads to pain and restriction of oral intake, and, in severe cases (eg, patients undergoing myeloablative therapy prior to HCT), necessitates total parenteral nutrition and increased use of narcotic analgesics. (medscape.com)
9 Medications such as palifermin 10 and caphasol 11 are indicated for the prevention of oral mucositis in patients undergoing high-dose myeloablative therapies. (touchoncology.com)

The data will come from a study design that calls for the enrollment of approximately 190 patients in a randomized, multinational, double-blind, placebo-controlled study to evaluate SGX942 for the treatment of severe oral mucositis in patients with squamous cell carcinoma of the oral cavity that are undergoing chemo-radiation therapy. (thenewsuniverse.com)

Healthcare professionals should identify early on the population at higher risk and focus on multiple toxicities, especially the management of pharynx mucositis, to improve nutritional status. (bmj.com)
The highest dose of 20 × 106 E-CEL/kg demonstrated robust effect in eliminating oral/GI severe regimen-related toxicities. (targetedonc.com)
Some of these are SRRT, which lead to high symptom burden and life-threatening organ toxicities. (targetedonc.com)

The takeaway is "that topical diclofenac significantly reduces the incidence of grade 2 or higher HFS in patients receiving capecitabine. (medscape.com)

Oral mucositis (OM) is one of the main problems in almost all patients undergoing head and neck radiotherapy (RT). (bvsalud.org)
Similar to radiotherapy, normal host cells with a high index of mitotic activity are also affected. (bvsalud.org)
Intestinal mucositis is a common side effect during radiotherapy that could be largely prevented by compounds possessing anti-inflammatory or anti-oxidant properties, including extracts of propolis containing a high proportion of flavonoids. (blogspot.com)
Oral mucositis (OM) is one of the most common adverse effects of chemotherapy and radiotherapy, especially for head and neck cancer (HNC). (biomedcentral.com)
Radiotherapy is delivered either by external beam radiation, which is similar to the way an x-ray is taken (however in much stronger doses) by the insertion of radioactive implants ( brachytherapy ) or via isotope therapy . (healthengine.com.au)
This method requires patients to receive ultra-high-dose radiotherapy or chemotherapy, sometimes in combination with other immunosuppressive drugs, to remove tumor cells and abnormal clone cells in the body, and then reinfuse hematopoietic stem cells collected from themselves or others to rebuild normal hematopoietic and Immune Function. (ecbasis.org)

Oral mucositis in its early stages presents with erythema, mild pain, and mild dysphagia that is manageable with over-the-counter medications. (touchoncology.com)

All but one patient developed treatment-related grade 3 or 4 mucositis. (nature.com)
Many times mucositis can affect cancer treatment because patients may have to be given a lower dose of a drug or stop treatment completely. (viho.es)
Gholizadeh N, Sheykhbahaei N, Sadrzadeh-Afshar MS. New Treatment Approaches of Oral Mucositis: A Review of Literature. (viho.es)
At the beginning of last century, the only treatment available for patients with solid tumors was surgery, associated with high morbidity and mortality. (bvsalud.org)
In patients undergoing HCT, oral mucositis is reported as the most debilitating aspect of their treatment. (medscape.com)
They are, however, not indicated for the treatment of oral mucositis after chemotherapy has been administered. (touchoncology.com)
Patient quality of life can be affected by oral mucositis, and its consequences can result in treatment delays, hospitalizations, and unintended increases in medical costs. (touchoncology.com)
Purpose: To determine the maximum-tolerable dose (MTD) of fluorouracil (5- FU) administered as a low-dose, prolonged continuous intravenous infusion (PCI) plus interferon-alfa (IFN-α) that would permit treatment for at least 28 consecutive days, and to determine the effect of IFN-α on 5-FU pharmacokinetics. (elsevierpure.com)
Princeton, NJ - January 2, 2018 - Soligenix, Inc. (Nasdaq: SNGX) (Soligenix or the Company), a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need, announced today that the United States (US) Patent Office has granted the patent entitled "Novel Peptides and Analogs for Use in the Treatment of Oral Mucositis. (soligenix.com)
Soligenix has reported positive Phase 2 results with SGX942 in the treatment of oral mucositis in head and neck cancer (HNC) patients. (soligenix.com)
SGX942 at a dose of 1.5 mg/kg successfully reduced the median duration of severe oral mucositis by 50% in all patients and by 67% in patients receiving the most aggressive chemoradiation therapy for treatment of their HNC. (soligenix.com)
In addition to the oral mucositis findings, an increased incidence of "complete response" of tumor at both the one month and twelve month follow-up visits were observed with SGX942 treatment, as well as decreases in mortality and infection rate. (soligenix.com)
This painful side effect can result in treatment interruption, dose reductions or even treatment discontinuation. (soothiefrost.com)
Thanks, Stickman for the response, I am hoping if you need any more treatments it is a light dose, hopefully, they can be confident that clear margins were attained and they will monitor you with periodic scans which they always do post-treatment. (cancer.org)
Even though the DNA is damaged at the standard dose of radiation used in cancer treatment, the rest of the cell structures remain viable and continue to work. (healthengine.com.au)
This positive CHMP opinion follows the European Commission's recent expedited approval of EUSA's dinutuximab beta, which is the only immunotherapy indicated for the treatment of high risk neuroblastoma in Europe. (ewhealthcare.com)
The treatment of older patients with AML or high-risk MDS presents particular challenges, including many patients not tolerating or responding to existing therapies," said Farhad Ravandi, M.D., Professor of Medicine, Department of Leukemia, University of Texas MD Anderson Cancer Center, and a study investigator. (baycitycapital.com)
Despite the spread of HCC, its treatment it's still a hard challenge, due to high rate of late diagnosis and to lack of therapeutic options for advanced disease. (wjgnet.com)
Knowledge regarding these cancer therapies will allow dental practitioners to provide these patients with the highest standard of care before, during, and after the patient's cancer treatment and management. (jrmds.in)
In the pre-treatment protocol for chemotherapeutics, periodontal treatment is helpful if conducted before high-dose chemotherapy [ 1 - 3 ]. (jrmds.in)
Furthermore, lenograstim may increase the patient's exposure to chemotherapy allowing patients to receive optimal dosing and duration of treatment, benefitting survival. (hindawi.com)
G-CSFs have been shown to reduce overall mortality risk [ 8 , 11 ], reduce the incidence of other adverse events (grade 2 or greater anaemia, asthenia, anorexia, myalgia, nail disorders, and oral mucositis) associated with docetaxel-based chemotherapy regimens, and increase health related quality of life and consequently treatment compliance [ 8 , 12 ]. (hindawi.com)
Based on this evidence, guidelines published by the American Society of Clinical Oncology and the European Organisation for Research and Treatment of Cancer state that when the overall risk of FN is 20% or greater, especially on "dose dense" regimens, primary prophylaxis with G-CSFs is justified [ 10 , 13 ]. (hindawi.com)
After several parenteral doses treatment can be switched over to the oral form. (janusinfo.se)
Prevention: Calcium folinate should be administered every day during treatment with trimetrexate and for 72 hours after the last dose of trimetrexate. (janusinfo.se)
In case of high dose pyrimethamine or prolonged treatment with low doses, calcium folinate 5 to 50 mg/day should be simultaneously administered, based on the results of the peripheral blood counts. (janusinfo.se)

High dose chemotherapy, and localized high dose radiation therapy to the head and neck region are the main factors that cause oral mucositis. (outsourcestrategies.com)
2 The incidence rate is also high in patients undergoing head and neck cancer treatments, 3 especially if they are receiving concurrent chemoradiotherapy. (touchoncology.com)
Title: Laser Mucite ORL: Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Neck Cancer (LaserMucite). (biomedcentral.com)

The killing of leukemia cells is proportional to the radiation absorbed dose. (nature.com)

The dose usually must be external (i.e., the source of radiation is outside of the patient's body). (cdc.gov)
In this document, the referenced absorbed dose is that dose inside the patient's body (i.e., the dose that is normally measured with personal dosimeters). (cdc.gov)
Mucositis has a very significant effect on the patient's quality of life & leads to several problems: open sore pain, inability to eat/nutritional concerns & increased risk of infection. (soothiefrost.com)

BIND-014 represents the first targeted and programmable Accurin nanomedicine to reach the clinic from BIND's proprietary drug development platform, which creates targeted therapeutics designed to accumulate at the site of disease for high drug concentration and maximum therapeutic effect. (tgen.org)
Currently, no approved preventive or therapeutic agent consistently prevents oral mucositis in all clinical settings. (medscape.com)
Soligenix continues to pursue broad patent coverage for its dusquetide technology, first with composition of matter claims followed by therapeutic use claims in oral mucositis," stated Christopher J. Schaber, PhD, President and Chief Executive Officer of Soligenix. (soligenix.com)

It is more expensive but has better bioavailability and a more convenient dosing regimen than acyclovir. (medscape.com)
In one study, childhood ALL patients failing induction therapy with a cytarabine-containing regimen were treated with the combination of teniposide 165 mg/m2 and cytarabine 300 mg/m2 intravenously, twice weekly for 8 to 9 doses. (wikidoc.org)
The low incidence of adverse effects and chemotherapy dose changes, delays, and withdrawals supports the use of lenograstim as effective primary prophylaxis in South African patients being treated with a docetaxel-based regimen. (hindawi.com)
The high‐dose induction chemotherapy regimen that will be used to treat this patient is profoundly myelosuppressive, and typically causes severe ulcerative oral mucositis for at least two weeks duration. (pocketdentistry.com)

Withhold fluorouracil until severe myelosuppression resolves, then resume at a reduced dose. (nih.gov)

In banal oral mucositis, the oral mucosa exhibits ulceration that, unlike other ulcerative conditions, shows a paucity of neutrophils in the fibrin clot. (medscape.com)
In an interventional study by Rosen et al evaluating patients with colorectal cancer being treated with 5-fluorouracil and leucovorin, the incidence of ulcerative mucositis was approximately 50% in the placebo group. (medscape.com)

Purpose: To update the 2013 Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines on oral cryotherapy for the management of oral mucositis (OM) caused by cancer therapies. (elsevierpure.com)

It often leads to dose reductions and sometimes even discontinuations, both of which limit the effectiveness of capecitabine, a standard oral chemotherapy drug widely used for colorectal and breast cancers. (medscape.com)
Hand-foot syndrome led to dose reductions of capecitabine in 13.5% of placebo but only 3.8% of those in the diclofenac group ( P = .002). (medscape.com)

A specially formulated aqueous extract of propolis (PWE) has been prepared in such a way to preclude the inclusion of flavonoids but contain mostly organic aromatic acids to study whether it would still protect against radiation-induced intestinal mucositis and to study the possible involvement of apoptotic pathways. (blogspot.com)
Rats were exposed to a gamma radiation dose of 8 Gy from a Cesium-137 source in order to inflict intestinal mucositis. (blogspot.com)

MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. (medscape.com)

Duration: 2 to 4 weeks after the last dose. (viho.es)

Oral mucositis is a common complication of cancer chemotherapy. (medscape.com)
However, it is frequently under-reported and leads to high morbidity and complication rates. (touchoncology.com)
According to the Oral Cancer Foundation , oral mucositis is probably the most common, debilitating complication of cancer treatments, particularly chemotherapy & radiation. (soothiefrost.com)

Calcium folinate can be administered either by the intravenous route at a dose of 20 mg/m2 for 5 to 10 minutes every 6 hours for a total daily dose of 80 mg/m2 or by oral route with four doses of 20 mg/m2 administered at equal time intervals. (janusinfo.se)

The patients received IMRT for seven to eight weeks (median dose was 72.0 Gy). (sciencedaily.com)
For example, polonium-210 (Po-210) has a specific activity of 166 terabecquerels per gm (TBq/g), and 1 mcg (about the size of a grain of salt) of Po-210 delivers a whole body dose of 50 Sv (~20 times the median lethal dose). (msdmanuals.com)

Oral mucositis (inflammation of the lining of the mouth) is a very common adverse effect when chemotherapy and radiation therapy are used to treat cancer. (viho.es)
The adverse events (AEs) reported on study were consistent with that in an AHCT population, and the maximum-tolerated dose was not reached, explained lead study author Carolyn Mulroney, MD, in a presentation during the meeting. (targetedonc.com)
Despite the abnormally high incidence of the fatal adverse effect, the ANSM is not, for now, recommending that the marketing of docetaxel be suspended. (medscape.com)

Dusquetide previously demonstrated positive results in a Phase 2 oral mucositis clinical trial and a pivotal Phase 3 study was recently initiated in 2017. (soligenix.com)

This Phase 1 trial has successfully established the safety and tolerability profile and maximum tolerated dose of BIND-014 in patients with advanced or metastatic solid tumor cancers," said Dr. Von Hoff, F.A.C.P., TGen's Distinguished Professor. (tgen.org)
In addition to confirming the safety, tolerability and maximum tolerated dose of BIND-014, these data also provide encouraging signs of anti-tumor activity in a variety of solid tumors," said Dr. Gregory Berk, Chief Medical Officer of BIND Therapeutics. (tgen.org)
Tumor in these nodes portends a high risk of recurrence. (ucsfhealth.org)

The benefit of x-ray therapy is that a high dose can be delivered directly to the cancer with minimal direct dosing to the skin. (healthengine.com.au)

We conclude that TBI dose escalation above the previously used 13.5 Gy dose is feasible using a high-energy source and high-dose etoposide. (nature.com)
Escalation to the next 5- FU dose level occurred if none of three or zero to two of six patients developed TLT before day 28. (elsevierpure.com)
In the phase 1 dose-escalation study (NCT03925935), investigators enrolled patients with non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma undergoing their first hematopoietic stem cell transplant who were eligible for HDT-AHCT and had an ECOG performance status of 0 to 1. (targetedonc.com)

LED produced a 47% reduction in pain of children suffering from oral mucositis. (researchgate.net)
Because the pain from mucositis can be so bad it can cause the inability to eat or drink, inability to talk, gagging and drooling. (viho.es)

The entire body (or a significant portion of it) must have received the dose.3 o Most radiation injuries are local, frequently involving the hands, and these local injuries seldom cause classical signs of ARS. (cdc.gov)

In 28 patients with advanced or metastatic solid tumors, BIND-014 - with its targeted docetaxel Accurin - was shown to be generally safe and well-tolerated at the established maximum dose of 60 mg/m2. (tgen.org)
In patients undergoing chemotherapy at standard doses, oral mucositis generally presents as grades 1 and 2 rather than grades 3 and 4. (touchoncology.com)

Established the maximum tolerated dose of 60 mg/m2 when administering BIND-014 on a once every 3 week (Q3W) schedule. (tgen.org)

We found a statistically significant higher progression free survival rates when comparing the outcomes of patients with HPV-positive tumors to those with HPV-negative tumors," explains Keith Unger, MD, lead author of the study. (sciencedaily.com)
GEE models showed that patients with cancer of the pharynx region, advanced stage, chemoradiotherapy and high RT dose perceived worse swallowing functional outcomes. (bmj.com)
This is particularly consequential for human papillomavirus (HPV) negative patients with literature demonstrating higher likelihood of missed treatments compared to their HPV positive counterparts, which compounds with baseline inferior disease-related outcomes [ 10 ]. (biomedcentral.com)

The diagnosis of chemotherapy-induced oral mucositis is based on clinical findings and the chronology of the development of lesions. (medscape.com)

South San Francisco, CA - Sunesis Pharmaceuticals, Inc. (Nasdaq:SNSS) today announced the presentation of results from an ongoing Phase 1b/2 University of Texas MD Anderson Cancer Center-sponsored trial of vosaroxin in combination with decitabine in older patients with previously untreated acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). (baycitycapital.com)
The poster (Poster #7, Hall A-E, Poster Section 38) is titled "Phase I/II study of vosaroxin and decitabine in older patients with acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS). (baycitycapital.com)
Acute radiation syndromes (ARS) Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (msdmanuals.com)
Acute radiation syndromes can be caused by a sufficient dose of some internally deposited radionuclides that are widely distributed in tissues and organs and have a high specific activity. (msdmanuals.com)

We adjusted the 5-FU infusion dose of the next cycle based on the AUC data of the previous cycle to achieve the target of 20-30 mg×h/L. (medscimonit.com)
Patients and Methods: Twenty-six assessable patients with advanced cancer received low-dose PCI 5-FU (150, 200, 250, and 300 mg/m 2 /d) plus IFN-α, 5 x 10 6 IU/m 2 administered subcutaneously (SC) at hour 48 of the 5-FU infusion, then thrice weekly thereafter in cohorts of at least three patients. (elsevierpure.com)

Anatomy5

Organisms3

Diseases23

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes6

Technology, Industry, Agriculture1

Information Science2

Health Care11

Toxicity14

Mucosal5

Severity8

Mouth Sores2

Prevent oral mucositis1

Conditioning regimens2

Risk of mucositis1

Severe mucositis3

Receiving high-dose chemotherapy2

Salivary gland2

Data on the incidence2

Undergoing radiation therapy1

Neutropenia10

Symptoms9

Melphalan6

Fluorouracil-based2

Efficacy5

Methotrexate9

Transplantation5

Systemic4

Myeloablative2

Oral cavity1

Toxicities3

Reduces the incidence1

Radiotherapy6

Dysphagia1

Treatment26

Head and neck3

Radiation abso1

Patient's3

Therapeutic3

Regimen4

Myelosuppression1

Ulcerative2

Cryotherapy1

Reductions2

Intestinal2

Secondary to cancer1

Duration1

Complication3

Intravenous1

Median2

Adverse3

Clinical trial1

Tumor3

Minimal1

Escalation3

Pain2

Signs1

Generally2

Maximum tolerated dose1

Outcomes3

Diagnosis1

Acute4

Infusion2