Loading...
  • cyclophosphamide
  • Single dose cyclophosphamide priming therapy for multiple myeloma prior to autologous stem cell transplant. (bccancer.bc.ca)
  • Cyclophosphamide (CP), also known as cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system. (wikipedia.org)
  • The main use of cyclophosphamide is with other chemotherapy agents in the treatment of lymphomas, some forms of brain cancer, neuroblastoma, leukemia and some solid tumors. (wikipedia.org)
  • Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced nausea and vomiting, bone marrow suppression, stomach ache, hemorrhagic cystitis, diarrhea, darkening of the skin/nails, alopecia (hair loss) or thinning of hair, changes in color and texture of the hair and lethargy. (wikipedia.org)
  • High-dose intravenous cyclophosphamide can cause the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and a potentially fatal hyponatremia when compounded by intravenous fluids administered to prevent drug-induced cystitis. (wikipedia.org)
  • While SIADH has been described primarily with higher doses of cyclophosphamide, it can also occur with the lower doses used in the management of inflammatory disorders. (wikipedia.org)
  • Intermittent dosing of cyclophosphamide decreases cumulative drug dose, reduces bladder exposure to acrolein and has equal efficacy to daily treatment in the management of lupus nephritis. (wikipedia.org)
  • Tumors
  • A computer guides high-precision radiation to treat tumors anywhere in the body while sparing normal tissues around it. (roswellpark.org)
  • Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. (wikipedia.org)
  • lower doses
  • Lower doses of azathioprine are used as a therapy in children with refractory or corticosteroid-dependent Crohn's disease, without causing many side effects. (wikipedia.org)
  • Also, the drugs can often be used at lower doses, reducing toxicity. (wikipedia.org)
  • lymphocytes
  • This divides leukemias into lymphoblastic or lymphocytic leukemias and myeloid or myelogenous leukemias: In lymphoblastic or lymphocytic leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (wikipedia.org)
  • The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. (wikipedia.org)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • Lymphoma (lymposarcoma) in animals is a type of cancer defined by a proliferation of malignant lymphocytes within solid organs such as the lymph nodes, bone marrow, liver and spleen. (wikipedia.org)
  • donors
  • 2004 The study of HLA haploidentical blood related and unrelated matched donors nonmyeloablative transplantation for the treatment of blood diseases. (wikipedia.org)
  • In the United States, it is currently approved by the Food and Drug Administration (FDA) for use in kidney transplantation from human donors, and for rheumatoid arthritis. (wikipedia.org)
  • cells
  • Giving high-dose chemotherapy with or without TBI before ASCT stops the growth of cancer cells by stopping them from dividing or killing them. (clinicaltrials.gov)
  • Because cancer cells grow very rapidly, they are very dependent on a high rate of nutrient flux into the cell. (gabriellesangels.org)
  • Although such attempts produced no positive benefit, further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation. (wikipedia.org)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (wikipedia.org)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • MCL, like most malignancies, results from the acquisition of a combination of (non-inherited) genetic mutations in somatic cells. (wikipedia.org)
  • MCL cells may also be resistant to drug-induced apoptosis, making them harder to cure with chemotherapy or radiation. (wikipedia.org)