Loading...
  • vivo
  • 24,25 Macrophages synthesize and secrete apoE, which makes contribution to the apoE pool in the blood circulation and associates with plasma lipoproteins and accelerates their clearance in vivo. (ahajournals.org)
  • precursor
  • Once miR-155 pri-miRNA is transcribed, this transcript is cleaved by the nuclear microprocessor complex, of which the core components are the RNase III type endonuclease Drosha and the DiGeorge critical region 8 (DGCR8) protein, to produce a 65 nucleotide stem-loop precursor miRNA (pre-mir-155) (see Figure 2). (wikipedia.org)
  • intestinal
  • Engel WK, Dorman JD, Levy RI, Fredrickson DS (1967) Neuropathy in Tangier disease: alpha lipoprotein deficiency manifesting as familial recurrent neuropathy and intestinal lipid storage. (springer.com)
  • acute
  • The pain most suggestive of an acute MI, with the highest likelihood ratio, is pain radiating to the right arm and shoulder. (wikipedia.org)
  • cardiovascular risk
  • Previously, the higher cardiovascular risk in men has been attributed in part to the negative effects of systemic testosterone, however, more recent research has highlighted the protective nature of testosterone against cardiovascular disease. (wikipedia.org)
  • diabetic
  • CETP activity was higher in diabetic subjects (mean 84 arbitrary units [AU]) than in nondiabetic subjects (80 AU, P = 0.028). (diabetesjournals.org)
  • Indeed, in the absence of nephropathy, type 1 diabetic patients often have higher HDL cholesterol (HDL-C) and lower LDL cholesterol (LDL-C) and triglycerides than the general population ( 1 ). (diabetesjournals.org)
  • The observation that CET is increased in type 1 diabetes ( 3 ) has not been replicated, and the higher HDL-C usually observed in well-controlled type 1 diabetic patients is not consistent with increased CET. (diabetesjournals.org)
  • insulin resistance
  • When the body produces insulin under conditions of insulin resistance, the cells are resistant to the insulin and are unable to use it as effectively, leading to high blood sugar. (wikipedia.org)
  • major
  • We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway. (stanford.edu)
  • treatment
  • These results indicate that chymase treatment of HDL3 specifically impairs the ABCA1-dependent pathway without influencing either aqueous or SR-BI-facilitated diffusion and that this effect is caused by depletion of lipid-poor pre-β-migrating particles in HDL3. (unimi.it)
  • Screening with ultrasound is indicated in those at high risk, prevention is by decreasing risk factors such as smoking, and treatment is either by open or endovascular surgery. (wikipedia.org)
  • Aortic rupture is a surgical emergency, and has a high mortality even with prompt treatment. (wikipedia.org)
  • increase
  • Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level. (wikipedia.org)
  • alpha
  • Kocen RS, Lloyd JK, Lascelles PT, Fosbrooke AS, Williams D (1967) Familial alpha lipoprotein deficiency (Tangier disease) with neurologic abnormalities. (springer.com)
  • Organisms can either by alpha-hemolytic, beta-hemolytic, or gamma-hemolytic (non-hemolytic). (wikipedia.org)
  • normal
  • Pathologists describe cells as well differentiated (low-grade), moderately differentiated (intermediate-grade), and poorly differentiated (high-grade) as the cells progressively lose the features seen in normal breast cells. (wikipedia.org)
  • results
  • The 2002 Women's Health Initiative of the National Institutes of Health found disparate results for all cause mortality with RHT, finding it to be lower when HRT was begun earlier, between age 50-59, but higher when begun after age 60. (wikipedia.org)
  • Ultimately, the study found disparate results for all cause mortality with HRT, finding it to be lower when HRT was begun during ages 50-59, but higher when begun after age 60. (wikipedia.org)