High content screening. Medical search. Frequent questions

HCS is related to high-throughput screening (HTS), in which thousands of compounds are tested in parallel for their activity in one or more biological assays, but involves assays of more complex cellular phenotypes as outputs. (wikipedia.org)
In addition to fluorescent labeling, various label free assays have been used in high content screening. (wikipedia.org)
Screening using cell-based assays has been performed for many years, but recent technologies allow screening of cells that are alive and changing. (genengnews.com)
Cell-based assays are becoming increasingly popular for small molecule discovery in high-throughput screening. (genengnews.com)
As cell-based assays are used more commonly in robotic high-throughput compound screening, cells themselves have become critical reagents. (genengnews.com)
We experimented with cells division-arrested with low level mitomycin C treatment and demonstrated that they perform with better consistency than non-division arrested counterparts in high-content screening imaging assays, says Zhong Zhong, vp of development at CMT. (genengnews.com)
We developed Redistribution cell-based assays for use in both primary screening and lead optimization of compounds targeting GPCRs. (genengnews.com)
Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers. (selectscience.net)
A striking example is High Content Screening (HCS), which utilizes automated microscopy to systematically access the wealth of information contained in biological assays. (genedata.com)
We compare 12 state-of-the-art feature selection methods (both supervised and unsupervised) by systematically testing them on two HCS datasets from drug screening imaging assays of high practical relevance. (genedata.com)
High content screening systems help pharmaceutical and biotechnology companies extract useful multiplex information from assays, thereby leading to a surge in demand for advanced high content screening systems from the pharmaceutical industry. (prnewswire.co.uk)
The procedure facilitates imaging-based assays of neurites, synapses, and late-expressing neuronal markers in a format compatible with light microscopy and high-content screening. (jove.com)
If used in combination with high-throughput systems and toxicity assays, high-content imaging has the benefit of being able to screen many compounds at a time to assess multiple parameters including small phenotypic changes. (enzolifesciences.com)
High-content screening differs from traditional drug discovery methods in that it provides richer datasets than traditional assays, allowing for the examination of the specific effect of compound treatments on specific sub-populations of cells, as well as providing access to more complex measurements than can be accomplished with traditional assay formats. (visikol.com)
The development of assays that offer a high-throughput and low-cost option in comparison to more traditional approaches has been a focus of recent years. (pmiscience.com)
COMAS major research goal is to identify bioactive compounds as modulators of biological functions by using biochemical and cell-based high-throughput assays. (aracelibio.com)
Although screening using pooled lentiviral sgRNA libraries is a powerful way to discover gene function, arrayed screening expands the types of phenotypic readouts from simple population enrichment or depletion to complex multiparametric high-content imaging and morphological assays. (drugtargetreview.com)
Intestinal organoids for automated screening assays. (moleculardevices.com)
In addition, methods to increase throughput, such as automated organoid assays and compound screening, are presented. (moleculardevices.com)
The complexity of 3D assays remains a hurdle for the wider adoption of organoid models in research and drug screening. (moleculardevices.com)

Unlike high-content analysis, high-content screening implies a level of throughput which is why the term "screening" differentiates HCS from HCA, which may be high in content but low in throughput. (wikipedia.org)
At a cellular level, parallel acquisition of data on different cell properties, for example activity of signal transduction cascades and cytoskeleton integrity is the main advantage of this method in comparison to the faster but less detailed high throughput screening. (wikipedia.org)
High-throughput screening has been around for a while, but it has only been in the last few years that doing so on a cellular level has been feasible. (genengnews.com)
Advanced high-throughput screening technologies require standardized, consistent cell culture as reagents to generate reliable results. (genengnews.com)
High-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. (selectscience.net)
Biopharmaceutical drug discovery, as of today is a highly automated, high throughput endeavor, where many screening technologies produce a high-dimensional measurement per sample. (genedata.com)
High throughput, simply programmable and user friendly. (selectscience.net)
Induced pluripotent stem cells are most useful when combined with a high throughput in vitro assay that can recognize hepatotoxicity. (enzolifesciences.com)
Platform for Quantitative Cell-Based Imaging Pittsburgh, PA - (June 30, 2014) - Cell biologists have a new imaging and analysis software available to them that offers speed, flexibility and efficiency for large-scale, high-throughput biology, including complex morphological analyses of cells, cell structure, and aggregations of cells in colonies. (labwrench.com)
The high throughput format enables a time-saving, unbiased acquisition and analysis of cells in a multiwall format, or on slides. (lu.se)
High content screening (HCS) or high content analysis (HCA) is screening approach to cell biology that involves quantitative data analysis in a high-throughput format using automated imaging for large-scale applications like systems biology and drug discovery. (zionmarketresearch.com)
High content screening is strictly high in content and low in throughput unlike high throughput screening. (zionmarketresearch.com)
High Content Screening (HCS) is conceptually a novel screening approach, whereby images of cells generated in large scale by means of automated high-throughput microscopy are analyzed by image analysis software to extract knowledge on selected cellular targets in their native milieu. (fraunhofer.de)
We also offer high-throughput microscopy as a service for the acquisition of a large set of image data. (fraunhofer.de)
A unique feature of our system is the availability of an environmental control unit for live-cell imaging and time-lapse analysis of cellular processes at high throughput under controlled growth conditions. (fraunhofer.de)
Using a method known as high-throughput screening, a huge number of drug candidates are screened in a brute-force fashion for the desired effect on the target compound. (phiab.com)
By using computerized imaging, high-content screening allows researchers to study the behavior of cultured cells and their complex response to drugs in a high-throughput manner. (phiab.com)
High-content screening is a type of drug discovery method that utilizes high-throughput imaging and analysis to assess multiple endpoints simultaneously at a cellular resolution. (visikol.com)
Visikol's future perspectives include incorporating high-throughput robotics and automation to seed cells and deliver compounds to microplates, improving high throughput technology in imaging and its computational image processing pipeline by integrating the data generated with AI and machine learning tools. (visikol.com)
Can be used for high throughput screening (HTS) and high content screening (HCS), is to help you carry out new drug screening, the emergence of new indications and other professional tools. (chemfaces.com)
Our lab automation for high-throughput, high-content screening include scientists and engineers who can customize our instruments, as well as automate entire workflows to meet the specific needs of your assay, method, or protocol. (moleculardevices.com)
Learn how high-throughput, high-content imaging and analysis paired with AI-based analytic tools can improve the accuracy of your organoid studies. (moleculardevices.com)
High throughput multiplex fluorescent screening was conducted using a high content imager. (cdc.gov)

High content screening is a combination of modern cell biology, with all its molecular tools, with automated high resolution microscopy and robotic handling. (wikipedia.org)
High-content screening technology is mainly based on automated digital microscopy and flow cytometry, in combination with IT-systems for the analysis and storage of the data. (wikipedia.org)
Today, high content screening uses a combination of automated microscopy and quantity analysis to increase the speed at which results are arrived at. (essaywriter.org)
DAPI ready made solution For Nuclear counterstain in immunoflourecence microscopy, High Content Screening (HCS), Chromosome staining and flow cytometry (FACS). (sigmaaldrich.com)
The current form of high-content screening is based on conventional microscopy. (phiab.com)
Our high content screening service facility offers advanced light microscopy imaging, precise cell segmentation, and accurate measurement of complex biological samples. (biodataanalysis.de)

In our work, we explore how chemical and biological information from different domains -such as ligand-target prediction, microarray readouts, and RNA-Seq information - can be used separately, or in combination, in order to understand the mode of action of a compound (such as a hit from high-content screening) in greater detail. (selectbiosciences.com)
We describe the combination of 3D culture of human tissues with ultra-high content 3D image analysis to screen compound libraries and identify and profile novel cancer therapeutics. (selectbiosciences.com)
High content screening market to grow from USD 557.1 million in 2017 to USD 909.0 million by 2022, at a Compound Annual Growth Rate (CAGR) of 10.3% during the forecast period. (emailwire.com)
To allow efficient screening of large compound libraries, intelligent screening workflows are needed that combine different assay formats and multiplex various readouts, including phenotypic information, to provide a more holistic view of compound effects. (selectscience.net)
This type of compound screening is crucial in the early stages of drug development in order to determine the potential toxic effects of the drug. (enzolifesciences.com)
HCS finds application for secondary compound screening, lead optimization, compound profiling, target identification and validation, ADME (absorption, distribution, metabolism and excretion) and toxicity studies in preclinical research. (fraunhofer.de)
The Compound Management and Screening Center (COMAS) has been implemented at the Max Planck Institute of Molecular Physiology in Dortmund as the central substance library of the Max Planck Society. (aracelibio.com)

New technologies have advanced both hardware and software for automated imagery analysis which allows researchers to screen images without limitation of the cell quantity being screened (Usaj et al, 2016). (essaywriter.org)

The HCS instruments market accounted for the largest share of HCS market primarily attributed to advances in instrumentation and automation techniques and high prices of the HCS instruments. (emailwire.com)
The instruments segment was the largest product segment in 2018 due to factors such as high price of instruments, technological advancements and automation in instrumentation. (zionmarketresearch.com)

High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner. (wikipedia.org)
High content imaging platforms are giving the opportunity to monitor cellular phenotype at the level of individual object. (selectbiosciences.com)
High content screening involves real time readout of various parameters to detect cell phenotype alteration by small molecules, RNAi or peptides. (zionmarketresearch.com)

They note that invasive endoscopic screening will impose "significant utilization of healthcare resources" and suggest that noninvasive screening may be preferable. (medscape.com)
Further elucidation and refinement of screening criteria, better understanding of risks and benefits of screening and surveillance, and high-performing, scalable, noninvasive modalities for screening are warranted before population implementation of screening for BE," the study team concludes. (medscape.com)

Unfortunately, these fluorescent labels release toxins and fade when imaged, making high-content screening unsuitable for observing living cells. (phiab.com)
The Operetta high content analysis (HCA) system is an automated fluorescent microscope that allows the fluorescent or brightfield imaging of large numbers of samples at high resolution. (ed.ac.uk)

Advancements in the software and services underpinning high content screening solutions are also being observed in the global market. (prnewswire.co.uk)
The major factors that are expected to be driving the high content screening market are need for cost containment in pharma R&D, growth in funding for cellular research, and technological advancements in HCS solutions are expected to support the growth of the HCS market during the forecast period. (emailwire.com)
The growth of this market is attributed to the technological advancements in image acquisition, data analysis, and storage capabilities and the need to obtain information on changes in cell morphology through high-quality images. (emailwire.com)
Worldwide technological advancements in the cell imaging instruments and solutions in terms of quality and efficiency drive the high content screening market growth. (zionmarketresearch.com)

1. The products in the ChemFaces screening libraries are all from plants. (chemfaces.com)
5. ChemFaces offers customized bioactive screening libraries , whereby you choose the specific compounds you want in the library, the quantities, plate map, concentration, and format (dry/solid or DMSO solution). (chemfaces.com)
Chemical synthesis of guide RNAs for CRISPR-Cas9 gene editing enables accurate and rapid production of CRISPR libraries and screening in an arrayed, one-gene-per-well fashion. (drugtargetreview.com)

We subjected diseased primary human lung fibroblasts to an advanced three-dimensional phenotypic high-content assay and screened a repurposing drug library of small molecules for inhibiting ECM deposition. (lu.se)

Hence high content screening is a type of phenotypic screen conducted in cells involving the analysis of whole cells or components of cells with simultaneous readout of several parameters. (wikipedia.org)
Activation of these GPCRs can involve their entry into cells and when this can be visualised it can be the basis of a systematic analysis of receptor function through chemical genetics, systematic genome wide screening or physiological manipulation. (wikipedia.org)
At Cambridge Healthtechs High Content Analysis conference, to be held in San Francisco later this month, companies will be presenting how their technology is making the bottom line a little thicker for major pharmaceutical companies. (genengnews.com)
We will discuss how cloud based high performance computing and storage provided by Perkin Elmer's Signals supports multiple aspects such as image management and analysis and high content data profiling. (selectbiosciences.com)
Three dimensional imaging and analysis are becoming standard practice within the field of High Content Imaging. (selectbiosciences.com)
To quantify the data from the screens the analysis software had to recognize not less 15 cells for validation (Simpson et al 2012). (essaywriter.org)
Back in 2012, analysis usually involved calculating deviations of single parameters but today machine learning and artificial intelligence is used for high-dimensional analysis of data. (essaywriter.org)
Exploiting HCS to its full potential traditionally requires extracting a high number of features from the images to capture as much information as possible, then performing algorithmic analysis and complex data visualization in order to render this high-dimensional data into an interpretable and instructive information for guiding drug development. (genedata.com)
Another factor that is expected to bode well for the high content screening market is the development of advanced software with instrumentation that facilitates both qualitative and statistical image analysis. (prnewswire.co.uk)
The new Thermo Scientific™ CellInsight™ CX5 High Content Screening (HCS) Platform, a high-content quantitative imaging and analysis platform-powered by new Thermo Scientific™ HCS Studio™ 2.0 Cell Analysis Software, continues to advance technologies and options for single cell analysis across Thermo Scientific's broad high content analysis portfolio. (labwrench.com)
High content screening (HCS) / Analysis (HCA). (lu.se)
Our core technology is the PerkinElmer's Opera QEHS system, a high-end fully automated spinning disk confocal microscope equipped with 10x up to 60x lenses, four excitation lasers for the simultaneous analysis of up to four labeled cellular targets. (fraunhofer.de)
The success of High Content Screening (HCS) systems depends on automatic image analysis. (mun.ca)
The number of adults in the United States who meet criteria for Barrett's esophagus (BE) screening is substantial yet highly variable, a new analysis shows. (medscape.com)
In an earlier systematic review and meta-analysis, Chandar and his co-authors found that BE screening and endoscopic surveillance may lead to earlier detection of EAC and improved survival. (medscape.com)

GuideScan produces high-density sets of gRNAs for single- and paired-gRNA genome-wide screens, that are more specific than those designed by existing tools3. (mskcc.org)

The mean MD (Mahalanobis distance) for either of the siRNAs was later calculated and later the secondary screens deviations was equated with that of the control cell (Simpson et al, 2012). (essaywriter.org)
Growing concerns of pharmaceutical companies towards toxicity studies is shifting focus on secondary cell screening. (prnewswire.co.uk)
EMAILWIRE.COM , January 15, 2021 ) HCS is used in several stages of the drug discovery process, including primary and secondary screening, target identification and validation and toxicity studies. (emailwire.com)
The primary and secondary screening application segment is expected to grow at highest CAGR during the forecast period. (emailwire.com)
The high growth can primarily be attributed to the wide use of HCS for secondary screening purposes. (emailwire.com)
Thus Target identification and validation is a must step for drug discovery process and thus accounted for largest market share in 2018 whereas primary and secondary screening segment is projected to register rapid growth in the coming years. (zionmarketresearch.com)

According to the report, global demand for high content screening market was valued at approximately USD 648.7 million in 2018, and is expected to generate revenue of around USD 1,228.8 million by end of 2025, growing at a CAGR of around 9.6% between 2019 and 2025. (zionmarketresearch.com)
Pharmaceutical and biotechnology companies accounted for largest market share in 2018 for high content screening market whereas CROs are projected to register rapid growth during the forecast period. (zionmarketresearch.com)
North America was the largest regional market in global high content screening in 2018. (zionmarketresearch.com)

Deep learning has proven to be a very helpful tool for discovering complicated structures in high-dimensional and big datasets. (mun.ca)
We used an imbalanced High Content Screening big dataset to predict MOAs with the main goal of understanding how to work properly with deep learning algorithms on imbalanced datasets when sampling methods, like Oversampling, Undersampling, and Synthetic Minority Over-sampling (SMOTE) algorithms are used for balancing the dataset. (mun.ca)

It may be used for photofootprinting of DNA, to detect annealed probes in blotting applications by specifically visualizing the double-stranded complex, and to study the changes in DNA and analyze DNA content during apoptosis using flow cytometry. (sigmaaldrich.com)

Planning and by the Science Foundation of Ireland, Strategic Research Cluster BioNanointeract and Centre for Research on Adaptive Nanostructures and Nanodevices, Higher Education Authority (Ireland) and Programme for Research in Third-Level Institutions (PRTLI) (Ireland). (cdc.gov)

This type of equipment has typically been used by big pharma companies for drug screening campaigns. (ed.ac.uk)

Software segment is expected to grow at a highest CAGR in the coming years. (zionmarketresearch.com)

In comparison to the currently implemented High Content Imager this results in an 94.9% reduction of the time used for image acquisition at similar resolution and well coverage. (aracelibio.com)

In high content screening, cells are first incubated with the substance and after a period of time, structures and molecular components of the cells are analyzed. (wikipedia.org)
High-content screening (HCS) in cell-based systems uses living cells as tools in biological research to elucidate the workings of normal and diseased cells. (wikipedia.org)
www.cmt-inc.net), makes it possible to use frozen assay-ready cells for screening as if they were ordinary assay reagents like enzymes or membrane preparations. (genengnews.com)
Cells can be produced en masse, treated to become irreversibly division-arrested, and cryopreserved. (genengnews.com)
To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
However, to be able to computer-process the recorded images, high-content screening requires that the cells are stained with chemical labels. (phiab.com)
How these cells grow and divide in thousands of different conditions can now be routinely screened using the Operetta. (ed.ac.uk)
In this work, five deep learning models inspired by AlexNet, VGG, and GoogleNet are developed to predict mechanism of actions (MOAs) based on phenotypic screens of a number of cells in dimly lit and noisy images. (mun.ca)
High Content Screening technologies have to deal with screening thousands of cells to provide a number of parameters for each cell, such as nuclear size, nuclear morphology, DNA replication, etc. (mun.ca)
A seroneutralization assay was performed by using baby hamster kidney cells to screen for neutralizing antibodies against CHIKV in heat-inactivated monkey serum samples. (cdc.gov)

An increasing demand for effective therapeutic cell purification protocols is being observed, leading to a surge in adoption of high content screening systems in the coming years. (prnewswire.co.uk)
High Content Screening Market : Expecting Major Surge in Revenue in Next FIVE Years. (emailwire.com)
Surge in high content screening outsourcing services by CROs and potential use of high content screening in precision medicine are expected to bring new growth avenues for major market players of high content screening. (zionmarketresearch.com)

CT is an excellent modality for detecting tumors anywhere in the body, but it has the disadvantage of ionizing radiation, which may become problematic in screening asymptomatic patients and at-risk relatives. (medscape.com)
andpopulation-based cancer screening programmes targeting asymptomatic people. (who.int)

Automated image based screening permits the identification of small compounds altering cellular phenotypes and is of interest for the discovery of new pharmaceuticals and new cell biological tools for modifying cell function. (wikipedia.org)
Given the increase in the use of phenotypic/visual screening as a cell biological tool, methods are required that permit systematic biochemical target identification if these molecules are to be of broad use. (wikipedia.org)
Thus, it has become essential to produce cell reagents with high consistency and quality. (genengnews.com)
For cell-based screening, it is possible to uncouple the cell production process from the screening process. (genengnews.com)
The team subtracted Texperiment from Tcontrol and multiplied the answer by 1/2 s.e.m control where T was the cell surface ratio tsO45G to total tsO45G in order to determine the secretion deviation value for the validation screens. (essaywriter.org)
Its selectivity for DNA and high cell permeability allows efficient staining of nuclei with little background from the cytoplasm. (sigmaaldrich.com)
This protocol facilitates the use of human pluripotent stem cell-derived neurons for high content screening applications. (jove.com)
One research Fellow position and one PostDoctoral position are available in the Cell-based High Content Screening (HCS) laboratory under the supervision of Manuela Morleo and Diego Medina. (tigem.it)
Cell Painting is a high-content, multiplexed image-based assay used for cytological profiling. (visikol.com)
High-content screening is a powerful tool for drug discovery, and Visikol's Cell Painting Assay is a game-changer in this field. (visikol.com)
4.Structurally diverse, medicinally active, and cell permeable, NMR and HPLC validated to ensure high purity. (chemfaces.com)
The automated organoid workcell includes the ImageXpress® Confocal HT.ai High-Content Imaging System , automated CO2 incubator, automated Biomek i7 liquid handler, collaborative robot and rail, and additional, optional instruments including an automated centrifuge, our ImageXpress® Pico Automated Cell Imaging System, and SpectraMax microplate reader. (moleculardevices.com)
Prenatal cell-free DNA screening, which uses cell-free DNA from the placenta and the fetus in the mother's bloodstream. (medlineplus.gov)

The software segment is expected to register the highest growth during the forecast period. (emailwire.com)
However, the Asia-Pacific market is expected to register the highest growth during the forecast period owing to increased research in drug discovery, government initiatives, growing focus of multinational companies on emerging markets, and developing R&D infrastructure. (emailwire.com)

These ready-to-use reagents can be thawed, plated, and used in screening with improved consistency and convenience. (genengnews.com)
Enzo Life Sciences offers a comprehensive product portfolio for advancing your discoveries in toxicity research with a whole portfolio of toxicity research reagents and kits, including the SCREEN-WELL® Hepatotoxicity library . (enzolifesciences.com)

Fluorescence was determined by using the Cellomics High Content Screening ArrayScan VTI imaging system (ThermoFisher Scientific, Waltham, MA, USA). (cdc.gov)

Contact screening in tuberculosis: can we identify those with higher risk? (up.pt)
This report from the Advisory Council for the Elimination of Tuberculosis updates and replaces previous recommendations for screening for tuberculosis (TB) and TB infection among high-risk populations. (cdc.gov)

Using national survey data and current guidance from four major gastroenterology societies, researchers found the US adult population eligible for BE screening ranges from nearly 20 million to roughly 120 million. (medscape.com)
To estimate the different potential burdens of BE screening, the researchers turned to 2012 data from the US National Health Interview Survey (NHIS), the most recent year of the annual household survey that included answers to a question about GERD symptoms. (medscape.com)
Decisions to screen particular groups should be based on local epidemiologic data and made in consultation with local health jurisdictions to ensure appropriate follow-up, evaluation, and management of persons having TB infection or disease. (cdc.gov)

With software and laser-based autofocus, this integrated system allows higher resolution of thicker samples such as tissues and organoids. (selectbiosciences.com)

One of the main objectives of such collaborations is to be able to offer high content screening instruments to end users on a large scale in the global market. (prnewswire.co.uk)

this makes Mongolia rank 7th as the country with highest prevalence of non-communicable diseases in the Western Pacific Region. (who.int)
Because of a higher prevalence of infection or a higher risk for disease for any given prevalence of infection among certain groups, the incidence of TB may be higher among these groups than among the total population. (cdc.gov)

We adopted quantitative reverse-transcription polymerase chain reaction (qRT-PCR) and Celigo high-content screening (HCS) technology to screen the downstream genes of THSD7A . (hindawi.com)

Target identification has been defined as the rate limiting step in chemical genetics/high-content screening. (wikipedia.org)
together with a summary of ongoing chemogenomics screening initiatives aimed at new target identification for hyperexcitability disorders. (selectbiosciences.com)

Work's topic will be the systematic reclassification of Variants of Unknown Significance in cancer-predisposing genes through machine learning applied to CRISPR-based functional screens. (tigem.it)
Gene knockout using the CRISPR-Cas9 system has emerged as a powerful technology for loss-of-function screening. (drugtargetreview.com)
Here, four pooled crRNA to the same target are shown to provide robust functional knockout in arrayed CRISPR screening experiments. (drugtargetreview.com)

However, lower adoption rate of high content screening due to higher cost of instruments may act as a restraining factor for the market growth. (zionmarketresearch.com)
Increasing adoption of high content screening technologies is the major driving factor for this growth. (zionmarketresearch.com)

This approach aids pharmaceutical research in solving drug discovery problems with high specificity and sensitivity with high temporal and spatial resolutions. (visikol.com)

Further, biotechnology and pharmaceutical companies are deploying high content screening solutions for effective risk assessment of critical illnesses to facilitate efficient drug discovery. (prnewswire.co.uk)
High R&D expenditure, the presence of major pharmaceutical market players, and increasing government support are some of the factors contributing to the large share of North America in the market. (emailwire.com)

BACKGROUND: For understanding cholesterol and phospholipid efflux pathways there is a need for cellular fluorescence-based high-content screens (HCS) to investigated the cholesterol and phospholipid content in human macrophages. (uni-regensburg.de)

North America is the largest market for high-content screening, followed by Europe, Asia-Pacific, Latin America, and the Middle East & Africa. (emailwire.com)

An AlphaLISA assay was run on the EnVision Multilabel Plate Reader as a primary screen and a number of active compounds were then selected to be further analyzed and verified in a cellular assay using the Operetta High Content Imaging System. (selectscience.net)

The third priority is screening populations at high risk for TB to locate persons infected with TB and giving complete therapy to prevent the infection from progressing to active, contagious disease (3,5). (cdc.gov)
Although screening high-risk populations for TB infection and providing preventive therapy are crucial to achieving the nation's goal of eliminating TB (6), completion of TB therapy and contact investigation should have priority over screening. (cdc.gov)

This conference brings together researchers from both academia and industry, and will discuss the development of techniques and tools implemented in High Content technologies and Phenotypic Screening applications. (selectbiosciences.com)
However, the population at risk for BE is defined by different combinations of risk factors in the societal guidance statements, which impacts the potential burden of screening, the researchers point out. (medscape.com)
The researchers calculated screen eligibility based on each societal guidance statement. (medscape.com)

The aim of the study was to screen the downstream functional genes of THSD7A and explore their functions in ESCC, based on the reported research into THSD7A function and on gene microarrays. (hindawi.com)
HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities. (cdc.gov)

Anatomy31

Organisms20

Diseases2

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes71

Disciplines and Occupations5

Technology, Industry, Agriculture18

Information Science9

Health Care11

Assays20

Throughput23

Microscopy6

Compound7

20161

Automation2

Phenotype3

Noninvasive2

Fluorescent2

Advancements4

Libraries3

Small molecules1

Analysis15

Genome wide1

Secondary6

20183

Datasets2

Apoptosis1

Centre1

Pharma1

CAGR1

Imager1

Cells10

Surge3

Asymptomatic2

Cell13

Growth during the forecast2

Reagents2

Cellomics1

Tuberculosis2

Data3

Organoids1

Main1

Prevalence2

Quantitative1

Target identification2

CRISPR3

Adoption2

Approach1

Pharmaceutical2

Fluorescence1

North America1

Imaging System1

POPULATIONS2

Researchers3

Genes2