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CatalaseAcatalasiaAmitroleHydrogen PeroxideSuperoxide DismutaseGlutathione PeroxidaseOxidative StressPeroxidasesAntioxidantsLipid PeroxidationMicrobodiesMercuryPeriodicals as TopicAccess to InformationJournal Impact FactorBibliometricsPublishingPeer Review, Research
SuperoxideEnzymesReactive oxygenReduction in catalase activityBroken down by catalaseConcentrationsEnzyme activityPeroxidase activitiesAcatalasiaDismutaseConcentrationLipid peroxidationHydrogen peroxide moleculesDeficiencyOxidationSpeciesUreaseProteinOxidative damageDecreaseWater and oxygenTemperatureDecreasesAminoReactivityAntioxidantsYieldLevelsContributesSignificantly lowerIncreaseVitro and in vivoAscorbic acidMoleculesSensitivityMicrobial biomassLiverExhibitExtractResultsGeneIncreasesAssessDoseChemistryGenetic
Superoxide14
Enzymes10
  • Extremely high or low pH values generally result in complete loss of activity for most enzymes. (meltingpointathens.com)
  • Once the temperature becomes too high the enzymes are denatured because the hydrogen bonds and ionic bonds are disrupted. (meltingpointathens.com)
  • The liver sustains a neutral pH of about 7, which creates the best environment for catalase and other enzymes. (meltingpointathens.com)
  • Catalase (Enzymes) Abstract In this laboratory exercise, studies of enzyme catalase, which accelerates the breakdown of hydrogen peroxide into water and oxygen. (educationindex.com)
  • The activities of antioxidant enzymes catalase, ascorbate peroxidase and peroxidase showed a very high increase in activity in Cu+Zn treatment as compared to Cu or Zn alone-treated plants. (unboundmedicine.com)
  • In fact, Cd-stressed olive plants treated with proline showed an increase of antioxidant enzymes activities, photosynthetic activity, nutritional status, plant growth and oil content of olive fruit. (unboundmedicine.com)
  • Some bacterial species produce enzymes that exhibit both catalase and broad-spectrum peroxidase activities [4]. (expasy.org)
  • Examples of such enzymes are: catalase HP I from Escherichia coli (gene katG) and perA from Bacillus stearothermophilus. (expasy.org)
  • Changes in the activities of certain oxidizing enzymes during germination and seedling development of Phaseolus mungo and Sorghum. (arccjournals.com)
  • 6]. Some of the best examples of high-molecular-weight sectors, workers are at increased risk of becoming sensitized occupational allergens are the fungal enzymes. (cdc.gov)
Reactive oxygen3
  • Reactive oxygen species (ROS), products of normal cell metabolism may cause damage to biological macromolecules leading to severe health threats when they are present in high concentrations. (degruyter.com)
  • If hydrogen peroxide is not broken down by catalase, additional reactions convert it into compounds called reactive oxygen species that can damage DNA, proteins, and cell membranes. (medlineplus.gov)
  • Both SOD and catalase may decrease radiation sensitivity via reactive oxygen species (ROS) scavenging. (e-roj.org)
Reduction in catalase activity2
Broken down by catalase1
  • The hypothesis was that hydrogen peroxide will be broken down by catalase into hydrogen and oxygen, where a higher concentration of inhibitor will yield less oxygen, resultant of a lower rate of reaction. (educationindex.com)
Concentrations11
  • Furthermore, the poison cyanide is a noncompetitive inhibitor of catalase at high concentrations of hydrogen peroxide.Arsenate acts as an activator. (wikipedia.org)
  • A significant increase of the bpm in adults exposed to high concentrations of smoked CB leachate was observed after 48 h of exposure. (easychair.org)
  • All of the strains could grow at different salt concentrations (8% and 15%) and temperatures (4 °C, 10 °C, and 37 °C). Four strains of S. saprophyticus showed strong lipolytic activity while nine strains of S. vitulinus had strong proteolytic activity. (tubitak.gov.tr)
  • Liver weights and plasma ApoA-II and high-density lipoprotein concentrations were significantly elevated in curcumin-supplemented groups. (elifesciences.org)
  • measure the enzyme activity of β-galactosidase in the different concentrations of o-Nitrophenylgalactoside (ONPG) using a spectrophotometer. (educationindex.com)
  • reactivity of the enzyme catalase on hydrogen peroxide while subject to different concentrations of an inhibitor. (educationindex.com)
  • The results also indicate that acetylcholinesterase activity (AChE) was inhibited in all CBZ concentrations during the 48 h exposure period. (scielo.br)
  • 1977). LP activity equivalent to enzyme protein concentrations between 20-40 mg/L is found frequently. (dairyscience.info)
  • Most of antitumor effects was observed at relatively high concentrations (20-50 µM) of TRO, while the clinically achievable concentrations are around 2-5 µM [ 28 , 29 ]. (e-roj.org)
  • Hepatic excretory capacity is low both because of low concentrations of the binding protein ligandin in the hepatocytes and because of low activity of glucuronyl transferase, the enzyme responsible for binding bilirubin to glucuronic acid, thus making bilirubin water soluble (conjugation). (medscape.com)
  • Workplace exposure assessment of BNNT from two manufacturing facilities measured boron concentrations in personal breathing zones from non-detectable to 0.95g/m3 and TEM structure counts of 0.0123 0.0094 structures/cm3, concentrations well below what was found with other engineered high aspect ratio nanomaterials like carbon nanotubes and nanofibers. (cdc.gov)
Enzyme activity11
  • In summary, mixed planting treatment was more helpful to improve soil enzyme activity, microbial biomass, and enrich soil microbial diversity, which was of great significance to maintain the balance of soil ecosystem. (bioone.org)
  • At what concentration does hydrogen peroxide inhibit enzyme activity? (researchgate.net)
  • LABORATORY REPORT Activity: Enzyme Activity Name: Natalie Banc Instructor: Elizabeth Kraske Date: 09.22.2016 Predictions 1. (ipl.org)
  • Sucrase activity increases with increasing sucrose concentration Materials and Methods Effect of pH on Enzyme Activity 1. (ipl.org)
  • At what pH is the rate of enzyme activity the highest? (meltingpointathens.com)
  • How does pH affect enzyme activity graph? (meltingpointathens.com)
  • How does temperature affect enzyme activity lab report? (meltingpointathens.com)
  • Enzyme pH levels also change the shape of the active site and affect the rate of enzyme activity. (meltingpointathens.com)
  • Why does enzyme activity decrease at low temperatures? (meltingpointathens.com)
  • As the temperature decreases, so does enzyme activity. (meltingpointathens.com)
  • The studies demonstrate that D. salina exhibits potent protective effects on UVB radiation-induced corneal oxidative damage in mice, likely due to both the increase of antioxidant enzyme activity and the inhibition of lipid peroxidation. (molvis.org)
Peroxidase activities1
  • The higher protective capacity of BEH on SOD, catalase and peroxidase activities was comparable to that of the vitamin C used as standard. (degruyter.com)
Acatalasia1
Dismutase1
  • Além disso, as atividades de superóxido dismutase e catalase apresentaram aumento significativo em relação ao contato com CBZ. (scielo.br)
Concentration3
  • The decomposition of hydrogen peroxide by catalase proceeds according to first-order kinetics, the rate being proportional to the hydrogen peroxide concentration. (wikipedia.org)
  • The three things that can cause the enzyme to denature is a large change in pH level, High Temperature, and substrate concentration. (ipl.org)
  • However, during the 96 h exposure period, AChE was only inhibited at the highest concentration. (scielo.br)
Lipid peroxidation2
Hydrogen peroxide molecules2
Deficiency2
  • However, catalase deficiency in mice may increase the likelihood of developing obesity, fatty liver, and type 2 diabetes. (wikipedia.org)
  • Goth L, Nagy T. Inherited catalase deficiency: is it benign or a factor in various age related disorders? (medlineplus.gov)
Oxidation2
  • Once in the bloodstream, mercury undergoes catalase and peroxidase-mediated oxidation in red blood cells and tissues and is transformed into inorganic mercuric mercury (Hg ++ ) and mercurous mercury (Hg + ), a process that limits its absorption [ 9 , 12 ]. (hindawi.com)
  • SWCNT with different iron content displayed different redox activity in a cell-free model system as revealed by EPR-detectable formation of ascorbate radicals resulting from ascorbate oxidation. (cdc.gov)
Species3
  • The pH optimum for other catalases varies between 4 and 11 depending on the species. (wikipedia.org)
  • however, these factors do not cause a high diversity in $GCC^{+}$ in terms of species. (tubitak.gov.tr)
  • The effect of salinity on photosynthetic activity in potassium-deficient barley species. (arccjournals.com)
Urease2
  • The results showed that the urease activity and microbial biomass nitrogen content of mixed planting were higher than other treatments. (bioone.org)
  • Three soil microbial indicators were evaluated, microbial biomass (carbon and nitrogen), microbial population (bacteria and fungi) and enzyme activities (urease, phosphatase, catalase and dehyrdogenase). (scialert.net)
Protein4
  • Three-dimensional protein structures of the peroxidated catalase intermediates are available at the Protein Data Bank. (wikipedia.org)
  • I will be thankful if anybody answer my question and send me a clear protocol to measure ABTS Radical scavenging activity of protein samples.I want to measure antioxidant capacity of my samples by ABTS assay. (researchgate.net)
  • The protein expressions of SOD and catalase, and catalase activities were measured at 2-10 µM of TRO for 24 hours. (e-roj.org)
  • By 5 µM TRO for 24 hours, the mRNA, protein expression and activity of catalase were increased in all three cell lines. (e-roj.org)
Oxidative damage1
  • In conclusion, X. aethiopica has a higher antioxidant and protective potential against ion-mediated oxidative damage and may be considered as a potential drug against metal-mediated toxicity. (degruyter.com)
Decrease4
  • There was a decrease in the rate of detection and among under-15-year-olds, but some regions maintained high endemicity during the study period. (scielo.br)
  • UVB irradiation caused significant damage to the corneas, including apparent corneal ulcer and severe epithelial exfoliation, leading to decrease in the activities of SOD, catalase, GSH-Px, GSH-Rd, and GSH content in cornea, whereas there was increased corneal MDA content as compared with the control group. (molvis.org)
  • 0.05) ameliorate corneal damage and increase the activities of SOD, catalase, GSH-Px, GSH-Rd, and GSH content, and decrease the MDA content in corneas when compared with the UVB-treated group. (molvis.org)
  • Our data showed a significant increase in GPx activity and decrease in serum level of MDA in Down syndrome individuals after treadmill exercise for 3 months. (who.int)
Water and oxygen1
  • Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals) which catalyzes the decomposition of hydrogen peroxide to water and oxygen. (wikipedia.org)
Temperature3
  • The temperature in our experiment was not very high which didn't result in denaturation of peroxidase. (ipl.org)
  • If the temperature was higher in pH 3 and low in pH 10, then it would cause pH 3 to denature even more which would make the pH 3 total about 4.0. (ipl.org)
  • Another activity critical control point is the temperature of the concentrate in the 'temperature controlled" jacketed pipe going to the atomiser. (dairyscience.info)
Decreases1
  • TRO increases radiation sensitivity through G0-G1 arrest or decreases radiation sensitivity through catalase-mediated ROS scavenging according to TRO dose or cell types. (e-roj.org)
Amino4
  • Catalase is a tetramer of four polypeptide chains, each over 500 amino acids long. (wikipedia.org)
  • The amino acid sequence of bovine catalase was determined in 1969, and the three-dimensional structure in 1981. (wikipedia.org)
  • Total soluble proteins and amino acids were the highest in plants from the MS medium with 1 mg·L −1 mT. Increased levels of hydrogen peroxide and catalase activity were observed on media with 1 mg·L −1 BA. (mdpi.com)
  • Benzyl amino purine had higher chlorophyll index than other treatments. (arccjournals.com)
Reactivity2
  • In addition, L-citrulline low and high-dose monotherapy demonstrated significant improvements in all evaluated parameters except vascular reactivity. (ijpsonline.com)
  • Specifically, the 9-cis isomer has demonstrated a higher antioxidant activity due to the higher reactivity of the cis bond compared to trans. (molvis.org)
Antioxidants1
Yield3
  • The aim of this investigation was to find a proper harvesting period and establishing fern number, which effects the spear yield, bioactive compounds and antioxidant activities of Asparagus officinalis L. Spears were harvested at 2, 4, and 6 weeks after sprouting. (nih.gov)
  • In harvest of 6 weeks long optimum spear yield was the highest and fern numbers were 5 ~ 8. (nih.gov)
  • Appropriate harvesting is effective for higher asparagus yield and its bioactivity. (nih.gov)
Levels11
  • The experiment aimed to compare the effects of BA and mT on the regeneration from explants of Daphne mezereum , on the levels of several chemical components, the catalase activity, and to assess genetic diversity of microcuttings. (mdpi.com)
  • The levels of chlorophyll and carbohydrates were the highest in microcuttings from the WPM with 0.1 mg·L −1 NAA. (mdpi.com)
  • Results: MDA levels were significantly higher in IG and PCT than in CG and PCG. (medscimonit.com)
  • Acatalasemia is a condition characterized by very low levels of an enzyme called catalase. (medlineplus.gov)
  • At low levels, it is involved in several chemical signaling pathways, but at high levels it is toxic to cells. (medlineplus.gov)
  • The high H2O2 tolerance of aerobic S. aureus cells was associated with priming by endogenous H2O2 levels, which was supported by an oxidative shift of the bacillithiol redox potential to −291 mV compared to −310 mV in microaerophilic cells. (fu-berlin.de)
  • Raw milk contains high but variable levels of LP activity (e.g. (dairyscience.info)
  • These are markedly in excess of the levels (0.5 μg/ml in absence of catalase) required for efficient LP system activation (Björck, 1978). (dairyscience.info)
  • Levels of both reduced glutathione and ascorbic acid (vitamin C) were considered relatively high in natural wild honey. (natmedtalk.com)
  • In saliva, SOD and CAT activities, and UA levels were significantly higher in RAS patients, while GSHPx activity was lower compared to control. (bvsalud.org)
  • ing high levels of oxidative stress [1]. (who.int)
Contributes2
  • Thus, KatA contributes to the high H2O2 resistance of aerobic cells and to microaerophilic H2O2 priming in order to survive the subsequent lethal triggering doses of H2O2, allowing the adaptation of S. aureus under infections to different oxygen environments. (fu-berlin.de)
  • Approximately 75% of bilirubin is derived from hemoglobin, but degradation of myoglobin, cytochromes, and catalase also contributes. (medscape.com)
Significantly lower2
  • The activity of SOD was significantly lower in IG and higher in PCG than in the other groups. (medscimonit.com)
  • The activities of CAT were significantly lower in IG and PCT than in the other groups and were significantly lower in IG than PCT. (medscimonit.com)
Increase5
  • The first and the second segments from the tip significantly increased with the increase of catalase (CAT). (nih.gov)
  • Significant increases in soil microbial biomass, microbial population and enzyme activities were recorded after addition of potassium fertilizer and these improvements became generally more noticeable with the increase of potassium applied rates. (scialert.net)
  • In addition, certain drugs (phenobarbital, dexamethasone, clofibrate) can be administered to increase UDPGT activity. (medscape.com)
  • The increase in chronic and degenerative diseases, such as chronic kidney disease (CKD), constitutes one of the most significant challenges of public health, as it is considered a worldwide social and economic problem, and associated to many co-morbidities, as well as to high expenses in public health 1,2 . (bvsalud.org)
  • As the material increased in purity, there are more high-aspect-ratio particulates and a corresponding distinct increase in cytotoxicity, nuclear factor-B transcription, and inflammasome activation. (cdc.gov)
Vitro and in vivo1
  • Some natural phenolic compounds extracted from plants exhibit certain anti-amyloid activity in vitro and in vivo ( Stefani and Rigacci, 2013 ). (elifesciences.org)
Ascorbic acid2
  • Increased catalase activity was observed in brassinolide treated plants followed by salicylic acid and ascorbic acid under salinity. (arccjournals.com)
  • The anticancer model's overall antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)
Molecules1
Sensitivity2
  • Cell cycle, and SOD and catalase may affect on radiation sensitivity. (e-roj.org)
  • bacteria culture is the gold standard in TB detection for its highest sensitivity, but requires weeks to obtain results. (cdc.gov)
Microbial biomass1
  • Changes of soil moisture contents caused marked effects on soil microbial biomass, microbial population and enzyme activities. (scialert.net)
Liver1
  • In 1937 catalase from beef liver was crystallized by James B. Sumner and Alexander Dounce and the molecular weight was measured in 1938. (wikipedia.org)
Exhibit1
  • Single-walled carbon nanotube s (SWCNT), nano-cylinders with an extremely small diameter (1-2 nm) and high aspect ratio, have unique physico-chemical, electronic and mechanical properties and may exhibit unusual interactions with cells and tissues, thus necessitating studies of their toxicity and health effects. (cdc.gov)
Extract3
  • This result was positively correlated to its higher phenolic content (30.74±0.44 CAE/g dried extract). (degruyter.com)
  • To determine the hepatoprotective and antioxidant effects of hydro-alcoholic extract of Prosopis farcta ( P farcta) leaves on high fat diet-fed (HFDF) rats. (uwi.edu)
  • These results indicate the lipid-lowering and antioxidative activity of extract of P farcta leaves. (uwi.edu)
Results5
  • Supporting activities include the development of epidemiological, experimental laboratory, and risk-assessment methods that could produce internationally comparable results, and the development of manpower in the field of toxicology. (inchem.org)
  • From the results, 0.9mM ONPG solution has the highest absorbance and 0.1mM ONPG solution has the least. (educationindex.com)
  • Results Six miRNAs were differentially expressed between LR and HR. However, after adjustment for Tanner stage, the association was maintained only for miR-126-3p and miR-221-3p with a higher expression in HR group compared to LR group. (unav.edu)
  • To discover differentially expressed proteins (DEPs) and their roles in dairy goat sperm with high or low freezability (HF or LF), we conducted 4D-DIA quantitative proteomics analysis, the results of which are presented in this work. (bvsalud.org)
  • Results: Plasma analysis showed significantly decreased SOD and CAT activities, and UA level in RAS patients compared to control group. (bvsalud.org)
Gene3
  • Mutations in the CAT gene greatly reduce the activity of catalase. (medlineplus.gov)
  • When both copies of the gene are altered, the activity of catalase is reduced to less than 10 percent of normal. (medlineplus.gov)
  • When only one of the two copies of the CAT gene has a mutation, the activity of catalase is reduced by approximately half. (medlineplus.gov)
Increases1
  • UDPGT activity is low at birth but increases to adult values by age 4-8 weeks. (medscape.com)
Assess1
  • To assess daily activity in individuals with an established amputation and to explore the amount of activity recorded from the prosthesis as compared to the overall activity. (humankinetics.com)
Dose5
  • 10.4194/TRJFAS20269 Viewed : 1244 - Downloaded : 14543 The aim of the study was to determine the developmental toxicity of high-dose administration of vitamin D 2 (vit. (trjfas.org)
  • The percentage of hatching, heartbeats/minute, velocity, body length, and survivability rate was downregulated in high dose vit. (trjfas.org)
  • Subsequently, the production of pro-inflammatory cytokines and intracellular ROS was upregulated in high-dose vit. (trjfas.org)
  • Collectively, quercetin ameliorated the developmental toxicity and teratogenic effects induced by high-dose vit. (trjfas.org)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
Chemistry1
  • Dr. Reid has also worked as a high school chemistry teacher with the United States Peace Corps in Tanzania. (northwestern.edu)
Genetic1
  • Researchers believe that other genetic and environmental factors can also influence the activity of catalase. (medlineplus.gov)