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  • CD59
  • Cell surface regulators of complement, 5I2 antigen, and CD59, in the rat eye and adnexal tissues. (arvojournals.org)
  • METHODS: After euthanasia of female Wistar rats, followed by orbital exenteration, eyelids and orbital tissue including the lacrimal gland were separated from the globes and immediately snap-frozen in liquid nitrogen at -70 degrees C. Tissues then were sectioned at -20 degrees C and examined immunohistochemically for 5I2 antigen and rat CD59. (arvojournals.org)
  • Corneal endothelial cells showed intense labeling for rat CD59 but not for 5I2 antigen. (arvojournals.org)
  • The retina showed labeling at multiple levels, with that of rat CD59 being more intense than that of 5I2 antigen. (arvojournals.org)
  • CONCLUSIONS: 5I2 antigen and rat CD59 are expressed in high levels and distributed similarly in the rat eye and lacrimal gland to DAF, MCP, and MIRL in the human eye and lacrimal gland. (arvojournals.org)
  • The constructs made in this work were subsequently used for cotransfection experiments together with BAC or PAC constructs carrying the genomic sequence of CD46 or CD59 to obtain either a human artificial chromosome (HAC) that carries several xenoprotective transgenes or multi-transgenic cells that express a battery of xenoprotective transgenes. (tum.de)
  • One animal revealed CD46 and CD55 expression and one multi-transgenic founder animal expressed CD46, CD55, CD59, HO1 and A20. (tum.de)
  • The aim of this thesis was to construct and validate a tissue microarray of ovarian cancer cases and to survey the expression and prognostic capabilities of immunological molecular markers: specifically HLA class I and the membrane bound complement regulatory proteins CD46, CD55 and CD59. (nottingham.ac.uk)
  • The array was then stained for HLA class I, B2microglobulin and CD59 using commercial antibodies and for CD55 and CD46 using in-house antibodies. (nottingham.ac.uk)
  • High expression of CD55 and CD59 were associated with worse prognosis, though not independently of other factors. (nottingham.ac.uk)
  • Immune
  • Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and play a key role in maintaining tolerance to self- and non-self-antigens. (bloodjournal.org)
  • Immune directed therapy is ideally suited for evaluation in first and subsequent clinical remission populations when the disease burden is lowest, and evaluating treatments designed to prolong the duration of such remissions remains the highest priority ( 3 ). (aacrjournals.org)
  • vitro
  • Prior studies from this group, led by Buchholz, have shown that similarly modified lentiviral vectors displaying ScFvs specific for human CD20, CD105, or CD133 can selectively transduce in vitro CD20 + B cells, CD105 + endothelial cells, or CD133 + hematopoietic progenitor cells at high efficiency even when these cells constitute only minor fractions of unstimulated or cytokine-mobilized PBMCs. (bloodjournal.org)
  • DC-10 isolated from peripheral blood or generated in vitro are potent inducers of antigen-specific IL-10-producing Tr1 cells. (bloodjournal.org)
  • Nielsen, Afzelius, Ersbøll, Nielsen, Hansen: Expression of the activation antigen CD69 predicts functionality of in vitro expanded peripheral blood mononuclear cells (PBMC) from healthy donors and HIV-infected patients. (antikoerper-online.de)
  • vaccine
  • To characterize the safety and immunogenicity of a heptavalent antigen-keyhole limpet hemocyanin (KLH) plus QS21 vaccine construct in patients with epithelial ovarian, fallopian tube, or peritoneal cancer in second or greater complete clinical remission. (aacrjournals.org)
  • membrane
  • Cells that express high levels of β1 integrins, MCSP, LRIG1 and DLL1 lie in clusters in the IFE basal layer that have a specific location relative to the topography of the underlying basement membrane. (biologists.org)
  • viral
  • Additionally, they also have some limitations, i.e. cultures may give false negative results if the patient already got antibiotics, while PCR may lead to false positive results, because of high sensitivity and presence of viral genome in the sample long after the infection . (termedia.pl)
  • In our iodixanol gradient purified preparation, we detected high levels of viral DNA by real-time PCR and viral proteins by metabolic labelling, silver staining and western blots. (nih.gov)
  • Quality
  • With fifteen years of experience, our experienced team employs the latest in instrumentation and specialized synthetic techniques to deliver high quality products on time at a great price. (abgent.com)
  • As a global market leader with numerous subsidiaries and distributors, Miltenyi Biotec is committed to providing our customers around the world with the highest quality products. (miltenyibiotec.com)
  • animals
  • Aberrant crypt foci, putative preneoplastic lesions identified microscopically in wholemounts of colons, have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer. (readbyqxmd.com)