• The small GTPase Rab5 was identified as a binding protein for the p110beta-catalytic subunit in a yeast two-hybrid screening system. (embl-heidelberg.de)
  • Overexpression of Ruk(l) in cultured primary neurons induces apoptosis, an effect that could be reversed by co-expression of constitutively activated forms of the p110 alpha catalytic subunit of PI 3-kinase or its downstream effector PKB/Akt. (embl-heidelberg.de)
  • 4. Recombinant Protein Phosphatase-1 Catalytic Subunit. (bioscience.org)
  • It consists of a catalytic subunit of 37 kDa, which is bound to a number of different regulatory or targeting subunits. (bioscience.org)
  • Today these earlier difficulties can be understood in terms of the concept that the enzyme system consists of a catalytic subunit that exists in complexes with a variety of targeting or regulatory subunits, generating multiple forms of different sizes and enzymatic behavior. (bioscience.org)
  • In this review we will focus on the enzymology of protein phosphatase-1, in particular that of the catalytic subunit, from the perspective of work performed in our laboratory during the past twenty five years, as well as on currently unresolved questions regarding its properties and regulation. (bioscience.org)
  • This gene encodes a protein that belongs to the type I cytokine receptor family. (genecards.org)
  • This antibody is purified through a protein A column, followed by peptide affinity purification. (mybiosource.com)
  • This protein functions as a part of the cytokine receptor complex. (mybiosource.com)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • Cardiotrophin-1, a secreted protein expressed at high levels in myocardium during cardiogenesis, has been shown to promote proliferation and survival of embryonic cardiomyocytes, suggesting a role for Cardiotrophin-1 in the activation of gp130 during cardiac development. (novusbio.com)
  • The structure and function of the LIF-R gene and protein and the role of its cytoplasmic domain in myeloid leukemia cells are reviewed. (antikoerper-online.de)
  • This mechanism relies on cargo recruitment to autophagosomes by receptors that bind to both the ubiquitin-like AUTOPHAGY8 (ATG8) protein through ATG8-interacting motifs (AIMs) and to the cargo to be degraded. (medworm.com)
  • In plants, two autophagy cargo receptors, ATG8-interacting protein 1 (ATI1) and 2 (ATI2), were identified early on, but their molecular properties remain poorly understood. (medworm.com)
  • The levels of C - reactive protein were higher in hypertensive patients than normotensives and inflammation-related genes were increased as well. (medsci.org)
  • Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein-Coupled Receptors. (abcam.com)
  • Background G-protein-coupled receptors (GPCRs) play an essential role in lots of natural processes and represent a significant class of drug targets. (exposed-skin-care.net)
  • We previously reported that the class-I heterodimeric PI 3-kinase consisting of p110beta-catalytic and p85-regulatory subunits is synergistically activated by two different types of membrane receptors, one possessing tyrosine kinase activity and the other activating trimeric G proteins. (embl-heidelberg.de)
  • Our investigations are aimed at understanding the molecular recognition properties governing the interactions of receptors with their ligands, and the subsequent molecular events which couple ligand recognition to receptor activation. (stanford.edu)
  • using combinatorial biology approaches, novel ligands for receptors, which may have altered activities, that may serve as therapeutic starting points. (stanford.edu)
  • Therefore, we attempt to check whether we'd elicit ligand-dependent behavioural reactions in em C. elegans /em by expressing mammalian GPCRs in the ASH and ADL gustatory neurons, because they are straight exposed to the surroundings allowing gain access to of proteins and peptide ligands towards the heterologous receptors. (exposed-skin-care.net)
  • In 2016, CD19-specific chimeric antigen receptor (CAR)-modified T cells were used to treat patients with relapsed and refractory CD19+ B cell malignancies, including B cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. (wikipedia.org)
  • B cell antigen receptor (BCR) engagement can lead to many different physiologic outcomes. (frontiersin.org)
  • Recognition of antigen by the B cell antigen receptor (BCR) is the main event in the B cell immune response and signaling through the BCR complex is tightly regulated by several different co-receptors. (frontiersin.org)
  • Both Siglec-G and CD22 have also recently been linked to toll-like receptor signaling and may provide a link in the regulation of the adaptive and innate immune response of B cells. (frontiersin.org)
  • We demonstrate that mammalian heterologous GPCRs can transmission via different endogenous 1062368-24-4 supplier G subunits in em C. elegans /em , based on which cells it really is indicated in. (exposed-skin-care.net)
  • The present invention relates to the use of alpha (2) macroglobulin complexes isolated from the serum of a mammal. (patents.com)
  • The invention also relates to methods for making such complexes and compositions comprising alpha (2) macroglobulin complexes, isolated from the serum of a mammal, wherein such compositions are used in methods for the treatment and prevention of cancer and infectious disease. (patents.com)
  • The invention also encompasses methods for production of alpha (2) macroglobulin complexes. (patents.com)
  • In checkpoint therapy, antibodies bind to molecules involved in T-cell regulation to remove inhibitory pathways that block T-cell responses, known as immune checkpoint therapy. (wikipedia.org)
  • Recent findings indicate that the ability of these two receptors to bind sialic acids might be important to induce tolerance to self-antigens. (frontiersin.org)
  • Somatostatin receptors bind two isoforms of the tetradecapeptide, SST-14 and -28 [9, (exposed-skin-care.net)
  • We demonstrate using infant rabbits that Shiga toxin-mediated intestinal damage requires A-subunit activity, and like the human colon, that of the infant rabbit expresses the Shiga toxin receptor Gb 3 . (frontiersin.org)
  • Minimum inhibitory concentration (MIC) assays showed that CGA-N9 had antimicrobial activity and exhibited time-dependent inhibition activity against Candida tropicalis, with high safety in human red blood cells (HRBCs) and mouse brain microvascular endothelial cells (bEnd.3). (medworm.com)
  • Interestingly, we found no apparent relationship between the clinical and the molecular phenotypes, except that patients with absent IRM and enzymatic activity tend to have higher levels of serum alpha-fetoprotein and an earlier clinical onset. (jci.org)
  • We are additionally studying the mechanisms by which CD72-deficiency leads to a partial abrogation of B cell anergic tolerance in mice in which all B cells express a transgenic B cell receptor specific for hen-egg lysozyme (HEL) and in which the antigen HEL is expressed in the serum. (stanford.edu)
  • As opposed to mammalian chemosensory systems, the em C. elegans /em sensory neurons exhibit multiple GPCRs in each sensory neuron using many G subunits per neuron for sensory transduction, hence enabling the nematode to react particularly to different environmental cues only using several sensory neurons [2- (exposed-skin-care.net)
  • The B cells in these mice are hyper-responsive to stimulation through the B cell receptor. (stanford.edu)
  • Description of T cell growth factor interleukin-2 (IL-2) in 1976 allowed T lymphocytes to be grown in vitro, often without loss of effector functions. (wikipedia.org)