• The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
  • Although elevated levels of glucose 6-phosphate activate the hexose monophosphate shunt, nucleotide formation is enhanced, leading to increased uric acid production and possible development of gout. (medscape.com)
  • G6PD deficiency, a defect in the hexose monophosphate shunt pathway, is the most common disorder of red blood cell (RBC) metabolism. (msdmanuals.com)
  • In this study, the facilitated diffusion transport system for hexose sugars of S. cerevisiae was replaced by hexose-proton symport. (biomedcentral.com)
  • Each of these simple but nutritionally important sugars is a hexose, which means it contains six carbon atoms , 12 hydrogen atoms, and six oxygen atoms. (jrank.org)
  • Slightly more complex sugars are the disaccharides which contain two hexose units. (jrank.org)
  • SYN: hexose-1-phosphate uridylyltransferase, phosphogalactoisomerase. (theodora.com)
  • Hexoses are extremely important in biochemistry, both as isolated molecules (such as glucose and fructose) and as building blocks of other compounds such as starch, cellulose, and glycosides. (wikipedia.org)
  • The aldohexoses are a subclass of the hexoses which, in the linear form, have the carbonyl at carbon 1, forming an aldehyde derivative with structure H-C(=O)-(CHOH)5-H. The most important example is glucose. (wikipedia.org)
  • To apply this strategy to increase the ethanol yield on sucrose, we constructed a platform strain in which all genes encoding hexose transporters, disaccharide transporters and disaccharide hydrolases were deleted, after which a combination of a glucose-proton symporter, fructose-proton symporter and extracellular invertase ( SUC2 ) were introduced. (biomedcentral.com)
  • In such environments, the high extracellular glucose concentration can drive the uptake of glucose by yeast cells via diffusion, which is exemplified by the occurrence of many hexose transporters with a facilitated diffusion mechanism in S. cerevisiae . (biomedcentral.com)
  • In chemistry, a hexose is a monosaccharide (simple sugar) with six carbon atoms. (wikipedia.org)
  • [ 1 ] Increased muscle glycogen content and high levels of hexose monophosphates were noted. (medscape.com)
  • The hexose monophosphates, which accumulate because of the enzymatic block, activate glycogen synthetase. (medscape.com)
  • In addition to the unconverted hexoses, the residue consists, mainly. (tue.nl)
  • After fermenting away the hexoses, the residue was treated with phenylhydrazine and an osazone separated. (dictionary.com)
  • Hexoses exist in two forms, open-chain or cyclic, that easily convert into each other in aqueous solutions. (wikipedia.org)
  • A qualitative and quantitative method of analysis for the acidic reaction products resulting from the oxidation of Hexoses in aqueous alkaline solutions with oxygen is described. (tue.nl)
  • Hexoses can form dihexose (like sucrose) by a condensation reaction that makes 1,6-glycosidic bond. (wikipedia.org)
  • After evolution, the resulting strain exhibited a 16.6% increased anaerobic ethanol yield (from 1.51 to 1.76 mol mol hexose equivalent −1 ) and 46.6% decreased biomass yield on sucrose. (biomedcentral.com)
  • The term "hexose" sometimes is assumed to include deoxyhexoses, such as fucose and rhamnose: compounds with general formula C 6H 12O 6-y that can be described as derived from hexoses by replacement of one or more hydroxyl groups with hydrogen atoms. (wikipedia.org)
  • To determine whether the carbohydrate content of serum proteins is related to overall glycemic control, we studied serum protein-bound hexose and glycosylated hemoglobin [HbA 1(a+b+c) ] in 37 ambulant diabetic patients and 32 nondiabetic controls. (diabetesjournals.org)
  • These are carbohydrate derivatives containing a hexose moiety in which the oxygen atom is replaced by an n-acyl group. (hmdb.ca)
  • In the yeast Saccharomyces cerevisiae , which is widely applied for industrial bioethanol production, uptake of hexoses is mediated by transporters with a facilitated diffusion mechanism. (biomedcentral.com)
  • The purpose of this study was to gain insights into the nature of the transport mechanism by creating conditions conducive to hexose efflux from the peeled berry. (edu.au)
  • Conclusions: These results lead us to the conclusion that the origin of the collected hexoses was vacuolar as opposed to vascular, and that the hexose efflux mechanism is differently sensitive to PCMBS at the two stages of ripening. (edu.au)
  • In anaerobic cultures, a higher ethanol yield can be achieved when transport of hexoses is proton-coupled, because of the lower net ATP yield of sugar dissimilation. (biomedcentral.com)
  • This study provides a proof-of-concept for the replacement of the endogenous hexose transporters of S. cerevisiae by hexose-proton symport, and the concomitant decrease in ATP yield, to greatly improve the anaerobic yield of ethanol on sugar. (biomedcentral.com)
  • Additionally, during the period of intensive sugar accumulation (one week after veraison) and two weeks later, hexose efflux was assessed following three modifications: (i) using berries excised from the vine, (ii) using MES buffer (2-(N-morpholino)ethanesulfonic acid, pH 5.5) containing PCMBS (p-chloromercuribenzenesulfonic acid, 1mM), and (iii) using cold (10°C) or warm (40°C) MES buffer. (edu.au)
  • H 2 O), a hexose sugar freely soluble in water. (drugs.com)
  • The chemical formula for all hexoses is C6H12O6, and their molecular weight is 180.156 g/mol. (wikipedia.org)
  • N-Sulfo-D-glucosamine belongs to the class of organic compounds known as hexoses. (hmdb.ca)
  • Significance and impact of the study: This simple technique was effective at providing insights into hexose transport within the grape berry at the cellular level. (edu.au)
  • Our findings provide mechanistic insight into hexose-mediated oligonucleotide delivery and have important implications for the development of DMD exon-skipping therapy. (ox.ac.uk)
  • In nine of the diabetic patients, mean protein-bound hexose and HbA 1(a+b+c) were significantly reduced during a period of intensive outpatient care, while two major serum glycoproteins, haptoglobins and alpha-1-antitrypsin, were unchanged. (diabetesjournals.org)
  • The open-chain form of a hexose, which usually is favored in solutions, has the general structure H-(CHOH)n−1-C(=O)-(CHOH)6−n-H, where n is 1, 2, 3, 4, 5. (wikipedia.org)
  • Shiraz berries was peeled in situ and, after an initial wash, hexose efflux into a collection medium (MES buffer) was monitored. (edu.au)
  • Methylene blue-mediated hexose monophosphate shunt stimulation in human red blood cells in vitro: independence from intracellular oxidative injury. (ox.ac.uk)
  • The red blood cell hexose monophosphate shunt (HMS) and proteolytic responses to several concentrations of Methylene Blue or sodium nitrite were measured. (ox.ac.uk)
  • A reduction of transketolase activity compromises the hexose monophosphate shunt. (medscape.com)
  • The chemical formula for all hexoses is C6H12O6, and their molecular weight is 180.156 g/mol. (wikipedia.org)
  • Detailed characterisation of members of the hexose transporter family is limited to SGLT1, 2 and 3, which are all inhibited in a competitive manner by phlorizin , a natural dihydrocholine glucoside, that exhibits modest selectivity towards SGLT2 (see [ 8 ] for an extensive review). (guidetopharmacology.org)
  • Hexose-phosphate transporter. (tcdb.org)
  • 7. Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7). (nih.gov)
  • 12. GLUT7: a new intestinal facilitated hexose transporter. (nih.gov)
  • The rs17368528 SNP results in an amino-acid substitution (proline to leucine) in the fifth exon of the hexose-6-phosphate dehydrogenase (H6PD) gene, in which some variants have been reported to attenuate or abolish H6PD activity, in individuals with cortisone reductase deficiency. (nih.gov)
  • Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness. (nih.gov)
  • Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1. (ox.ac.uk)
  • We recently established that cortisone reductase deficiency is a digenic disease requiring mutations in both the gene encoding 11 beta-HSD1 and in the gene for a novel enzyme located within the lumen of the endoplasmic reticulum (ER), hexose-6-phosphate dehydrogenase (H6PDH). (ox.ac.uk)
  • We performed a genetic association study in 854 members of 224 families to assess the relationship between polymorphisms in the gene coding for hexose-6 phosphate dehydrogenase (H6PD) and carotid intima-medial thickness. (dundee.ac.uk)
  • Fructose that corresponds to a natural hexose was developed as a low-calorie sugar substitute. (hindawi.com)
  • 5. Insight into the "odd" hexose transporters GLUT3, GLUT5, and GLUT7. (nih.gov)
  • 17. Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer-effects of hypoxia. (nih.gov)
  • The term "hexose" sometimes is assumed to include deoxyhexoses, such as fucose and rhamnose: compounds with general formula C 6H 12O 6-y that can be described as derived from hexoses by replacement of one or more hydroxyl groups with hydrogen atoms. (wikipedia.org)
  • hexuronic acid The acid derived from a hexose sugar by oxidation of the hydroxyl group on carbon‐6. (encyclopedia.com)
  • WcaJ belongs to a large family of polyisoprenyl-phosphate hexose-1-phosphate transferases (PHPTs) sharing a similar predicted topology consisting of an N-terminal domain containing four transmembrane helices (TMHs), a large central periplasmic loop, and a C-terminal domain containing the fifth TMH (TMH-V) and a cytosolic tail. (qub.ac.uk)
  • Effects of insulin receptor down-regulation on hexose transport in human erythrocytes. (ox.ac.uk)
  • [ 1 ] Increased muscle glycogen content and high levels of hexose monophosphates were noted. (medscape.com)
  • Hexoses exist in two forms, open-chain or cyclic, that easily convert into each other in aqueous solutions. (wikipedia.org)
  • Link to all annotated objects annotated to phosphoramidate-hexose phosphotransferase activity. (planteome.org)
  • Link to all direct and indirect annotations to phosphoramidate-hexose phosphotransferase activity. (planteome.org)