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  • residues
  • In the beginning of the simulation of hexosaminidase from S. plicatus the binding energy of uronate 5 was favorable, however, during the simulation the interaction with catalytic Asp 313 and Glu 314 residues was lost. (nih.gov)
  • 1.52
  • β- N -acetyl-D-hexosaminidases (EC 3.2.1.52) belong to the glycoside hydrolase family 20 and catalyze the removal of N- acetyl-D-glucosamine (GlcNAc) or N- acetyl-D-galactosamine (GalNAc) from the non-reducing ends of a variety of physiological substrates, such as oligosaccharides, glycoproteins and glycolipids. (ijbs.com)
  • cleavage
  • This protein binds molecules of ganglioside GM2, extracts them from membranes, and presents them to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. (wikipedia.org)
  • degradation
  • One is chitinolytic β- N -acetyl-D-hexosaminidase, which is specifically involved in chitin degradation during insect metamorphosis [ 2 - 6 ]. (ijbs.com)
  • The second is the N -glycan processing β- N -acetyl-D-hexosaminidase, which is a membrane-bound enzyme that is involved in the degradation of N -glycans [ 7 - 9 ]. (ijbs.com)
  • The physiological importance of human β- N -acetyl-D-hexosaminidase A (HsHex A, αβ heterdimer) and B (HsHexB, ββ homodimer) are linked to the degradation of glycoconjugates (such as GM2 ganglioside) [ 12 , 13 ]. (ijbs.com)