Loading...
  • sequence
  • A sequence in the beta 1 chain that is involved in cell attachment chemotaxis and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. (bio-rad.com)
  • It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. (origene.com)
  • Renal nursing a practical approachand the donor sera to which they are also predisposing factors particularly high risk for coexistent pneumothorax bleeding can be used over minutes continue alternating midazolam and fentanyl patient controlled analgesia systems pca is a sequence containing the probe however the identii cation of heterotrimeric laminins and cloning of a transplanted kidney. (nationalnewstoday.com)
  • mutations
  • Promoter-reporter constructs harboring 4 kb upstream regions, each of the three genes encoding Laminin-322 as well as deletion and mutations constructs were established. (biomedcentral.com)
  • Mutations in laminin 211 cause muscular dystrophy in mice and humans (Tome et al. (springer.com)
  • Lamc1
  • To characterize morphologic and physiological alterations in the retina of three laminin mutant zebrafish, bashful ( bal , lama1), grumpy ( gup , lamb1), and sleepy ( sly , lamc1), which were identified in forward genetic screens and were found to be impaired in visual functions. (arvojournals.org)
  • tumor
  • This same tumor is the primary source for commercially available mouse laminin. (sigmaaldrich.com)
  • We hypothesize that this divergence in modular regulation of the three promoters may lay the ground for uncoupled regulation of Laminin-332 in Smad4-deficient tumor cells in response to stromally expressed cytokines acting on budding tumor cells. (biomedcentral.com)
  • Processing of laminin-5 promotes tumor invasion. (stanford.edu)
  • kalinin
  • Rousselle P, Golbik R, van der Rest M, Aumailley M «Structural requirement for cell adhesion to kalinin (laminin-5). (wikipedia.org)
  • Lama5
  • Here, we examined the role of podocyte-derived laminin α5 via podocyte-specific inactivation of Lama5 and podocyte-specific rescue of the Lama5 neo mutation. (asnjournals.org)
  • Podocyte-specific restoration of laminin α5 production using two distinct strategies in Lama5 neo/neo mice resulted in the resolution of proteinuria, hematuria, and PKD. (asnjournals.org)
  • Laminin α5 is widely expressed, 17 and Lama5 −/− mice die at late fetal stages with multiple developmental defects. (asnjournals.org)
  • Lack of laminin-10 in lama5 -/- mice results in aberrant tissue development. (stanford.edu)
  • mice
  • These results suggest that the development of normal GBM structure and function requires podocyte-derived laminin α5 during and after glomerulogenesis and present a unique mechanism for the pathogenesis of PKD in these mice. (asnjournals.org)
  • Under homeostatic conditions, no defects in BBB integrity and cerebral blood flow (CBF) were observed in α5-PKO mice, suggesting that mural cell-derived laminin-α5 is dispensable for BBB maintenance and CBF regulation under homeostatic conditions. (biomedcentral.com)
  • domains
  • Laminin G domains can vary in their function, and a variety of binding functions have been ascribed to different LamG modules. (embl.de)
  • Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins. (embl.de)
  • Composition
  • The BMs around muscle fibers, NMJs, nerves, and blood vessels of the majority of EOMs of ALS donors had rather normal appearance and laminin composition, but heterogeneity was observed among EOM samples of individual ALS donors and between ALS donors. (arvojournals.org)
  • The EOMs maintained a normal laminin composition in their NMJs, which may be instrumental for the fact that they are not typically affected in ALS. (arvojournals.org)