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  • collagen
  • It was found that Tango1 , a protein thought to exclusively mediate collagen secretion, is also important for laminin secretion in glia via a collagen-independent mechanism. (sdbonline.org)
  • Collagen XVII is a transmembrane collagenous protein that interacts with alpha-4 integrin and BP230 intracellularly and with laminin-332 extracellularly. (medscape.com)
  • These structures contain the extracellular portions of collagen XVII (BP180) and alpha-6-beta-4 integrin. (medscape.com)
  • The BM structure is thought to be set by laminin and collagen IV. (sigmaaldrich.com)
  • The other protein components of the BM are thought to be non-covalently immobilized in the matrix formed by laminin and collagen IV6. (sigmaaldrich.com)
  • Collagen I is a heterotrimeric extracellular matrix protein found in the skin and other connective tissues. (thermofisher.com)
  • The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. (lsbio.com)
  • These segments were found surrounded by non-myelinated Schwann cells (NMSCs) showing strong intracellular expression of laminin-β2/collagen IV.Their BMs express laminin-β2/collagen IV and reaches the BM of the sensory epithelium at the habenula perforata.We speculate that the NMSCs protect SGNs from further degeneration following dendrite loss. (nih.gov)
  • The non-myelinated zones varied considerably in length but could be up to 50 microns (Fig. 2A, E). Typically, as opposed to the SGCs, the NMSCs showed rich expression of intracellular laminin-β2 and collagen IV (Figs. 2E, F, and 3). (nih.gov)
  • name laminin
  • Following, it was purified in quantities sufficient for biochemical , structural and immunological characterisation, and given the name laminin. (edu.au)
  • LAMC1
  • To characterize morphologic and physiological alterations in the retina of three laminin mutant zebrafish, bashful ( bal , lama1), grumpy ( gup , lamb1), and sleepy ( sly , lamc1), which were identified in forward genetic screens and were found to be impaired in visual functions. (arvojournals.org)
  • Laminin γ1 chain gene ( LAMC1 ) promoter contains several GC/GT- rich motifs including the bcn-1 element . (dict.md)
  • Because its role is so important , regulation of laminin γ1 chain (LAMC1) gene expression has generated considerable interest (7,10-14). (dict.md)
  • LAMC1 gene expression is responsive to a multitude of extracellular signals , including glucose (14), IGF (14), IL-1β, TGF -β, phorbol esters (11) and retinoic acid (10). (dict.md)
  • Considering the fact that laminin is a multifunctional protein, it is not surprising that LAMC1 gene expression is responsive to many signals. (dict.md)
  • This assortment of transcriptional elements renders the LAMC1 promoter responsive to multiple extracellular signals. (dict.md)
  • The multiplicity of the transcriptional elements allows the LAMC1 gene to respond to various extracellular signals that call for laminin expression to fulfill one of its many specific cellular functions . (dict.md)
  • Mutations
  • Mutations in laminin 211 cause muscular dystrophy in mice and humans (Tome et al. (springer.com)
  • Mutations in the human laminin α 2 ( LAMA2 ) gene result in the most common form of congenital muscular dystrophy (MDC1A). (pnas.org)
  • Here we show that the degenerative muscle phenotype in the zebrafish dystrophic mutant, candyfloss ( caf ) results from mutations in the laminin α 2 ( lama2 ) gene. (pnas.org)
  • Muscle samples collected at autopsy from ALS donors and from transgenic mice overexpressing human superoxide dismutase type I mutations (D90A or G93A), and age-matched controls were analyzed with immunohistochemistry using antibodies against laminin chain (Ln)α2, Lnα4, Lnα5, Lnβ1, Lnβ2, and Lnγ1. (arvojournals.org)
  • receptors
  • The assembled laminin molecule forms a cross-like structure that can bind to other extracellular matrix molecules and to cellular receptors, which helps anchor organized tissue cells to the membrane. (biolamina.com)
  • There are many binding sites on the full-length laminin molecule which can interact with cell membrane receptors, triggering vital intracellular signaling pathways and regulate cellular responses, such as cell anchorage, survival, proliferation, migration, organization and specialization. (biolamina.com)
  • Cellular
  • Recent studies have implicated activation of the heterotrimeric G protein subunit Galphai and the subsequent decrease in cellular 3',5'-cyclic adenosine monophosphate (cAMP) levels in promoting the Hh response in flies and mammals. (sdbonline.org)
  • larval locomotion
  • Accumulation of laminin monomers in Drosophila glia leads to glial endoplasmic reticulum stress and disrupted larval locomotion. (sdbonline.org)
  • The physiological consequences of disruption of laminin secretion in glia included decreased larval locomotion and ultimately lethality. (sdbonline.org)
  • Laminin is a heterotrimer composed of an alpha (LanA or Wb), beta (LanB1) and gamma (LanB2) subunit and we demonstrate that LanB2 loss in glia results in accumulation of LanB1 leading to distended ER, ER stress and glial swelling in addition to decreased larval locomotion and lethality. (ubc.ca)
  • Together, the results in this thesis highlight the role of perineurial glia in secreting laminin, facilitating larval locomotion and regulating both central and peripheral nervous system morphology in Drosophila. (ubc.ca)
  • structural
  • Laminins are major structural components of basal laminae and exist as heterotrimeric complexes of one α, one β, and one γ chain. (pnas.org)
  • The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. (nih.gov)
  • glia
  • This study demonstrates that loss of the laminin γ subunit (LanB2) in the peripheral glia of Drosophila melanogaster results in the disruption of glial morphology due to disruption of laminin secretion. (sdbonline.org)
  • Therefore, we have focused on perineurial glia and the role of laminin, an integrin ligand, and basigin, a transmembrane protein known to interact with integrin. (ubc.ca)
  • LAMA2
  • The incidence of CMDs has been estimated to be approximately one in 21,500 ( 2 ), with laminin α2- (LAMA2) deficient CMD (MDC1A) accounting for ≈40-50% of the CMD cases in European countries ( 3 ). (pnas.org)
  • compartments
  • This is also the case in the retina, where laminins are present in many different compartments-namely, Bruch's membrane, the interphotoreceptor matrix, the external limiting membrane (ELM), the outer plexiform layer (OPL), inner plexiform layer (IPL), and inner limiting membrane (ILM). (arvojournals.org)
  • 3 Because of the presence in these retinal compartments, laminins are thought to play a central role in development and maintenance of photoreceptor structure and synaptic function. (arvojournals.org)
  • sequence
  • Using a new method for construction and database searches of sequence consensus strings, we have identified a new superfamily of protein modules comprising laminin G, thrombospondin N and the pentraxin families. (embl.de)
  • Recombinant protein encompassing a sequence within the C-terminus region of human Laminin alpha 4. (genetex.com)
  • plasma membrane
  • Anchoring filaments extend from the basal cell plasma membrane into the extracellular environment and span the lamina lucida, connecting hemidesmosomes with the lamina densa. (medscape.com)
  • composition
  • The BMs around muscle fibers, NMJs, nerves, and blood vessels of the majority of EOMs of ALS donors had rather normal appearance and laminin composition, but heterogeneity was observed among EOM samples of individual ALS donors and between ALS donors. (arvojournals.org)
  • The EOMs maintained a normal laminin composition in their NMJs, which may be instrumental for the fact that they are not typically affected in ALS. (arvojournals.org)