Kir stations are tetramers made up of four similar (homotetrameric) or homologous (heterotetrameric) membrane-spanning subunits encircling a water-filled pore by which K+ ions move down their electrochemical gradient. (bio2009.org)
Binds2
Unexpectedly, the heterotetrameric complex binds to the acidic patch present on all nucleosomes raising questions as to how specificity of methylation is obtained. (umich.edu)
Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. (cusabio.com)
Subunits1
Insulin-like growth factor I receptor (IGF-I R) is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. (rndsystems.com)
Alpha subunit1
The encoded protein exists in a heterotetrameric complex containing the Bckdh alpha subunit to form the E1 catalytic component of Bckdh complex. (nih.gov)
Protein4
Ion-exchange chromatography is useful for isolating specific heterotetrameric protein assemblies, allowing purification of specific complexes according to both the number and the position of charged peptide tags. (wikipedia.org)
The enzyme is composed of the heterotetrameric MoFe protein that is transiently associated with the homodimeric Fe protein . (bionity.com)
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. (thermofisher.com)
In cells, the majority of Sec61 is stably associated with a heterotetrameric membrane protein complex, the translocon-associated protein complex (TRAP), yet the mechanism by which TRAP assists in polypeptide translocation remains unknown. (lu.se)
Complex6
Fig. 2: Cryo-EM structure of the heterotetrameric ALK-ECR ABR -ALKAL2 complex. (nature.com)
HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex ( AP3BA ), which assists in the vesicle formation from the trans-Golgi network or late endosome. (medscape.com)
Electron microscopy, small angle X-ray scattering, and ultracentrifugation data of human and P. furiosus MR reveal a dual functional complex consisting of a (Mre11)2/(Rad50)2 heterotetrameric DNA processing head and a double coiled-coil linker. (rcsb.org)
The NasS and NasT proteins co-purify as a stable heterotetrameric regulatory complex, NasS-NasT. (ox.ac.uk)
HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex (ADTB3A), which resides on chromosome 5. (medscape.com)
Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. (icr.ac.uk)
Receptor1
The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. (rndsystems.com)
Enzyme1
subunit of heterotetrameric ?2?2 enzyme from Moorella thermoacetica (CODHMt), formerly Clostridium thermoaceticum. (tamu.edu)
Family1
BbsCD represents a novel clade of related enzymes within the SDR family, which adopt a heterotetrameric architecture and catalyze the β-oxidation of aromatic succinate adducts. (nih.gov)
Specific2
MALDI-MS equipped with high mass detection was used to follow the cross-linking reaction using bis[sulfosuccinimidyl] suberate (BS3) and confirm the heterotetrameric stoichiometry of the specific stabilized subcomplex. (covalx.com)
From this analysis, the researchers were able to confirm the heterotetrameric stoichiometry of the specific stabilized subcomplex. (covalx.com)
Homo1
7. Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B. (nih.gov)
Disulfide-linked1
The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. (rndsystems.com)
Subunit3
Insulin acts through a disulfide-bonded heterotetrameric cell surface receptor comprised of an extracellular alpha subunit coupled via disulfide bonds to a transmembrane and intracellular beta subunit. (nih.gov)
HPS-2 is caused by a mutation in the gene encoding the beta-3A subunit of the heterotetrameric AP3 complex ( AP3BA ), which assists in the vesicle formation from the trans-Golgi network or late endosome. (medscape.com)
AP-1 heterotetrameric complex contains a gamma-adaptin subunit bearing a gamma-ear at its carboxy terminus, while Ggas are monomeric adaptor proteins containing a C-terminal domain related to the ear domain of gamma-adaptin. (eu.org)
Complexes3
Ion-exchange chromatography is useful for isolating specific heterotetrameric protein assemblies, allowing purification of specific complexes according to both the number and the position of charged peptide tags. (wikipedia.org)
Adaptor protein complexes (AP1-4) are ubiquitously expressed, evolutionarily conserved heterotetrameric complexes that mediate different types of vesicle formation and the selection of cargo molecules for inclusion into these vesicles. (nih.gov)
These signals function as "bar codes" that are decoded by adaptors such as the AP-1, AP-2, AP-3 and AP-4 heterotetrameric complexes, the monomeric GGA1, GGA2, and GGA3 proteins, and several others, all of which are components of protein coats associated with the cytosolic face of membranes (e.g., clathrin coats). (nih.gov)
Proteins4
The DPOR holoenzyme is comprised of two component proteins, the dimeric BchL protein and the heterotetrameric BchN/BchB protein. (rcsb.org)
A heterotetrameric transcription factor composed of two distinct proteins. (nih.gov)
the operon, encoding two proteins which form the heterotetrameric positive transcriptional regulator of the class II genes. (biomasswars.com)
The light chains (KLCs) of the heterotetrameric microtubule motor kinesin-1, that bind to cargo adaptor proteins and regulate its activity, have a capacity to recognize short peptides via their tetratricopeptide repeat domains (KLCTPR). (diamond.ac.uk)
Monomeric1
It can exist in a monomeric form or in a heterotetrameric form with the S100A10 dimer. (bvsalud.org)
Crystal2
Crystal structure of a heterotetrameric NMDA receptor ion channel. (nih.gov)