Infectious mononucleosis (IM, mono), also known as glandular fever, is an infection usually caused by the Epstein-Barr virus (EBV). (wikipedia.org)
When caused by EBV, infectious mononucleosis is classified as one of the Epstein-Barr virus-associated lymphoproliferative diseases. (wikipedia.org)
Infectious mononucleosis is caused by Epstein-Barr virus (EBV, human herpesvirus type 4) and is characterized by fatigue, fever, pharyngitis, and lymphadenopathy. (merckmanuals.com)
1. Johannsen EC, Kaye KM: Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus-Associated Malignant Diseases, and Other Diseases). (msdmanuals.com)
These include Epstein-Barr nuclear antigen (EBNA)-1, EBNA-2, EBNA-3A, EBNA-3B, EBNA-3C, EBNA-leader protein (EBNA-LP) and latent membrane proteins (LMP)-1, LMP-2A and LMP-2B and the Epstein-Barr encoded RNAs (EBERs). (wikidoc.org)
EBNA-1 possesses a glycine - alanine repeat that impairs antigen processing and MHC class I-restricted antigen presentation thereby inhibiting the CD8-restricted cytotoxic T-cell response against virus infected cells. (wikidoc.org)
The presence or absence of EBV viral capsid antigen (VCA) IgG, VCA IgM and EBV nuclear antigen (EBNA) IgG antibodies was recorded. (who.int)
Viral1
The lytic cycle or productive infection results in staged expression of a host of viral proteins with the ultimate objective of producing infectious virions. (wikidoc.org)
At best, the Monospot test may indicate that a person has a typical case of infectious mononucleosis, but does not confirm the presence of EBV infection. (cdc.gov)
However, specific antibody tests may be needed to identify the cause of illness in people who do not have a typical case of infectious mononucleosis or have other illnesses that can be caused by EBV infection. (cdc.gov)
At the time, their article was entitled "Mononuclear leukocytosis in reaction to acute infection (infectious mononucleosis)" because the causative organism, EBV, had yet to be described. (medscape.com)
The humoral immune response directed against EBV structural proteins is the basis for the test used to diagnose EBV infectious mononucleosis, but the T-lymphocyte cellular response is critical in determining the clinical expression of EBV infection. (medscape.com)
Answer 9.1.1 The correct answer is "E." This presentation is consistent with an acute retroviral syndrome, which occurs very early in the infection and is characterized by a mononucleosis-like illness that can last several weeks. (mhmedical.com)
Since the antibody to HIV will not develop for at least 2 to 8 weeks after infection and the retroviral syndrome typically occurs before seroconversion, HIV antibody tests, including rapid detection methods ("B"), may well be negative. (mhmedical.com)
For clinical aspects of the disease, see Mononucleosis . (wikidoc.org)
Commonly1
Mononucleosis most commonly affects those between the ages of 15 and 24 years in the developed world. (wikipedia.org)
Syndrome1
CMV, HIV, Toxoplasma, human herpesvirus type 6 (HHV-6), hepatitis B and HHV-7 present similarly to EBV induced IM and should be considered in a heterophile-negative mononucleosis-like syndrome. (medscape.com)
[ 5 ] In US institutions characterized by the presence of many young adults, such as universities and the armed forces, the annual incidence for infectious mononucleosis ranges from 11 to 48 cases per 1000 persons. (medscape.com)
Test1
The monospot test is not recommended for general use due to poor accuracy. (wikipedia.org)
Case1
Candy B, Chalder T, Cleare AJ, Wessely S, White PD, Hotopf M. Recovery from infectious mononucleosis: a case for more than symptomatic therapy? (medscape.com)
Primary1
This chapter focuses on the primary care aspects of HIV/AIDS including initial evaluation, drug side effects, and infectious disease prophylaxis. (mhmedical.com)
Disease1
Articles in this edition include "Achilles Tendon Ruptures, "Sever's Disease: When Bones Grow Too Fast for Tendons," "Infectious Mononucleosis: Know the Risks" and "Research in Brief. (pennstatehealthnews.org)