• Proton therapy shows great promise for patients such as the one described here, and is available to many patients with solid and brain tumors who travel from around the world to receive treatment at The Children's Hospital of Philadelphia/Roberts Proton Therapy Center. (chop.edu)
  • Schwannomas comprise 8.6% of central nervous tumors in the Unites States,[ 19 ] and these tumors are the third most common benign brain tumors. (surgicalneurologyint.com)
  • Frank Winkler from University Hospital Heidelberg continued the microenvironment session by presenting his lecture titled "Malignant Networks in the Brain: A New View on Brain Tumors and its Clinical Implications. (wfnos.org)
  • Soft tissue sarcomas, the fifth most common solid tumors in children, are relatively rare and account for about 6-7% of all childhood malignancies. (medscape.com)
  • NPM is over-expressed in solid tumors of diverse histological origin 6 or is involved in tumor progression 7 - 9 In several hematologic malignancies, the NPM1 locus is lost 10 or translocated leading to the formation of oncogenic fusion proteins. (haematologica.org)
  • Soft tissue sarcomas (STSs) are a group of rare and heterogeneous solid tumors of mesenchymal cell origin with distinct clinical and pathologic features [ 1 ]. (hindawi.com)
  • One possible explanation of this tumor heterogeneity is that human tumors are not merely monoclonal expansions of a single transformed cell, but rather caricatures of normal tissues, and their growth is sustained by cancer stem cells (CSCs). (dtic.mil)
  • ras Oncogenes are observed in more human tumors and at a higher frequency than any other oncogene, and activation of the proto-oncogene may occur at various stages of the carcinogenic process. (nih.gov)
  • Numerous proto-oncogenes other than the ras genes have been shown to be activated in human tumors and to a lesser extent in rodent tumors. (nih.gov)
  • Amplification of proto-oncogenes and possibly gene overexpression during the absence of gene amplification occur in the development of many human tumors. (nih.gov)
  • The etiology of the genetic alterations observed in most human tumors is unclear at present. (nih.gov)
  • The genetic alterations observed in most human tumors are probably generated by both spontaneous events and exogenous conditions. (nih.gov)
  • Medical imaging is therefore highly needed for early detection and exact localization of symptomatic or potentially malignant tumors. (nih.gov)
  • Brainstem gliomas, medulloblastomas, ependymomas, and certain pineal tumors are relatively common primary malignant tumors of the CNS in children. (nih.gov)
  • Malignant tumors of the heart constitute approximately 10% of all pediatric tumors. (sts.org)
  • Secondary metastasis or contiguous spread to the heart constitutes the most common malignant tumors. (sts.org)
  • Malignant tumors of the heart mostly occur due to metastatic or contiguous spread and are more common than primary malignant tumors. (sts.org)
  • The most common primary malignant tumors of the heart are sarcomas (rhabdomyosarcoma and angiosarcoma). (sts.org)
  • However, the single agent is only modestly effective on suppressing tumour progression. (nature.com)
  • The acquisition of immune evasion by tumour cells is one of the major mechanisms of tumour progression, 5 and mainly consists of immunosuppressive cells in the tumour microenvironment and loss of immune checkpoint signalling. (nature.com)
  • 10 Several studies have shown that infiltration of MDSCs is positively associated with the drug resistance as well as the tumour progression. (nature.com)
  • Here we describe the case of a 14-year-old female adolescent with severe HTN, metabolic alkalosis, and hypokalemia, secondary to a renin-secreting juxtaglomerular cell tumor diagnosed after 2 years of HTN progression. (bvsalud.org)
  • Clinical lymphadenopathy may develop (stage IIA), sometimes with progression of the plaques to form tumors (stage IIB), or tumors may form from plaques in the absence of lymphadenopathy (stage IIB). (medscape.com)
  • FDG PET represents a noninvasive means of estimating tumor aggressiveness and can be used to detect progression or regression of disease. (pdfslide.us)
  • We hypothesized that CTC id ahead of removal of the principal tumor would anticipate worse progression-free and general success in non-metastatic breasts cancer sufferers, irrespective of principal tumor features, axillary lymph node position, or if they acquired received neoadjuvant chemotherapy or not really. (woofahs.com)
  • Quantitative real-time RT-PCR was used to determine LunX, CK19, CEA, VEGF-C and hnRNP A2/B1 mRNA levels in peripheral blood and pleural fluid from NSCLC patients, compared with those from patients with other epithelial cancer (esophagus cancer and breast cancer), benign lung disease (pneumonia and tuberculo pleurisy) and from healthy volunteers. (biomedcentral.com)
  • In peripheral blood LunX mRNA was detectable in 75.0% (33/44) of patients with NSCLC, but not in patients with other epithelial cancer (0/28), benign lung disease (0/10) or in healthy volunteers (0/15). (biomedcentral.com)
  • Neurofibromatosis type 1 (NF1) is a rare genetic disorder, characterized by the development of benign and malignant nerve tumors. (jci.org)
  • Pediatric cardiac tumors are extremely rare, and the vast majority are benign. (sts.org)
  • The most common benign tumors of the heart are rhabdomyoma, fibroma, teratoma and myxoma. (sts.org)
  • These are benign tumors that arise from the cardiac myocyte and constitute the most common pediatric cardiac tumors. (sts.org)
  • Peripheral nerves are affected by a number of disease processes like trauma, infection, inflammation, benign and malignant tumours, as well as entrapment neuropathies. (scirp.org)
  • In summary, many benign bone tumors and tumor-like lesions, including most connective- tissue and fibro-osseous lesions of bone, can reli- ably be diagnosed by radiography and do not require further imaging. (pdfslide.us)
  • The presentation and stage at diagnosis, as well as the associated prognosis, may be very heterogeneous. (chop.edu)
  • The objective of this study was to examine the cellular and molecular mechanisms underlying this association in order to identify new molecular targets for diagnosis, prognosis or therapy of these tumors. (endocrine-abstracts.org)
  • Prognosis depends on several factors, including a patient's age and the location, size, depth, histologic grade, and stage of the tumor [ 1 ]. (hindawi.com)
  • The prognosis of MPNST patients is dismal due to invasive tumor growth, metastatic proclivity and resistance to radiation and conventional chemotherapy, posing an urgent need for improved effective therapeutic modalities for this challenging disease. (curesarcoma.org)
  • ATRT was first described as a histological variant of Wilm's tumor, which mainly occurs in infants and has unfavorable prognosis. (pediatricneurosciences.com)
  • Low TILs and changed appearance of particular genes connected with tumor-immune systems connections emerged as unbiased risk factors, linked to poor relapse and prognosis within 2?years in advanced LSCC. (onlycoloncancer.com)
  • CT will show large, multilobulated masses with heterogenous contrast enhancement and peripheral calcification of the pineal gland. (wikipedia.org)
  • On MRI, pineoblastomas again appear as masses with heterogenous enhancement. (wikipedia.org)
  • The addition of contrast agents provides differential enhancement of tumor and normal soft tissues, thus further improving the delineation of hepatic and extrahepatic tumor (Figure 2). (cancernetwork.com)
  • Administration of gadolinium showed heterogeneous peripheral enhancement and central necrotic change. (cdc.gov)
  • It was slightly hypodense with respect to muscle on the plain study with a CT value of 35-45 HU and showed a mild heterogeneous enhancement in contrast study (CT value 55-65 HU). (thieme-connect.com)
  • Axial T1-weighted image after administration of gadolinium demonstrating peripheral nodular enhancement of right parietal mass. (hindawi.com)
  • On enhanced MRI, the tumor showed progressive enhancement of peripheral and solid components with delayed enhanced pseudo-capsule. (cttacn.org.cn)
  • MRI showed that the tumor was of moderately high intensity, accompanied by cystic components on T2-weighted images and heterogeneous enhancement mainly in the peripheral area with gadolinium (Gd) on T1-weighted images [ Figures 1a and b ]. (surgicalneurologyint.com)
  • T1-PG-lesion shows heterogeneous post contrast enhancement. (pediatricneurosciences.com)
  • Due to the aggressive nature of the disease, tumor spread at the time of diagnosis is common. (wikipedia.org)
  • Diagnosis also requires CSF sampling via lumbar puncture to assess for cytology and tumor markers. (wikipedia.org)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • The diagnosis is neuroblastoma, a malignancy that arises from embryonic neural crest cells of the peripheral nervous system and is the most common extra-cranial solid tumor of childhood. (chop.edu)
  • The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification). (nih.gov)
  • Conclusions: The imaging findings of SHC were consistent with the pathological features, which was helpful to deep understanding of specific imaging manifeatations, and the diagnosis and differential diagnosis of liver tumors. (cttacn.org.cn)
  • Molecular diagnosis using RT-PCR technique can detect tumor marker-expressing cells undetectable by other means in patients with localized or metastatic cancer, and may offer the most effective solution for detecting micrometastases at the molecular level in various types of cancer patients [ 16 ]. (biomedcentral.com)
  • We discuss the preoperative radiological diagnosis, origin, and treatment of this tumor. (surgicalneurologyint.com)
  • 2010) 2 (3), 325-340 MRI of bone tumors: advances in diagnosis and treatment assessment REVIEW MRI is a unique imaging technique that allows direct visualization of bone marrow with high spatial resolution and is considered the best tool for local staging of bone tumors. (pdfslide.us)
  • Lastly, he discussed application of a novel peptide-HLA-based T cell screening technology in site-directed biopsy samples to identify tumor-wide neoantigens and TCRs in a genetically heterogenous IDH mutant glioma human sample at diagnosis and recurrence (in collaboration with PACT Pharma, Inc). Together these studies exemplified the application of novel Omics approaches to understand T cell responses in gliomas. (wfnos.org)
  • This tumor is locally aggressive, but rarely metastatic, and occurs in the extremity in 70% of patients. (medscape.com)
  • Nadas and Ellison reported the prevalence of pediatric cardiac tumors (primary and metastatic) to be 0.027% in 11,000 pediatric autopsies. (sts.org)
  • Background Circulating tumor cells (CTCs) could be discovered in approximately 25% of non-metastatic breasts cancer patients (BC), and data are rising relating to their prognostic significance. (woofahs.com)
  • Complete tumor resection is only seen in about 30% of cases. (wikipedia.org)
  • The current treatment paradigm for children with high-risk neuroblastoma is intensive multi-agent induction chemotherapy followed by surgical resection of the primary tumor, high-dose chemotherapy followed by autologous stem cell transplant (ASCT), radiation therapy, and immunotherapy. (chop.edu)
  • He then underwent a right parietal craniotomy with maximal safe resection of the tumor. (hindawi.com)
  • Subsequently, the patient was transferred to an outlying institution for additional management where he underwent reopening craniotomy with microsurgical resection of the tumor with Gliadel wafer placement approximately 17 weeks from his initial resection. (hindawi.com)
  • Although resection can be achieved with low morbidity, the incidence of recurrence is highest among all tumors. (sts.org)
  • Five months before, he underwent surgical resection of an intracranial tumor at a private institution. (pediatricneurosciences.com)
  • Conclusions A number of CTCs discovered ahead of resection of the primary breast tumor expected worse relapse-free and overall survival, Sh3pxd2a irrespective of main tumor size, grade, or lymph node positivity. (woofahs.com)
  • 1. Peripheral T-cell lymphoma: aggressive disease with heterogeneous immunotypes. (nih.gov)
  • Overview of Lymphoma Lymphomas are a heterogeneous group of tumors arising in the reticuloendothelial and lymphatic systems. (msdmanuals.com)
  • Zaleskis G, Garberytė S, Pavliukevičienė B, Valinčius G, Characiejus D, Mauricas M, Kraśko JA, Žilionytė K, Žvirblė M, Pašukonienė V. Doxorubicin uptake in ascitic lymphoma model: resistance or curability is governed by tumor cell density and prolonged drug retention. (jcancer.org)
  • The study was performed on ascitic EL4 lymphoma in an exponential growth phase focusing on the rapidly changing tumor susceptibility to the Dox treatment. (jcancer.org)
  • DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular goiter, adenomas, and/or thyroid cancer), ovarian tumors (Sertoli-Leydig cell tumor, gynandroblastoma, and sarcoma), and cystic nephroma. (nih.gov)
  • There are more than 50 subtypes of STS, including leiomyosarcoma, undifferentiated pleomorphic sarcoma, synovial sarcoma, liposarcomas, and malignant peripheral nerve sheath tumors [ 5 ]. (hindawi.com)
  • Childhood Neurogenic Sarcoma A malignant peripheral nerve sheath tumor occurring in children. (nih.gov)
  • Primary synovial sarcoma arising in the anterior abdominal wall is rare and is a rare extra-articular tumor site. (thieme-connect.com)
  • Synovial sarcoma is a rare malignant mesenchymal tumor. (thieme-connect.com)
  • These studies suggest that MEK inhibitors should be further explored as potential sarcoma therapies in patients with tumors containing NF1 deletion. (duke.edu)
  • My mother had a 7lb sarcoma tumor taken out of her intensinal area on April 1, 2018 and it burst in her system. (cancer.org)
  • Neurofibromatosis (NF) is a neurocutaneous syndrome characterized by the development of tumors of the central or peripheral nervous system including the brain, spinal cord, organs, skin, and bones. (mdpi.com)
  • The sudden multifocal development of tumors of apparent mycosis fungoides may rarely occur without preceding patches or plaques. (medscape.com)
  • Peripheral nerve sheath tumors are hallmark findings in neurofibromatosis types 1 and 2. (nih.gov)
  • With increasing size, they typically lead to neurological symptoms, and NF1 patients have a lifetime risk of 8-13% for developing malignant peripheral nerve sheath tumors. (nih.gov)
  • In this proposal, we are introducing our data in detection of CSCs in malignant peripheral nerve sheath tumors (MPNSTs) for the first time, and explain our plans for targeting these cells with a novel oncolytic virus developed in our lab. (dtic.mil)
  • MPNST (malignant peripheral nerve sheath tumors) are highly aggressive soft tissue sarcomas of Schwann cell (SC) origin, representing a major cause of mortality in neurofibromatosis (NF) patients, which affects 1 in 3500 individuals worldwide. (curesarcoma.org)
  • The mice develop either high-grade myogenic sarcomas or malignant peripheral nerve sheath tumor (MPNST)-like tumors, respectively. (duke.edu)
  • Furthermore, with increasing numbers of cutaneous neurofibromas, the odds ratio of malignant peripheral nerve sheath tumor increased. (jci.org)
  • Seddon defined 3 grades of nerve injury neurapraxia, axonotmesis, and neurotmesis based on the extent of injury to the three structural components of the peripheral nerve. (scirp.org)
  • However, many pediatric tumors differ from their adult counterparts in terms of clinical behaviors and outcomes. (medscape.com)
  • Development of lymph nodes that are histologically positive for tumor (stage IVA) and/or visceral lesions (stage IVB) may occur rather rapidly after tumor-stage disease develops and/or clinical lymphadenopathy is detected. (medscape.com)
  • Here we investigated the effects of combined Prostate GVAX/ipilimumab immunotherapy on myeloid subsets in peripheral blood of castration-resistant prostate cancer (CRPC) patients as well as the putative predictive value of baseline and on-treatment myeloid parameters on clinical outcome. (bmj.com)
  • Frequencies and activation status of peripheral blood DC (PBDC) and MDSC were determined before, during and after treatment by flowcytometric analysis and related to clinical benefit. (bmj.com)
  • Additionally, expression of LunX mRNA in the peripheral blood of NSCLC patients decreased shortly after clinical treatment (P = 0.005). (biomedcentral.com)
  • The purpose of this study was to evaluate the known molecular markers, LunX, CK19, CEA, VEGF-C and hnRNP A2/B1 , for their expression in lung cancer cells in peripheral blood and pleural fluid using real-time RT-PCR, with the ultimate goal of establishing a more reliable molecular diagnostic method as an adjunct to clinical decision-making. (biomedcentral.com)
  • Surface engineering for efficient capture of circulating tumor cells in renal cell carcinoma: From nanoscale analysis to clinical application. (aprofarm.org)
  • Although all individuals with NF1 harbor genetic alterations in the same gene, the clinical manifestations of NF1 are extremely heterogeneous even among individuals who carry identical genetic defects. (jci.org)
  • Considering the significant clinical history and imaging appearance, recurrence of the primary tumor was considered. (pediatricneurosciences.com)
  • Dr. Heimberger emphasized the need for distribution of effector immune cells uniformly within the tumor by highlighting localization of CMV T cells mainly within the perivascular space in a clinical trial of adoptive transfer of CMV-specific T cells in glioblastoma [6]. (wfnos.org)
  • The purpose of this study was to count the number of lymphatic channels present in colorectal adenocarcinoma and correlate it with site, size, and stage of tumor, lymph node metastasis. (ijpmonline.org)
  • The genes affected include both oncogenes and tumor-suppressor genes and genes that accelerate cell proliferation and metastasis. (nih.gov)
  • She described the varying immune cell composition of glioblastoma and brain metastasis within a surgical wedge of tissue divided into the infiltrating edge, the tumor, and the necrotic core using multiplex immunohistochemistry. (wfnos.org)
  • Metastasis is definitely a complex, multi-step process orchestrated by a subpopulation of cells within a heterogeneous tumor that acquire the ability to disseminate from the primary tumor and enter the bloodstream and/or lymph nodes. (woofahs.com)
  • Currently, lymph node metastasis is considered to become the most powerful prognostic predictor for breast tumor, and forms the basis of the current pN category of the American Joint Percentage on Malignancy (AJCC) Tumor Node Metastasis (TNM) staging system. (woofahs.com)
  • Pathological features polygonal and fusiform tumor cells with extensive necrosis and hemorrhage were found on HE staining. (cttacn.org.cn)
  • These cells were functionally heterogeneous, produced barrier-protective cytokines, and stimulated intestinal stromal and epithelial cells via interleukin 17A, interferon gamma, and tumor necrosis factor. (ox.ac.uk)
  • The pro-inflammatory cytokine tumor necrosis factor (TNF) plays a central role in the pathogenesis of RA, and TNF inhibitors effectively repress inflammatory activity in RA. (uib.no)
  • Heterogeneity of tumor-associated antigen expression alone cannot explain this maldistribution of MAbs in tumors. (aacrjournals.org)
  • Cancer stem cells (CSCs) are small subpopulations of cancer cells harboring the self-renewal ability to drive tumor growth and cause tumor heterogeneity [ 6 ]. (nature.com)
  • MPNST are heterogeneous tumors with a distinct microenvironment that contributes to the establishment of a tumor niche. (curesarcoma.org)
  • Taken together, our results use a primary tumor model to show that sarcomas can be generated by loss of NF1 and Ink4a/Arf, and that these tumors are sensitive to MEK inhibition by direct effects on tumor cells and the surrounding microenvironment. (duke.edu)
  • The imaging evaluation of oncology patients requires accurate depiction and characterization of all hepatic and extrahepatic tumors. (cancernetwork.com)
  • Extrahepatic tumors may cause an extrinsic impression, with indentation or infiltration of the stomach or duodenum on an upper gastrointestinal barium series. (medscape.com)
  • Extrahepatic tumors are divided into proximal, middle, and distal ductal tumors. (medscape.com)
  • Soft tissue sarcomas are a rare entity of very heterogeneous tumors, both epidemiological, histological and molecular. (curesarcoma.org)
  • MM is a genetically heterogeneous cancer of plasma cells characterized by multiple focal lesions in the bone marrow (BM). (muni.cz)
  • This article presents an overview of the state-of-the-art of MRI in staging bone lesions, discusses the role that this technique plays in tumor characterization and provides a quick look at future technological advancements. (pdfslide.us)
  • Juxtaglomerular cell tumors and glomus tumors both arise from perivascular mesenchymal cells. (bvsalud.org)
  • It is a rare malignant mesenchymal tumor. (thieme-connect.com)
  • The efficacy of CAR-T cells bearing a multispecific DARPin CAR for treating tumors with heterogeneous antigen expression was evaluated in vivo . (aacrjournals.org)
  • The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. (frontiersin.org)
  • Cancer immunotherapy harnesses a patient's CD4+ and CD8+ T cell responses toward peptide neoantigens, which are displayed on the surface of tumor cells by major histocompatibility complex molecules [MHC, termed human leukocyte antigen (HLA) in humans] ( 1 ). (frontiersin.org)
  • For a specific tumor type, amplification of any one proto-oncogene may occur at a low frequency, but the frequency of tumors in which at least one proto-oncogene is amplified can be much higher. (nih.gov)
  • This assay is capable of monitoring specific tumor clonotypes. (clonoseq.com)
  • Magnetic resonance images display a much wider range of soft-tissue contrast, making tumor masses easier to distinguish from adjacent soft tissues (Figure 1). (cancernetwork.com)
  • A) Contrast-enhanced T1-weighted magnetic resonance imaging of the brain showing a cerebral tumor-like chagoma in the axial. (cdc.gov)
  • In contrast, glomus tumors have been described at numerous anatomic sites and may show significant morphologic and immunophenotypic overlap with juxtaglomerular tumors when occurring in the kidney. (bvsalud.org)
  • Contrast-enhanced MRI of the spine was also done in keeping with the high predilection of these tumors for cerebrospinal fluid (CSF) and leptomeningeal spread. (pediatricneurosciences.com)
  • Owing to its high natural contrast resolution, it can depict specific tissue components useful for tumor characterization. (pdfslide.us)
  • Several tumors can occur in the area of the pineal gland, with the most aggressive being pineoblastoma. (wikipedia.org)
  • The majority of tumors occur in individuals younger than age 40 years. (nih.gov)
  • Introduction: The autosomal dominant multiple endocrine neoplasia type 1 (MEN1), characterized by parathyroid hyperplasia (PH), neuroendocrine digestive tumours (NET) and pituitary adenomas (PA), is due to mutations in the tumor suppressor gene MEN1 encoding a 610-amino acid protein, menin. (endocrine-abstracts.org)
  • Recently, mutations in the neurofibromin 1 (NF1) tumor suppressor gene were identified in multiple subtypes of human soft-tissue sarcomas. (duke.edu)
  • About half of these tumors are rhabdomyosarcomas , and nonrhabdomyosarcoma soft tissue sarcomas (NRSTSs) account for the remainder (ie, about 4% of childhood malignancies). (medscape.com)
  • 7. Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. (nih.gov)
  • Cardiac magnetic resonance imaging provides further characterization of cardiac masses and tumors for diagnostic purposes. (sts.org)
  • The higher fetal prevalence as compared to the pediatric autopsy studies highlight probable in-utero demise or the natural post-natal regression that occurs with certain primary cardiac tumor subtypes. (sts.org)
  • Indeed, NY-ESO-1-targeting vaccines and adoptive cellular therapy (ACT) can induce regression of these tumors, but these responses are rarely durable. (curesarcoma.org)
  • The monospecific anti-EGFR E01 DARPin conferred potent tumor regression against EGFR + targets that was comparable with an anti-EGFR scFv CAR. (aacrjournals.org)
  • Due to the potential of tumor regression, most patients with rhabdomyoma undergo conservative management. (sts.org)
  • Linear regression was performed to determine correlations between variables and peripheral blood markers. (e-roj.org)
  • DICER1 germline mutations cause a tumor predisposition syndrome, and should be considered in patients with pineoblastoma. (wikipedia.org)
  • Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancers. (nih.gov)
  • We propose that in addition to the heterogeneous blood perfusion, hindered diffusion in the interstititum, and extravascular binding of MAbs, elevated interstitial pressure is responsible for the poor penetration of MAbs into tumors. (aacrjournals.org)
  • The key result of these models is that the filtration of fluid from blood vessels in a uniformly perfused tumor is ( a ) spatially heterogeneous, ( b ) a result of elevated interstitial pressure, and ( c ) sufficient to explain the heterogeneous distribution of macromolecules in tumors. (aacrjournals.org)
  • Primary sites of disease include peripheral blood, bone marrow. (msdmanuals.com)
  • results of peripheral blood smear examination were negative for circulating trypomastigotes. (cdc.gov)
  • Of several commonly used genetic markers, LunX mRNA is the most specific gene marker for lung cancer and has potential diagnostic utility when measured in the peripheral blood and pleural fluid of NSCLC patients. (biomedcentral.com)
  • Delicate detection of circulating tumor cells (CTCs) from sufferers' peripheral blood facilitates on-demand monitoring of tumor development. (aprofarm.org)
  • Microbiota-reactive CD4+ T cells were mainly of a memory phenotype, present in peripheral blood mononuclear cells and intestinal tissue, and had a diverse T-cell receptor Vβ repertoire. (ox.ac.uk)
  • CONCLUSIONS: In an analysis of peripheral blood mononuclear cells and intestinal tissues from patients with inflammatory bowel diseases vs controls, we found that reactivity to intestinal bacteria is a normal property of the human CD4+ T-cell repertoire, and does not necessarily indicate disrupted interactions between immune cells and the commensal microbiota. (ox.ac.uk)
  • In our study, patient-specific, clonotypic rearrangement of immunoglobulin heavy chain (IgH) gene, identified in bone marrow samples, was used for qPCR analysis of cfDNA samples from peripheral blood. (muni.cz)
  • Tumors can arise from the endocardium, myocardium, blood vessels and pericardium. (sts.org)
  • Median pre- and post-SBRT peripheral blood markers were compared with the Mann-Whitney U test. (e-roj.org)
  • MRD is based on measurements of tumor cells detected in peripheral blood and/or bone marrow. (clonoseq.com)
  • Outcome for patients with MRD detectable in bone marrow but not in peripheral blood (PB-/BM+) may differ according to type of therapy. (clonoseq.com)
  • We employed mass cytometry (CyTOF) with a panel of 13 phenotyping and 10 functional markers to explore signaling in unstimulated and TNF-stimulated peripheral blood mononuclear cells from 20 newly diagnosed, untreated RA patients and 20 healthy donors. (uib.no)
  • Finally, MHC tetramer staining of peripheral blood mononuclear cells from HLA-matched donors shows that the two neoepitopes are recognized by CD8+ T cells. (frontiersin.org)
  • Next, he highlighted findings describing the effective use of single-cell RNA sequencing, including T cell receptor (TCR) clonotype sequencing, to track vaccine-reactive T cells in the peripheral blood and tumor specimen in the poly-ICLC-associated tumor lysate vaccine trial in low grade glioma (NCT02549833, data not published). (wfnos.org)
  • Circulating tumor cells (CTCs) are rare cells (1CTC/106 hematopoietic cells)(5) within the peripheral blood that usually remain undetected by high-resolution imaging systems. (woofahs.com)
  • Diagnosc & Intervenonal Radiology, University of Pisa, Via Paradisa, 2 56100 Pisa, Italy Tel.: +39 050 995 551 Fax: +39 050 573 905 [email protected] The evaluation of bone tumors often requires more than one imaging modality, including radio- graphy, bone scintigraphy, CT, MRI and PET. (pdfslide.us)
  • Finally, abdomi- nal and chest CT remains the fundamental tool in the staging of patients with bone tumors. (pdfslide.us)
  • Owing to its exquisite evaluation of bone mar- row, MRI is considered the best tool for local staging of bone tumors, providing an accu- rate depiction of bone marrow and soft tissue involvement. (pdfslide.us)
  • This tumor combination is more aggressive than an isolated pineoblastoma. (wikipedia.org)
  • Primary central nervous system atypical teratoid/rhabdoid tumor (AT/RT) is a highly aggressive, malignant tumor, which occurs in infancy and early childhood. (pediatricneurosciences.com)
  • Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a rare, aggressive, malignant tumor of childhood. (pediatricneurosciences.com)
  • The goal of this study was to provide a detailed evaluation of lung cancer tumor markers indicative of molecular abnormalities and to assess their diagnostic utility in non-small cell lung cancer (NSCLC) patients. (biomedcentral.com)
  • A demonstration of the diagnostic utility of these various tumor markers requires a detailed, direct comparison using reliable, sensitive methodologies. (biomedcentral.com)
  • His neurologic symptoms persisted, and he was hospitalized after cranial computed tomography (CT) showed a 6-cm, heterogeneous, centrally necrotic mass in the corpus callosum. (cdc.gov)
  • An ultrasound followed by computed tomography and magnetic resonance imaging of the abdomen were performed for knowing the extent of the tumor. (thieme-connect.com)
  • Magnetic resonance imaging showed that the tumor was mainly located in the clivus, and a computed tomography (CT) scan revealed an osteolytic lesion with expansion of the clivus and preservation of the bony cortex. (surgicalneurologyint.com)
  • All of these features combine to produce a versatile imaging examination with exquisite sensitivity for depicting abdominal and pelvic tumors. (cancernetwork.com)
  • The extent to which we are able to distinguish tumor from normal abdominal soft tissues is central to our ability to accurately depict the dimensions of a tumor. (cancernetwork.com)
  • CT image of the abdominal mass shows a right lower rectus muscle heterogeneous collection: axial a and coronal b views. (yqtltx.com)
  • Diffusion restriction was identified mostly within peripheral portions of the lesion. (cdc.gov)
  • On MRI, a sizeable lobulated well-defined expansile lesion was seen with diffuse heterogeneous mixed signal intensity and well-defined hypo-intense capsule in T1WI axial and coronal images (figure 2a,2b).Eccentrically placed distal femur with hypo-intense trabeculation seen extending into the lesion on axial images. (eurorad.org)
  • T2* GRE axial image (fig 4) shows widespread areas of GRE blooming within the lesion and into the peripheral rim. (eurorad.org)
  • The lesion is heterogeneous in appearance with areas of internal low signal intensity. (radsource.us)
  • On the corresponding STIR coronal image, the majority of the lesion suppresses similar to fat, though areas of internal and peripheral hyperintensity (arrowheads) are present. (radsource.us)
  • Although monoclonal in origin, most tumors appear to contain heterogeneous populations of cancer cells. (dtic.mil)
  • Juxtaglomerular cells are specialized renin-secreting myoendocrine cells in the afferent arterioles adjacent to glomeruli, and juxtaglomerular tumors derived from these cells are therefore unique to the kidney. (bvsalud.org)
  • We also examined the effects of MEK inhibition on the native tumor stroma and find that PD325901 decreases VEGFα expression in tumor cells with a corresponding decrease in microvessel density. (duke.edu)
  • In this study, the anti-tumor activity of CIK cells against hepatocellular carcinoma was evaluated in vitro and in vivo. (elsevierpure.com)
  • In addition, a dose of 1 × 10 6 CIK cells per mouse inhibited 60% of SNU-354 tumor growth in irradiated nude mice. (elsevierpure.com)
  • Through this process, a large and heterogeneous pool of p/MHC antigens is continuously generated in healthy, pathogen infected, or tumor cells as a means of displaying a cell's peptide repertoire to the immune system ( 4 ). (frontiersin.org)
  • One such therapy utilizes in vitro -activated, autologous CTLs to selectively target tumor cells ( 7 ). (frontiersin.org)
  • Histopathology review at our institute revealed a cellular tumor comprising sheets of tumor cells with moderate amount of dense eosinophilic cytoplasm, eccentric nuclei with vesicular chromatin and prominent nucleoli Few characteristic rhabdoid cells with intracytoplasmic eosinophilic inclusions were also identified. (pediatricneurosciences.com)
  • Based on the preoperative imaging, intraoperative and histopathological findings, the tumor was considered to be an intraosseous schwannoma in the clivus, and no recurrence was observed after 1 year of postoperative follow-up. (surgicalneurologyint.com)
  • In this study, microarray analysis was used to identify pathways and networks related to pituitary tumour physiology using key de-regulated genes and bioinformatics analysis. (endocrine-abstracts.org)
  • The accumulation of genetic damage in the forms of activated proto-oncogenes and inactivated tumor-suppressor genes is the driving force in the evolution of a normal cell to a malignant cell. (nih.gov)
  • For example, both the activation of ras oncogenes and the inactivation of several suppressor genes, including p53, have been observed in the development of human colon and lung tumors. (nih.gov)
  • Non-ras genes have been detected by DNA transfection assays in both human and rodent tumors. (nih.gov)
  • The epidemiological data on the prevalence of cardiac tumors is based on post mortem autopsy studies. (sts.org)
  • They represent up to 25% of all soft tissue sarcomas (STS) and are the most common form of STS in the U.S. next to gastrointestinal stromal tumors (GISTs). (curesarcoma.org)
  • Soft-tissue sarcomas are a heterogeneous group of tumors arising from connective tissue. (duke.edu)
  • Reference soft tissue nodule within the left upper quadrant measures up to 23 mm and demonstrates peripheral FDG activity measuring SUV max 2.6. (cancer.org)
  • Nevertheless, clinically important seize of renal cell carcinoma CTCs (RCC-CTCs) stays elusive as a result of their heterogenous floor receptor expression. (aprofarm.org)
  • CTCs weren't connected with tumor size, quality, or lymph node position (P= NS). (woofahs.com)
  • Cholangiocarcinoma is a slow-growing malignancy of the bile duct and is the second most common primary hepatic tumor after hepatoma. (medscape.com)
  • Solitary well-demarcated tumors are difficult to differentiate from primary hepatocellular carcinomas (HCCs). (medscape.com)
  • The peripheral lymphatic system originates from the primary lymph sacs, then spreads by endothelial sprouting into the surrounding tissues and organs, where local capillaries are formed. (slideshare.net)
  • Until now, surgical management of primary tumors remains the gold standard of localized RCC treatment. (nature.com)
  • 1) However, even lower grade, lymph node bad individuals have relapse rates of 20% over 10 years, and the relapse rate raises to 30% for node bad individuals with high grade tumors. (woofahs.com)
  • Activation of proto-oncogenes by chromosomal translocation has been detected at a high frequency in several hematopoietic tumors. (nih.gov)
  • Despite the high vascular permeability and interstitial transport coefficients in tumor tissue compared to several normal tissues, MAbs and their fragments do not distribute homogeneously in a tumor. (aacrjournals.org)
  • Well distinguishable tumor response patterns (curability, remission-relapse, resistance) were selected to unveil Dox intratumoral uptake and drug tissue persistence. (jcancer.org)
  • Congenital cardiac tumor is defined as a congenital malformation consisting of growth of abnormal tissue within the heart. (sts.org)
  • These tumors reflect the histologic properties and spectrum of sarcomas found in patients. (duke.edu)
  • Patients with cardiac tumors can be asymptomatic or may present with arrhythmia, heart failure, or sudden death. (sts.org)
  • Compared with the other techniques, endoscopic retrograde cholangiopancreatography (ERCP) is a more definitive investigation that can depict the periampullary tumor. (medscape.com)
  • SHC showed heterogeneous signal intensity on T1WI and T2WI with visible cystic degeneration and necrotic area while DWI displayed obvious diffusion restricted changes. (cttacn.org.cn)
  • It is a rare tumor with a posterior fossa predilection, arises in the posterior fossa in an off-midline location, and may secondarily involve bones. (pediatricneurosciences.com)
  • The NF1 gene is located on chromosome 17q11.2, which encodes for a tumor suppressor protein, neurofibromin, that functions as a negative regulator of Ras/MAPK and PI3K/mTOR signaling pathways. (mdpi.com)
  • RCC is a very heterogeneous class of tumors, which comprises different populations of tumors that originate from the highly heterogeneous epithelium of renal tubules [ 5 ]. (nature.com)
  • Several diagnostic elements factor into risk stratification, including patient age, disease stage, tumor cell ploidy, histopathology, MYCN gene copy number, and other genetic aspects of the tumor. (chop.edu)