• Venezuelan (VEEV) and eastern (EEEV) equine encephalitis viruses, encodes a unique peptide containing a classical nuclear localization signal and a supraphysiological nuclear export signal, which mediate the formation of a tetrameric complex with the nuclear export receptor CRM1 and importin-α/β ( 3 ). (asm.org)
  • The accumulation of these complexes in virus-infected cells rapidly blocks the function of nuclear pores preventing nuclear import, which ultimately leads to the inhibition of cellular transcription. (asm.org)
  • Specific exon skipping can be achieved using synthetic oligonucleotides or viral vectors encoding modified small nuclear RNAs (snRNAs), by masking important splicing sites. (ox.ac.uk)
  • Here we evaluate the self-splicing efficiency of group I introns from transcripts expressed by RNA polymerase II in human cells to directly measure ribozyme catalysis in a therapeutically relevant setting. (asm.org)
  • Herein we set out to begin to directly evaluate this important reaction parameter, which we call catalytic efficiency, for group I ribozymes inside human cells. (asm.org)
  • In addition to the gene-based classification (14) , the ability to prognosticate on the basis of gene expression data from biopsy harvests could have important therapeutic implications for this group of unfortunate patients. (aacrjournals.org)
  • Experimental approaches in which trans -splicing group I ribozymes may be evaluated for substrate specificity and RNA repair efficiency in mammalian cells have recently been described ( 15 , 16 ). (asm.org)
  • Subsequent studies performed by other groups on the basis of our findings showed in animal and cellular models that alterations in hnRNPs do indeed interfere in the neuron myelination process and may impair cerebral connectivity," said Martins-de-Souza. (medicalxpress.com)
  • We investigated the expression of high-mobility group box 2 (HMGB2) in patients with hepatocellular carcinoma (HCC) and its clinical effects with underlying mechanisms. (aacrjournals.org)
  • The current study showed for the first time through large-scale real-time reverse transcription-PCR and immunohistochemistry that high-mobility group box 2 (HMGB2) expression is significantly associated with prognosis of HCC patients. (aacrjournals.org)
  • Using both dChip and SAM, neural networks constructed a common 27 gene classifier, which was associated with either the high-risk and low-risk group of patients. (aacrjournals.org)
  • Our hypothesis is that gene arrays performed on operative specimens from uniformly treated mesothelioma patients could predict survival and time to progression, and could cluster groups of patients as good or poor risk. (aacrjournals.org)
  • All of the patients had cytoreductive surgery, mediastinal lymph node dissection with staging by the International Mesothelioma Interest Group staging system (15) , followed by postoperative cisplatinum-based chemotherapy. (aacrjournals.org)