Heterogeneity are poorly understood. Medical search. Frequent questions

CD14+ monocytes from IBD patients had significantly decreased cleaved H3T22, suggesting they were epigenetically primed for macrophage differentiation.We describe the first systems-level quantification of histone modifications across immune cells from IBD patients at a single-cell resolution revealing the increased epigenetic heterogeneity that is not possible with traditional ChIP-seq profiling. (stanford.edu)
So far there are only few data on the epigenetic heterogeneity of sperm within a given sample and how to select the best sperm for successful infertility treatment. (uni-wuerzburg.de)

Hot spots of DS and MDR TB incidence were observed in the central parts of Ho Chi Minh City, and substantial heterogeneity was observed across wards. (cdc.gov)
We used epigenetic profiling by time-of-flight (EpiTOF) to investigate changes in histone modifications within peripheral blood mononuclear cells from IBD patients.We discovered substantial heterogeneity in histone modifications across multiple immune cell types in IBD patients. (stanford.edu)

While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly understood. (nature.com)
The molecular mechanisms that drive heterogeneity of disease outcomes remain poorly understood. (hhs.gov)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
Dr. Gubatan's research is focused on translational studies using single-cell genomics to understand mechanisms of biologic therapy failure, elucidate the role of host immune and gut microbiome interactions in the pathogenesis of inflammatory bowel disease (IBD), and develop precision medicine strategies to improve outcomes in patients with IBD. (stanford.edu)
The mechanisms producing those patterns are still poorly understood and the knowledge of long-term fluctuations in regeneration processes is very limited. (afs-journal.org)
However, the full promise of regenerative medicine has been difficult to achieve so far, partly due to our incomplete understanding of the genetic and epigenetic mechanisms regulating differentiation of stem cells to specific lineages and tissues. (confex.com)
Further, while cell-to-cell heterogeneity in gene expression has been shown to drive dramatic phenotypic variations, the upstream epigenetic mechanisms regulating this heterogeneity remain largely unknown 8 . (confex.com)
The molecular mechanisms that contribute to disease heterogeneity remain poorly understood. (lu.se)
The mechanisms by which epidermal damage and cell death contribute to hyperkeratosis and erythematous areas are poorly understood. (medlineplus.gov)
Understanding of the molecular and ionic mechanisms underlying cardiac conduction is essential for the appreciation of the pathogenesis of conduction abnormalities in structurally normal and altered hearts. (medscape.com)

Our research focuses on developing machine learning frameworks for: (1) Modeling spatial transcriptome data to understand the interplay of intrinsic and spatial factors that contribute to cell identity. (cmu.edu)
The natural regeneration of shade-tolerant tree species is characterized by large spatial heterogeneity and temporal variability. (afs-journal.org)
As cities of the developing world continue to grow at unprecedented rates, it becomes increasingly important to better understand the role of spatial heterogeneity and the related spatial scales at which to aggregate the system to consider the influence of socio-economic and environmental factors, including climate variables. (confex.com)

Pancreatic tumors span the spectrum of T cell infiltration, but the basis for this heterogeneity is poorly understood. (technologynetworks.com)
To understand the molecular basis of this phenomenon, the team searched for factors released by cold tumors that could attract myeloid cells. (technologynetworks.com)
Despite extensive study of the TME in PDAC, the cellular and molecular signaling networks remain poorly understood, largely due to the tremendous heterogeneity across tumors. (stanford.edu)

The problem lies within the tumor itself, with cells that often have individual genetic characteristics, known as intratumor heterogeneity. (medicalxpress.com)
Previous single cell DNA sequencing methods have emerged as powerful tools for understanding intratumor heterogeneity, but they delete information about individual tumor cells' precise location within the tissue. (medicalxpress.com)
In a new study published this week in Immunity , researchers probe the role of "tumor heterogeneity," a cancer cells' ability to move, replicate, metastasize, and respond to treatment. (technologynetworks.com)
In the future, these tumor cell lines could help to further identify and optimize therapies for specific subsets of patients with various states of tumor heterogeneity. (technologynetworks.com)
While earlier work characterized PDAC as an immunologically privileged tumor poorly recognized by the immune system, recent studies revealed the important and nuanced roles of immune cells in the pathogenesis of PDAC. (stanford.edu)

We have employed whole genome sequencing, RNA sequencing, and functional assays in a large cohort of primary patient samples to understand the genetic basis of CTCLs. (hhs.gov)
Interphase chromosomes in higher eukaryotic cells are organized in a complex 3D structure in the nucleus, but the principles behind this organization and its functional impacts are not well understood. (cmu.edu)
The mammalian glycome contains extensive structural and functional heterogeneity that can vary temporally and spatially during development and in different tissues. (uga.edu)
Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity. (nih.gov)
Our combined experience and novel datasets mean that we will develop a detailed understanding of the functional alterations in the monocyte/macrophage-lineage and the impacts these have on susceptibility to infection and treatment failure. (europa.eu)
Type 1 diabetes results from the poorly understood process of islet autoimmunity, which ultimately leads to the loss of functional pancreatic beta cells. (springer.com)
We advance the hypothesis that antigen presentation by beta cells, their stress responses and functional heterogeneity are critical factors that will provide clues towards solving the enigma posed by islet autoimmunity in type 1 diabetes. (springer.com)

This conundrum brings to question whether cancer ST6GAL1 overexpression is beneficial or ultimately detrimental to long-term patient outcomes and highlights the incomplete mechanistic understanding of how ST6GAL1 is involved in cancer progression. (nature.com)
Molecular or genetic factors contribute to disease heterogeneity, but the reasons for different outcomes are poorly understood. (ox.ac.uk)

The pathogenesis of IS is still poorly understood. (scielo.br)
This fellowship will broaden our understanding of CTCL pathogenesis and T cell exhaustion, identify potential novel therapeutic strategies, and provide the necessary foundation for my future career as a research scientist. (hhs.gov)
Osteopontin is a multifunctional phosphoprotein with an important but poorly understood role in non-small cell lung cancer pathogenesis. (nih.gov)
Human brain organoids are used for understanding pathogenesis and investigating therapeutic options for neurodevelopmental, neuropsychiatric, neurodegenerative, and neurological disorders. (mdpi.com)

The intuitive BF heterogeneity methods used can be readily used in clinical studies. (frontiersin.org)
The study allows further understanding of this specific process with clinical implications. (elifesciences.org)
To tailor CRC treatment, it is essential to first model this heterogeneity by defining subtypes of patients with homogeneous biological and clinical characteristics and second match these subtypes to cell lines for which extensive pharmacological data is available, thus linking targeted therapies to patients most likely to respond to treatment. (tudelft.nl)
Hereditary spastic paraplegias (HSP) are a group of rare neurodegenerative disorders of the upper motor neurons characterized by extreme clinical and genetic heterogeneity. (hsp-info.de)
Yet, cascade testing is poorly implemented in clinical practice. (cdc.gov)

Imaging data suggests that dialysis increases myocardial blood flow (BF) heterogeneity, but its causes remain poorly understood. (frontiersin.org)
The compositions of different cells in various human tissues remain poorly understood. (cmu.edu)
Urban environments contain pronounced heterogeneity in environmental conditions, population density and wealth, whose effects on infectious disease dynamics remain poorly understood. (confex.com)
Although significant progress has been made in the last decade in the management of flash floods related risks, these events remain poorly understood and their predictability is limited by a high non-linearity in the hydrological response, related to threshold effects and structured heterogeneity at all scales. (copernicus.org)
However, the true incidence and prevalence of SBI remain controversial, and our understanding of risk factors limited. (biomedcentral.com)

To understand how the genome and epigenome regulates cellular function, development of high-throughput sequencing methods, known as next-generation sequencing, are beginning to unravel genome-wide correlations between the genome, epigenome and transcriptome within a large population of cells or tissues. (confex.com)
To overcome this limitation, recent advances in molecular biology have enabled genome-wide single-cell measurements of the transcriptome, genome or certain epigenetic marks that capture this cell-to-cell heterogeneity. (confex.com)

heterogeneity, where hydraulic property of 3D fracture network with heterogeneous aperture distribution remains poorly understood. (onepetro.org)
Background Colorectal cancer (CRC) is a heterogeneous and biologically poorly understood disease. (tudelft.nl)
Notwithstanding this achievement, we are still far from a nuanced understanding of how islet autoimmunity originates and propagates during the development of type 1 diabetes and why it is so heterogeneous among individuals. (springer.com)

Such rare events, such as fork stall or collapse, are highly biologically significant, but we understand little of where and when they may occur across a genome. (mskcc.org)

Indeed, the heterogeneity of response of healthy tissue to ionizing radiation is poorly understood. (medscape.com)
Exactly how DCIS invasion occurs genomically remains poorly understood due to several technical challenges in tissue analysis. (medicalxpress.com)
In spite of their role in peritoneal host defence and tissue homeostasis, the immunobiology of peritoneal macrophages remains poorly understood. (europa.eu)
Human organoids are small, self-organized, three-dimensional (3D) tissue cultures that have started to revolutionize medical science in terms of understanding disease, testing pharmacologically active compounds, and offering novel ways to treat disease. (mdpi.com)

The precise mechanism whereby the kidney cells and tissues malfunction after this injury remains poorly understood. (medscape.com)

We will apply an approach of simultaneous genetic search for several trait-causing loci that will allow identification of novel loci, genes and disease-causing mutations, respecting at the same time the genetic heterogeneity of HSP. (hsp-info.de)

Her research has redefined the molecular map of breast cancer and led to new paradigms in understanding the origins of human cancers, as well as how they evolve and metastasize. (stanford.edu)
The study provides new insight into how DCIS leads to invasive ductal carcinoma (IDC), and provides a clearer understanding of why some of these cancers go undetected. (medicalxpress.com)
Project: Developing novel single-cell genomics methods to quantify cell-to-cell heterogeneity in cancers and stem cells. (confex.com)

ABSTRACT Understanding the behaviour of malaria vectors is crucial for planning mosquito control programmes. (who.int)

Imaging showed that stress and therapy potentially increased mean and total BF, while reducing heterogeneity. (frontiersin.org)

Whether improvement along dimensions of depressive symptoms relates to separable neural networks remains poorly understood. (uib.no)
Two key knowledge gaps currently limit the development of more predictive and general models of pathogen transmission: (1) the physiological basis of heterogeneity in host contribution to pathogen transmission (reservoir potential) remains poorly understood, and (2) a general means of integrating the ecological dynamics of host communities has yet to emerge. (usgs.gov)
The etiology of pathological eating in anorexia nervosa (AN) remains poorly understood. (frontiersin.org)
The etiology of pathological eating in AN remains poorly understood, though recent research has implicated neural substrates underlying altered reward processing ( 3 - 5 ), cognitive control ( 6 - 8 ), and interoception ( 9 , 10 ). (frontiersin.org)
Understanding of Post-COVID Conditions remains incomplete. (cdc.gov)

Many challenges in the world today - disease dynamics, collective and artificial intelligence, belief propagation, financial risk, national security, and ecological sustainability - exceed traditional academic disciplinary boundaries and demand a rigorous understanding of complexity. (santafe.edu)
Current understanding of histone post-translational modifications (histone modifications) across immune cell types in patients with inflammatory bowel disease (IBD) during remission and flare is limited. (stanford.edu)
The aetiology of the most common forms of Parkinson's Disease (PD), whether sporadic or familial, is poorly understood. (biomedcentral.com)
The HSP disease is currently untreatable and poorly understood, warranting research on its etiology and potential targets for intervention. (hsp-info.de)
Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies. (ox.ac.uk)

Understanding this question is complicated by the diversity of chromatin structure and the heterogeneity of replication reactions. (mskcc.org)
MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. (nature.com)
Our first goal is to use the mouse brain as a model to really understand the diversity of cells in the brain and how they're regulated," says Salk Professor and Howard Hughes Medical Institute Investigator Joseph Ecker, co-director of the BICCN. (neurosciencenews.com)
We analysed the dependency of habitat specialist diversity to climate, topographic heterogeneity and geographical distance to potential refugia. (muni.cz)

From an engineering perspective, gene expression regulation can be viewed as the output of a network of complex chemical and physical processes, and understanding how these processes interact and integrate to govern cellular phenotypes has been a major focus of my graduate and postdoctoral research. (confex.com)
Our broad experience of mouse models has highlighted extensive macrophage heterogeneity and has established a broad gene expression database. (europa.eu)

However, regulation of the assembly of these ubiquitous, non-template driven post-translational modifications is currently poorly understood. (uga.edu)

Understanding how case symptoms and characteristics contribute to norovirus transmission can lead to more informed outbreak control measures in LTCFs. (cdc.gov)

Understanding what differentiates brain cells can lead to new research and potential therapies for brain disorders. (neurosciencenews.com)
The NIH Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is "a large-scale effort that seeks to deepen understanding of the inner workings of the human mind and to improve how we treat, prevent and cure disorders of the brain. (neurosciencenews.com)
Thus, my research interests are to develop novel single-cell genomics methods to better understand how changes in the epigenetic landscape during normal development regulates cellular differentiation, information that is critical towards realizing the full potential of regenerative medicine. (confex.com)
His current research interests include drug discovery and using genomic tools to understand the regulation of glycosylation in human diseases. (uga.edu)
Undoubtedly, sustained efforts by the global type 1 diabetes research community to understand the basis of T cell-driven autoimmunity in type 1 diabetes have paid dividends. (springer.com)

Ph.D. Dissertation: A computational and experimental approach to understanding HIV-1 evolution and latency for the design of improved antiviral therapies. (confex.com)
We use large-scale sequencing and array-based analyses of bulk and single cells as well as experimental systems to understand whether aneuploidy is always associated with chromosomal instability (CIN) and to delineate the pathways by which aneuploidy arise. (lu.se)

e.g. inflammation, genotoxicity, and This chapter focuses on issues as- ellers, growth factors, growth factor epigenetic alterations) and can have sociated with the understanding and receptors, signal transducers, and both genetic and epigenetic origins. (who.int)

Depression symptom heterogeneity limits the identifiability of treatment-response biomarkers. (uib.no)

Although poorly understood, the drivers of geographic heterogeneity in TB are believed to reflect the complex interplay between the infectious and susceptible host, the infecting organism, the physical environment, and distal determinants such as poverty ( 13 ). (cdc.gov)

The molecular basis of male infertility is poorly understood, the majority of cases remaining unsolved. (uni-wuerzburg.de)

In summary, we deciphered the cellular heterogeneity and the molecular dynamics during fibrocartilage differentiation. (elifesciences.org)

BF heterogeneity was differentially affected by large or small vessel blocking. (frontiersin.org)

The nuances of this heterogeneity are difficult to understand, as prior studies typically utilise a single data source, often crash reports or hospital discharge records, to investigate a single crash- or injury-related outcome. (bmj.com)

[ 3 ] Nodal cells have less well-organized actin and myosin filaments and a poorly developed sarcoplasmic reticulum. (medscape.com)

This study aimed to characterize trends and investigate the heterogeneity of MVC-related disparities in North Carolina across several data sources. (bmj.com)

2) Integrating multimodal single-cell assays to uncover cellular heterogeneity. (cmu.edu)

Moura-Castro LH, Peña-Martínes P, Castor A, Galeev R, Larsson J, Järås M, Yang M, Paulsson K. Sister chromatid cohesion defects are associated with chromosomal copy number heterogeneity in high hyperdiploid childhood acute lymphoblastic leukemia. (lu.se)

Ultimately, human biology must be understood in the context of evolution. (cmu.edu)

Although the discussion is wide ranging and concerned primarily with topics distant from those usually discussed by the Department of the Navy and DOD modeling communities, understanding how those topics relate to one another is essential for appreciating both the potential and the enormous intellectual challenges associated with advanced modeling and simulation in the decades ahead. (nationalacademies.org)

Steady state simulations were performed to investigate the effects of altered aortic pressure and blood vessel diameters on myocardial BF heterogeneity. (frontiersin.org)
Finally, the effects of augmented aortic pressure in the presence of blood vessel blocking shows differential effects on BF heterogeneity as well as transmural BF. (frontiersin.org)

The authors provided convincing evidence for the heterogeneity of postnatal enthesis growth and the molecular dynamics and signaling networks during enthesis formation. (elifesciences.org)

This mathematical modeling study explores some of the coronary vasculature based causes of myocardial blood flow (BF) heterogeneity. (frontiersin.org)
This study aimed to describe the current interaction between osteopaths and people with DCM and understand how this may be targeted to enhance the DCM diagnostic pathway. (jmir.org)
The houses are poorly area at the Sudan-Egypt border, the In the present study, we used poly- constructed and the use of bednets is whole population is considered to be merase chain reaction (PCR) for the not common. (who.int)

A biophysical model of human coronary vasculature was used to explain the imaging observations, and highlight causes of coronary BF heterogeneity. (frontiersin.org)

Therefore, understanding the complex process of the enthesis morphogenesis and maturation during development may inform strategies for enhanced BTJ healing. (elifesciences.org)

have put us in the interesting position of being limited less by our inability to sense and actuate, to compute and communicate, and to fabricate and manufacture new materials, than by how well we understand, design, and control their interconnection and the resulting complexity. (nationalacademies.org)

The total transmural BF as well as transmural BF heterogeneity reduced due to large artery stenosis, generating large patches of very low BF regions downstream. (frontiersin.org)

Despite the importance of DNA replication, numerous aspects of this process are still poorly understood. (mskcc.org)

Anatomy29

Organisms6

Diseases12

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment80

Psychiatry and Psychology1

Phenomena and Processes94

Disciplines and Occupations8

Anthropology, Education, Sociology and Social Phenomena3

Information Science13

Named Groups3

Health Care42

Geographicals3

Epigenetic heterogeneity2

Substantial heterogeneity2

Mechanisms10

Spatial3

Tumors3

Tumor5

Functional7

Outcomes2

Pathogenesis4

Clinical5

Remain5

Transcriptome2

Heterogeneous3

Biologically1

Tissue4

Tissues1

Mutations1

Cancers3

Malaria1

Potentially1

Remains5

Disease5

Diversity4

Gene expression2

Post-translational1

Symptoms1

Research5

Experimental2

Genetic and epigenetic1

Limits1

Interplay1

Molecular basis1

Differentiation1

Affected by large1

Studies1

Cells1

Data1

Single-cell1

High1

Ultimately1

Potential1

Effects2

Evidence1

Study3

Model1

Complex1

Complexity1

Large1

Process1