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Integrin alpha5beta1Integrin alpha5Integrin alpha2Integrin alpha2beta1Integrinssrc-Family KinasesIntegrin alpha3beta1Integrin alpha1beta1Integrin alpha6Integrin alpha6beta4Integrin alpha3Integrin alpha ChainsIntegrin alpha6beta1Integrin alpha1Integrin alphaVbeta3Integrin beta3Integrin alpha4Cell AdhesionIntegrin beta ChainsPhosphatidylinositol 3-KinasesSignal TransductionIntegrin alpha4beta1Integrin beta4Antigens, CD29Protein-Tyrosine KinasesPhosphorylationMolecular Sequence DataIntegrin alphaVProtein BindingProtein-Serine-Threonine KinasesReceptors, VitronectinMAP Kinase Signaling SystemAmino Acid SequenceProto-Oncogene Proteins c-fynFibronectinsProtein KinasesCell LineReceptors, CollagenProtein Kinase InhibitorsCell MovementTransfectionCells, CulturedProto-Oncogene Proteins c-hckBinding SitesReceptors, FibronectinPlatelet Glycoprotein GPIIb-IIIa ComplexProto-Oncogene Proteins c-yesBase SequenceRecombinant ProteinsProtein Structure, TertiaryEnzyme ActivationTyrosineDimerizationCalcium-Calmodulin-Dependent Protein KinasesFocal Adhesion Protein-Tyrosine KinasesFocal Adhesion Kinase 1Protein Kinase CCell Line, TumorRecombinant Fusion ProteinsMutationAntigens, CDLigandsOligopeptidesTumor Cells, CulturedProto-Oncogene ProteinsKineticsp38 Mitogen-Activated Protein KinasesLamininBlotting, WesternMice, KnockoutCHO CellsMitogen-Activated Protein Kinase 1Blood PlateletsRNA, MessengerCricetinaeSequence Homology, Amino AcidCollagenCell Adhesion MoleculesInterleukin-1betaCyclic AMP-Dependent Protein KinasesGene Expression RegulationPrecipitin TestsProtein SubunitsIntracellular Signaling Peptides and ProteinsCloning, MolecularPhosphoproteinsProto-Oncogene Proteins pp60(c-src)Mice, Inbred C57BLExtracellular Signal-Regulated MAP KinasesMitogen-Activated Protein Kinase KinasesAntibodies, MonoclonalMitogen-Activated Protein KinasesPyrimidinesJNK Mitogen-Activated Protein KinasesVitronectinProtein ConformationMitogen-Activated Protein Kinase 3Models, Biologicalsrc Homology DomainsImmunoblotting
ProteinsBetaAlphaCells
Proteins1
Beta18
  • Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. (wikipedia.org)
  • These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens. (wikipedia.org)
  • Integrin beta 1 is expressed as at least four different isoforms. (wikipedia.org)
  • In cardiac muscle and skeletal muscle, the integrin beta-1D isoform is specifically expressed, and localizes to costameres, where it aids in the lateral force transmission from the Z-discs to the extracellular matrix. (wikipedia.org)
  • Abnormal levels of integrin beta-1D have been found in limb girdle muscular dystrophy and polyneuropathy. (wikipedia.org)
  • Integrin beta-1 can exist as different isoforms via alternative splicing. (wikipedia.org)
  • All integrins, alpha and beta forms, have large extracellular and short intracellular domains. (wikipedia.org)
  • The cytoplasmic domain of integrin beta-1 binds to the actin cytoskeleton. (wikipedia.org)
  • Integrin beta-1 is the most abundant beta-integrin expressed and associates with at least 10 different integrin-alpha subunits. (wikipedia.org)
  • Beta-integrins are primarily responsible for targeting integrin dimers to the appropriate subcellular locations, which in adhesive cells is mainly focal adhesions. (wikipedia.org)
  • Integrin beta-1 mutants lose the ability to target to sites of focal adhesions. (wikipedia.org)
  • Three novel isoforms of integrin beta-1 have been identified, termed beta-1B, beta-1C and beta-1D. (wikipedia.org)
  • Integrin beta-1B is transcribed when the proximal 26 amino acids of the cytoplasmic domain in exon 6 are retained and then succeeded by a 12 amino acid stretch from an adjacent intronic region. (wikipedia.org)
  • The integrin beta-1B isoform appears to act as a dominant negative in that it inhibits cell adhesion. (wikipedia.org)
  • The cytoplasmic domain of integrin beta-1D replaces the distal 21 amino acids (present in integrin beta-1A) with an alternative stretch of 24 amino acids (13 unique). (wikipedia.org)
  • Integrin beta-1D appears to be developmentally regulated during myofibrilogenesis, appearing immediately following the fusion of myoblasts in C2C12 cell with rising levels throughout myofibrillar differentiation. (wikipedia.org)
  • Integrin beta-1D is specifically localized to costameres and intercalated discs of cardiac muscle and costameres, myotendinous junctions and neuromuscular junctions of skeletal muscle, and it appears to function in general like other integrins, as the clustering of beta-1D integrins on the surface of CHO cells resulted in tyrosine phosphorylation of pp125FAK and induced mitogen-activated protein kinase activation. (wikipedia.org)
  • In patients with limb girdle muscular dystrophy, type 2C, beta-1D integrin has been shown to be severely reduced in skeletal muscle biopsies, coordinate with a reduction in alpha 7B-integrin and filamin 2. (wikipedia.org)
Alpha2
  • This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. (wikipedia.org)
  • It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. (wikipedia.org)
Cells1
  • Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. (wikipedia.org)