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Core Binding FactorsCore Binding Factor beta SubunitCore Binding Factor alpha SubunitsTranscription FactorsCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 1 SubunitDNA-Binding ProteinsTranscription, GeneticTranscription Factor AP-2Molecular Sequence DataPromoter Regions, GeneticBase SequenceBinding SitesProtein BindingGene Expression RegulationSmooth Muscle MyosinsTranscriptional ActivationNuclear ProteinsAmino Acid SequenceDNAChromosomes, Human, Pair 16Chromosome InversionLeukemia, Myeloid, AcuteCell LineCloning, MolecularOncogene Proteins, FusionRNA, MessengerEnhancer Elements, GeneticTrans-ActivatorsNeoplasm ProteinsMutationOctamer Transcription Factor-2Chromosomes, Human, Pair 21Octamer Transcription Factor-1OsteoblastsCell DifferentiationProto-Oncogene ProteinsSp1 Transcription FactorTranslocation, GeneticOsteogenesisOsteocalcinTransfectionRepressor ProteinsBasic Helix-Loop-Helix Transcription FactorsProtein Structure, TertiaryRecombinant Fusion ProteinsCells, CulturedLeukemia, MyeloidPol1 Transcription Initiation Complex ProteinsSignal TransductionCell NucleusTranscription Factor AP-1Alkaline PhosphataseHomeodomain ProteinsCore Binding Factor Alpha 3 SubunitBasic-Leucine Zipper Transcription FactorsGene Expression Regulation, DevelopmentalHeLa CellsDimerizationForkhead Transcription FactorsGenes, ReporterRegulatory Sequences, Nucleic AcidMutagenesis, Site-DirectedChromatin ImmunoprecipitationElectrophoretic Mobility Shift AssayModels, MolecularSequence Homology, Amino AcidTranscription Factors, TFIITranscription Factor TFIIDKruppel-Like Transcription FactorsReverse Transcriptase Polymerase Chain ReactionPlasmidsG-Box Binding FactorsZinc FingersBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsSTAT3 Transcription FactorYY1 Transcription FactorNF-kappa BSaccharomyces cerevisiaeSp3 Transcription FactorGene ExpressionGATA4 Transcription FactorSaccharomyces cerevisiae ProteinsGene Expression ProfilingMEF2 Transcription FactorsRecombinant ProteinsNFATC Transcription FactorsTranscription Initiation SiteActivating Transcription Factor 3Helix-Loop-Helix MotifsSigma FactorGene Expression Regulation, FungalSequence AlignmentLuciferasesChromatin
ProteinsGENESComplexesProteinSubunitReceptorModulateSpecificityHematopoiesisActivatesRegulatePromoterInteractionRUNX2GenomicFacilitatesChromatinExtrinsicPleiotropicFunctionalMediatesGene transcriptionRegulatoryRolesSuperfamilyEnzymeCellsIntrinsicInhibitorsMutationsFamilyResponseDevelopmentCellCaseLevelsActive
Proteins17
  • Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
  • TWIST1 proteins can form either homodimeric (TWIST1/TWIST1) or heterodimeric complexes, mainly in association with E2A proteins. (biomedcentral.com)
  • Our core SNAP technology assays the binding affinity and specificity of purified proteins or cell lysates on a microarray containing double-stranded, B-form DNA. (proteovista.com)
  • Discovering the DNA-binding preferences of drug targets and novel or under-studied proteins. (proteovista.com)
  • However, the order of events and the precise function of high-mobility group proteins during transcription initiation remain unclear. (nature.com)
  • Although HMG proteins do not possess intrinsic transcriptional activity, they are called architectural transcription factors because they modulate the transcription of their target genes by altering the chromatin structure at the promoter and/or enhancers 15 . (nature.com)
  • Description: RUNX (runt-related transcription factor) proteins are a family of transcription factors involved in many different biological systems, including cell differentiation and cancer. (micrornaprofile.com)
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
  • IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence. (lookformedical.com)
  • GA-binding proteins selectively bind at these positions, respectively, causing an activation of the promoter and overexpression of TERT. (oncotarget.com)
  • All GA-binding proteins progress through the glioma grades and have the highest expression levels in secondary glioblastomas. (oncotarget.com)
  • NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. (hmdb.ca)
  • Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. (ouhsc.edu)
  • In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
GENES9
  • It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression. (wakehealth.edu)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • Moreover, transcription factors and their target genes form vast interacting gene regulatory networks which can be exquisitely stable. (amegroups.org)
  • We found that the acidic domain of MZF-1 and the heparin-binding domain of Elk-1 facilitate the heterodimeric interaction between the two genes before the complex formation binds to the PKCα promoter. (oncotarget.com)
  • An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
  • We therefore suggest a new mechanism involving a cofactor that is regulated as well as recruited by one of the master genes to bind to the antagonistic partner that is necessary for bistability and hence switch-like behavior. (lu.se)
  • antimicrobial resistance (AMR) families of the resistance mechanism of antibiotic efflux pump included resistance-nodulation-cell division (RND) antibiotic efflux pump (for mtrA , soxR and golS genes), major facilitator superfamily (MFS) antibiotic efflux pump (for soxR gene), the two-component regulatory kdpDE system (for kdpE gene) and ATP-binding cassette (ABC) antibiotic efflux pump (for efrA gene). (springeropen.com)
  • The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. (hmdb.ca)
  • p50 binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. (hmdb.ca)
Complexes1
  • NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. (hmdb.ca)
Protein14
  • Here we show that high-mobility group AT-hook 2 protein (HMGA2) induces DNA nicks at the transcription start site, which are required by the histone chaperone FACT complex to incorporate nucleosomes containing the histone variant H2A.X. Further, phosphorylation of H2A.X at S139 (γ-H2AX) is required for repair-mediated DNA demethylation and transcription activation. (nature.com)
  • Here we will focus on HMG AT-hook 2 protein (HMGA2), a member of the HMGA family that mediates transforming growth factor beta 1 (TGFB1, commonly known as TGFβ1) signaling 16 . (nature.com)
  • We have previously shown that HMGA2-induced transcription requires phosphorylation of H2A.X at S139, which in turn is mediated by the protein kinase ataxia telangiectasia mutated (ATM) 10 . (nature.com)
  • It is a nuclear protein with an Runt DNA-binding domain. (micrornaprofile.com)
  • This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. (micrornaprofile.com)
  • RUNX2 is an essential factor in bone development, acting as a scaffold protein for nucleic acids and regulatory factors involved in skeletal gene expression. (micrornaprofile.com)
  • This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. (micrornaprofile.com)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. (lookformedical.com)
  • We show that ionizing radiation specifically enhances the motility and invasiveness of human GSCs through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activates the Junction-mediating and regulatory protein (JMY). (nature.com)
  • We show that radiation-induced migration/invasion occurs through the stabilization and nuclear accumulation of the transcription factor hypoxia-inducible factor 1 alpha (HIF1α), which drives the transcription of Junction-mediating and regulatory protein (JMY) 27 that stimulates GSC migration through its actin nucleation-promoting activity. (nature.com)
  • PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)
  • In transgenic mice models the HCV core protein has been found to induce insulin resistance via TNF production. (isciii.es)
  • AMR families of the resistance mechanism of antibiotic target protection included bacterial RNA polymerase-binding protein (for RbpA gene), while those of the resistance mechanism of antibiotic inactivation included rifampin ADP-ribosyltransferase (for arr-1 gene). (springeropen.com)
Subunit5
  • Core Binding Factor beta Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • A non-DNA binding transcription factor that is a subunit of core binding factor. (wakehealth.edu)
  • This graph shows the total number of publications written about "Core Binding Factor beta Subunit" by people in this website by year, and whether "Core Binding Factor beta Subunit" was a major or minor topic of these publications. (wakehealth.edu)
  • Below are the most recent publications written about "Core Binding Factor beta Subunit" by people in Profiles. (wakehealth.edu)
  • It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. (micrornaprofile.com)
Receptor4
  • Peroxisome proliferator-activated receptor-γ(PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors [ 10 ]. (biomedcentral.com)
  • Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)
  • A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
  • Insulin, after binding its receptor, induces the phosphorylation of receptor substrates in the liver and muscles, and induces several steps toward the transactivation of GLUT-4, which increases glucose uptake by cells and its storage as glycogen, and inhibits the net production of glucose by the liver, thus blocking glycogenolysis and neoglycogenesis. (isciii.es)
Modulate1
Specificity1
  • Examining changes in specificity caused by a heterodimeric partner. (proteovista.com)
Hematopoiesis1
  • In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
Activates1
  • In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
Regulate1
  • Upon binding of their respective ligands and activation, intracellular signalling cascades, often involving phophorylation are induced which eventually terminate at inducible TFs and regulate their activity. (amegroups.org)
Promoter2
  • Blocking the formation of the heterodimer by transfection of MZF-1 60-72 or Elk-1 145-157 peptide fragments at the MZF-1 / Elk-1 interface decreases DNA-binding activity of the MZF-1 / Elk-1 complex at the PKCα promoter. (oncotarget.com)
  • tightly you dissipate your download, contribute the nursing of it, and bind in with your triphosphatase endocytosis promoter and bilayer pore( the activation Early occurs to the endocytic 4 products of your source phosphorylation). (evakoch.com)
Interaction1
  • These data suggest that the next therapeutic strategy in treating PKCα-related cancer will be developed from blocking MZF-1/Elk-1 interaction through their binding domain. (oncotarget.com)
RUNX23
  • Core binding factors are composed of: a non-DNA-binding CBFβ chain (CBFB) a DNA-binding CBFα chain (RUNX1, RUNX2, RUNX3) de Bruijn M, Speck N (2004). (wikipedia.org)
  • Description: Runx2 is a member of the RUNX family of transcription factors. (micrornaprofile.com)
  • Description: Core binding factor A1(CBFA1/RUNX2) is a runt-like transcription factor essential for osteoblast differentiation. (micrornaprofile.com)
Genomic1
  • Designing therapeutics to disrupt transcription factor binding at a specific genomic location. (proteovista.com)
Facilitates1
  • The histone chaperone FACT (facilitates chromatin transcription) is a heterodimeric complex, consisting of SUPT16 and SSRP1 (Spt16 and Pob3 in yeast) that is responsible for the deposition of H2A/H2B-dimers onto DNA 11 , 12 . (nature.com)
Chromatin6
Extrinsic1
  • We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)
Pleiotropic1
  • NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (hmdb.ca)
Functional1
  • Identifying functional SNPs that alter transcription factor binding for personalized medicine applications. (proteovista.com)
Mediates1
  • A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS . (lookformedical.com)
Gene transcription1
  • NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. (ouhsc.edu)
Regulatory1
  • An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. (lookformedical.com)
Roles1
  • There coalesce roles that NOTCH2 Actively binds with breast inner tyrosine 1-beta( HNF1B) in wtih response( Massa et al. (evakoch.com)
Superfamily1
  • TWIST1 is a transcription factor belonging to the basic helix-loop-helix (bHLH) superfamily. (biomedcentral.com)
Enzyme1
  • m7G-Seq utilizes chemical reduction and deamination to selectively convert the m7G site into the basic site, and by reverse transcription enzyme to successfully detect the m7G signal within the mRNA (11). (beds.ac.uk)
Cells2
  • It is also involved in cancer cell movement, activating factors involved in the metastasis of prostate and breast cancer cells to bone. (micrornaprofile.com)
  • Specific molecular sites or structures on or in cells with which interferons react or to which they bind in order to modify the function of the cells. (lookformedical.com)
Intrinsic1
  • GM-CSF down-regulates inhibited by factors( T-lymphocytes, mouse heterotrimers, necessary phosphatidylinositol, p46 acids) estimated at acids of intrinsic tissues. (evakoch.com)
Inhibitors1
  • ABSTRACT: The discovery of novel 4-hydroxy-2-(heterocyclic)pyrimidine-5-carboxamide inhibitors of hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) are described. (her2-signaling.com)
Mutations1
  • These mutations affect the dimerizing ability and the DNA-binding properties of TWIST1. (biomedcentral.com)
Family1
Response1
  • A second dose of DETA NO, administered after 4 hours, did not pro long the growth inhibition, suggesting that stress response factors and NO defence mecha nisms may have been activated by the first dose. (igf-1rinhibitors.com)
Development2
  • The bHLH transcription factor TWIST1 plays a key role in the embryonic development and in tumorigenesis. (biomedcentral.com)
  • Cross-sectional and case-cohort studies support a role for hepatitis C as a factor implied in the development of type-2 diabetes in high-risk patients (male patients, older than 40 years, and overweight). (isciii.es)
Cell2
  • In addition, they also serve as cell wall bound seed storage com pounds as in the case of members of the Primulaceae and also in C. persicum. (igf-1rinhibitors.com)
  • In contrast, if zinc binding cysteine residues of MT3 are oxidized, MT3 may release zinc and result in much more cell death. (ilreceptor.com)
Case1
Levels1
  • In our previous study, we discovered the infarct core exhibits markedly enhanced levels of labile zinc in all cellular components, raising the probability that zinc toxicity may contribute to infarct formation. (ilreceptor.com)
Active1
  • Discovery of N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3- yl)pyrimidine-5-carboxamide ( MK-8617 ) an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. (her2-signaling.com)