SynthesisPolycyclicChemistryAminesHydrazineBiologicalDerivativesNitrogen CompoundsMoietyStructuresAlkylInhibitorsHybrid compoundsFlavor and fragranceIntermediatesQuinolineSulfurDrugsStructuralMoleculesAnticancerCytotoxicSolubilityVolatileAlkaloidsCarbonPetroleumHydrocarbonsProductsComplexMechanismToxicCharacterizationInhibitoryDyesOccurrenceBiomassCommerciallyJournalMethodologyExposurePotentFragmentsClassificationSuppliersPharmaceuticalHigh
Synthesis10
- The compound, Di-tert-butyl dicarbonate, also known as Dicarbonic acid, bis(1,1-dimethylethyl) ester, is an ester of an inorganic acid indicated for use as a reagent in organic synthesis. (faqs.org)
- As a result, alkaloids find applications in various industries, including medicine, agriculture, and even the synthesis of fine chemicals. (selfgrowth.com)
- As one of the longest-running Gordon Research Conferences, the 2023 Heterocyclic Compounds GRC will continue to provide a platform for disclosures of new strategies for the discovery, synthesis, incorporation, and application of powerful heterocycles. (grc.org)
- Reaction of tetrafluoropyridazine with catechol gives a tricyclic 9,10-dioxa-1,2-diaza-anthracene system by a sequential nucleophilic aromatic substitution ring annelation process, further extending the use of perfluoroheteroaromatic derivatives for the synthesis of unusual polyfunctional heterocyclic architectures. (beilstein-journals.org)
- Drug discovery programmes are continually searching for viable synthetic routes to highly novel classes of heterocyclic compounds with the aim of exploring chemical 'drug-like' space [1] and uncovering valuable biological activity for hit-to-lead generation of new chemical entities by parallel synthesis techniques. (beilstein-journals.org)
- Methodology for the ready synthesis of new organic frameworks is still required and, in this context, heterocyclic scaffolds based on novel molecular architecture that bear multiple functionality and can be rapidly processed into many analogues by parallel synthesis are particularly valuable [5,6] . (beilstein-journals.org)
- The developed methodology will be applied to the synthesis other oxa-Michael heterocyclic products. (broadinstitute.org)
- The synthesis of novel polycyclic heterocyclic ring systems via photocyclization. (elsevierpure.com)
- Dive into the research topics of 'The synthesis of novel polycyclic heterocyclic ring systems via photocyclization. (elsevierpure.com)
- This protocol has the potential to replace traditional chemical synthesis routes for the synthesis of nitrogen-containing heterocyclic compounds. (bvsalud.org)
Polycyclic1
- Special care has been taken to elaborate IUPAC nomenclature of certain chemical classes like steroids, eicosanoids, polycyclic aromatic compounds and heterocyclic compounds. (researchandmarkets.com)
Chemistry10
- Investigations of the chemical transformations of such compounds are certainly of interest for theoretical, practical and synthetic organic chemistry, as well as for the search of compounds with favorable practical properties, such as thermal stability, electrical conductivity (even superconductivity), biological activity, nonlinear optical effects, etc. [ 39 ]. (degruyter.com)
- The last two chapters on polynuclear aromatic hydrocarbons and heterocyclic compounds, though not exactly the part of the curriculum of chemistry of natural products, but are essential to understand the chemistry of natural products. (researchandmarkets.com)
- Considering the importance of chemistry of such compounds, these two chapters have been included in this book. (researchandmarkets.com)
- Undergraduate and postgraduate students of science and pharmacy would find the book very handy and useful in the study of their course on chemistry of heterocyclic chemistry. (researchandmarkets.com)
- In the realm of organic chemistry, one class of compounds has captured the scientific community's attention for decades - alkaloids. (selfgrowth.com)
- The Atmospheric Chemistry Group, directed by Dr. Vera Samburova, is a research group developed for chemical analysis of organic species in the atmosphere. (dri.edu)
- The course consists of the following: -the environmental work at Chemistry Center and Lund University -hazards concerning chemicals -protection gear -safety regulations -laws and regulations for environmental safety -hazard evaluations -accidents. (lu.se)
- Journal of Heterocyclic Chemistry , 29 (6), 1613-1615. (elsevierpure.com)
- Handbook of Heterocyclic Chemistry by Alan R. Katritzky et al. (lu.se)
- The highly experienced team of compilers from the renowned Institute of the Chemistry of Plant Substances in Tashkent have expertly assessed the international literature and include data only when confident of its validity, e.g. excluding data where measurement processes cause degradation of the original compound. (lu.se)
Amines2
- Values for the negative logarithm of the acid dissociation constant, pKa, of the conjugated acid of amines, diamines and cyclic organic nitrogen compounds, shown together with the molecular structure of the acids. (engineeringtoolbox.com)
- A method using UPLC-MS/MS and a core-shell C18 column was developed to simultaneously determine 21 heterocyclic amines (HAs) in 15 min. (nycu.edu.tw)
Hydrazine2
- In the present work, valence stabilization of divalent iron during gamma irradiation was studied in presence of some organic additives, belonging to some other classes of organic compounds such as Phenol (aromatic alcohol), Acetone (aliphatic ketone), 4-Aminopyridine (heterocyclic amino compound) and Hydrazine hydrate (aliphatic amino compound) to complement our previous studies. (scirp.org)
- In the present work, the protective effect occurring due to the presence of additives belonging to different classes of organic compounds namely, Phenol (aromatic alcohol), Acetone (aliphatic ketone), 4-Aminopyridine (aromatic heterocyclic nitrogen compound) and Hydrazine hydrate (aliphatic amine) on divalent iron ions during extended gamma irradiation, has been studied. (scirp.org)
Biological4
- Heterocyclic molecules are significant due to their abundance in nature, as well as their chemical and biological importance. (perfumerflavorist.com)
- These naturally occurring compounds are known for their diverse chemical structures and profound biological activities. (selfgrowth.com)
- The complex interactions leading to a wide range of biological activity can be probed, enhanced, and harnessed through heterocyclic compounds. (grc.org)
- Since 1971, more than 950 chemicals, complex mixtures, occupational expo sures, physical agents, biological agents, personal habits, and household exposures have been reviewed, some of them several times as new information has become available. (who.int)
Derivatives2
- The compounds, 5-Nitrosalicylaldehyde and 5-Bromosalicylaldehyde are halogenated derivatives of an aldehyde-phenol (Salicylaldehyde) indicated for use as pharmaceutical intermediates. (faqs.org)
- The electrochemical reduction of 4-nitrosodiphenylamine, 3-methyl-4-amino-5-nitrosouracil and 1,3-dimethyl-4-amino-5-nitrosouracil was studied in connection with the development of methods of electrosynthesis of some amino derivatives, intermediate compounds in the production of medicinal preparations and antioxidants of polymeric materials. (cas.cz)
Nitrogen Compounds1
- See also boiling and melting point of different kinds of organic compounds , boiling and melting point of organic nitrogen compounds , pKa of phenols, alcohols and carboxylic acids and pKa of inorganic acids and bases , as well as acid and base pH indicators and Acid-base properties of aqueous solutions of salts with ions from both acids and bases . (engineeringtoolbox.com)
Moiety1
- Correlations are attempted between chemical structure of the X moiety and antibacterial activity of obtained compounds. (heterocycles.jp)
Structures4
- A class of organic compounds containing three ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. (harvard.edu)
- Alkaloids can be classified into several subclasses based on their chemical structures and origin. (selfgrowth.com)
- The chemical structures of the compounds prepared were characterized through IR, 1 H NMR and 13 C NMR spectral data. (heterocycles.jp)
- Each volume systematically covers occurrence of the compounds in plants, illustrations of chemical structures plus physical-chemical, spectral, and pharmacological data. (lu.se)
Alkyl1
- Our main products are all kinds of fine chemical intermediates: Alkyl carbonates (including dimethyl carbonate, dimethyl malonate, diethyl malonate, ethyl acetoacetate, ethylene carbonate, diethyl carbonate, etc. (chinachemnet.com)
Inhibitors4
- Fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design were used to identify novel inhibitors for BACE-1. (rcsb.org)
- These compounds were designed to comply with the general features of sulfonamide pharmacophore which act as Cyclooxygenase (COX-2) inhibitors. (scirp.org)
- Based on the reported synthetic lethality of the combination of PARP inhibitor olaparib with the natural product alantolactone, we designed several series of new PARP1 inhibitors by structurally merging both compounds into a single hybrid compound. (bvsalud.org)
- The results validated that merging PARP inhibitors with other DNA-damage related compounds would produce more potent PARP inhibitors for anticancer studies. (bvsalud.org)
Hybrid compounds1
- However, the poor aqueous solubility and low cell penetration of the current hybrid compounds call for further structural optimization. (bvsalud.org)
Flavor and fragrance1
- In the flavor and fragrance industry, heterocyclic compounds are of interest because of their varied occurrence in food flavors and their valuable organoleptic characteristics. (perfumerflavorist.com)
Intermediates1
- Uyanchem is a professional manufacturer of OLED intermediates and fine chemicals. (uyanchem.com)
Quinoline1
- A high production volume chemical, quinoline is used to produce a variety of drugs and dyes. (cdc.gov)
Sulfur2
- The main heterocyclic aroma chemicals are oxygen-, sulfur- and nitrogencontaining rings. (perfumerflavorist.com)
- The sulfur-containing aroma chemicals belong to the thiophene family and, together with nitrogen, to the thiazole and dithiazine systems. (perfumerflavorist.com)
Drugs1
- Continuing the restructuring of the D category D (Chemicals and Drugs), several subcategories were abolished, their descriptors eliminated or relocated to other subcategories. (bvsalud.org)
Structural1
- This structural feature gives them unique physical and chemical properties, enabling them to exert pharmacological effects on living organisms. (selfgrowth.com)
Molecules4
- Simply burning these materials as a low-value energy source is wasting opportunities for wealth creation: while the energy value of bark is in the range of 10-20 € per ton, its value as growth substrate is more than tenfold, and as a source of bioactive molecules for high value-added products in medicine, cosmetics, industrial chemicals, or plant protection products, the potential value is several orders of magnitude greater. (europa.eu)
- The interest in oxazoline compounds bearing ferrocenyl substituents in the molecules can be traced back to the discovery of ferrocene [ 37 ]. (degruyter.com)
- Of the ca. 20 million chemical compounds presently characterized, almost half are heterocyclic molecules. (perfumerflavorist.com)
- Compounds arising from this methodology possess 3D characteristics found in many naturally occurring small molecules. (broadinstitute.org)
Anticancer1
- In this study, anticancer properties of heterocyclic salicylaldimines and their Cu(II) complexes on K562 human chronic myelogenous leukemia cell line were investigated. (ijpsonline.com)
Cytotoxic2
- The metal complexes of the compounds had stronger cytotoxic effects and cleaved caspase-3 expression than their ligands. (ijpsonline.com)
- In vitro testing of the new compounds against HepG-2, MCF-7, and HCT-116 cell lines confirmed their potent cytotoxic activity with low IC50 values. (bvsalud.org)
Solubility1
- This can be compounded by the solubility of nitrothiophene in oils, which can cause the rubber to degrade further. (marcorubber.com)
Volatile2
- 2018), quantification of volatile organic species emitted from cannabis plants (Samburova et al, 2019), chemical characterization of fire emissions (Sengupta et al. (dri.edu)
- No special techniques for handling perfluoroheteroaromatic compounds are required, apart from the usual laboratory precautions, because these systems are generally volatile, colourless liquids. (beilstein-journals.org)
Alkaloids2
- Alkaloids represent a large and diverse group of organic compounds characterized by the presence of a nitrogen-containing heterocyclic ring. (selfgrowth.com)
- Alkaloids are a fascinating group of naturally occurring chemical compounds found in various plants, fungi, and some animals. (selfgrowth.com)
Carbon1
- Cyclization by intramolecular sulphonyl-amidomethylation at an aromatic carbon atom provides fused heterocyclic compounds in high yields. (rsc.org)
Petroleum1
- A process for the hydrodesulfurization (HDS) of the multiple condensed ring heterocyclic organosulfur compounds present in petroleum and chemical streams. (justia.com)
Hydrocarbons1
- Physical properties and chemical reactivity of alternant hydrocarbons and related compounds. (cas.cz)
Products4
- Traces of CMIT/MIT are found in several water-based products, while the compound is also used in several industrial processes, fuels, paints, detergents, and glue production. (clickpress.com)
- Chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) market continues to remain underpinned by adoption of the compound in small quantities in consumer products such as cleaning wipes and personal care products. (clickpress.com)
- Radiolysis and self irradiation problems encountered during chemical reprocessing of nuclear fuel or during chemical separation of transuranium elements or fission products are extremely important. (scirp.org)
- Founded in 1995, Shanghai Huiyuan Industry Co., Ltd. is a chemical research company and a comprehensive research, development and trade enterprise of chemical products and technologies. (chinachemnet.com)
Complex1
- These compounds can transfer, deposit, and undergo a complex homogeneous and heterogenous chemical transformation. (dri.edu)
Mechanism3
- Valence change of polyvalent ions in aqueous acidic solutions in strong gamma irradiation fields can seriously affect the mechanism of some chemical processes. (scirp.org)
- Further mechanism study indicated that these compounds activated the cell cycle checkpoints, and subsequently induced G2/M arrest and apoptosis. (bvsalud.org)
- Mechanism study revealed that compound 8h could suppress the HepG2 cell proliferation via prompting the acetylation of histone 3 (H3) and α-tubulin, and activating the p53 signal pathway as designed. (bvsalud.org)
Toxic2
- The USA EPA has registered CMIT/MIT as an industry insecticide, designating CMIT/MIT as secondary inhalation toxic compound. (clickpress.com)
- Recent research projects of Dr. Samburova researches have focused on analysis of toxic compounds in human breath of e-cigarette users (Samburova et al. (dri.edu)
Characterization1
- The characterization of the new compounds was done by IR, 1 H- and 13 C-NMR spectroscopy, mass-spectrometry, elemental analysis and X-ray diffraction studies. (degruyter.com)
Inhibitory3
- After 72 h incubation, colorimetric 3-[4,5-dimethylthiazol-2- yl]-2,5 diphenyl tetrazolium bromide test was performed to determine half-maximal inhibitory concentration values of each compound. (ijpsonline.com)
- Among them, compounds 20e and 25a displayed not only high biochemical activity (IC50 = 2.99 nM and 5.91 nM vs 11.36 nM), but also higher inhibitory effects against proliferation of BRCA1-deficient UWB1.289 cells than olaparib (IC50 = 0.27 µM and 0.41 µM vs 0.66 µM). (bvsalud.org)
- IC50 values determination demonstrated Topo II inhibitory activities and DNA intercalating affinities of the tested compounds at a micromolar level. (bvsalud.org)
Dyes1
- It forms the core structure for various chemicals, most notably fluorone dyes, including fluorescein, erythrosine and rhodamine. (wikipedia.org)
Occurrence1
- The entries are preceded by tabulated information on the occurrence of the compounds in plants etc. (lu.se)
Biomass1
- All extracts and the isolated and synthesized compounds were subjected to screening of bioactivity for medical, cosmetic, and plant protection purposes, for industrial applications, and the use of the total or remaining biomass in production of growth substrates, organic fertilizers, and bioremediation materials was investigated. (europa.eu)
Commercially1
- But these fragments have been confined to commercially flat heteroaromatic compounds. (broadinstitute.org)
Journal1
- Journal of Chemical and Engineering Data, 55 (11), 5009 - 5017. (up.pt)
Methodology1
- The innovation of new chemical methodology and a fundamental mechanistic understanding connects it all. (grc.org)
Exposure2
Potent3
- Due to the highly potent odor character of a majority of the heterocyclic compounds used in flavors and fragrances, the term ϕ Value will be used for some of the materials described. (perfumerflavorist.com)
- Among the target compounds, 8h possessed nano-molar IC50 values toward the tested cancer cells and HDAC subtypes, which was more potent than the HDAC inhibitor SAHA (vorinostat). (bvsalud.org)
- Amongst, compound 9d was the most potent member. (bvsalud.org)
Fragments1
- Because of their flat nature, the current heteroaromatic fragments do not take full advantage of the chemical space, so the expansion of fragments' chemical space through the preparation of more globular compounds is needed. (broadinstitute.org)
Classification2
- In your letter dated September 20, 2007 you requested a tariff classification ruling concerning five chemical compounds. (faqs.org)
- An overview is given of the nature of, and methods for, classification of chemical reactions. (researchgate.net)
Suppliers1
- Chemicals suppliers from many countries are registered with Carbanio. (carbanio.com)
Pharmaceutical1
- Lianyungang Qunsheng Chemical Co., Ltd.(ChangZhou QiRong Pharmaceutical Co. Ltd. (loto371.com)
High3
- Even though heterocyclic aroma chemicals are found only in minute amounts in foods, their powerful odors and low odor thresholds, as expressed by high ϕ values (see below), make them key in boosting flavors and fragrances. (perfumerflavorist.com)
- The product, also used in the manufacture of high-performance polymers, is a U.S. Environmental Protection Agency (EPA) registered chemical. (faqs.org)
- This problem can be addressed by fragment-based drug discovery, which has proven to be an effective means of producing high quality lead-like compounds for the last ten year. (broadinstitute.org)