A series of heterocyclic, azole-based compounds are described that preferentially inhibit P. falciparum LDH at sub-micromolar concentrations, typically at concentrations about 100-fold lower than required for human lactate dehydrogenase inhibition. (rcsb.org)
Student aquire the basic knowledge base about the structure, physico-chemical properties, syntetic preparation and typical reactivity of amines, carbonyl compounds and their derivatives, amino acids and peptides, saccharides, heterocyclic compounds, nucleosides a nucleic acids. (stuba.sk)
Heterocyclic compounds have an immense role in drug discovery and development. (biomedres.us)
Among the various medical applications, heterocyclic compounds play an active role as anti-bacterial, anti- viral, anti-fungal, anti-tumor, and anti-covid-19 agents as well [2]. (biomedres.us)
Ruthenium on Carbon is a ruthenium-based catalyst with numerous applications such as the hydrogenation of substituted anilines to cyclohexylamines, carboxylic acids to alcohols, allyl and heterocyclic aromatic compounds, Fischer-Tropsch synthesis etc. (sinocata.com)
Derivatives5
Pyrimidine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes. (chemicalland21.com)
A series of N -substituted 4 H -thieno[3,2- b ]pyrrole-5-carboxylic acids and their imidazolyl derivatives was synthesized. (osi.lv)
4-Methyl-, 4-allyl-, and 4-benzyl derivatives of (4 H -thieno[3,2- b ]pyrrol-5-yl)carboxylic acid or their imidazolides were used in reactions with EtNH 2 and indole sodium salt, providing the respective amides. (osi.lv)
1,2-Ethylenediamine readily forms heterocyclic imidazolidine derivatives, because of its bifunctional nature, having two amines. (atamanchemicals.com)
We have synthesized a novel class of carboxamide derivatives by coupling various substituted aromatic acid hydrazides and triazoleamine with pyrrolidine carboxylic acid by using coupling agents. (uni-mysore.ac.in)
Alcohols1
The tertiary benzylic alcohols of the 4-membered rings are selectively activated using Brønsted acid catalysis and reacted with simple alcohols to form the ethers and maintain the oxetane ring intact. (imperial.ac.uk)
Ketones1
This catalyst was found to actively control radical reactions and enabled production of more than 35 species of bulky dialkyl ketones from an aliphatic aldehyde and an aliphatic carboxylic acid derivative through a radical relay mechanism. (asiaresearchnews.com)
A biosensor typically consists of a bio-receptor (enzyme/antibody/cell/nucleic acid/aptamer), transducer component (semi-conducting material/nanomaterial), and electronic system which includes a signal amplifier, processor & display. (erasingdavid.com)
Carbene2
A new generation of octahedral iron(ii)-N-heterocyclic carbene (NHC) complexes, employing different tridentate C^N^C ligands, has been designed and synthesized as earth-abundant photosensitizers for dye sensitized solar cells (DSSCs) and related solar energy conversion applications. (lu.se)
We designed a thiazolium-type N-heterocyclic carbene catalyst having an N-neopentyl group. (asiaresearchnews.com)
Its conjugate acid is called pyridinium cation, C 5 H 5 NH + , used as a oxidation agent for organic synthesis. (chemicalland21.com)
Carboxy group1
An indole-3-carboxylic acid carrying a carboxy group at position 3. (mcw.edu)
Proteins1
Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
Nitrogen3
PYRIDINE, also called azabenzene and azine, is a heterocyclic aromatic tertiary amine characterized by a six-membered ring structure composed of five carbon atoms and a nitrogen which replace one carbon-hydrogen unit in the benzene ring (C 5 H 5 N). The simplest member of the pyridine family is pyridine itself. (chemicalland21.com)
This work introduces a linearly aligned push-pull design principle that reaches from the ligand having nitrogen-based electron donors, over the Fe(ii) centre, to the ligand having an electron withdrawing carboxylic acid anchor group. (lu.se)
Thiazole, also known as 1,3-thiazole, is a type of heterocyclic compound that includes both nitrogen and sulfur atoms. (ambeed.com)
Organic2
The competition reaction between the short-chain carboxylic acid from salix pyrolysis and a long-chain carboxylic acid from digestate pyrolysis was one of the main reasons for the synergistic reaction regarding the composition of the organic fraction. (kth.se)
3-Methylthiophene-2-carboxylic acid is a heterocyclic organic compound that belongs to the thiophene family. (thebiotek.com)
Biologically1
Design of chemically novel, biologically potent small heterocyclic molecules with anticancer activities, which targets the enzyme heparanase has gained prominent clinical interest. (uni-mysore.ac.in)
Chemical1
The chemical structure of 3-Methylthiophene-2-carboxylic acid consists of a thiophene ring with a carboxylic acid group and a methyl group attached to it. (thebiotek.com)
Future trends and prospects in the application of 3-Methylthiophene-2-carboxylic acid in scientific research include the development of new drugs and therapies for various diseases and the use of this compound in environmental and industrial applications. (thebiotek.com)
This review covers the different classes of pre-existing drugs constituting various heterocyclic analogs that have been repurposed for the possible treatment of the COVID-19 disease. (biomedres.us)
Consists1
Sensory irritation during acute exposures to carboxylic acids--A The auditory startle test consists of 3 min of acclimation to the comparison of acetic and propionic acid arena followed by two consecutive stimuli performed with a 1 min interval. (cdc.gov)
Consist1
N ucleotide consist of either a nitrogenous heterocyclic base (purine or pyrimidine). (chemicalland21.com)
Enzyme1
Crystal structures show these competitive inhibitors form a network of interactions with amino acids within the active site of the enzyme, stacking alongside the nicotinamide ring of the NAD(+) cofactor. (rcsb.org)
Biological2
The mechanism of action and biological targets of 3-Methylthiophene-2-carboxylic acid are not fully understood. (thebiotek.com)
The current limitations in the use and study of 3-Methylthiophene-2-carboxylic acid include the lack of understanding of its mechanism of action and biological targets. (thebiotek.com)
Group1
Ethylenediaminetetraacetic acid (EDTA) is a derivate of 1,2-Ethylenediamine and it is a versatile chelating agent, which could form chelates with both transition-metal ions and main-group ions. (atamanchemicals.com)
Carbon1
There are several methods for synthesizing 3-Methylthiophene-2-carboxylic acid, including the reaction of 3-methylthiophene with carbon dioxide and a base, the reaction of 3-methylthiophene with carbon monoxide and a palladium catalyst, and the reaction of 3-methylthiophene with carbon disulfide and a base. (thebiotek.com)
In medical research, 3-Methylthiophene-2-carboxylic acid has been studied for its potential role in drug development. (thebiotek.com)
High2
High σ1 affinity was achieved for 2-benzazepines with linear or branched alk(en)yl residue s containing at least an n-butyl substructure . (idexlab.com)
M. jaboticaba reportedly contains peonidin 3-glucoside and its aglycone (5), and the related camu-camu berry ( M. dubia ), an edible fruit known for its high levels of ascorbic acid, contains Compound 3 and delphinidin 3-glucoside (Compound 4) as its main pigments (6). (justia.com)
Widely1
Thus, the auditory startle test system is now fully validated and pionic acid are widely used in the working environment. (cdc.gov)
Study1
Therefore, the present study the low concentration we investigated, carboxylic acids might act aims at investigating these effects, emphasizing also distractive via ASIC receptors that are not involved in neurogenic responses. (cdc.gov)
Potential1
However, the potential therapeutic and toxic effects of 3-Methylthiophene-2-carboxylic acid are not fully understood and require further investigation. (thebiotek.com)