Heterocyclic aromatic amines (HCAA) are an important class of carcinogens formed during combustion of cigarettes and cooking meats at high temperature (Turesky, R.J., Zhang, L., et al. (cdc.gov)
Heterocyclic aromatic amines in urine are measured by an isotope-dilution high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (ID HPLC-ESI MS/MS). For "total" HCAA assays, the urine samples are fortified with internal standards (ISTD), and hydrolyzed in basic condition at 70°C for 5 hours. (cdc.gov)
Heterocyclic aromatic amines were measured in a special smoking subsample of persons 18 years and older. (cdc.gov)
Industrial hygiene surveys were conducted, and air samples were collected for analysis of polynuclear aromatic hydrocarbons, polynuclear aza heterocyclic hydrocarbons, aromatic amines, metals, common toxic gases, and other organic compounds. (cdc.gov)
Aromatic amines, phenolic compounds and simple aromatic solvents were occasionally present at very low levels. (cdc.gov)
According to several websites, a 'study' by the University of Minnesota Medical School has confirmed that cookingmeat over high temperatures (without mentioning exactly what the temperature levels were) creates Heterocylic Amines, which are 'known' carcinogens. (professorshouse.com)
First-off, Heterocylic Amines are present in many things, including vitamins, and they are not 'known' carcinogens, but merely 'suspected', based on very thin evidence. (professorshouse.com)
Meats, organic or not, that are cooked at high temperatures tend to contain sizable quantities of heterocyclic amines, carcinogens that form as meat cooks. (forksoverknives.com)
HCAs4
Heterocyclic amines, also sometimes referred to as HCAs, are chemical compounds containing at least one heterocyclic ring, which by definition has atoms of at least two different elements, as well as at least one amine (nitrogen-containing) group. (wikipedia.org)
When meat, poultry, pork, or fish is cooked over flames or very high temperatures, muscle proteins react with the heat to form compounds called heterocyclic amines (HCAs). (webmd.com)
Two chemicals, polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs), develop naturally when cookingmeat. (cancer.net)
Carcinogenic compounds called heterocyclic amines (HCAs) can form under these circumstances. (coolthings.com)
Meat6
Carcinogenic heterocyclic amines are created by high temperature cooking of meat and smoking of plant matter like tobacco. (wikipedia.org)
Research has shown that heterocyclic amine formation in meat occurs at high cooking temperatures. (wikipedia.org)
And be aware that charring meat, especially red meat, can produce cancer-causing chemicals known as heterocyclic amines. (ewg.org)
Cooking meat can lead to charring, which generates carcinogenic compounds known as heterocyclic amines. (huffpost.com)
Cancer chemopreventive mechanisms of tea against heterocyclic aminemutagens from cooked meat. (oregonstate.edu)
A 2005 amines study showed that nearly 80 percent of studies in humans found a connection between cancer incidence and consumption of well-done meat. (forksoverknives.com)
Carcinogenic2
Heterocyclic amines are the carcinogenic chemicals formed from the cooking of muscle meats such as beef, lamb, pork, fish and poultry. (wikipedia.org)
I'm happy to report a news article highlighting one of the subjects, carcinogenic heterocyclic amines, discussed in the Guide. (dogcancerblog.com)
Five-membered2
Pyrrole is another compound made up of molecules with a five-membered heterocyclic ring. (wikipedia.org)
Although L-proline is a poor substrate, aromatic heterocyclic carboxylates containing a five-membered ring and various heteroatoms (X = NH, O, S) are good ligands (K(d, X=NH) = 1.37 mM) and form charge-transfer complexes with MSOX. (rcsb.org)
Methyl4
N30 (N-(4-nitrophenyl methyl) benzothiazole-6-amine, Fig. 1a ) was originally provided by Professor Zhuorong Li at the Institute of Medicinal Bioechnology Chinese Academy of Medical Sciences, Beijing, China. (biomedcentral.com)
A series of novel heterocyclic sulfonyl-carboximidamides were synthesized in satisfactory yields via condensation of heterocyclic methyl carbimidates with 2-chlorobenzenesulfonamide and 4-chloropyridine-3-sulfonamide. (springer.com)
We undertook the synthesis of structures that were condensates of heterocyclic methyl carbimidates with 2-chlorobenzenesulfonamide and 4-chloropyridine-3-sulfonamide. (springer.com)
Human sulfotransferase 1A1 (SULT1A1) is involved in the bioactivation of some dietary procarcinogens, including the N -hydroxy metabolite of the food-borne heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo(4,5- b ) pyridine. (aacrjournals.org)
Nitrogen4
Typically it is a nitrogen atom of an amine group that also makes the ring heterocyclic (e.g., pyridine), though compounds exist in which this is not the case (e.g., the drug Zileuton). (wikipedia.org)
Pyrimidine is a heterocyclic amine that contains two nitrogen atoms in an unsaturated six-membered ring. (wikipedia.org)
This work includes synthesis of new five, six, and seven-heterocyclic nitrogen compounds by closure reactions of tetraacetylethane (3) with primary amines in refluxing ethanol and acetonitrile as solvents and without using any catalysts. (ijpsr.com)
These findings prompted us to extend our search for biologically active compounds among nitrogen heterocyclic derivatives. (springer.com)
Pyridine1
Nicotine is a molecule containing a pyrrolidine ring attached to a ring of pyridine (other heterocyclic amine). (wikipedia.org)
1999. Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. . (oregonstate.edu)
Derivatives1
In early study, we established a series of novel benzo-heterocyclic amine derivatives and determined their in vitro antiviral activities. (biomedcentral.com)
Meats1
Heterocyclic Amines are present in all cooked meats to a more or lesser degree. (professorshouse.com)
React1
Among others they react with amines giving amidines as the products. (springer.com)
Foods1
In this context, it seems a bit far-fetched that we would shift, en masse, to a strict diet of raw, unprocessed foods. (huffpost.com)
Pathway1
The finding of heterocyclic alkanes with destructive quantum interference charts a pathway for chemical design of short molecular insulators using organic molecules. (rsc.org)
Abstract1
abstract = "A method using UPLC-MS/MS and a core-shell C18 column was developed to simultaneously determine 21 heterocyclic amines (HAs) in 15 min. (nycu.edu.tw)
Atom1
The subject of this work was to study the reactions of heterocyclic carbimidates with sulfonamides that have a chlorine atom as a substituent in the ortho position to the sulfonamide group. (springer.com)
Group2
The single-crystal structures confirmed the presence of a primary amine group in the amidine moiety. (springer.com)
The carboxyl group of sarcosine is essential for binding since none is observed with simple amines. (rcsb.org)
Study1
Heterocylic Amines are also suspected neurotoxins, but the study failed to address any concerns that barbecue could contribute to Alzhiemer's or other forms of Demitia, Parkinson's Disease, ADD or any other neurological disorders. (professorshouse.com)
Series1
Here, we present results for a series of small saturated heterocyclic alkanes where we show that conductance is suppressed due to destructive interference. (rsc.org)
Human1
Induction of glucose production by heterocyclic amines is dependent on N-acetyltransferase 2 genetic polymorphism in cryopreserved human hepatocytes. (cdc.gov)
Polycyclic1
Contaminants that are formed during food processing, such as acrylamide, heterocyclic amines, polycyclic aromatic hydrocarbons or 3-MCPD, could also be responsible. (foodnavigator.com)
Dietary3
13. Dietary modulation of the carcinogenicity of the heterocyclic amines. (nih.gov)
3. DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components. (nih.gov)
Human sulfotransferase 1A1 (SULT1A1) is involved in the bioactivation of some dietary procarcinogens, including the N -hydroxy metabolite of the food-borne heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo(4,5- b ) pyridine. (aacrjournals.org)
Organic2
Industrial hygiene surveys were conducted, and air samples were collected for analysis of polynuclear aromatic hydrocarbons, polynuclear aza heterocyclic hydrocarbons, aromatic amines, metals, common toxic gases, and other organic compounds. (cdc.gov)
Details for: Some aromatic amines, organic dyes, and related exposures. (who.int)
Prostate cancer risk2
We recently reported that heterocyclic amines (HCA) are associated with prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. (nih.gov)
Aliphatic and heterocyclic amine chemistry. (up.ac.za)
N-heterocyclic carbenes (NHCs) can be easily modified by introducing functional groups at the nitrogen atoms, which leads to versatile coordination chemistry as well as diverse catalytic applications of the resulting complexes. (mdpi.com)
Molecules1
Pyrrole is another compound made up of molecules with a five-membered heterocyclic ring. (wikipedia.org)
Formation2
When added to beef patties before cooking, black pepper reduced the formation of heterocyclic amines (a potential carcinogen). (marksdailyapple.com)
Turmeric and rosemary are especially great when cooking to offset the formation of unhealthy compounds (e.g., heterocyclic amines) that form in the presence of heat. (ledgertranscript.com)
Found1
Saturated fat, cholesterol, and heterocyclic amines found in animal products may contribute to disease development associated with mortality. (pcrm.org)
High1
Heterocyclic aromatic amines in urine are measured by an isotope-dilution high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (ID HPLC-ESI MS/MS). For "total" HCAA assays, the urine samples are fortified with internal standards (ISTD), and hydrolyzed in basic condition at 70°C for 5 hours. (cdc.gov)
Analysis1
Thermo Scientific™ TraceGOLD TG-5MS AMINE GC Column enables analysis of ppm levels of amines without column priming. (fishersci.com)
Levels2
18. Effect of CYP1A2 deficiency on heterocyclic amineDNA adduct levels in mice. (nih.gov)
Aromatic amines, phenolic compounds and simple aromatic solvents were occasionally present at very low levels. (cdc.gov)
Food2
3. The food-derived heterocyclic amines and breast cancer: a 1995 perspective. (nih.gov)
5. Heterocyclic amines produced in cooked food: unavoidable xenobiotics. (nih.gov)