• Tetrahymena
  • Loss of H3K23me3 in Tetrahymena through deletion of the methyltransferase Ezl3p caused mislocalization of meiosis-induced DNA double-strand breaks (DSBs) to heterochromatin, and a decrease in progeny viability. (nih.gov)
  • Moreover
  • Moreover, cenH and the RNAi machinery cooperate to nucleate heterochromatin assembly at the endogenous mat locus but are dispensable for its subsequent inheritance. (sciencemag.org)
  • euchromatic
  • Virtually all previous investigations have centered on drug-mediated effects occurring throughout active euchromatic regions of the genome, with very little known concerning the impact of cocaine exposure on the regulation and maintenance of heterochromatin in adult brain. (nih.gov)
  • stability
  • Other methyltransferases, such as Suv39h, can add another two methyl groups (H3K9me3) to the single-methylated histone and thus further increase heterochromatin stability. (mpg.de)