• This review highlights the structural and functional characteristics of BoHV-1, BoHV-5 and where appropriate, Human herpesvirus gD, as well as its role in viral entry and interactions with host cell receptors. (biomedcentral.com)
  • Important prototypes of this family comprise human herpesviruses, such as Human herpesvirus (HHV)-1 and -2 (known as herpes simplex virus (HSV)-1 and -2), and animal herpesviruses. (biomedcentral.com)
  • SuHV-1 is now used in model studies of basic processes during lytic herpesvirus infection, and for unravelling molecular mechanisms of herpesvirus neurotropism. (wikipedia.org)
  • Research on SuHV-1 in pigs has pioneered animal disease control with genetically modified vaccines. (wikipedia.org)
  • New strategies for vaccine development against both BoHV-1 and BoHV-5 have been focused on the design of marker vaccines, which differentiate infected from vaccinated animals (also known as DIVA vaccines). (biomedcentral.com)
  • BoHV-5 infection occurs at the same potential entry sites as BoHV-1, i.e. nasal cavity, eyes, oropharynx and genital tract. (biomedcentral.com)
  • Cells were fixed with acetone/methanol, and immunofluorescence staining was carried out by using monoclonal and polyclonal antibodies against different species of Alphaherpesvirinae, including HHV-1 and -2, suid (SuHV-1), equid (EHV-1 to -4), bovine (BoHV-1), and nonhuman primate (CeHV-1) viruses. (medscape.com)
  • SuHV-1 is now used in model studies of basic processes during lytic herpesvirus infection, and for unravelling molecular mechanisms of herpesvirus neurotropism. (wikipedia.org)
  • A 229-bp fragment was amplified, indicative of HHV-1 in the patient sample (lane S). Lanes 1 and 2 represent amplification products of HHV-1 strain Wal (229 bp) and HHV-2 strain D316 (241 bp), respectively (Figure). (medscape.com)
  • Positive staining was obtained with several monoclonal anti-HHV-1 antibodies directed against major glycoproteins (gC, gD, gE) as well as nonstructural proteins (infectious cell protein 0). (medscape.com)
  • Because reaction was also found to type-specific monoclonal antibodies such as HC1, HC2, and HC3 [ 1 ] , raised against gC of HHV-1, that virus was identified as the etiologic virus type. (medscape.com)
  • Demzufolge könnte dieses Modell auch die Entwicklung von Medikamenten beispielsweise gegen das Epstein-Barr virus oder das herpes simplex virus 1 ermöglichen. (uni-greifswald.de)
  • In cells infected with herpesviruses, two capsid-associated, or inner tegument, proteins, UL37 and UL36, control cytosolic trafficking of capsids by as yet poorly understood mechanisms. (rcsb.org)
  • We propose that herpesviruses may have co-opted the MTC functionality of UL37 to bring capsids to cytoplasmic budding destinations and further on to cell junctions for spread to nearby cells. (rcsb.org)
  • Lanes 1 and 2 show fragments of 229-bp DNA amplified from Human herpesvirus 1 (HHV-1) and 241 bp from HHV-2 control strains, respectively. (medscape.com)
  • [ 3 ] . When these authors' published set of primers was used, an HHV-1-specific fragment was also amplified (data not shown). (medscape.com)
  • Therefore, two multiplex real-time PCR (qPCR) assays for the genetic differentiation of wild-type and gE-deleted vaccine SuHV-1 strains have been developed. (nih.gov)
  • To discriminate between HHV-1 and HHV-2, type-specific PCR was performed according to the protocol of Piiparinen and Vaheri, using their published primers [ 2 ] . (medscape.com)