• Using the dimeric protease (Pr) from Kaposi's sarcoma-associated herpesvirus (KSHV) as a model system, we sought to dissect a putative allosteric network linking a cryptic site at the dimerization interface to enzyme function. (rcsb.org)
  • The seroprevalence of human herpesvirus-8 (HHV-8)-also known as Kaposi sarcoma-associated herpesvirus (KSHV)-varies worldwide and is estimated to be 1% to 5% in the general U.S. population 1,2 compared with 10% to 20% in certain Mediterranean countries and 30% to 80% in parts of sub-Saharan Africa. (hiv.gov)
  • Human herpesvirus 8 (HHV-8), also called Kaposi sarcoma (KS)-associated herpesvirus (KSHV), is a gamma human herpesvirus most closely related to Epstein-Barr virus. (hiv.gov)
  • In order to better treat this disease, it is essential to understand the functioning of Kaposi's sarcoma-associated herpesvirus (KSHV), which causes it. (pasteur.fr)
  • Human herpesvirus 8 (HHV-8), also called Kaposi sarcoma-associated herpesvirus (KSHV), is a γ-2 herpesvirus originally identified in Kaposi sarcoma (KS) lesions. (ashpublications.org)
  • and by analogy to other saliva borne herpesviruses, KSHV in saliva is a likely source for transmission. (prn.org)
  • In the setting of HIV disease, Epstein-Barr Virus (EBV) and Kaposi's Sarcoma-associated Herpesvirus (KSHV/HHV-8) may transform B cells into lymphomas. (prn.org)
  • The Costantini laboratory studies oncogenic human herpesviruses, specifically Kaposi's sarcoma herpesvirus (KSHV, HHV-8). (nccu.edu)
  • HHV-8 is etiologically associated with all forms of Kaposi sarcoma (KS) including classic, endemic, transplant-related, and AIDS-related, as well as rare neoplastic disorders (primary effusion lymphoma [PEL] and solid organ variants) and the lymphoproliferative disorder known as multicentric Castleman's disease (MCD). (hiv.gov)
  • 10 HHV-8 viremia typically accompanies symptomatic episodes of multicentric Castleman's disease. (hiv.gov)
  • A Patient With Human Herpesvirus 8-Positive Multicentric Castleman's Disease Who Met Criteria for TAFRO Syndrome: Controversy in Practice? (journalmc.org)
  • Human herpesvirus 8 (HHV-8) infection is associated with the development of primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. (biomedcentral.com)
  • Has been involved, along with HHV-8 viral proteins pro-inflammatory and / or other angiogenic, in HHV-8-related Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD), in addition to an MCD -related disorders involving elevation of systemic pro-inflammatory cytokines, including human vIL-6 and IL-6 (HIL-6). (ilgenetics.org)
  • Experimental and clinical evidence indicates that vIL-6 is important for the onset and / or progression of the pathology associated with HHV-8 B-cells, and endothelial, including AIDS-related Kaposi's sarcoma and multicentric Castleman's disease. (ilgenetics.org)
  • High-level human herpesvirus-8 viremia and multicentric Castleman's disease following initiation of highly active antiretroviral therapy. (ox.ac.uk)
  • We conducted a meta-analysis among PLWHA in China to describe the prevalence of major cancer risk factors including tobacco smoking, alcohol consumption, overweight and obesity, and cancer-related viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV), human papillomavirus (HPV), Epstein-Barr virus (EBV) and human herpes virus 8 (HHV8). (nature.com)
  • Antibody (or DNA testing) for HHV-8 is insufficiently sensitive/specific to predict risk of Kaposi sarcoma. (hiv.gov)
  • Effective suppression of HIV replication with ART is recommended to reduce the risk of HHV-8-associated Kaposi sarcoma (strong, low) . (hiv.gov)
  • Effective suppression of HIV replication with ART is recommended for all patients with evidence of active Kaposi sarcoma and other HHV-8-associated malignant lymphoproliferative disorders (strong, very low) . (hiv.gov)
  • Life-long ART is recommended for all individuals with evidence of active or treated Kaposi sarcoma or other HHV-8-associated malignant lymphoproliferative disorders (strong, low) . (hiv.gov)
  • O sarcoma de Kaposi é a neoplasia mais diagnosticada em pacientes com SIDA e a expressão do antígeno nuclear latente-1 do herpesvírus humano tipo-8 (HHV-8) tem se mostrado útil no seu diagnóstico histológico. (fiocruz.br)
  • Positividade à imuno-histoquímica para o antígeno nuclear latente 1 do HHV-8 foi observada nos 49 casos de sarcoma de Kaposi e nenhuma reação foi detectada nos 60 simuladores analisados, resultando em 100% de sensibilidade e especificidade. (fiocruz.br)
  • A detecção do HHV-8 por imuno-histoquímica é uma ferramenta útil para o diagnóstico de sarcoma de Kaposi, especialmente na lesão inicial cujo caráter neoplásico não é evidente, e contribui para seu diagnóstico diferencial histológico. (fiocruz.br)
  • Human herpesvirus 8 (HHV-8) is etiologically associated with Kaposi sarcoma (KS), the most common AIDS-associated malignancy. (ashpublications.org)
  • The breakthrough came in 1994, when the Kaposi sarcoma-associated herpes virus (human herpesvirus type 8 [HHV-8]) was identified using representational difference analysis. (medscape.com)
  • HHV-8 has been linked closely with all 4 types of Kaposi sarcoma, ie, classic (traditional), endemic (African), epidemic (AIDS related), and iatrogenic (related to immunosuppression). (medscape.com)
  • [ 3 ] Since then, much research has shown that HHV-8 appears to be necessary to, but not sufficient for, the development of Kaposi sarcoma. (medscape.com)
  • Kaposi sarcoma and its causative agent, Karposi sarcoma-associated herpesvirus, have distinctive largely unexplained geographic distributions. (medscape.com)
  • Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in Israel. (cdc.gov)
  • Molecular epidemiology of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 strains from Russian patients with classic, posttransplant, and AIDS-associated Kaposi's sarcoma. (cdc.gov)
  • 3. Lacoste V, Kadyrova E, Chistiakova I, Gurtsevitch V, Judde JG, Gessain A. Molecular characterization of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 strains from Russia. (cdc.gov)
  • Seroprevalence of Kaposi's sarcoma-associated herpesvirus and risk factors in Xinjiang, China. (cdc.gov)
  • High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations. (cdc.gov)
  • Variability and evolution of Kaposi's sarcoma-associated herpesvirus in Europe and Africa. (cdc.gov)
  • Here, we show that the product of the K14 open reading frame from human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) interacts with human CD200R and is expressed at the surfaces of infected cells solely during the lytic cycle. (ox.ac.uk)
  • Their fundamental role in anti-viral responses has been unveiled in patients with NK cell deficiencies suffering from severe Herpesvirus infections. (frontiersin.org)
  • This lifelong challenge has contributed to the development of numerous evasion mechanisms by Herpesviruses, many of which devoted to elude NK cell surveillance from viral reactivations rather than primary infections. (frontiersin.org)
  • There is growing evidence that host cells try to control Herpesvirus infections by activating the autophagic machinery. (mdpi.com)
  • Panel on Sexually Transmitted Infections including those due to Human Immunodeficiency Virus, was posted on the WHO web site in February 2006 for a discussion and submission of comments by Member States. (who.int)
  • All herpesviruses establish lifelong infections in hosts. (nccu.edu)
  • Infectious causes of glomerulonephritis included streptococcal infections, human immunodeficiency virus (HIV) infection, and hepatitis viral infections, both hepatitis C (HCV) and hepatitis B (HBV). (medscape.com)
  • Famciclovir is a human antiviral agent used in the treatment of Feline Herpes (FHV-1) infections. (medi-vet.com)
  • The original VIPS study, completed in 2016, enrolled more than 700 children at 37 hospitals worldwide and established that common childhood infections, particularly herpesviruses, can trigger arterial ischemic stroke. (ucsf.edu)
  • Previous results indicate that the HHV-8 viral transactivator ORF50 interacts synergistically with Tat protein in the transactivation of human immunodeficiency virus (HIV) long terminal repeat (LTR), leading to increased cell susceptibility to HIV infection. (ashpublications.org)
  • Bull , T.M. et al "Primary pulmonary hypertension, Castleman's disease and human herpesvirus‐8. (ersjournals.com)
  • This cross-sectional study evaluated the presence of the Human Herpes Virus-8 genome in 138 formalin-fixed and paraffin-embedded (FFPE) breast cancer tissues, using real-time PCR. (org.ir)
  • The HHV-8 genome is normally around 170 kbp long and contains a lot more than 80 Rabbit Polyclonal to BCAS3 genes (40). (thetechnoant.info)
  • Open up reading structures with homology to genes of herpesvirus saimiri (HVS) 2514-30-9 had been numbered according with their position over the HVS genome. (thetechnoant.info)
  • Organized analyses of most HHV-8 genes for the consequences of one genes and gene combos on NF-B activity aren't available because of the huge genome of HHV-8, including at least 86 genes (36, 43). (thetechnoant.info)
  • The example that probably leaps first into people's minds is the human microbiome: the more that is discovered about important microbes living on and in us, the more the concepts of 'me'/'my'/'mine' (e.g., my body, my genome, my behavior) become hazier (a sort of metaphysical Dunning-Kruger effect ? (asmblog.org)
  • Some are embedded within the human genome. (asmblog.org)
  • Of these, some are harmless, defanged by the passage of time, like the endogenous retroviruses that comprise 1-8% of the human genome or the ribozymes related to the Hepatitis D virus. (asmblog.org)
  • Order Herpesvirales contains three families, the Herpesviridae, which contains the long-recognized herpesviruses of mammals, birds, and reptiles, plus two new families - the family Alloherpesviridae which incorporates herpes viruses of bony fish and frogs, and the family Malacoherpesviridae which contains viruses of molluscs. (wikipedia.org)
  • The Herpesviruses (family herpesviridae) are a very important group of double stranded DNA viruses that replicate inside the nuclei of their host cells. (rkm.com.au)
  • Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). (loinc.org)
  • The human herpes viruses (HHV) take part of a virus family - Herpesviridae- and these viruses have human as only host. (bvsalud.org)
  • HHV-8 immunohistochemical detection is an effective tool for diagnosing Kaposi's sarcoma, especially in early lesions in which neoplastic features are not evident. (fiocruz.br)
  • 4-6 Injection drug use may also be a risk factor for HHV-8 seropositivity, 7 although this association has not been consistently observed. (hiv.gov)
  • These closely related viruses are two of the nine known herpesviruses that have humans as their primary host. (wikipedia.org)
  • During maturation of HHV-6 virions, human cell membranes are used to form viral lipid envelopes (as is characteristic of all enveloped viruses). (wikipedia.org)
  • Upon infection many viruses, including Herpesviruses, target T cell function via specific interactions with TCR and HLA-I molecules. (frontiersin.org)
  • Herpesvirus simiae (B virus) is a member of the herpes group of viruses that is enzootic in rhesus (Macaca mulatta), cynomolgus (M. fascicularis) and other Asiatic monkeys of the genus Macaca. (cdc.gov)
  • This paper is a review about the human herpes viruses types, their treatments and emphasizes their oral manifestations. (bvsalud.org)
  • Herpesviruses however, generate a complicated balance with the host immune system through their latency cycle moving between immune control and viral reactivation. (frontiersin.org)
  • HHV-8 infection induces also HIV reactivation in chronically infected cell lines and in peripheral blood mononuclear cells (PBMCs) from patients with asymptomatic HIV, suggesting the possibility that similar interactions might take place also in vivo. (ashpublications.org)
  • [ 5 ] The "oncoweed" hypothesis states that biologic plants in the environment account for the lytic reactivation of human herpesvirus 8. (medscape.com)
  • Human herpesvirus 6 (HHV-6) is a herpesvirus that causes roseola infantum (or exanthema subitum [sixth disease]) in infants and children. (medscape.com)
  • The exact mechanism by which HHV-8 infection leads to neoplastic disease has not been fully elucidated, but seroconversion to HHV-8 antibody positivity virtually always precedes development of the tumors. (hiv.gov)
  • This extreme degree of morbidity and mortality has given the impression that B virus infection in humans nearly always results in severe or fatal disease. (cdc.gov)
  • A recent study offers new modellings of one of the virus' a surface proteins, and its receptor, on human cells. (pasteur.fr)
  • In contract with this, the inhibition of NF-B signaling delays the development of HHV-8-linked lymphomas within a mouse model (24) and regulates the creation of infectious HHV-8 virions (5, 50). (thetechnoant.info)
  • These studies indicate that the massive apoptosis induced by 3 mM butyrate could be diminished and delayed by reduction of butyrate concentration to 0.3 mM, thereby allowing expression of high levels of lytic-associated genes and production of high yields of HHV-8 virions. (houstonmethodist.org)
  • Is there an indication for serologic testing for human herpesvirus 8 (HHV-8) in asymptomatic HIV-infected children (compared with not testing) to guide clinical management? (hiv.gov)
  • The inset box shows the location of the 3 districts where samples were obtained during this study, Ust-Orda, Ulan-Ude, and Chita, as well as distribution of the molecular subtypes of HHV-8 strains characterized. (cdc.gov)
  • Unrooted phylogenetic tree of human herpesvirus 8 (HHV-8) strains generated by using the neighbor joining (NJ) method with a 586-bp fragment of the K1 gene. (cdc.gov)
  • Primary or transformed monocytic and endothelial cells were infected with a cell-free HHV-8 inoculum and subsequently infected with lymphotropic or monocytotropic strains of HIV. (ashpublications.org)
  • Similar to other herpesviruses, HHV-6 infects a wide variety of cells and remains latent after initial infection. (medscape.com)
  • Kaposi's sarcoma is the most common neoplasia diagnosed in AIDS patients and the expression of the human herpesvirus-8 (HHV-8) latent nuclear antigen-1 has been useful for its histological diagnosis. (fiocruz.br)
  • It protects HHV-8-contaminated cells against spontaneous apoptosis (25) and maintains the latent viral lifestyle routine (5, 67). (thetechnoant.info)
  • A study in which the Structural Virology team at the Institut Pasteur participated investigates the way this herpesvirus manages to infect human cells. (pasteur.fr)
  • The article shows how the virus interacts with a receptor on human cells, the EphA2 receptor, via a surface protein complex made of glycoproteins H and L (gH/gL). (pasteur.fr)
  • The prevalence of antibodies to HHV-8 varies widely with age, geography, and certain risk factors. (hiv.gov)
  • Using BCBL-1 cells that harbour HHV-8 but lack Epstein-Barr virus, we demonstrate that sodium butyrate is much more effective than the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) at inducing high levels of class II and III virus transcription and viral DNA replication, but also initiates apoptosis. (houstonmethodist.org)
  • Here, we analyze the effect of HHV-8 infection on HIV replication in monocyte-macrophage and endothelial cells, as potential targets of coinfection. (ashpublications.org)
  • The results show that HHV-8 coinfection markedly increases HIV replication in both cell types. (ashpublications.org)
  • Most individuals latently infected with HHV-8 are asymptomatic. (hiv.gov)
  • contributions interaction of vIL-6 protein to HHV-8 lytic biology. (ilgenetics.org)
  • 9 Patients who are HHV-8 seropositive and exhibit HHV-8 viremia are at increased risk (approximately nine-fold) for developing KS relative to those without HHV-8 viremia. (hiv.gov)
  • Therefore, routine testing to identify HHV-8-seropositive, HIV-infected patients is not recommended (strong, very low) . (hiv.gov)
  • 1 Since then, HHV-8 has been identified as the etiologic agent of all epidemiologic forms of KS, including classical, endemic African, and AIDS types. (ashpublications.org)
  • Map of Siberia (top) showing geographic distribution of human herpesvirus 8 (HHV-8) subtypes according to previous phylogenetic studies based on the complete or partial K1 gene/protein analysis. (cdc.gov)
  • The K1 gene of HHV-8 is expressed in tumor cells as a transmembrane protein with an immunoglobulin-like domain in its ectodomain and an immunoreceptor tyrosine-based activation motif (ITAM). (biomedcentral.com)
  • HHV-8 genes without homologous counterparts in HVS had been numbered individually and provided the prefix K (K genes) (16, 36, 40, 43). (thetechnoant.info)
  • Just a few HHV-8 genes have already been studied because of their effect on NF-B signaling. (thetechnoant.info)
  • Currently, it isn't known whether these genes will be the just HHV-8 genes which work on NF-B or whether different HHV-8 genes cooperate favorably or adversely in the legislation of this essential signaling pathway. (thetechnoant.info)
  • Organized analyses of most single-gene and pairwise-combination ramifications of HHV-8 genes on NF-B need nearly 4,000 transfection tests. (thetechnoant.info)
  • HHV-6 was the sixth herpesvirus discovered, and infection in humans is nearly ubiquitous in the first two years of life, with seroprevalence rates surpassing 95% in most studies. (medscape.com)
  • Among MSM without HIV infection, the seroprevalence ranges from 13% to 20% and HHV-8 seroprevalence increases to 30% to 35% among MSM with HIV infection. (hiv.gov)
  • [ 8 ] Acute HHV-6 infection is rare in immunocompetent adults but may manifest as a mononucleosislike illness characterized by fever, lymphadenopathy, and hepatitis . (medscape.com)
  • An infection with HHV-8 constitutively 2514-30-9 activates the transcription aspect nuclear factor-kappa B (NF-B) in endothelial cells and lymphocytes (25, 44). (thetechnoant.info)
  • The results suggest that HHV-8 might be a cofactor for HIV progression and that HHV-8-infected endothelial cells might play a relevant role in transendothelial HIV spread. (ashpublications.org)
  • Little 2514-30-9 interfering RNA-mediated knockdown of ORF75 manifestation demonstrated that gene contributes considerably to NF-B activation in HHV-8-contaminated cells. (thetechnoant.info)
  • Although the precise pathogenesis for these tumors remains unclear, infection with HHV-8 precedes their development. (hiv.gov)
  • The major mechanisms of recognition and effector responses employed by NK cells against Herpesviruses, related to their genomic organization will be addressed, including those allowing NK cells to generate memory-like responses. (frontiersin.org)
  • Human herpesvirus-8 (HHV-8) is a gammaherpesvirus that is present primarily in a state of low level persistence in primary effusion lymphoma cell lines. (houstonmethodist.org)
  • Recent reports of KS occurring at higher CD4 cell counts in the United States 26,27 suggest that clinicians caring for patients with HIV should be vigilant for the clinical manifestations of KS in patients at risk of HHV-8 infection, regardless of CD4 cell count. (hiv.gov)
  • Electron microscopy revealed a novel virus that they named Human B-Lymphotrophic Virus (HBLV). (wikipedia.org)
  • However, the constant stimulus provided by virus-host interplay has also favored NK-cell adaptation to Herpesviruses. (frontiersin.org)
  • 14.9% (95% CI: 12.4-17.4%) for human herpes virus 8 infection. (nature.com)
  • The report of a case of encephalitis caused by B virus in a monkey handler in 1932 indicated that B virus can be highly pathogenic for humans (1). (cdc.gov)
  • Seventeen additional cases of B virus infection in humans were described through 1973 (2)* and four cases, including the first known case of person-to-person transmission of the virus, occurred in Pensacola, Florida, in 1987 (5). (cdc.gov)
  • The purpose of the working group was to supplement existing methods with specific guidelines intended to minimize transmission of B virus infection from macaque monkeys to humans. (cdc.gov)
  • As with herpes simplex virus I infection in humans, primary infection with B virus in macaques may result in gingivostomatitis with characteristic buccal mucosal lesions, but it probably occurs frequently without such signs. (cdc.gov)
  • Except for one instance of person-to-person transmission, however, all cases of B virus infection in humans have occurred in persons exposed to monkeys or monkey tissues. (cdc.gov)
  • Both in vivo (8) and in vitro efficacy of acyclovir (Southwest Foundation for Biomedical Research, unpublished data) against B virus has been demonstrated. (cdc.gov)
  • Human herpesvirus 8 (HHV-8) virus interleukin-6 (vIL-6) is a cytokine that is secreted and most poorly translated into the endoplasmic reticulum (ER). (ilgenetics.org)
  • The herpesviruses cause many major diseases. (rkm.com.au)
  • 28 Immunocompetent children and organ transplant recipients infected with HHV-8 may develop a primary infection syndrome consisting of fever, rash, lymphadenopathy, bone marrow failure, and occasional rapid progression to KS. (hiv.gov)
  • Infection with human papillomavirus increases the probability of developing carcinoma of the cervix, which is the second leading cause of cancer- related mortality in females worldwide, killing some 240 000 women per year.1 Making a correct diagnosis of a sexually transmitted infection is essential for the provision of appropriate and effective treatment. (who.int)
  • Although it is commonly believed that transmission to humans occurs by exposure to contaminated monkey saliva through bites or scratches, such exposure has not been consistently documented. (cdc.gov)