Herpes viruses. Medical search. Frequent questions

B virus infection is extremely rare, but it can lead to severe brain damage or death if you do not get treatment immediately. (cdc.gov)
Symptoms typically start within one month of being exposed to a monkey with B virus infection, but could appear in as little as three to seven days. (cdc.gov)
Antiviral therapy, topical or oral, is an effective treatment for epithelial herpes infection. (medscape.com)
Infection occurs by direct contact of skin or mucous membrane with virus-laden lesions or secretions. (medscape.com)
After the primary infection, the virus spreads from the infected epithelial cells to nearby sensory nerve endings and is transported along the nerve axon to the cell body located in the trigeminal ganglion. (medscape.com)
Recurrent ocular HSV infection traditionally has been thought of as reactivation of the virus in the trigeminal ganglion, which migrates down the nerve axon to produce a lytic infection in ocular tissue. (medscape.com)
Varicella zoster virus (VZV) infection may activate dormant herpes simplex virus (HSV-1), leading to neuroinflammation and accumulation of Alzheimer's disease (AD)-related proteins in the brain, new research suggests. (medscape.com)
HSV-1 is a common chronic infection that is the cause of most oral herpes or cold sores. (cdc.gov)
They observed that the healthy virus outran the mutated version down nerves to the neuron body to insert DNA and establish infection. (sciencedaily.com)
May 31, 2023 Influenza epidemics, caused by influenza A or B viruses, result in acute respiratory infection. (sciencedaily.com)
Both the molecular and physical properties of a virus determine the course of infection. (news-medical.net)
The result of the present study is a first step towards the goal of developing a drug and we already have positive preliminary data showing that a herpes infection can be stopped for all types of herpes virus including the resistant strains. (news-medical.net)
A cold sore usually lasts two to three weeks with the first herpes infection. (aafp.org)
An infection with this virus type can also have serious consequences. (uni-wuerzburg.de)
Seventeen additional cases of B virus infection in humans were described through 1973 (2)* and four cases, including the first known case of person-to-person transmission of the virus, occurred in Pensacola, Florida, in 1987 (5). (cdc.gov)
This extreme degree of morbidity and mortality has given the impression that B virus infection in humans nearly always results in severe or fatal disease. (cdc.gov)
The frequency of mild or asymptomatic B virus infection, however, has never been adequately assessed. (cdc.gov)
The occurrence of the four 1987 cases of B virus infection prompted CDC to convene a working group to discuss guidelines for preventing B virus infection in monkey handlers. (cdc.gov)
The purpose of the working group was to supplement existing methods with specific guidelines intended to minimize transmission of B virus infection from macaque monkeys to humans. (cdc.gov)
As with herpes simplex virus I infection in humans, primary infection with B virus in macaques may result in gingivostomatitis with characteristic buccal mucosal lesions, but it probably occurs frequently without such signs. (cdc.gov)
Except for one instance of person-to-person transmission, however, all cases of B virus infection in humans have occurred in persons exposed to monkeys or monkey tissues. (cdc.gov)
The working group recognizes that B virus infection may occur in persons not handling live macaques. (cdc.gov)
One case of B virus infection occurred following the person's exposure to contaminated cell cultures of simian origin, and one case occurred after the patient had cleaned a monkey skull (2). (cdc.gov)
Although transmission of infection has not been documented for persons working with B virus in the laboratory, such work is potentially hazardous. (cdc.gov)
The working group also recognizes that the paucity of information regarding the transmissibility of B virus, the efficacy of measures to prevent transmission, and the chemotherapy of B virus infection have rendered these guidelines difficult to formulate. (cdc.gov)
Some children don't have symptoms with the first infection of herpes simplex virus. (uhhospitals.org)
The herpes simplex virus infection that causes cold sores is a life-long infection. (uhhospitals.org)
These medicines work best if started as soon as possible after the first sign of a herpes infection or recurrence. (uhhospitals.org)
The healthcare provider may advise keeping your child home from school during the first infection of herpes simplex virus. (uhhospitals.org)
A rare disorder caused by infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. (orpha.net)
The virus from cold sores can spread to the eyes, which can lead to HSV keratitis , an infection of the cornea-the clear dome that covers the colored part of the eye. (healthychildren.org)
Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion . (online-medical-dictionary.org)
To examine the sensitivity of human oral mucosa to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infection, human gingival mucosa explants were infected with either HSV-1 or HSV-2 in vitro and the expression of virus specific antigen was examined by the immunofluorescent antibody technique. (nih.gov)
These findings indicate that human gingival mucosa is sensitive to infection with HSV-2, as well as HSV-1, and that the virus may replicate in the undifferentiated epithelial cells of mucosal epithelium. (nih.gov)
Upon infection many viruses, including Herpesviruses, target T cell function via specific interactions with TCR and HLA-I molecules. (frontiersin.org)
Packaging cell PA317/TK was successfully constructed, and we acquired SW1990/TK through virus progeny infection. (wjgnet.com)
HHV-2, also known as HSV-2, causes genital herpes and occasionally causes oral disease that is clinically similar to that of HHV-1 infection. (medscape.com)
HHV-3, also known as varicella-zoster virus (VZV), causes the primary infection chickenpox and the secondary reactivation disease herpes zoster. (medscape.com)
HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
[ 5 , 6 ] In a localized primary infection, the virus penetrates the mucosal epithelium and invades the cells of the basal layer, where the viral DNA inserts into the host DNA. (medscape.com)
Objective: To investigate the effect of sodium polyanethol sulfonate (SPS) on herpes simplex virus type 1 (HSV-1) infection in vitro. (molvis.org)
Herpes simplex virus type 1 (HSV-1) infection is extremely common in humans, and approximately 50% and 75% of the adult populations in the United States [ 1 ] and Germany [ 2 ], respectively, have been infected with this virus. (molvis.org)
Several ND10 components are rapidly recruited to sites that are closely associated with herpes simplex virus type 1 (HSV-1) genomes during the earliest stages of infection, and this property correlates with the efficiency of ND10 mediated restriction of HSV-1 replication. (mdpi.com)
Human infection with herpes simplex viruses (HSV), in particular of type 1, is frequent and the responsible viruses are exclusively circulating in the human population. (dpz.eu)
The viruses first infect mucosal cells and then establish a latent infection in sensory ganglia. (dpz.eu)
Finally, infection of new world NHP and prosimians with HSV of humans and with herpes B virus can result in severe disease. (dpz.eu)
Herpes B virus infection of humans can be fatal. (dpz.eu)
Roughly 50 cases of herpes B virus infection of humans are known of which 21 took a fatal course. (dpz.eu)
However, important questions regarding herpes B virus infection remain unanswered. (dpz.eu)
It is unknown why all documented cases of human infection with herpes B virus occurred in the US, frequently within primate centers. (dpz.eu)
Moreover, it is unknown why herpes B virus infection was never observed in persons with frequent contact to macaques in the wild. (dpz.eu)
Antibodies against herpes B virus serve as marker for infection. (dpz.eu)
For detection of herpes B virus infection PCR (detects viral genomes) and ELISA/ Western blot (detect antibodies) are used. (dpz.eu)
After primary infection, herpes simplex virus type 1 (HSV-1) remains latent in neurons of the host. (gla.ac.uk)
During infection of cells with in1814 at low multiplicity of infection (MOI), only a minor proportion of infecting viruses undergo replication, whereas the majority of viral genomes enter a quiescent state. (gla.ac.uk)
In 2008, the Old World Monkey Taxon Advisory Group requested the assistance of Lincoln Park Zoo epidemiologists in conducting a risk analysis that sought to answer the question "What is the risk of AZA employees acquiring herpes B infection from macaques? (vin.com)
While there are no documented cases of B virus infection in humans from an exposure occurring in an AZA (Association of Zoos and Aquariums) institution, the advisory group sought to further understand the risk that may exist. (vin.com)
Neurotropic alphaherpesviruses initiate infection in exposed mucosal tissues and, unlike most viruses, spread rapidly to sensory and autonomic nerves where life-long latency is established 1 . (northwestern.edu)
This principle of viral assimilation may prove relevant to other virus families and offers new strategies to combat infection. (northwestern.edu)
Arduino PG, Porter SR. Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features. (medscape.com)
Jones CA, Walker KS, Badawi N. Antiviral agents for treatment of herpes simplex virus infection in neonates. (medscape.com)
None of the therapies used as treatment gives a cure to the viral infection, once the drugs only have their effect during the virus active phase. (bvsalud.org)
Genital herpes is a sexually transmitted infection. (medlineplus.gov)
Herpes simplex virus infection appears to double the risk of developing Alzheimer's disease (AD), claim Swedish researchers in two separate studies. (medscape.com)
In a nested case-control study , Hugo Lövheim, MD, PhD, from Umeå University, in Sweden, and colleagues found that the risk for AD was significantly associated with prior herpes simplex virus type 1 (HSV1) infection. (medscape.com)
Herpes simplex infection is treatable with antiviral drugs, like acyclovir, so there is at least the possibility that treatment with those drugs might also be able to affect the progression to Alzheimer's disease," he said. (medscape.com)
Including human immunodeficiency virus (HIV) infection that leads to acquired immunodeficiency syndrome (AIDS), they have been recognized as a major public health problem for many years. (who.int)
Herpes simplex virus type 2 infection is the leading cause of genital ulcer disease in developing countries. (who.int)
Herpes simplex virus type 2 infection plays an important role in the transmission of HIV. (who.int)
A vaccine to prevent hepatitis B virus infection, and thereby reduce the incidence of liver cancer, exists. (who.int)

HSV-2 is typically sexually transmitted and causes genital herpes but can also cause infections in the mouth. (cdc.gov)
Herpes virus infections are lifelong, with latency periods between recurring reactivations, making treatment difficult. (news-medical.net)
We hope that our research will contribute to the fight against viral infections that have so far been incurable', says Alex Evilevitch, Associate Professor and senior lecturer at Lund University who, together with his research team, Virus Biophysics, has published the new findings. (news-medical.net)
The drugs available today for combatting viral infections are highly specialised against the viral proteins, and if the virus mutates, which regularly occurs, the drug is rendered ineffective. (news-medical.net)
However, if you succeed in developing a treatment that attacks the physical properties of a virus, such as lowering the pressure inside the herpes virus shell, it should be possible to counter many different types of viral infections within the same virus family using the same drug. (news-medical.net)
Herpes simplex virus (HSV) is a virus that usually causes skin infections. (ny.gov)
There is growing evidence that host cells try to control Herpesvirus infections by activating the autophagic machinery. (mdpi.com)
Congenital Cytomegalovirus and Neonatal Herpes Simplex Virus Infections: To Treat or Not to Treat? (lww.com)
Over the past 2 decades, therapies have been recommended by the American Academy of Pediatrics Red Book Committee for the management of neonatal herpes simplex virus (HSV) and congenital cytomegalovirus (CMV) infections. (lww.com)
Their fundamental role in anti-viral responses has been unveiled in patients with NK cell deficiencies suffering from severe Herpesvirus infections. (frontiersin.org)
This lifelong challenge has contributed to the development of numerous evasion mechanisms by Herpesviruses, many of which devoted to elude NK cell surveillance from viral reactivations rather than primary infections. (frontiersin.org)
Members of the human herpesvirus (HHV) and human papillomavirus (HPV) families cause the most common primary viral infections of the oral cavity. (medscape.com)
Herpesviruses establish latent permanent infections in their hosts, although clinical signs of disease may not be detected. (medscape.com)
Primary ocular infections tend to appear in youths, and after primary infections are cleared, the virus hides in the trigeminal ganglia or cornea, where it maintains a state of latency. (molvis.org)
Herpes simplex virus (HSV) infections are usually chronically recurrent in the normal population and represent a significant cause of morbidity in immunocompromised patients. (unboundmedicine.com)
Molecular Evolution of Herpes Simplex Virus 2 Complete Genomes: Comparison between Primary and Recurrent Infections. (emmes.com)
Herpes simplex virus 1 (HSV-1) and HSV-2 are large, double-stranded DNA viruses that cause lifelong persistent infections characterized by periods of quiescence and recurrent disease. (emmes.com)
Herpes simplex virus infections in neonates and early childhood. (medscape.com)
Herpes simplex virus infections of the newborn. (medscape.com)
Managing genital herpes infections in pregnancy. (medscape.com)
Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. (medscape.com)
Corey L, Wald A. Maternal and neonatal herpes simplex virus infections. (medscape.com)
Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. (medscape.com)
Millions of viral sexually transmitted infections also occur annually, attributable mainly to HIV, human herpesviruses, human papillomaviruses and hepatitis B virus. (who.int)
A study in Mwanza (United Republic of Tanzania), showed that 74% of HIV infections in men and 22% in women could be attributable to the presence of herpes simplex virus type 2. (who.int)

High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations. (cdc.gov)
There, the virus genome enters the nucleus of a neuron, where it persists indefinitely in a latent state. (medscape.com)
The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted. (news-medical.net)
It does not lead to resistance and acts independently of mutations in the genome of the virus. (news-medical.net)
The virus consists of a thin protein shell, a capsid, and inside it lies its genome, the genes. (news-medical.net)
He, with the help of preclinical studies at the National Institutes of Health in the United States, has identified small molecules that are able to penetrate the virus and 'turn off' the pressure in the genome of the virus without damaging the cell. (news-medical.net)
The genome of the herpes simplex virus 1 was decoded using new methods. (uni-wuerzburg.de)
A comprehensive systems biological analysis of the herpes virus genome has caused some surprises. (uni-wuerzburg.de)
Until now, scientists had assumed that there are about 80 so-called open reading frames (ORFs) in the genome of herpes simplex virus 1 (HSV-1). (uni-wuerzburg.de)
Deep to the tegument is the icosahedral capsid (pale blue), that contains the DNA genome (red body in centre of virus). (rkm.com.au)
A key process in the herpesvirus life cycle involves the recruitment of an ATP-driven terminase to a unique portal vertex to recognize, package and cleave concatemeric dsDNA, ultimately giving rise to a pressurized, genome-containing virion 4,5 . (rcsb.org)
Although this process has been studied in dsDNA phages 6-9 -with which herpesviruses bear some similarities-a lack of high-resolution in situ structures of genome-packaging machinery has prevented the elucidation of how these multi-step reactions, which require close coordination among multiple actors, occur in an integrated environment. (rcsb.org)
To better define the structural basis of genome packaging and organization in herpes simplex virus type 1 (HSV-1), we developed sequential localized classification and symmetry relaxation methods to process cryo-electron microscopy (cryo-EM) images of HSV-1 virions, which enabled us to decouple and reconstruct hetero-symmetric and asymmetric elements within the pseudo-icosahedral capsid. (rcsb.org)
Finally, our atomic models of portal vertex elements reveal how the fivefold-related capsid accommodates symmetry mismatch imparted by the dodecameric portal-a longstanding mystery in icosahedral viruses-and inform possible DNA-sequence recognition and headful-sensing pathways involved in genome packaging. (rcsb.org)
This work showcases how to resolve symmetry-mismatched elements in a large eukaryotic virus and provides insights into the mechanisms of herpesvirus genome packaging. (rcsb.org)
Our 3D reconstruction of the portal-vertex also shows that one end of the viral genome extends outside the portal in the manner described for some bacteriophages but not previously seen in any eukaryote viruses. (gla.ac.uk)
We determined the genome sequences of viruses isolated from two subjects in the Herpevac Trial for Women who experienced primary HSV-2 genital disease and compared them with sequences of viruses isolated from the subsequent fifth or sixth episode of recurrent disease in the same individuals. (emmes.com)
Little genetic drift was detected in viruses shed by the same subjects following repeated reactivation events, suggesting strong selective pressure on the viral genome to maintain sequence fidelity during reactivations from its latent state within an individual host. (emmes.com)

As members of the Herpesviridae virus family, there are two strains of the herpes simplex virus, HSV-1, which is responsible for cold sores, and HSV-2, which is responsible for genital herpes. (eol.org)
It is associated with several types of recurring diseases, including cold sores, genital herpes, chicken pox, and shingles. (sciencedaily.com)
Cold sores are caused by a type of virus called herpes, which is contagious. (aafp.org)
Your doctor usually can tell if you have the type of herpes that causes cold sores by looking at the sores on your lips or mouth. (aafp.org)
The herpes virus stays in your body even when you don't have cold sores. (aafp.org)
If the virus becomes active again, it causes cold sores to return. (aafp.org)
Herpes simplex viruses of type 1 (HSV-1) are known to many people as the cause of unpleasant itching cold sores. (uni-wuerzburg.de)
About 70 percent of all adults in the U.S. are infected with HSV-1 and may shed virus in their saliva at any time during their lifetime, even if they don't have symptoms like sores in the mouth or cold sores. (ny.gov)
Newborns can sometimes get HSV-1 from close contact with someone who is shedding HSV-1 virus in their saliva or has an active HSV-1 outbreak (cold sores). (ny.gov)
Cold sores are small blisters around the mouth caused by the herpes simplex virus. (uhhospitals.org)
The most common cause of cold sores is the virus called herpes simplex virus 1. (uhhospitals.org)
A child is more at risk for cold sores if they live with someone infected with the herpes simplex virus. (uhhospitals.org)
Keep in mind that the virus may be in saliva even when there are no cold sores. (uhhospitals.org)
Cold sores (also called fever blisters or oral herpes) start as small blisters that form around the lips and mouth. (healthychildren.org)
In children, cold sores are usually caused by the herpes simplex virus type 1 (HSV-1). (healthychildren.org)
While the virus remains in the body for the rest of your life, the recurrence of cold sores is highly variable. (healthychildren.org)
When the virus does reactivate, cold sores tend form again at the same spot but usually not inside of the mouth. (healthychildren.org)
Herpesviruses are enveloped viruses that are prevalent in the human population and are responsible for diverse pathologies, including cold sores, birth defects and cancers. (rcsb.org)

The virus can occasionally turn deadly, resulting in encephalitis in some. (sciencedaily.com)
The report of a case of encephalitis caused by B virus in a monkey handler in 1932 indicated that B virus can be highly pathogenic for humans (1). (cdc.gov)
In rare cases, the herpes simplex virus can cause inflammation of the brain (encephalitis). (uhhospitals.org)
Kimberlin D. Herpes simplex virus, meningitis and encephalitis in neonates. (medscape.com)
Encephalitis and poor neuronal death-mediated control of herpes simplex virus in human inherited RIPK3 deficiency. (bvsalud.org)

In 'Shingles' or 'Herpes Zoster' painful skin rashes appear usually on the side of chest wall. (medindia.net)
It is caused by chicken pox virus called varicella zoster. (medindia.net)
Hizmali L. Herpes zoster (zona zoster). (turkiyeklinikleri.com)
Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus. (gla.ac.uk)
Distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neck. (medscape.com)
The HHV-3 causes Varicella, mainly in children, and, by reinfection, can be the cause of the appearance of Herpes-zoster. (bvsalud.org)

Congenital Cytomegalovirus and Neonatal Herpes Simplex Virus. (lww.com)
Application of the polymerase chain reaction to the diagnosis and management of neonatal herpes simplex virus disease. (medscape.com)

Although extensive antigenic cross-reactivity exists between the two viral types of herpes, a viral glycoprotein specific for herpes simplex virus type 2 (HSV-2) (designated gG-2) and a glycoprotein specific for herpes simplex virus type 1 (HSV-1) (designated gG-1) have been identified. (cdc.gov)

Herpesvirus family members are icosahedral DNA viruses. (medscape.com)
Herpes virions contain a large icosahedral capsid that has a portal at a unique 5-fold vertex, similar to that seen in the tailed bacteriophages. (gla.ac.uk)

HHV-1, also known as herpes simplex virus (HSV)-1, causes primary herpetic gingivostomatitis, or oral herpes. (medscape.com)
The HSV 1 and 2 are usually associated to Primary Herpetic Gingivostomatitis, Recurrent Labial Herpes and Reccurent Intra-Oral Herpes. (bvsalud.org)

Subsequently, the virus remains latent in the host and may reactivate spontaneously or in times of stress, resulting in shedding of virus in saliva and/or genital secretions. (cdc.gov)
When stimulation occurs, such as weakened immunity, corneal injuries, or ultraviolet exposure, latent viruses are activated, producing many infectious virus particles that result in recurrent keratitis. (molvis.org)

For over 30 years, physicians have assumed that any expectant mother with genital herpes lesions at delivery must deliver her baby by Caesarian section to minimize chances of transmission of the disease to the infant, although there was no clinical or research information supporting that practice. (scienceblog.com)
Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. (medscape.com)
Cesarean delivery for women presenting with genital herpes lesions. (medscape.com)

Unrooted phylogenetic tree of human herpesvirus 8 (HHV-8) strains generated by using the neighbor joining (NJ) method with a 586-bp fragment of the K1 gene. (cdc.gov)
Molecular epidemiology of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 strains from Russian patients with classic, posttransplant, and AIDS-associated Kaposi's sarcoma. (cdc.gov)
3. Lacoste V, Kadyrova E, Chistiakova I, Gurtsevitch V, Judde JG, Gessain A. Molecular characterization of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 strains from Russia. (cdc.gov)
These molecules proved to have a strong antiviral effect that was several times higher than the standard treatment against certain herpes types with the drug Aciclovir, as well as against resistant herpesvirus strains where Aciclovir does not work. (news-medical.net)
Genital herpes is usually caused by a different strain, herpes simplex virus type 2 (HSV-2), although both virus strains can cause sores in any part of the body. (healthychildren.org)

HSV is a DNA virus that commonly affects humans. (medscape.com)
Herpesvirus is widespread in humans and affects more than 90 percent of adults in the United States. (sciencedaily.com)
The virus can live dormant in humans for a lifetime, and most infected people do not know they are disease carriers. (sciencedaily.com)
Researchers at University of California, San Diego, suggest that the ancestors of modern humans may have caught herpes virus from chimpanzees before going their separate ways on the evolution path. (medindia.net)
According to the study, the ancestors of modern humans were infected by the Herpes Simplex Virus-1 from chimpanzees more than 6 million years ago, before the evolutionary split, while Herpes Simplex Virus-2, which causes genital warts, jumped from chimpanzees to Homo erectus 1.6 million years ago, long before the rise of early modern humans. (medindia.net)
The results help us to better understand how these viruses evolved and found their way into humans. (medindia.net)
Understanding where our viruses come from will help guide us in preventing future viruses from making the jump into humans", lead researcher Joel Wertheim said. (medindia.net)
The type species of SIMPLEXVIRUS causing most forms of non- genital herpes simplex in humans . (online-medical-dictionary.org)
In their natural hosts, these viruses display similar biological properties as HSV in humans. (dpz.eu)
It is believed that herpes B virus transmission to humans invariably causes disease. (dpz.eu)
Moreover, detection of herpes B virus-specific antibody responses in humans is complicated by the cross-reactivity of antibodies raised against HSV. (dpz.eu)
This paper was prepared in response to the need for clear communication regarding the risk of transmission of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 in humans and the general societal concern of potential contamination of aquatic animals used as food or their products with the virus. (who.int)

Our discovery marks a breakthrough in the development of antiviral drugs as it does not target specific viral proteins that can rapidly mutate, causing the development of drug resistance - something that remains unresolved by current antiviral drugs against herpes and other viruses. (news-medical.net)
Several cell membrane proteins have been identified as herpes simplex virus (HSV) entry mediators (Hve). (nih.gov)
These quiescent genomes can be reactivated by expression within the cell of the HSV-1 encoded protein Vmwl 10 and probably by other herpesvirus proteins functionally equivalent to Vmw110. (gla.ac.uk)

Acciptrid herpesvirus 1 (AcHV-1) is an unaccepted species of virus suggested to belong to the order Herpesvirales and family Herpesviridae. (wikipedia.org)
Other related viruses which may be members of the family Herpesviridae but have not been approved as species Acciptrid herpesvirus 1 (AcHV-1) (Bald eagle herpesvirus)[dead link] Docherty DE et al (1983) Avian Dis 27, 1162 Mahy, Brian W J (2001). (wikipedia.org)
This negatively-stained transmission electron micrograph (TEM) revealed the presence of numerous herpes simplex type-2 virions, members of the Herpesviridae virus family. (eol.org)
The Herpesviruses (family herpesviridae) are a very important group of double stranded DNA viruses that replicate inside the nuclei of their host cells. (rkm.com.au)
The human herpes viruses (HHV) take part of a virus family - Herpesviridae- and these viruses have human as only host. (bvsalud.org)

Herpesvirus simiae (B virus) is a member of the herpes group of viruses that is enzootic in rhesus (Macaca mulatta), cynomolgus (M. fascicularis) and other Asiatic monkeys of the genus Macaca. (cdc.gov)

The knowledge of the types of herpes virus, its clinical characteristics and oral manifestations is of paramount importance for the correct diagnosis of the disease to obtain treatment success and, consequently, maintenance of population health. (bvsalud.org)

Map of Siberia (top) showing geographic distribution of human herpesvirus 8 (HHV-8) subtypes according to previous phylogenetic studies based on the complete or partial K1 gene/protein analysis. (cdc.gov)
Scientists have identified a component of the herpesvirus that "hijacks" machinery inside human cells, allowing the virus to rapidly and successfully invade the nervous system upon initial exposure. (sciencedaily.com)
The team studied the herpesvirus in animals, and also in human and animal cells in culture under high-resolution microscopy. (sciencedaily.com)
Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. (news-medical.net)
To investigate the in vitro effects of suicide gene therapy system of herpes simplex virus thymidine kinase gene (HSV-TK) in combination with the treatment of nucleotide analog-ganciclovir (GCV) on human pancreatic cancer, and to provide a novel clinical therapeutic method for human pancreatic cancer. (wjgnet.com)
Herpes simplex viruses have also been isolated from non-human primates (NHP), including herpes B virus of macaques, SA8 of African green monkeys, herpes virus papio 2 (HVP-2) of baboons and saimiriine herpes virus 1 of squirrel monkeys (SaHV-1). (dpz.eu)
Human Herpes Virüsler. (turkiyeklinikleri.com)
This paper is a review about the human herpes viruses types, their treatments and emphasizes their oral manifestations. (bvsalud.org)

This negatively-stained transmission electron micrograph (TEM) revealed the presence of numerous herpes simplex virions, located inside a cell nucleus in this tissue sample. (eol.org)
Here, using herpes simplex virus type I and pseudorabies virus as model alphaherpesviruses, we show that a cellular kinesin motor is captured by virions in epithelial cells, carried between cells, and subsequently used in neurons to traffic to nuclei. (northwestern.edu)

Diagnosis of herpes simplex virus in the era of polymerase chain reaction. (medscape.com)

Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. (medscape.com)
Gentle epithelial débridement may be performed to remove infectious virus and viral antigens that may induce stromal keratitis. (medscape.com)
NATtrol Herpes Simplex Virus Type 2 (NATHSV2-0001, NATHSV2-0002, NATHSV2-0003, NATHSV2-0004, and NATHSV2-0005) is formulated with purified, intact viral particles that have been chemically modified to render them non-infectious and refrigerator stable. (zeptometrix.com)

Genital herpes affects the skin or mucous membranes of the genitals. (medlineplus.gov)

Herpes simplex virus (HSV) in infants can be severe. (cdc.gov)
Moreover, the saimiriine herpesvirus 1 (SaHV-1) can cause severe disease upon transmission to marmosets (callithrix spp), tamarines (saguinus spp) and owl monkeys (aotus trivirgatus). (dpz.eu)

Seroepidemiology and molecular epidemiology of Kaposi's sarcoma-associated herpesvirus among Jewish population groups in Israel. (cdc.gov)
Seroprevalence of Kaposi's sarcoma-associated herpesvirus and risk factors in Xinjiang, China. (cdc.gov)
Variability and evolution of Kaposi's sarcoma-associated herpesvirus in Europe and Africa. (cdc.gov)

Herpes simplex virus (HSV) is a lifelong virus that is categorized into two distinct herpesvirus species, herpes simplex virus 1 (HSV-1) and herpes simplex virus 2 (HSV-2). (cdc.gov)
Herpes B virus can display extreme neuropathogenicity upon transmission to species other than the natural reservoir (macaques). (dpz.eu)

Mothers should also follow appropriate hand hygiene practices to avoid transmission of herpes to her infant. (cdc.gov)
The Association campaigns against the transmission of herpes being treated as a criminal offence. (wikipedia.org)

Both in vivo (8) and in vitro efficacy of acyclovir (Southwest Foundation for Biomedical Research, unpublished data) against B virus has been demonstrated. (cdc.gov)
Medicines that fight viruses (such as acyclovir or valacyclovir) may be prescribed. (medlineplus.gov)

Herpesviruses however, generate a complicated balance with the host immune system through their latency cycle moving between immune control and viral reactivation. (frontiersin.org)
This delicate equilibrium can be altered in proportions of healthy individuals promoting virus reactivation and, more often, in immunocompromised subjects. (frontiersin.org)
In addition, the mechanisms underlying virus reactivation or control will be discussed. (frontiersin.org)

The major challenge lies in the fact that all existing antiviral drugs to treat herpes viruses lead to rapid development of resistance in patients with compromised immune systems where the need for herpes treatment is the greatest (e.g. newborn children, patients with HIV, cancer or who have undergone organ transplantation). (news-medical.net)

In captivity, as well as in the wild, sexually mature macaques are more likely to have been exposed to the virus and more likely than immature animals to be shedding virus at any given time. (cdc.gov)
Disease Risk Analysis: What is the Risk of AZA Employees Acquiring Herpes B Virus From Macaques? (vin.com)

Since all types of herpes viruses have similar structure and physical properties, this antiviral treatment works on all types of viruses within the herpes family. (news-medical.net)
2020) Pressurized DNA state inside herpes capsids-A novel antiviral target. (news-medical.net)

It's a one-two punch of two viruses that are very common and usually harmless, but the lab studies suggest that if a new exposure to VZV wakes up dormant HSV-1, they could cause trouble," Cairns said. (medscape.com)
Once a child is infected with the herpes simplex virus, the virus becomes inactive (dormant) for long periods of time. (uhhospitals.org)

Beyond the uncomfortable sores that the virus can cause, HSV is usually harmless. (healthychildren.org)
You are most likely to get HSV if you touch the skin of someone who has herpes sores, blisters, or a rash. (medlineplus.gov)
But the virus can still be spread, even when no sores or other symptoms are present. (medlineplus.gov)
Many people with genital herpes never have sores. (medlineplus.gov)

HSV-1 is typically transmitted by oral-oral contact to cause oral herpes but can also cause genital herpes through oral-genital contact. (cdc.gov)
The viruses also may be transmitted via oral-genital contact. (medscape.com)

In recent years it has been discovered that components of cellular nuclear structures known as ND10 or PML nuclear bodies contribute to intrinsic resistance against a variety of viruses, notably of the herpesvirus family. (mdpi.com)

Monoclonal antibodies and affinity chromatography have been used to purify these glycoproteins and thus provide antigens for type-specific herpes serologic assays. (cdc.gov)

Evidence suggests that the virus also may subsist latently within corneal tissue, serving as another potential source of recurrent disease and causing donor-derived HSV disease in transplanted corneas. (medscape.com)
Ichihashi M, Nagai H, Matsunaga K. Sunlight is an important causative factor of recurrent herpes simplex. (medscape.com)

Led by Gregory Smith, associate professor in immunology and microbiology at Northwestern University Feinberg School of Medicine, researchers found that viral protein 1-2, or VP1/2, allows the herpesvirus to interact with cellular motors, known as dynein. (sciencedaily.com)
Once the protein has overtaken this motor, the virus can speed along intercellular highways, or microtubules, to move unobstructed from the tips of nerves in skin to the nuclei of neurons within the nervous system. (sciencedaily.com)
Yet the herpesvirus uses one protein, no others required, to transport its genetic information over long distances without stopping. (sciencedaily.com)
Smith's team conducted a variety of experiments with VP1/2 to demonstrate its important role in transporting the virus, including artificial activation and genetic mutation of the protein. (sciencedaily.com)
In one experiment, scientists mutated the virus with a slower form of the protein dyed red, and raced it against a healthy virus dyed green. (sciencedaily.com)
Remarkably, this viral protein can be artificially activated, and in these conditions it zips around within cells in the absence of any virus. (sciencedaily.com)
Researchers in Pennsylvania say they've successfully stimulated the production of a pain-blocking protein in mice by using a modified herpes virus to attach the appropriate genes onto the animals' DNA. (scienceblog.com)
The treatment consists of new molecules that penetrate the protein shell of the virus and prevent genes from leaving the virus to infect the cell. (news-medical.net)
The HSV-1 protein Vmw65 is an essential structural component of the virus tegument. (gla.ac.uk)
Firstly, the regulatory region controlling transcription of the gene encoding the IE protein Vmwl 10 has been replaced by the Moloney murine leukaemia virus (MMLV) enhancer. (gla.ac.uk)
The findings explain a critical component of the alphaherpesvirus neuroinvasive mechanism and demonstrate that these viruses assimilate a cellular protein as an essential proviral structural component. (northwestern.edu)

most other viruses passively hitch a ride into the nervous system. (sciencedaily.com)
Overtaking the cellular motor to invade the nervous system is a complicated accomplishment that most viruses are incapable of achieving. (sciencedaily.com)
He says that understanding how the viruses move within people, especially from the skin to the nervous system, can help better prevent the virus from spreading. (sciencedaily.com)
Additionally, Smith says, "By learning how the virus infects our nervous system, we can mimic this process to treat unrelated neurologic diseases. (sciencedaily.com)
Even now, laboratories are working on how to use herpesviruses to deliver genes into the nervous system and kill cancer cells. (sciencedaily.com)

These are viruses that are used in immunological therapies of certain tumor diseases, such as malignant melanoma. (uni-wuerzburg.de)
The herpesviruses cause many major diseases. (rkm.com.au)

Genital herpes is a sexually- transmitted disease (STD) that affects the genitals. (medindia.net)
Hepatitis B virus, which may be transmitted sexually and through needle sharing, blood transfusion and from mother to child, results in an estimated 350 million cases of chronic hepatitis and at least one million deaths each year from liver cirrhosis and liver cancer. (who.int)

Sera from NHANES examinees aged 14-49 were tested for antibody to herpes simplex virus type 1 (HSV-1). (cdc.gov)

However, the constant stimulus provided by virus-host interplay has also favored NK-cell adaptation to Herpesviruses. (frontiersin.org)

However, it is well-known that Herpesviruses are smart pathogens and several, such as HSV-1, HCMV and HHV-8, are known to have developed numerous defense strategies for evading the host's immune response. (mdpi.com)

Anatomy16

Organisms103

Diseases36

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes43

Disciplines and Occupations1

Information Science4

Health Care4

Geographicals1

Infection70

Infections25

Genome18

Cold sores18

Encephalitis5

Zoster6

Neonatal herpes simpl2

Glycoprotein1

Icosahedral2

Primary herpetic gingivostomatitis2

Latent2

Genital herpes lesions3

Strains5

Humans12

Proteins3

Herpesviridae5

Simiae1

Types of herpes virus1

Human8

Virions2

Diagnosis1

Infectious3

Skin or mucous1

Severe2

Kaposi's3

Species2

Transmission of herpes2

Acyclovir2

Reactivation3

Treat herpes1

Macaques2

Antiviral2

Dormant2

Sores4

Oral-genital contact2

Notably1

Glycoproteins1

Recurrent2

Protein11

Nervous system5

Diseases2

Sexually2

Antibody1

Interplay1

Pathogens1