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  • Gastric Cancer
  • Phase III study designed to assess lapatinib in combination with chemotherapy for advanced HER2-positive gastric cancer in 2013 failed to meet the primary endpoint of improved overall survival (OS) against chemotherapy alone. (wikipedia.org)
  • antibody
  • The antibodies were characterized, and antibody pair combinations were evaluated in a two-site assay to find the antibody combination with the highest sensitivity towards native HER2. (bibsys.no)
  • In SKBR-3 cells, ZD1839 exhibited a greater growth-inhibitory effect than Herceptin, a monoclonal antibody against the HER2 ectodomain. (aacrjournals.org)
  • In the present study, a bispecific antibody was designed that links a conventional antigen‑binding fragment (Fab) against cluster of differentiation 3 antigen (CD3) to a camel single domain antibody (VHH) against human epidermal growth factor receptor 2 (HER2). (spandidos-publications.com)
  • The purified bispecific antibody is able to trigger T cell‑mediated HER2‑specific cytotoxicity in vitro and in vivo. (spandidos-publications.com)
  • The present study reports on a T-cell engaging bispecific antibody, cluster of differentiation (CD)3-S-Fab, which targets HER2 tumor cells. (spandidos-publications.com)
  • Distinct from previous studies (28-30), CD3-S-Fab was designed by linking a camel anti-HER2 single-domain antibody (VHH) to the C-terminal of a conventional anti-CD3 antigen-binding fragment (Fab). (spandidos-publications.com)
  • 1) The antibody component is guiding AVEC to the targeted molecule, e.g., to epidermal growth factor receptor 2 (HER2)on breast cancer cells. (wikipedia.org)
  • For example, the person vaccinated against hepatitis B virus, but suffering from HER2+ breast cancer receives AVEC consisting of the antibody against HER2 and vaccine against HBV (AVEC: anti-HER2 - HBV). (wikipedia.org)
  • Afatinib
  • Efficacy generated by afatinib in a lung adenocarcinoma patient harboring HER2 S310Y mutation. (bioportfolio.com)
  • Afatinib exhibits therapeutic efficacy for lung adenocarcinoma patients harboring HER2 exon 20 insertions. (bioportfolio.com)
  • pathway
  • Each dimeric receptor complex will initiate a distinct signaling pathway by recruiting different Src homology 2 (SH2)-containing effector proteins. (acris-antibodies.com)