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  • gene
  • Here, we used a genetic approach to disengage HIF activation from EPO synthesis and found that HIF-mediated suppression of the hepcidin gene (Hamp1) required EPO induction. (jci.org)
  • Mice deficient in the gene encoding erythroferrone have transient maturational hemoglobin deficits and impaired hepcidin suppression in response to plebotomy with a delayed recovery from anemia. (wikipedia.org)
  • agonists
  • Hepcidin agonists are a new class of compounds that regulate blood iron levels and limit iron absorption, and could improve the treatment of hemochromatosis, β-thalassemia, polycythemia vera, and other disorders where disrupted iron homeostasis causes disease or contributes to it. (bloodjournal.org)
  • Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease. (bloodjournal.org)
  • These data led us to suggest that therapeutics that could increase hepcidin levels or act as hepcidin agonists might help treat the abnormal iron absorption in individuals with β-thalassemia and related disorders. (jci.org)
  • plasma hepcidin
  • Net regional release was not calculated because mean venous plasma hepcidin concentrations were lower than mean arterialized concentrations indicating no net release. (hindawi.com)
  • Significant correlations between AbScAT venous and arterialized plasma hepcidin concentrations with anthropometric variables were not observed. (hindawi.com)
  • anemia
  • Here we demonstrate that a moderate increase in expression of hepcidin in β-thalassemic mice limits iron overload, decreases formation of insoluble membrane-bound globins and reactive oxygen species, and improves anemia. (jci.org)
  • demonstrate that increasing hepcidin expression to induce iron deficiency in murine β-thalassemia not only mitigates the iron overload, but also the severity of the anemia. (jci.org)
  • Before the recent discovery of hepcidin and its function in iron metabolism, anemia of chronic disease was seen as the result of a complex web of inflammatory changes. (wikipedia.org)
  • inhibits
  • ABT-207 is a humanized antibody that inhibits repulsive guidance molecule C and thus downregulate hepcidin. (psmarketresearch.com)
  • Erythroferrone is produced by erythroblasts, inhibits the action of hepcidin, and so increases the amount of iron available for hemoglobin synthesis. (wikipedia.org)
  • levels
  • GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance," Journal of Diabetes Research , vol. 2016, Article ID 1240843, 5 pages, 2016. (hindawi.com)
  • Patients with β-thalassemia also have low hepcidin levels. (jci.org)
  • Obesity is associated with elevated hepcidin concentrations and iron depletion suggesting that the exaggerated fat mass in obesity could contribute significantly to circulating hepcidin levels consequently altering iron homeostasis. (hindawi.com)
  • Higher ferritin and CRP levels as well as lower TIBC levels significantly predicted hepcidin levels in the study group, control group, and the entire sample. (hindawi.com)
  • There was no significant difference in hepcidin levels between the patients and controls. (hindawi.com)
  • Children with exacerbations had significantly higher hepcidin levels than those with stable disease. (hindawi.com)
  • OBJECTIVE: To determine hepcidin levels and markers of iron status during long-term exercise training in female runners with depleted and normal iron stores. (biomedsearch.com)
  • Hepcidin levels in the liver are dramatically depressed in these knockout animals. (wikipedia.org)
  • assays
  • The SW480 colorectal cancer cells were co-cultured with DAS in the presence or absence of leptin, IL-6 or hepcidin inhibitors and cellular viability and proliferation assays were performed. (spandidos-publications.com)
  • synthesis
  • While HIF, a central mediator of cellular adaptation to hypoxia, directly regulates renal and hepatic EPO synthesis under hypoxia, the molecular basis of hypoxia/HIF-mediated hepcidin suppression in the liver remains unclear. (jci.org)