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  • accumulate iron
  • These results begin to provide insight into fundamental ways in which iron is perturbed in cancer and suggest that the cancer cell has subverted this tightly regulated physiologic pathway to accumulate iron. (aacrjournals.org)
  • anemia of chro
  • This connection between hepcidin and inflammatory pathways has provided a molecular explanation for the pathophysiology of the anemia of chronic disease, a common and heretofore poorly understood consequence of many common medical conditions, including cancer. (aacrjournals.org)
  • pathway
  • Mounting evidence indicates that ERFE requires some basal BMP-SMAD activity, 4 but excessive activation of the BMP-SMAD pathway prevents its suppressive effects on hepcidin. (haematologica.org)
  • maternal
  • During pregnancy, fetal hepcidin controls the transfer of maternal iron across the placenta to the fetus. (sciencemag.org)
  • In primigravidae and their newborns, hepcidin and other iron parameters were evaluated in groups and classified according to placental P. falciparum and maternal anemia status. (ajtmh.org)
  • We conclude that maternal hepcidin is not significantly altered as a function of placental infection and/or anemia. (ajtmh.org)