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  • induction of hepcidin
  • Transferrin receptor-2 activation by its ligand holotransferrin led to extracellular signal regulated kinase (ERK)/mitogen activated protein kinase pathway stimulation and the ERK specific inhibitor U0-126 blunted holotransferrin-mediated induction of hepcidin. (haematologica.org)
  • In monocytes incubation with IL-6 and interferon- (INF) elevated hepcidin mRNA within a dose-dependent way, 10-fold greater than in charge hepatocyte civilizations (HepG2 cells), aswell as quicker (top induction of hepcidin mRNA in monocyte was at one hour of incubation and in HepG2 cells at 3 - 6 hours) (are necessary for defensive reasons. (research-matters.net)
  • Molecular
  • Our goal was to establish an ex vivo iron-sensing model and to characterize the molecular mechanisms linking iron to hepcidin. (haematologica.org)
  • Samples from these trials will be available for analysis using cutting edge platforms including 16S rRNA gene sequencing for microbiota, CyTOF and flow cytometry, and molecular characterization, for example using high throughput RNA sequencing. (edu.au)
  • iron metabolism
  • Using the recessive diplotype approach revealed a novel susceptibility hemochromatosis gene and has extended our understanding of the mechanisms involved in iron metabolism. (bloodjournal.org)
  • phylogenetic
  • Channel catfish hemoglobin genes: Identification, phylogenetic and syntenic analysis, and specific induction in response to heat stress. (auburn.edu)
  • Phylogenetic and gene synteny analyses showed that SsaMx1-SsaMx3 are most closely related to the main group of teleost Mx proteins. (readbyqxmd.com)
  • genome-wide
  • A genome-wide association study in catfish reveals the presence of functional hubs of related genes within QTLs for columnaris disease resistance. (auburn.edu)