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  • suggest that hepcidin
  • Emerging evidence from studies of inherited defects does however, suggest that hepcidin expression in the liver is influenced by hemojuvelin (HJV), transferrin receptor 2 [TfR2, a recently described liver-specific homolog of transferrin receptor-1 (TfR1)] and HFE. (haematologica.org)
  • induces
  • Bertinato J, Iskandar M, L'Abbe RM (2003) Copper deficiency induces the upragulation of the copper chaperone for Cu/Zn superoxide dismutase in weaning male rats. (springer.com)
  • iron-regulatory
  • During iron deficiency, IRPs inhibit the translation of FPN by binding to the iron regulatory element (IRE) located in the 5′ untranslated region (UTR) of FPN messenger RNA (mRNA), leading to lower FPN protein levels, decreased export of iron, and cellular iron retention . (prolekare.cz)
  • expression
  • Approaches to target hepcidin expression or function have emerged as attractive strategies to reverse the complications of functional iron deficiency. (bloodjournal.org)
  • Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. (biomedcentral.com)
  • Here, we report a novel iron-responsive mechanism for the post-transcriptional regulation of FPN, mediated by miR-485-3p, which is induced during iron deficiency and represses FPN expression by directly targeting the FPN 3′UTR. (prolekare.cz)
  • expression of immune-responsive genes, including hepcidin and defbl2, was altered, as shown by qPCR. (curehunter.com)
  • Mutations
  • Different mutations of HJV are responsible for juvenile hemochromatosis (or type 2 hemochromatosis), 1 a severe disease with an early onset, characterized by hepcidin insufficiency which leads to clinical complications of iron overload, in particular hypogonadism and cardiomyopathy. (haematologica.org)
  • infants
  • In infants, children, and adolescents, iron deficiency develops when iron requirements for growth surpass the supply from stores and diet. (cancertherapyadvisor.com)
  • Other non-hematologic manifestations of iron deficiency include diminished immunity and resistance to infection, decreased physical endurance and work capacity, and impairments in attention, concentration, and other cognitive functions, along with a variety of behavioral and neuropsychological abnormalities, especially in infants and children. (cancertherapyadvisor.com)