• The clinical course of individuals with MF is characterized by constitutional symptoms (fevers, night sweats, and weight loss), bone marrow myeloproliferation and reticulin/collagen fibrosis, worsening cytopenias, thrombosis, and progressive symptomatic splenomegaly. (cancernetwork.com)
  • Budd-Chiari syndrome is an uncommon condition induced by thrombotic or nonthrombotic obstruction of the hepatic venous outflow and is characterized by hepatomegaly, ascites, and abdominal pain. (medscape.com)
  • Periportal fibrosis had a negative relationship with abdominal pain (OR = 0.45) and hepatomegaly detected by physical examination and ultrasonography (ORs = 0.72 and 0.68), but it was associated with splenomegaly (ORs = 4.14 and 3.55). (ajtmh.org)
  • Splenomegaly can result in early satiety that further adds to weight loss, abdominal bloating, and severe left-upper-quadrant abdominal pain from splenic infarcts. (cancernetwork.com)
  • physical examination revealed low intercostals retraction, superficial polypnea, hepatomegaly and splenomegaly. (sld.cu)
  • Chronic myeloid leukemia is characterized by splenomegaly and leukocytosis, and shows first a chronic phase with few symptoms, and then the blastic phase that is similar to acute leukemia of fatal prognosis. (fundacionmapfre.org)
  • Splenomegaly, which occurs in about 50% of cases, is maximal during the 2nd and 3rd week and usually results in only a barely palpable splenic tip. (merckmanuals.com)
  • While not a curative option, ruxolitinib offers great palliative potential and results in significant reduction in splenomegaly and improvement in constitutional symptoms in the majority of treated patients, thus improving their quality of life and performance status. (cancernetwork.com)
  • Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
  • In the United States, the most common etiologies of splenomegaly are chronic liver disease, malignancies, and infections. (aafp.org)
  • 6 People who are born in tropical regions, global travelers, and military personnel deployed to tropical regions are at risk for parasitic infections that can lead to splenomegaly, most commonly schistosomiasis and chronic malaria. (aafp.org)
  • The presence of a radiologic opacity at this level in a patient with a history of chronic anemia with or whithout splenomegaly, or with previous splenectomy should rise the suspection of intrathoracic extramedullar hemopoiesis. (symptoma.com)
  • Cerezyme is a hydrolytic lysosomal glucocerebrosidase-specific enzyme indicated for treatment of adults and pediatric patients 2 years of age and older with Type 1 Gaucher disease that results in one or more of the following conditions: anemia, thrombocytopenia, bone disease, hepatomegaly or splenomegaly. (nih.gov)
  • Systemic examination of abdomen revealed tender hepatomegaly and splenomegaly. (pediatriconcall.com)
  • Specific oral hypoglycemic agents that interfere with serum en viagra efecto hace cuanto en tiempo la hombres ige levels, this disorder as the double helix on the upper intestine, compared with heparin immediately even before a definitive diagnosis can be delineated by prospective studies. (elastizell.com)
  • In the United States, infectious mononucleosis is a common etiology of splenomegaly in adolescents and young adults. (aafp.org)
  • Splenomegaly can be due to several mechanisms but is almost always a sign of a systemic condition. (aafp.org)
  • Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged children. (nih.gov)
  • Malaria and schistosomiasis are common in tropical regions, where as many as 80% of people may have splenomegaly. (aafp.org)
  • Physical examination will typically reveal splenomegaly, but abdominal ultrasonography is recommended for confirmation. (aafp.org)
  • Patient habits, travel, and medical conditions can increase risk of splenomegaly and suggest etiology. (aafp.org)