• In mouse hepatocytes, p38γ induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. (nature.com)
  • Fig. 1: p38γ phosphorylates Rb and promotes liver proliferation after PHx. (nature.com)
  • Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes. (joplink.net)
  • Small molecule that concentration dependently induces proliferation and enhances the functions of mature human primary hepatocytes. (axonmedchem.com)
  • Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. (nih.gov)
  • Among adult organs, the liver is unique in its intrinsic ability to regenerate after injury through the proliferation of fully differentiated cells. (atlasofscience.org)
  • It has already been established that a transient increase of transforming growth factor β1 (TGF-β1) in the liver promotes fibrosis with the formation of extracellular matrix (ECM) components and suppresses hepatocyte proliferation. (vin.com)
  • Prolonged overexpression of TGF-β1 suppresses cell proliferation, is pro-apoptotic, and induces a deposition of ECM proteins, resulting in fibrosis in major organs such as the liver. (vin.com)
  • Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)
  • Hepatocyte proliferation proceeded rapidly as indicated by two peaks of the mitotic index. (morfolhum.ru)
  • Journal Article] Transplantation of Thy1+ cells accelerates liver regeneration by enhancing the growth of small hepatocyte-like progenitor cells via IL17RB signaling. (nii.ac.jp)
  • The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • The only curative treatment for ALF is liver transplantation, but there are many restrictions on the application of liver transplantation because of financial considerations, a shortage of donor livers, and immunosuppression-related complications [ 3 ]. (springer.com)
  • Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
  • Therefore, MSCs may help resolve issues restricting the application of hepatocyte transplantation. (springer.com)
  • Acetaminophen (APAP) poisoning is one of the leading causes of acute hepatic failure and liver transplantation is often the only lifesaving alternative. (mdpi.com)
  • 13 ] investigated the use of CT texture analysis in liver regeneration prediction and found that texture analysis can be useful in predicting the liver regeneration rate in patients with liver transplantation. (hindawi.com)
  • Curative therapies for HCC include surgical resection, liver transplantation, and tumor ablation. (ajmc.com)
  • Considering the advantage of exosomes as its non-living nature and dosing adjustability over MSC, exosome will be one alternative of MSC transplantation. (biomedcentral.com)
  • [ 3 ] The HALT-C trial was a multicenter, randomized controlled study that evaluated whether long-term interferon would suppress HCV, prevent progression to cirrhosis, prevent liver cancer, and reduce the need for liver transplantation. (medscape.com)
  • Many patients are not candidates given the advanced stage of their cancer at diagnosis or their degree of liver disease and, ideally, could be cured by liver transplantation . (medscape.com)
  • and (iv) as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. (springer.com)
  • Clinical trials have shown that silymarin exerts hepatoprotective effects in acute viral hepatitis, poisoning by A. phalloides , toxic hepatitis produced by psychotropic agents and alcohol-related liver disease, including cirrhosis, at daily doses ranging from 280 to 800mg, equivalent to 400 to 1140mg of standardised extract. (springer.com)
  • Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis, cancer, and liver failure. (wjgnet.com)
  • Cirrhosis of the liver is the end stage of a complex process-resulting from hepatocyte injury and the response of the liver-that leads to partial regeneration and fibrosis of the liver. (medscape.com)
  • Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and conversion of the normal liver architecture into structurally abnormal nodules. (medscape.com)
  • The progression of liver injury to cirrhosis may occur over weeks to years. (medscape.com)
  • Coronal localizer magnetic resonance imaging (MRI) scan shows marked enlargement of the left lobe of the liver in another patient with cirrhosis. (medscape.com)
  • 1,2 Sustained inflammation, hepatocyte necrosis and regeneration, and fibrotic deposition lead to development of cirrhosis. (ajmc.com)
  • The pathogenesis and clinical manifestations of hepatitis B are due to the interaction of the virus and the host immune system, which lead to liver injury and, potentially, cirrhosis and hepatocellular carcinoma. (medscape.com)
  • Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)
  • Whereas in the past, HCC generally presented at an advanced stage with right-upper-quadrant pain, weight loss, and signs of decompensated liver disease, it is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis , using cross-sectional imaging studies and serum alpha-fetoprotein (AFP) measurements. (medscape.com)
  • There is also a growing problem with cirrhosis, which develops in the setting of nonalcoholic fatty liver disease (NAFLD), or nonalcoholic steatohepatitis (NASH). (medscape.com)
  • Specific medical therapies may be applied to many liver diseases in an effort to diminish symptoms and to prevent or forestall the development of cirrhosis. (medscape.com)
  • Given that the survival of mice was remarkably decreased, hepatocyte de-differentiation could be correlated with the protection of liver tissue. (nii.ac.jp)
  • Removal of two-thirds of the liver in mice causes the remaining liver tissue to regrow to its original size and restore function within 7-10 days . (medicalnewstoday.com)
  • Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. (nature.com)
  • We found that rhT β 4 significantly increased the survival rate of mice infected with MHV-A59 through inhibiting virus replication, balancing the host's immune response, alleviating pathological damage, and promoting repair of the liver. (hindawi.com)
  • These mice go on to develop the two forms of liver cancer that are most common in humans, suggesting that liver stem cells may be the cells of origin of these tumors. (vetscite.org)
  • The researchers found that infant mice lacking functioning NF2 in their livers developed dramatic overgrowth of liver stem cells, to the point of crowding out hepatocytes. (vetscite.org)
  • Mice that did not die from a lack of functioning liver cells soon developed the two major types of liver cancer, and the fact that stem cell overgrowth preceded tumor development strongly suggested that the undifferentiated progenitors were the source of the tumors. (vetscite.org)
  • Blocking the expression of NF2 in the livers of adult mice had minimal effect on the animals unless a portion of the liver was surgically removed, setting off the regeneration process and leading to the same stem cell overproliferation and tumor development. (vetscite.org)
  • Analyses of these mice revealed that Gadd45{beta} is required for liver regeneration, and the regenerative response is associated with selective attenuation of JNK2 isoform. (imperial.ac.uk)
  • To investigate liver cells more closely, a research team led by Dr. Hao Zhu from the Children's Medical Center Research Institute at UT Southwestern Medical Center used 14 different lines of mice, 11 of which they created for the new study. (nih.gov)
  • Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
  • The collected exosomes or MSCs were injected intravenously into liver injury mice that had been prepared by the intravenous con-A injection. (biomedcentral.com)
  • FABP4 expression was mainly distributed in liver sinusoidal endothelial cells (LSECs), which was significantly increased in HFD mice. (bvsalud.org)
  • Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
  • Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
  • During the course of hepatocyte necrosis, an intense accumulation of neutrophils is often observed within the liver microenvironment. (mdpi.com)
  • Silymarin protects against its toxic principle α-amanitin by preventing its uptake through hepatocyte membranes and inhibiting the effects of tumour necrosis factor-α, which exacerbates lipid peroxidation. (springer.com)
  • These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
  • To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)
  • Twenty-four male rat DCD donor livers were randomly and averagely divided into normal, static cold storage (SCS), NMP, and NMP combined with BMMSCs groups. (medscimonit.com)
  • Liver function, bile secretion, and pathological features of DCD donor livers were detected to evaluate the protective effects of NMP and BMMSCs on DCD donor livers. (medscimonit.com)
  • BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
  • BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. (medscimonit.com)
  • The following is a list of human hepatocyte nuclear factors (see also boxes to the right for additional information about these proteins): Members of the HNF1 subfamily contain a POU-homeodomain and bind to DNA as homodimers. (wikipedia.org)
  • Identification of small molecules for human hepatocyte expansion and iPS differentiation. (axonmedchem.com)
  • To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
  • While hepatocytes in zones 1 and 3 produce specific enzymes for metabolism, the function of those in zone 2 has been less clear. (nih.gov)
  • He is currently studying changes in metabolism, especially in the context of fatty liver disease (NAFLD) and diabetes. (lu.se)
  • To predict the regenerative rate of liver in patients with HCCs after right hepatectomy using texture analysis on preoperative CT combined with clinical features. (hindawi.com)
  • The use of texture analysis on preoperative CT combined with clinical features can be helpful in predicting the liver regeneration rate in patients with HCCs after right hepatectomy. (hindawi.com)
  • This may be explained by the fact that the remnant liver volume is inadequate after hepatectomy and cannot meet the body's normal metabolic needs and may directly lead to liver dysfunction, liver failure, and even death [ 7 - 9 ]. (hindawi.com)
  • To our knowledge, few studies have investigated the relationship between the results of CT texture analysis and rate of liver regeneration after right hepatectomy in patients with HCCs. (hindawi.com)
  • In this study we focus on the immunoreactivity of the monoclonal antibody VEGF (C-1) in order to analyze its expression in two cell populations of regenerating mouse liver (hepatocytes and endothelial cells) after partial hepatectomy, and two transplanted hepatocarcinomas (ES2 and SS1K). (unlp.edu.ar)
  • FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth. (nih.gov)
  • These functions (and especially functions involving the liver) include development and metabolic homeostasis of the organism. (wikipedia.org)
  • Liver homeostasis is maintained by midlobular zone 2 hepatocytes. (nih.gov)
  • Hepatocellular carcinoma (HCC) typically arises in fibrotic or cirrhotic livers, which are characterized by pathogenic angiogenesis. (cancerindex.org)
  • Philipp Kaldis is a professor in "Metabolic disorders and liver disease" at the Department of Clinical Sciences and a vice-coordinator of the Lund University Diabetes Centre (LUDC), where he contributes to the leadership of the centre. (lu.se)
  • There were decreases in ALT, liver necrotic areas, and the extent of apoptosis indicated by the single-stranded DNA index of groups that received multiple injections of MSC-derived exosomes, but an increase in the Ki-67 index. (biomedcentral.com)
  • Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)
  • Journal Article] Isolation of Bipotential Liver Progenitor Cells from Neonatal Mouse Liver. (nii.ac.jp)
  • Journal Article] Hepatocytic parental progenitor cells of rat small hepatocytes maintain a self-renewal capability after long-term culture. (nii.ac.jp)
  • These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
  • Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • The results showed strongly immunopositivity reaction for VEGF either in hepatocytes or endothelial cells of mouse regenerating liver. (unlp.edu.ar)
  • Unlike most organs, the liver has two major sources of blood. (medicalnewstoday.com)
  • The liver has a unique capacity among organs to regenerate itself after damage. (nih.gov)
  • HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
  • Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
  • Three hepatic veins remove blood from the liver. (medicalnewstoday.com)
  • Immunostaining against collagen I and III on normal liver tissues showed normal staining of the collagens in portal tracts, around the hepatic veins, as well as in the parasinoidal space (particularly centrolobular). (vin.com)
  • The primary venous drainage of the liver is through three large hepatic veins that enter the inferior vena cava adjacent to the diaphragm. (medscape.com)
  • Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of genes into proteins. (wikipedia.org)
  • Hence hepatocyte nuclear factors function to ensure liver specific expression of certain genes. (wikipedia.org)
  • The key TF were identified by functional enrichment analysis from the list of differentially expressed genes identified in liver samples between 35 pigs fed with 1.5% or 3.0% soybean oil. (nature.com)
  • In the August 15 issue of Genes & Development, a Massachusetts General Hospital (MGH) research team describes finding that the protein called merlin, encoded by the NF2 (neurofibromatosis type 2) gene, controls the activity of adult stem cells that give rise to the two major types of liver cells. (vetscite.org)
  • 3 Over time, the accumulation of somatic genomic alterations in genes and epigenetic modifications in hepatocytes favors development of HCC. (ajmc.com)
  • Here, we identify a role for nuclear receptor-dependent bile acid signaling in normal liver regeneration. (nih.gov)
  • Others have implicated normal liver cells, called hepatocytes. (nih.gov)
  • Zhu and his team found that normal hepatocytes-not stem cells-in zone 2 did the bulk of the work of normal liver maintenance. (nih.gov)
  • The hepatic artery supplies 30% of the blood flow to the normal liver parenchyma but greater than 90% to hepatic tumors, including both HCC and metastatic lesions. (medscape.com)
  • Thus, accurate estimation of remnant liver volume and evaluation of remnant liver regenerative ability after surgery are of pivotal importance in avoiding postoperative liver insufficiency and even liver failure. (hindawi.com)
  • When hepatocytes were transplanted via the spleen, cells were distributed immediately in periportal areas, fibrous septa, and regenerative nodules of the cirrhotic liver. (elsevierpure.com)
  • Furthermore, we found that part of hepatocyte express SOX9 during formation of hepatocellular carcinoma induced by diethylnitrosamine. (nii.ac.jp)
  • Liver cancer is the third leading cause of cancer-associated mortality, of which hepatocellular carcinoma (HCC) represents 90% of all primary liver cancers. (wjgnet.com)
  • Hepatocellular carcinoma (HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. (wjgnet.com)
  • This review will examine the role mitochondria play in the pathophysiology of common liver diseases, including alcohol-related liver disease, non-alcoholic fatty liver disease, chronic hepatitis B and hepatocellular carcinoma. (imperial.ac.uk)
  • Journal Article] Identification and In Vitro Expansion of Adult Hepatocyte Progenitors from Chronically Injured Livers. (nii.ac.jp)
  • Since liver progenitors need to be poised to regenerate in case of injury, they may be particularly sensitive to the loss of merlin's regulatory function. (vetscite.org)
  • The recommended surveillance modality is abdominal ultrasound, but it is limited in obese patients and those with nonalcoholic fatty liver disease. (medscape.com)
  • The main risk factors for HCC include alcohol, tobacco, nonalcoholic fatty liver disease, and hepatitis B and C viruses, and an increase in incidence is anticipated due to the rise in hepatitis C infection corresponding to the opioid epidemic. (ajmc.com)
  • Mohammad, Ghulam Abstract: Probiotics are defined as live microbial food ingredients that produce several beneficial ef-fects to human health. (tu-dortmund.de)
  • Tissue regeneration is the process of renewal and growth to repair or replace tissue that is damaged or suffers from a disease. (labroots.com)
  • ON the other hand, Grhl2 null cholangiocytes isolated from chronically injured liver differentiated into hepatocytes in vitro. (nii.ac.jp)
  • Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)
  • Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
  • When hepatocytes were introduced with the intracellular domain of Notch 2 and Grhl2, they transdifferentiated into CK19(+) cholangiocyte-like cells after chronic injury. (nii.ac.jp)
  • The present study was conducted to evaluate the hepatoprotective effects of the Centella asiatica extract in carbon tetrachloride-induced liver injury in rats. (ijpsonline.com)
  • Centella asiatica extract exhibited hepatoprotective action against carbon tetrachloride-induced liver injury. (ijpsonline.com)
  • The present study reports the protective effects of a water-dispersable extract of Centella asiatica leaves in CCl 4 -induced liver injury in rats. (ijpsonline.com)
  • Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ levels. (medscimonit.com)
  • Researchers uncovered the roles that different cells in the liver play in organ maintenance and regeneration after injury. (nih.gov)
  • These findings show that which hepatocytes help in recovery after liver injury depends on the location of the injury. (nih.gov)
  • This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. (biomedcentral.com)
  • This research is undertaken to evaluate the effect of MSC-derived exosome on concanavalin-A (con-A)-induced liver injury. (biomedcentral.com)
  • Suppression of con-A-induced liver injury by injection of exosomes was observed as same extent as MSC. (biomedcentral.com)
  • In this study, we investigated the suppressive effect of exosomes on an immune-induced liver injury model. (biomedcentral.com)
  • The liver injury was induced by injection of concanavalin A (con-A), a lectin derived from jack beans. (biomedcentral.com)
  • This type of liver injury is mediated through activation of the adaptive immune system including natural killer and Kupffer cells, which is employed as a method to evaluate the induction liver tolerance [ 19 - 21 ]. (biomedcentral.com)
  • The suppressive effects of MSC-derived exosomes and the MSCs in this injury model were evaluated by the level of plasma alanine aminotransferase (ALT), histopathological examinations, the messenger RNA (mRNA) expression of pro- and anti-inflammatory cytokines, and the population alteration of regulatory T cells (Treg) among non-parenchymal liver cells (NPCs). (biomedcentral.com)
  • l liver protection: a variety of polysaccharides in Ganoderma lucidum have strong anti hepatotoxin properties, which show liver protection under chemical induced injury in the laboratory environment, including the protection of carbon tetrachloride, a highly toxic and lethal substance. (xuhuangbiotech.com)
  • l white peony extract can significantly improve the antioxidant capacity of liver and serum, thereby inhibiting liver injury and various inflammatory reactions caused by oxidative stress. (xuhuangbiotech.com)
  • Despite significant differences in pathophysiology between chronic liver diseases, common mitochondrial defects are described, including increased mitochondrial reactive oxygen species production and impaired oxidative phosphorylation. (imperial.ac.uk)
  • Understanding how these processes work could lead to new strategies to treat liver diseases and injuries. (nih.gov)
  • Expressed at higher levels in liver, skin and spleen. (joplink.net)
  • [ 2 , 3 ] The software application uses quantitative analysis of nuclear medicine liver-spleen images to determine the severity of liver disease and to predict clinical outcomes. (medscape.com)
  • [ 3 ] The developer notes that Hepatiq "automates the Quantitative Liver Spleen Scan (QLSS) that has been proven to be an accurate predictor of clinical outcomes in the recently concluded HALT-C [ H epatitis C A ntiviral L ong-term T reatment against C irrhosis] trial. (medscape.com)
  • Liver, spleen, kidney, heart, and lung samples were collected and fixed in 10% neutral buffered formalin and processed for routine histopathology and in liquid nitrogen for RNA real-time reverse transcription quantitative PCR. (cdc.gov)
  • moreover, treatment with silymarin was associated with an increase in survival in a placebo-controlled clinical trial in alcoholic liver disease. (springer.com)
  • Alcoholic hepatitis (AH) is a florid presentation of alcoholic liver disease characterized by liver failure in the context of recent and heavy alcohol consumption. (imperial.ac.uk)
  • BACKGROUND AND AIMS: Non-alcoholic liver disease (NAFLD) is emerging as the leading cause of end-stage liver disease with a serious threat to global health burden. (bvsalud.org)
  • It makes sense that cells in zone 2, which are sheltered from toxic injuries affecting either end of the lobule, would be in a prime position to regenerate the liver. (nih.gov)
  • The current study was designed to investigate the role of NF2 and merlin in the fetal and adult mouse liver, including possible involvement with tumor development. (vetscite.org)
  • However HNFs are also expressed and play important roles in a number of other tissues so that the name hepatocyte nuclear factor is somewhat misleading. (wikipedia.org)
  • ASCs are present in a number of posnatal tissues and are responsible for normal tissue renewal as well as for regeneration and healing after injuries. (bvsalud.org)
  • Enlargement of the left lobe and caudate lobe, believed to be the result of lobar-relative regeneration rather than fibrosis, secondary to an accident of vascular supply, is recognized by any cross-sectional technique, such as computed tomography (CT) scanning, magnetic resonance imaging (MRI), or ultrasonography (US), each depicted in the images below. (medscape.com)
  • We analyzed liver fibrosis using several molecular and biochemical techniques (Q-PCR, Western blotting, and semi-quantitative immunohistochemistry on ECM proteins). (vin.com)
  • In CCl4-induced rodent models of liver fibrosis, TGF-β1 and procollagen mRNAs were increased, including procollagen I, III, and IV. (vin.com)
  • In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
  • A protein known to be involved in a rare hereditary cancer syndrome may have a role in the regulation of liver stem cells and the development of liver cancer. (vetscite.org)
  • We found that mutation of the NF2 tumor suppressor gene in the mouse liver led to a dramatic overproliferation of liver stem cells - the cells that contribute to the liver's remarkable ability to regenerate," says Andrea McClatchey, PhD, of the MGH Center for Cancer Research, who led the study. (vetscite.org)
  • These liver stem cells have been identified in rodents, and potential equivalents found but not confirmed in humans. (vetscite.org)
  • Previous research also indicated that liver stem cells may be the source of some tumors in animals, and suggested that the tumor suppressor gene NF2 may help prevent tumor development. (vetscite.org)
  • and suggests that liver tumors may originate from liver stem cells and that excess EGFR signaling leads to liver tumor development. (vetscite.org)
  • Some studies have suggested that stem cells can produce new liver cells. (nih.gov)
  • We review the current literature on mitochondrial-targeted therapies, which have the potential to open new therapeutic avenues in the management of patients with chronic liver disease. (imperial.ac.uk)
  • Liver repopulation using disease-resistant hepatocytes will be applicable in chronic conditions, such as viral hepatitis or Wilson's disease. (elsevierpure.com)
  • Patients with advanced HCC are at a high risk of adverse effects because of baseline hepatic dysfunction, comorbidities associated with chronic liver disease, and potential drug−drug interactions. (ajmc.com)
  • 2005. Comparative hepatic toxicity: Prechronic/chronic liver toxicity in rodents. (nih.gov)
  • The hematoxylin and eosin (H&E) stain below depicts "ground-glass" cells seen in approximately 50-75% of livers affected by chronic HBV infection. (medscape.com)
  • Ground-glass cells are present in 50% to 75% of livers with chronic HBV infection. (medscape.com)
  • The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. (medscape.com)
  • The American Cancer Society estimates nearly 43,000 patients will be diagnosed with liver and intrahepatic bile duct cancers in 2020, with an estimated 30,160 deaths. (ajmc.com)
  • Histopathologic and immunohistochemical findings in the livers of neotropical nonhuman primates that died of yellow fever, Espirito Santo, Brazil, January 2017. (cdc.gov)
  • A complete understanding of the surgical and interventional approach to the liver requires a comprehensive understanding of its anatomy and vascular supply. (medscape.com)
  • The roles of the liver include detoxification, protein synthesis, and the production of chemicals that help digest food. (medicalnewstoday.com)
  • After subtotal resection, we found no additional mechanisms of liver damage such as enhanced synthesis of TNFa causing increased cell death. (morfolhum.ru)
  • Journal Article] Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver. (nii.ac.jp)
  • Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
  • Although radiation has been thought to be, based on findings in high dose ranges, harmful no matter low the dose is, recent investigation revealed that living organisms possess the ability to respond to low-dose radiation in very sophisticated ways. (go.jp)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • Lobules are the functional units of the liver and consist of millions of cells called hepatocytes. (medicalnewstoday.com)
  • The liver or bone marrow stores iron released from hemoglobin, which makes the next generation of blood cells. (medicalnewstoday.com)
  • The liver stores iron from hemoglobin in the form of ferritin, ready to make new red blood cells. (medicalnewstoday.com)
  • Cells involved in immune activity, Kupffer cells, are found in high numbers in the liver. (medicalnewstoday.com)
  • These cells destroy disease-causing viruses, bacteria, or other microorganisms that might enter the liver through the gut. (medicalnewstoday.com)
  • In addition, the remnant liver volume can not only directly reflect the amount of the normal hepatic cells, but provide the chance to further evaluate the hepatic function [ 10 , 11 ]. (hindawi.com)
  • It was observed that in male Wistar rats, the administration of asiaticoside derivatives of Centella asiatica caused the restoration of 40% of the damaged liver cells to normal state [ 4 ]. (ijpsonline.com)
  • At 1 week, transplanted cells were fully integrated in the liver parenchyma, along with expression of glucose-6-phosphatase and glycogen as reporters of hepatic function. (elsevierpure.com)
  • At 1 year, transplanted hepatocytes formed large clusters containing several-fold more cells than normal control animals, which was in agreement with increased cell turnover in the cirrhotic rat liver. (elsevierpure.com)
  • But the exact types of cells within the liver that do such repair-and where in the liver they're located-has been controversial. (nih.gov)
  • Each mouse line was engineered to have different groups of liver cells express a fluorescent marker. (nih.gov)
  • Those cells could then be tracked over time, before and after damage to different parts of the liver. (nih.gov)
  • They divided to replace liver cells in all zones that had reached the end of their natural lives. (nih.gov)
  • Further work identified a specific cell-signaling pathway that appeared to drive zone 2 liver cells to repopulate damaged tissue. (nih.gov)
  • In the same issue of Science , a second research team from the Shanghai Institute of Biochemistry and Cell Biology reported similar results using a different method for tracking the origins of new liver cells. (nih.gov)
  • HGF was cloned as a growth factor for hepatocytes ( 1 , 2 ), is identical to scatter factor (SF) and was originally discovered as a fibroblast-derived cell motility factor for epithelial cells ( 3 ). (spandidos-publications.com)
  • Phenotypical change of non-parenchymal liver cells was also evaluated by flow cytometry. (biomedcentral.com)
  • Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. (nature.com)
  • However, more investigation is needed to understand the different cell types in the human liver," Zhu says. (nih.gov)
  • In vivo experiments were conducted using a co-implantation xenograft mouse model with live cell imaging and immunohistochemistry. (cdc.gov)
  • The Barcelona Clinic Liver Cancer criteria used to guide treatment considers performance status and assessment of liver function by Child-Pugh score in addition to tumor size and location. (ajmc.com)
  • Because rodents typically feed at night, the degree of glycogen accumulation within hepatocytes is typically highest in the early morning hours and wanes throughout the day. (nih.gov)
  • The morphologic appearance of glycogen in hepatocytes is distinctive, allowing glycogen accumulation or depletion to be readily diagnosed in most cases. (nih.gov)
  • If, in contrast to the control animals, there is a treatment-related increase in glycogen in the hepatocytes, glycogen accumulation should be diagnosed in the treated animals and assigned a severity grade. (nih.gov)
  • As the name suggests, hepatocyte nuclear factors are expressed predominantly in the liver. (wikipedia.org)
  • Samples of regeneration liver, ES2 and SS1K tumors were processed for histology and immunostained with VEGF (C-1) mouse monoclonal IgG2a antibody. (unlp.edu.ar)
  • Other individuals have a multitude of the most severe symptoms of end-stage liver disease and a limited chance for survival. (medscape.com)