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  • induces
  • Therefore, TLR4-activation by LPS in hepatocytes induces a p62-mediated, not beclin1-mediated, autophagy-like clearance pathway that is hepatoprotective by clearing aggregate-prone or misfolded proteins from the cytosol and preserving energy homeostasis under stress. (hindawi.com)
  • tumor
  • The increase in genetic diversity within the liver could give rise to hepatocytes lacking proper growth control, potentially resulting in tumor formation and cancer. (plos.org)
  • In these mice, HBV replication is exquisitely sensitive to the inflammatory cytokines IFN-γ and tumor necrosis factor α, responding with a strong reduction of viral replication in all hepatocytes within 24-48 h of inoculation of virus-specific cytotoxic T lymphocytes ( 16 ). (pnas.org)
  • knockout mice
  • Our group previously showed that transplantation of wild-type bone marrow into fumarylacetoacetate hydrolase ( Fah ) knockout mice leads to the generation of fusion-derived hepatocytes , . (plos.org)
  • 2017
  • Das N et al (2017) Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice. (springer.com)
  • Hepatic
  • Hepatocytes are arranged around a central vein in units called lobules , in close association with branches of the hepatic portal vein, hepatic artery, and bile canaliculi. (encyclopedia.com)
  • Our study provides a comprehensive picture of the gene expression landscape in hepatocytes grown on different substrate stiffness, offering insights into the role of substrate stiffness in hepatic pathology. (springer.com)
  • viability
  • To maximize post-thaw viability and recovery of Corning cyropreserved hepatocytes, a cryohepatocyte recovery kit was developed (Cat. (corning.com)
  • Any increase in the temperature of the cryovials before an experiment threatens the viability, functionality, and activity of the hepatocytes. (thermofisher.com)
  • researchers
  • Comprehensive and cutting-edge, Hepatocyte Transplantation: Methods and Protocols is an ideal guide for researchers setting out in the rapidly progressing field of hepatocyte transplantation, as well as those who already have experience with this new therapy for liver disease. (springer.com)
  • The researchers "developed a system for mass manufacture of stem cell derived hepatocytes in numbers that would be useful for clinical application," creating possibilities for future "immune matched cell based therapies," says Hay. (medindia.net)
  • livers
  • We estimated the amount of hepatocyte turnover in the livers of three woodchucks undergoing clearance of a transient woodchuck hepatitis infection by determining the fate of integrated viral DNA as a genetic marker of the infected cell population. (pnas.org)
  • cytoplasmic
  • Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fine basophilic granules. (hindawi.com)
  • Under the electron microscope, chromatin margination, mitochondrial cristae disappearance, karyopyknosis and cytoplasmic vacuolization can be observed in the hepatocytes of mice treated with ritonavir. (sigmaaldrich.com)
  • Wistar
  • Hepatocytes were treated with plasma collected from Wistar rats that were fed a high-fat diet (HF), raspberry polyphenolic extract (PP), serine-type protease inhibitors as an agonist of TLR4 (TD) or a combination of PP with HF or TD treatments. (mdpi.com)
  • Hepatocytes isolated from male Wistar rats and C57Bl/6J mice were exposed to APAP for up to 24 h. (sigmaaldrich.com)
  • Methods
  • In Hepatocyte Transplantation: Methods and Protocols , an international panel of experts provide up-to-date laboratory and clinical techniques covering the many key areas necessary for successful transplantation, such as cryopreservation, quality assurance, detection of cell engraftment, and the future of the field with the development of foetal hepatoblasts and stem cell derived hepatocytes. (springer.com)
  • Development of enzymatic methods for isolated hepatocyte preparation. (elsevier.com)
  • normally
  • Virus infection of hepatocytes is not normally cytopathic and therefore, in chronic infections, particularly those not associated with disease, it is common for all hepatocytes to be persistently and productively infected. (pnas.org)
  • cellular
  • The 24-hour incubation with EGCG in concentrations of 10 μ mol/L and higher led to signs of cellular injury and to a decrease in hepatocyte functions. (hindawi.com)
  • experiments
  • Support for this notion comes from experiments with HBV transgenic mice, which replicate HBV in hepatocytes from a transgene that encodes the HBV pregenome ( 15 ). (pnas.org)