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  • heterogeneity
  • Therefore, the present review highlights the role of of SWI/SNF regulating lipid metabolism under nutritional and hormonal control, which may be associated with hepatocyte heterogeneity. (biomedcentral.com)
  • In this review, we have discussed that under the control of nutritional and hormonal signals, the regulation of hepatic lipid metabolism by SWI/SNF may be involved in the heterogeneity of hepatocytes. (biomedcentral.com)
  • Whereas some of the disagreement among reports must arise from the factors discussed above (ie, genetic, etiologic, and environmental heterogeneity), a substantial proportion may be because of poorly defined inclusion criteria or inadequate appreciation of the importance of statistical power and replication. (ahajournals.org)
  • assays
  • Tag SNPs were selected and genotyped using restriction digestion and fluorescence polarization assays for 128 nuclear families with 133 severely myopic (mean spherical equivalent [MSE] ≤ −10.0 D) offspring. (arvojournals.org)
  • insulin
  • Understanding how islet cells sense changes in the concentration of blood glucose is an important question for human health since defective glucose-stimulated insulin release is a contributory factor in non-insulin-dependent diabetes mellitus (NIDDM). (physiology.org)
  • pathogenesis
  • 3 Consequently, researchers must attempt to tease out what must be a dynamic interplay among heterogeneous genetic backgrounds, diverse environmental factors, and differential etiologies in the pathogenesis of this disorder, all of which make attempts to understand the genetic basis of hypertension a challenge. (ahajournals.org)
  • Virulence factors, pathogenesis, and vaccines. (springer.com)
  • VIII
  • 2. a preparation of factor VIII administered intravenously for the prevention or treatment of hemorrhage in patients with hemophilia A and the treatment of von Willebrand disease , hypofibrinogenemia , and coagulation factor XIII deficiency. (thefreedictionary.com)
  • human
  • Here, we showed in transgenic mice and HepG2 hepatoblastoma cells that monosaccharides (glucose and fructose) reduce human SHBG production by hepatocytes. (jci.org)
  • complex
  • Myopia is a complex trait in which multiple genes, multiple environmental factors, and their interactions have been all implicated. (arvojournals.org)
  • Genetic condition (e.g., monogenic and polygenic mutations) and environmental factor (e.g., overweight, obesity, and inactivity), and their complex interaction can contribute to development of DM. (ijbs.com)
  • The presence of C/EBPα in this complex was confirmed by supershift analysis with antiserum to this factor. (aspetjournals.org)
  • known
  • Both USF1 and nuclear factor-kappa B are well known to interact with STAT1, but the other five TFs are previously unreported STAT1 interaction partners. (curehunter.com)
  • treatment
  • 13 14 15 16 Others have also reported antiapoptotic actions of bFGF under serum-free treatment 17 18 and of VEGF under tumor necrosis factor-α treatment. (ahajournals.org)
  • suggest
  • The modular structure and the nuclear-cytoplasmic shuttling of c-Abl suggest that it integrates multiple signals to coordinate F-actin dynamics with the cellular decision to differentiate or to die. (biologists.org)