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  • PROTEIN
  • We have previously reported the discovery of an islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) that is predominantly expressed in islet β-cells. (diabetesjournals.org)
  • Islet-specific glucose-6-phosphatase (G6Pase) catalytic subunit-related protein (IGRP) is a putative enzyme that is specifically expressed in the islets of Langerhans ( 1 - 3 ), where it is localized predominantly in insulin-producing β-cells ( 4 ). (diabetesjournals.org)
  • J:106102 Carter AM, Nygard K, Mazzuca DM, Han VK, The expression of insulin-like growth factor and insulin-like growth factor binding protein mRNAs in mouse placenta. (jax.org)
  • C-reactive protein (CRP) an acute-phase reactant inflammatory protein is synthesized in hepatocytes in response to cytokines that are released from leucocytes within the tumor microenvironment. (hindawi.com)
  • Hnf6
  • Despite this success, many of the factors necessary for proper islet morphogenesis and function remain uncharacterized.We exploited the dysmorphic islets in Hnf6 transgenic animals as a tool to identify factors important for islet morphogenesis.This study provides a unique dataset that can act as a starting point for other investigators to explore the role of the identified genes in pancreatogenesis, islet morphogenesis and mature beta cell function. (nih.gov)
  • We exploited the dysmorphic islets in Hnf6 transgenic animals as a tool to identify factors important for islet morphogenesis. (nih.gov)
  • Here we report the identification of genes with an altered expression in Hnf6 transgenic animals and highlight factors with potential importance in islet morphogenesis. (nih.gov)
  • islet
  • Despite this success, many of the factors necessary for proper islet morphogenesis and function remain uncharacterized. (nih.gov)
  • First, most reports indicate that in isolated mouse islets and islet-derived cell lines, in which IGRP expression is high, G6Pase activity is low ( 6 - 9 ). (diabetesjournals.org)
  • Second, a similar low level of islet G6Pase activity is found in both rat and mouse islets ( 6 - 9 ), although IGRP is not expressed in the rat ( 3 ). (diabetesjournals.org)
  • Among these factors, the basic helix-loop-helix (bHLH) factor neurogenin3 (ngn3) plays a central role in initiating the differentiation of the islet cells. (diabetesjournals.org)
  • pancreas
  • In the adult pancreas, Foxo1 expression is restricted to β-cells ( 6 , 7 ), where it modulates metabolic flexibility (i.e., the ability to switch between glucose and lipids as a source of acyl-CoA for mitochondrial oxidative phosphorylation [ 8 ]) and enforces the β-cell fate, allowing β-cells to retain terminally differentiated features ( 9 ). (diabetesjournals.org)
  • Isl1
  • MN diversification depends on the coordinated action of several transcriptional regulators including the LIM-HD factor Isl1, which is crucial for MN survival and fate determination. (biologists.org)
  • We provide evidence that Onecut factors directly stimulate Isl1 expression in specific MN subtypes and are therefore required to maintain Isl1 production at the time of MN diversification. (biologists.org)
  • controls
  • RESULTS: In an intention-to-treat analysis, we found no significant difference between groups in 6-month cumulative mortality: 44.4% of patients died in the intensive enteral nutrition group (95% confidence interval [CI], 32.2%-55.9%) and 52.1% of controls died (95% CI, 39.4%- 63.4%) (P ¼ .406). (ac.be)
  • growth
  • This cancer-related inflammation facilitates promotion and progression of tumor growth [ 6 ]. (hindawi.com)
  • survival
  • The primary end point was patient survival for 6 months. (ac.be)
  • family
  • A clear heritable predisposition to hypertensive renal disease exists that results in familial clustering, with family history of renal disease being the major risk factor for renal disease in hypertensive and diabetic subjects. (ahajournals.org)
  • function
  • The spatial arrangement of the G6Pase system also serves to limit the function of the G6Pase catalytic subunit, which, in permeabilized microsomal membrane preparations, demonstrates relatively nonspecific phosphatase activity ( 6 - 9 ). (diabetesjournals.org)
  • Patients
  • 001). Patients previously treated with anti-tumor necrosis factor agents or those with more than 1 resection were at greater risk for clinical recurrence. (ac.be)
  • major
  • In the absence of Onecut factors, we observed major alterations in MN fate decision characterized by the conversion of somatic to visceral MNs at the thoracic levels of the spinal cord and of medial to lateral MNs in the motor columns that innervate the limbs. (biologists.org)
  • control
  • Taken together, these data elucidate a comprehensive model wherein Onecut factors control multiple aspects of MN subtype diversification. (biologists.org)
  • model
  • However, the favored model includes a catalytic subunit and transporters for G6P, glucose, and phosphate ( 6 - 9 ). (diabetesjournals.org)
  • active
  • The G6Pase catalytic subunit has its catalytic site oriented toward the lumen of the endoplasmic reticulum, so a G6P transporter is essential for delivering G6P from the cytosol to this active site ( 6 - 9 ). (diabetesjournals.org)
  • similar
  • To account for this, Altmetric has included the context data for articles of a "similar age" (published within 6 weeks of either side of the publication date of this article). (nature.com)
  • studies
  • Studies are underway to better understand what awakens this factor and how it encourages epithelial cells to cease providing their services and instead to multiply, until becoming cancerous. (deduveinstitute.be)
  • Other linkage and association studies also indicated a connection between RGS4 polymorphisms and SCZ risk ( 4 - 6 ). (frontiersin.org)