ReceptorHNF4ReceptorsHNF4AProteinTranscription factorsDimerization cofactorProteinsHepatic nuclear factorMutationsRegulationHNF1aAlphaPromoterModulateLipidInhibitionInsulinBacteriaGenesCoagulationGeneticMolecularLiverCytochromeHumanPrimaryZebrafishComplementPathogenesisSerumDiagnosisSymbolSubstancesSourceCommonly
Receptor6
- HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical for liver development. (wikipedia.org)
- The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)
- In this report, DAX-1, a nuclear receptor family member with corepressor properties, was identified as a potent CAR regulator. (aspetjournals.org)
- MT 2 receptor is associated with 4 mutation . (guidetopharmacology.org)
- Damcott CM , Moffett SP, Feingold E, Barmada M, Marshall JA, Hamman RF, Ferrell RE (2003) Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. (umaryland.edu)
- With respect to cadherin 1 (CDH1) and fibroblast growth factor receptor 2 (FGFR2), the mutational rates for non-neoplastic colorectal mucosa were similar to those in sporadic CRC. (iiarjournals.org)
HNF45
- The ligand binding domain of HNF4, as with other nuclear receptors, adopts a canonical alpha helical sandwich fold and interacts with co-activator proteins. (wikipedia.org)
- This gene codes for hepatocyte nuclear factor 4-alpha (HNF4-α) protein also known as transcription factor 14 (TCF14). (wikipedia.org)
- MODY can result from mutations in any one of the six different genes, one of which encodes the glycolytic enzyme Glucokinase, associated with MO-DY2 and the other five encode transcription factors HNF4-alpha associated with MODY 1, HNF1-alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO-DY6. (scirp.org)
- HDAC3 and PROX1 co-localize extensively on the mouse liver genome, and are co-recruited by Hepatocyte Nuclear Factor 4α (HNF4α). (nih.gov)
- The acronym 'HNF4' stands for hepatocyte nuclear factor 4, a transcription factor that plays a crucial role in regulating genes involved in liver development, metabolism, and function. (spellchecker.net)
Receptors2
- Regulation of gene transcription is controlled in part by nuclear receptors that function coordinately with coregulator proteins. (aspetjournals.org)
- Hepatic cytochrome P450s, phase II enzymes and nuclear receptors are downregulated in a Th2 environment during Schistosoma mansoni infection. (harvard.edu)
HNF4A4
- Hepatocyte nuclear factor 4 alpha (HNF4A) has been suggested as a potential marker in these cases. (biomedcentral.com)
- HNF4A is a nuclear transcription factor that binds DNA as a homodimer. (biomedcentral.com)
- During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)
- In this study, we set out to find a novel molecular marker of RCC by using hepatocyte nuclear factor 4A (HNF4A), a transcription factor implicated in RCC progression and malignancy, as a blueprint. (lu.se)
Protein5
- Hatzis P, Kyrmizi I, Talianidis I. (2006) Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression. (forth.gr)
- Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
- complement component 4 binding protein b. (gsea-msigdb.org)
- poly(A) binding protein cytoplasmic 4 [S. (gsea-msigdb.org)
- adaptor related protein complex 4 subu. (gsea-msigdb.org)
Transcription factors3
- These findings underscore the importance of specific combinations of transcription factors and coregulators in the fine tuning of organismal metabolism. (nih.gov)
- This microbiota-diet interaction leads to changes in histone modification at active enhancers that are enriched for binding sites for signal responsive transcription factors. (biomedcentral.com)
- These findings suggest that the gut microbiome, under specific dietary exposures, stimulates a reprogramming of the enhancer landscape in the colon, with downstream effects on transcription factors. (biomedcentral.com)
Dimerization cofactor1
- To confirm that the selected candidate genes were regulated by dietary Mg(2+) availability, the expression levels of solute carrier family 41, member 3 (Slc41a3), pterin-4 α-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1α (Pcbd1), TBC1 domain family, member 4 (Tbc1d4), and uromodulin (Umod) were determined by RT-PCR analysis. (nih.gov)
Proteins1
- 5 , 6 In concordance with the role of nodal cilia in L-R asymmetry, mutations in the motor proteins Kif3A and Kif3B, and the transcription factor Foxj1 in the mouse have demonstrated that ciliary motility is important for L-R asymmetry. (bmj.com)
Hepatic nuclear factor1
- The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is necessary for proper development of islet β-cells. (diabetesjournals.org)
Mutations3
- Recent studies have shown that mutations in the transcription factor hepatocyte nuclear factor (HNF)-1α are the cause of one form of maturity-onset diabetes of the young (MODY3). (diabetesjournals.org)
- This mutation is located in a highly conserved region of the promoter and disrupts the binding site for the transcription factor HNF-4α, mutations in the gene encoding HNF-4α being another cause of MODY (MODY1). (diabetesjournals.org)
- Studies related to mutations in the MODY genes have led to a better understanding of the genetic causes of the Beta cell dysfunction as genetic factors plays a great role in this disorder. (scirp.org)
Regulation1
- Identifying the underlying molecular mechanisms by which BA regulation is disrupted by endogenous and/or xenobiotic factors will aid in not only understanding disease pathogenesis, but also providing novel strategies to prevent and/or treat diseases associated with BA dysregulation. (aspetjournals.org)
HNF1a4
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Hepatocyte Nuclear Factor 1 Alpha (HNF1a) in Tissue homogenates, cell lysates and other biological fluids. (wildpalm.net)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Hepatocyte Nuclear Factor 1 Alpha (HNF1a) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (wildpalm.net)
- Description: Quantitativesandwich ELISA kit for measuring Rat Hepatocyte nuclear factor 1-alpha (HNF1A) in samples from serum, plasma, cell culture supernates, tissue homogenates. (wildpalm.net)
- Identification of a novel hepatocyte nuclear factor-1 alpha (HNF1A) variant in maturity onset diabetes of the young type 3 (HNF1A-MODY). (cdc.gov)
Alpha6
- Direct interaction between CAR and DAX-1 was demonstrated with both alpha-screen and coimmunoprecipitation experiments, and this interaction was enhanced in the presence of the CAR activator 6-(4-chlorophenyl)imidazo[2,1- b ]thiazole-5-carbaldehyde O -(3,4-dichlorobenzyl)oxime (CITCO). (aspetjournals.org)
- Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha. (ucsf.edu)
- Description: A sandwich ELISA kit for detection of Hepatocyte Nuclear Factor 1 Alpha from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (wildpalm.net)
- Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. (harvard.edu)
- Objective: To investigate the mutation pattern in the different transcription factor genes with special reference to HNF1-alpha which are highly penetrant with 63% mutation carriers manifesting clinical diabetes by the age of 25 years. (scirp.org)
- 1998).Linkage and molecular scaning analysis of MODY 3/hepatocyte nuclear factor 1-alpha gene in typical familial type 2 diabetes: Evidence for novel mutation in exon 8 and 10. (scirp.org)
Promoter1
- Unlike hepatic expression, hepatocyte nuclear factor-4 binding to the promoter is not required for ectopic FVII expression, although Sp1 binding is essential. (figshare.com)
Modulate1
- T2DM is a complex trait where common genetic variants having modest individual effects act together and interact with environmental factors to modulate the risk of the disease. (scialert.net)
Lipid1
- Steatosis is a term used to denote lipid accumulation within hepatocytes. (nih.gov)
Inhibition1
- Results obtained in primary human hepatocytes further demonstrated DAX-1 inhibition of CAR-mediated CITCO induction of the CYP2B6 target gene. (aspetjournals.org)
Insulin1
- Sustained expression of Hnf6 also results in downregulation of the β-cell-specific transcription factor MafA and a decrease in total pancreatic insulin. (diabetesjournals.org)
Bacteria2
- Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)
- Although bacteria, Degenerating hepatocytes were noted (GenBank accession no. (cdc.gov)
Genes2
- Diet-induced obesity led to altered acetylation of lysine 27 on histone H3 (H3K27ac) and to altered monomethylation of lysine 4 on histone H3 (H3K4me1) at numerous loci, with concomitant changes in the expression of genes that were functionally relevant to intestinal cancers. (biomedcentral.com)
- Strong associations were also found for SNPs near the ODZ3 and CDH17 genes on chromosomes 4 and 8 (rs908084, p = 8.59 × 10(-9) and rs2514805, p = 1.22 × 10(-8), respectively). (cdc.gov)
Coagulation6
- Tissue factor/coagulation factor VII (fVII) complex formation on the surface of cancer cells plays important roles in cancer biology, such as cell migration and invasion, angiogenesis, and antiapoptotic effects. (figshare.com)
- coagulation factor X [Source:HGNC Symbol. (gsea-msigdb.org)
- coagulation factor XII [Source:HGNC Symb. (gsea-msigdb.org)
- coagulation factor V [Source:HGNC Symbol. (gsea-msigdb.org)
- coagulation factor VIII [Source:HGNC Sym. (gsea-msigdb.org)
- coagulation factor IX [Source:HGNC Symbo. (gsea-msigdb.org)
Genetic1
- The T2DM is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. (scialert.net)
Molecular1
- Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates. (ucsf.edu)
Liver2
- 1) Understanding the role of the physical environment and mechano-signal transduction in regulating hepatocyte function in healthy and diseased liver. (ucsf.edu)
- 3) Developing surgical strategies for efficient orthotopic engraftment of hepatocytes and hepatic organoids into the liver. (ucsf.edu)
Cytochrome1
- cytochrome P450 family 4 subfamily F m. (gsea-msigdb.org)
Human1
- [ 4 ] This possible role of bilirubin in early protection against oxidative injury, coupled with identification of multiple neonatal mechanisms to preserve and potentiate bilirubin production, has led to speculation about an as-yet-unrecognized beneficial role for bilirubin in the human neonate. (medscape.com)
Primary1
- Through transcriptomic analyses, we show that the nuclear factor I A (NFIA)-driven transcription network is active in primary RCC and that higher levels of NFIA confer a survival benefit. (lu.se)
Zebrafish1
- FIGURE 4 Confocal images of the motile cilia lining the zebrafish nasal (olfactory) pit. (xenbase.org)
Complement1
- complement factor B [Source:HGNC Symbo. (gsea-msigdb.org)
Pathogenesis1
- Since epithelial cell signaling during NEC has been an important factor in deciphering the pathogenesis of the disease [ 11 , 12 ], we focused this study on the epithelial cell methylome signature. (biomedcentral.com)
Serum1
- It was speculated that early discharge of term infants (before their serum bilirubin concentration peaks) could be a factor in the reemergence of this devastating neurologic affliction, and medical research focused on developing surveillance and treatment paradigms to eliminate the condition. (medscape.com)
Diagnosis1
- An intravenous glucose infusion rate greater than 8 mg/kg/min (normally, 4-6 mg/kg/min) strongly supports the diagnosis. (medscape.com)
Symbol1
- platelet factor 4 [Source:HGNC Symbol;Ac. (gsea-msigdb.org)
Substances1
- MRLs are derived for hazardous substances using the no-observed-adverse-effect level/uncertainty factor approach. (cdc.gov)
Source1
- von Willebrand factor [Source:HGNC Symbo. (gsea-msigdb.org)
Commonly1
- [ 1 ] The term kernicterus literally means "yellow kern," with kern indicating the most commonly afflicted region of the brain (ie, the nuclear region). (medscape.com)