• HNF4A Activity Verified in a DNA-binding Assay: HNF4A (TP317924, transcript variant 3) activity was measured in a colorimetric DNA-binding assay. (origene.com)
  • In fact, viral replication is not only regulated by host factors [ 9 ], but also can cause changes in the level and activity of host factors, which would result to severe hepatic damage due to cell dysfunction. (biomedcentral.com)
  • Electrophoretic mobility shift assays showed evidence of a factor(s) that binds to this sequence. (asm.org)
  • Although Smad8 Δ exon3 /Δ exon3 embryos are phenotypically normal, homozygotes of another hypomorphic allele of Smad8 (Smad8 3loxP ) containing a neomycin cassette within intron 3, phenocopy an embryonic brain defect observed in roughly 22% of Smad1 +/ − embryos analyzed at embryonic day 11.5. (asm.org)
  • Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. (acris-antibodies.com)
  • Other domains found in ILF include a nucleotide binding site, an N-glycosylation motif, a signal for ubiquitin-mediated degradation, and a potential nuclear localization signal. (patents.com)
  • Androgens and mesenchymal factors are essential extracellular signals for the development as well as the functional activity of the prostate epithelium. (nih.gov)
  • These tumor cells are derived from tissues where the lineage factors play essential developmental and maintenance roles. (pnas.org)
  • Recent studies of genomic amplification in cancer demonstrated that certain master regulatory factors, involved in both embryogenesis and subsequent tissue maintenance, are often selectively amplified in tumors arising from the lineages where the factors play an important developmental role ( 14 ⇓ ⇓ - 17 ). (pnas.org)
  • Recent studies have proposed a lineage-dependency (addiction) model of human cancer whereby amplification of certain lineage transcription factors predisposes a survival mechanism in tumor cells. (pnas.org)
  • This review examines the role of key transcription factors in various stem cell types, and emphasizes on their control of downstream gene expression, which ultimately contributes to cellular function. (stembook.org)
  • Among these factors, Shh is an epithelium-secreted ligand that plays a crucial role in prostate morphogenesis. (biologists.org)
  • In the present study, we identify a highly amplified transcription factor, GATA6 , in EAC using integrative genomic approaches and show that GATA6 has properties of a lineage-survival oncogene in EAC. (pnas.org)
  • Antibody supershift experiments indicated that the factor(s) is not related to NF-κB component p50 or p52. (asm.org)