Transcription factor hepatocyte nuclearProteinsProteinHNF1aIncluding glycogen storageHepaticGenesDifferentiationReceptorsPromoterMutationsMiceDeletionEpithelial CellsFoxa2Liver specificSpecificityModulateMorphologicalMesenchymalFunctionalExpressionReceptorPhysiologyDiabetesMeSHMouseAlphaRolesAmniotic fluidFamilyThyroidForkheadMolecularDownstreamCoagulationFunctionVitroHumanMutationDevelopmentGeneticBetaCellsGrowthLevels
Transcription factor hepatocyte nuclear2
- Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta. (uchicago.edu)
- The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver. (taconic.com)
Proteins7
- Hepatocyte nuclear factors (HNFs) are a group of phylogenetically unrelated transcription factors that regulate the transcription of a diverse group of genes into proteins. (wikipedia.org)
- These proteins include blood clotting factors and in addition, enzymes and transporters involved with glucose, cholesterol, and fatty acid transport and metabolism. (wikipedia.org)
- The following is a list of human hepatocyte nuclear factors (see also boxes to the right for additional information about these proteins): Members of the HNF1 subfamily contain a POU-homeodomain and bind to DNA as homodimers. (wikipedia.org)
- The HNF-1β protein is one of a large group of transcription factors called homeodomain proteins. (medlineplus.gov)
- Transforming growth factor family proteins like TGFß1 can oppose these effects. (medscape.com)
- To circumvent the hepatic functional redundancy of the Foxa proteins, we used the T-77 transgenic (TG) mouse line in which the -3-kb transthyretin (TTR) promoter functioned to increase hepatocyte expression of the Foxa2 cDNA. (duke.edu)
- 5 , 6 In concordance with the role of nodal cilia in L-R asymmetry, mutations in the motor proteins Kif3A and Kif3B, and the transcription factor Foxj1 in the mouse have demonstrated that ciliary motility is important for L-R asymmetry. (bmj.com)
Protein10
- The HNF1B gene provides instructions for making a protein called hepatocyte nuclear factor-1 beta (HNF-1β). (medlineplus.gov)
- Based on this role, the protein is called a transcription factor. (medlineplus.gov)
- Kutasy B, Friemacher F, Duess JW, Puri P. Prenatal administration of retinoic acid increases the trophoblastic insulin-like-growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. (medscape.com)
- Studies on rodent UGT genes have demonstrated that the transcription factors hepatocyte nuclear factor 1 (HNF1) and CAAT-enhancer binding protein are important positive regulators of UGT expression in the liver (Hansen et al. (aspetjournals.org)
- Silencing of TFEB decreases the level of autophagy-related protein LC3BII/I and increases p62 expression level in hepatocytes after exposure to Hcy. (lu.se)
- Although there are often found on insulin-like growth factor-1 binding protein excretion or indirectly. (lorenzopetrantoni.com)
- Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)
- Hatzis P, Kyrmizi I, Talianidis I. (2006) Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression. (forth.gr)
- Despite the massive reduction of Dio1 and Sepp1 mRNAs, significantly more corresponding protein was detected in primary hepatocytes lacking Secisbp2 than in cells lacking tRNA[Ser]Sec. Regarding selenoprotein expression, compensatory nuclear factor, erythroid-derived, like 2 (Nrf2)-dependent gene expression, or embryonic development, phenotypes were always milder in Secisbp2-deficient than in tRNA[Ser]Sec-deficient mice. (nih.gov)
- Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
HNF1a4
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Hepatocyte Nuclear Factor 1 Alpha (HNF1a) in Tissue homogenates, cell lysates and other biological fluids. (wildpalm.net)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Hepatocyte Nuclear Factor 1 Alpha (HNF1a) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (wildpalm.net)
- Description: Quantitativesandwich ELISA kit for measuring Rat Hepatocyte nuclear factor 1-alpha (HNF1A) in samples from serum, plasma, cell culture supernates, tissue homogenates. (wildpalm.net)
- Identification of a novel hepatocyte nuclear factor-1 alpha (HNF1A) variant in maturity onset diabetes of the young type 3 (HNF1A-MODY). (cdc.gov)
Including glycogen storage1
- Furthermore, these cells exhibited hepatic functions in vitro , including glycogen storage, albumin production, urea secretion and functional assessment of hepatocytes. (niscair.res.in)
Hepatic4
- Overexpression of hepatocyte nuclear factor (Foxa-2), a master regulator significantly enhances the hepatic differentiation by triggering targeted liver-specific gene expression for liver development. (niscair.res.in)
- Our study confirmed that induction of functional hepatocyte shows typical epithelial morphology, express hepatic genes and acquire hepatocyte functions. (niscair.res.in)
- Unlike hepatic expression, hepatocyte nuclear factor-4 binding to the promoter is not required for ectopic FVII expression, although Sp1 binding is essential. (figshare.com)
- 3) Developing surgical strategies for efficient orthotopic engraftment of hepatocytes and hepatic organoids into the liver. (ucsf.edu)
Genes7
- Hence hepatocyte nuclear factors function to ensure liver specific expression of certain genes. (wikipedia.org)
- As is the case with many transcription factors, HNFs regulate the expression of a wide variety of target genes and therefore functions. (wikipedia.org)
- MODY can result from mutations in any one of the six different genes, one of which encodes the glycolytic enzyme Glucokinase, associated with MO-DY2 and the other five encode transcription factors HNF4-alpha associated with MODY 1, HNF1-alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO-DY6. (scirp.org)
- Studies related to mutations in the MODY genes have led to a better understanding of the genetic causes of the Beta cell dysfunction as genetic factors plays a great role in this disorder. (scirp.org)
- Objective: To investigate the mutation pattern in the different transcription factor genes with special reference to HNF1-alpha which are highly penetrant with 63% mutation carriers manifesting clinical diabetes by the age of 25 years. (scirp.org)
- A forkhead transcription factor that regulates expression of metabolic GENES and is involved in EMBRYONIC DEVELOPMENT. (reference.md)
- A shortage of this transcription factor disrupts the activity of genes that direct the development and function of certain tissues and organs. (medlineplus.gov)
Differentiation5
- Several growth factors such as fibroblast growth factor (FGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF), promote cell proliferation and differentiation. (medscape.com)
- The transcription factors SPDEF and FOXA3 are both selectively expressed in epithelial cells lining the conducting airways, where they regulate goblet cell differentiation and mucus production. (nih.gov)
- We further provide evidence to support the hypothesis that transcription factors (TFs) required to drive induction, differentiation, and maintenance of midbrain dopaminergic neural progenitor cells which give rise to terminally differentiated SNpc neurons are uniquely involved in both developmental patterning and metabolism, a dual function unlike other TFs that program neurons in other brain regions. (frontiersin.org)
- We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
- Signals from these growth factors are integrated with environmental influences, such as lung fluid volume and hyperoxia, to cause cellular proliferation and differentiation. (medscape.com)
Receptors3
- HNF3α/FOXA1 (forkhead box A1) HNF3β/FOXA2 (forkhead box A2) HNF3γ/FOXA3 (forkhead box A3) Members of the HNF4 subfamily are nuclear receptors and bind to DNA either as homodimers or RXR heterodimers. (wikipedia.org)
- The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)
- Therefore, the expression of a number of growth factors and their receptors, all of which affect fetal lung development, is temporally and spatially regulated. (medscape.com)
Promoter1
- Using the electromobility shift and DNase I footprinting experiments, we have identified a hepatocyte nuclear factor 1-binding site in the mouse UGT1A1 promoter that confers responsiveness to both factors HNF1α and HNF1β in HEK293 cells. (aspetjournals.org)
Mutations2
- Diabetes in subjects with hepatocyte nuclear factor (HNF)-1α gene mutations (maturity-onset diabetes of the young [MODY]-3) is characterized by impaired insulin secretion. (diabetesjournals.org)
- Mutations in the hepatocyte nuclear factor (HNF)-1α gene cause the most common form of maturity-onset diabetes of the young (MODY), type 3 ( 1 ). (diabetesjournals.org)
Mice2
- The postnatal TG mice displayed significant reduction in serum glucose levels and in hepatocyte glycogen storage without increased serum levels of ketone bodies and free fatty acid suggesting that they are not undergoing a starvation response. (duke.edu)
- In conclusion, our model proposes that in response to reduction in hepatocyte glycogen storage, the TTR-Foxa2 TG mice survive by maintaining sufficient serum levels of glucose through gluconeogenesis using deaminated amino acids with dicarboxylate products of peroxisomal lipid beta-oxidation shuttled through the tricarboxylic acid cycle. (duke.edu)
Deletion2
- Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo. (taconic.com)
- Conditional deletion of Secisbp2 in hepatocytes significantly decreased selenoprotein expression. (nih.gov)
Epithelial Cells1
- HGF was cloned as a growth factor for hepatocytes ( 1 , 2 ), is identical to scatter factor (SF) and was originally discovered as a fibroblast-derived cell motility factor for epithelial cells ( 3 ). (spandidos-publications.com)
Foxa21
- The Forkhead box (Fox) transcription factor Foxa2 (HNF-3beta) and related family members Foxa1 (HNF-3alpha) and Foxa3 (HNF-3gamma) act in concert with other hepatocyte nuclear factors (HNF) to coordinately regulate liver-specific gene expression. (duke.edu)
Liver specific1
- The functional hepatocyte was determined by observing morphological changes, expression of liver specific markers through immunocytochemical analysis, qRT-PCR, Western Blot and specific liver function assays. (niscair.res.in)
Specificity1
- The factors that govern this specificity of UGT expression remain largely unknown. (aspetjournals.org)
Modulate2
- Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha. (ucsf.edu)
- T2DM is a complex trait where common genetic variants having modest individual effects act together and interact with environmental factors to modulate the risk of the disease. (scialert.net)
Morphological1
- HNF1B maturity-onset diabetes of the young (MODY) (previously named MODY5) is a syndrome due to heterozygous molecular anomalies of the hepatocyte nuclear factor (HNF)1B that may associate diabetes, morphological and functional abnormalities of the kidneys and of the pancreas, liver test anomalies, and genital tract malformations ( 1 , 2 ). (diabetesjournals.org)
Mesenchymal4
- We have developed a robust and efficient method to differentiate mesenchymal stem cells into induced functional hepatocytes, which exhibits characteristics of mouse hepatocytes. (niscair.res.in)
- Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)
- Growth factors are produced by mesenchymal tissue and are present in amniotic fluid. (medscape.com)
- A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer. (lu.se)
Functional1
- Apparently, induction of functional hepatocytes will pave a better cellular therapy or effective cell source within a short timeline to facilitate the development of hepatocytes for future clinical applications of regenerative medicine. (niscair.res.in)
Expression5
- Furthermore, we found novel nuclear targets of basal hepatocytic and ectopic FVII expression. (figshare.com)
- Many tumor microenvironments, including lymphoma and carcinoma, are enriched in immune suppressive cells that contribute to immune exhaustion by means expression of inhibitory ligands, suppressive cytokines, and tumor-promoting factors. (researchgate.net)
- Here, we investigate the relationship between Hcy-induced autophagy level and the expression of nuclear transcription factor EB (TFEB). (lu.se)
- Various growth factors, cytokines, and prostaglandins upregulate HGF gene expression, including basic fibroblast growth factor, oncostatin M, hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) ( 9 ). (spandidos-publications.com)
- By contrast, transforming growth factor (TGF)-β1 was demonstrated to markedly downregulate HGF gene expression ( 10 , 11 ). (spandidos-publications.com)
Receptor1
- The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)
Physiology1
- Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes. (lu.se)
Diabetes1
MeSH1
- Hepatocyte Nuclear Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Mouse1
- In hepatocyte-specific conditional mouse models, Secisbp2 gene inactivation is less detrimental than tRNA[Ser]Sec inactivation. (nih.gov)
Alpha1
- Description: A sandwich ELISA kit for detection of Hepatocyte Nuclear Factor 1 Alpha from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (wildpalm.net)
Roles2
- However HNFs are also expressed and play important roles in a number of other tissues so that the name hepatocyte nuclear factor is somewhat misleading. (wikipedia.org)
- Tissue factor/coagulation factor VII (fVII) complex formation on the surface of cancer cells plays important roles in cancer biology, such as cell migration and invasion, angiogenesis, and antiapoptotic effects. (figshare.com)
Amniotic fluid2
- Bedaiwy MA, Burlingame JM, Hussein M, Flyckt R, Assad R, Falcone T. Assessment of vascular endothelial growth factor, basic fibroblast growth factor and transforming growth factor levels in amniotic fluid. (medscape.com)
- The presence of growth factors in amniotic fluid indicates that lung development is not solely a pressure phenomenon. (medscape.com)
Family2
- Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)
- Lung development is regulated by several transcription factors, such as thyroid transcription factor 1 (TTF-1) family, hepatocyte nuclear family, and peptide growth factors. (medscape.com)
Thyroid1
- Thyroid transcription factor 1 (TTF-1) is thought to be the earliest embryologic marker associated with cells committed to pulmonary development. (medscape.com)
Forkhead1
- Scholars@Duke publication: Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. (duke.edu)
Molecular2
- Identifying the underlying molecular mechanisms by which BA regulation is disrupted by endogenous and/or xenobiotic factors will aid in not only understanding disease pathogenesis, but also providing novel strategies to prevent and/or treat diseases associated with BA dysregulation. (aspetjournals.org)
- Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates. (ucsf.edu)
Downstream1
- A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
Coagulation1
- Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. (taconic.com)
Function2
- Together, these results provide evidence for a major regulatory function of this liver-enriched transcription factor in UGT1A1 activity in both rodents and human. (aspetjournals.org)
- 1) Understanding the role of the physical environment and mechano-signal transduction in regulating hepatocyte function in healthy and diseased liver. (ucsf.edu)
Vitro1
- Glibenclamide uptake into hepatocytes was dramatically decreased in vivo and in vitro. (diabetesjournals.org)
Human1
- 12] "The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha. (tcdb.org)
Mutation1
- Hepatocyte nuclear factor-4-α is associated with 5 mutation . (guidetopharmacology.org)
Development3
- Oligohydramnios is considered to be an independent risk factor for the development of pulmonary hypoplasia. (medscape.com)
- Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model. (medscape.com)
- Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development. (uc.edu)
Genetic1
- The T2DM is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. (scialert.net)
Beta1
- The hepatocyte nuclear factor-1-beta and display the evidence of abnormal platelet of available. (lorenzopetrantoni.com)
Cells2
- Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
- Transcript-specific and gender-selective effects on selenoprotein mRNA abundance were greater in Secisbp2-deficient hepatocytes than in tRNA[Ser]Sec-deficient cells. (nih.gov)
Growth1
- Hepatocyte growth factor (HGF). (spandidos-publications.com)
Levels1
- Conversely, higher levels of BA and cyclooxygenase-2 (COX-2) are risk factors for inflammation and cancer of the colon. (cancerindex.org)