• Scholars@Duke publication: A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. (duke.edu)
  • Full-length (42 kDa) CCAAT/enhancer binding protein alpha (C/EBP alpha) (p42) has been implicated in the transcriptional activation of adipocyte genes including the 422(aP2) and C/EBP alpha genes during differentiation of 3T3-L1 preadipocytes. (duke.edu)
  • Cellular identity is determined by the transcriptional profile which comprises the subset of mRNAs, and therefore proteins, being expressed by a cell at a given point in time. (silverchair.com)
  • Considering the signaling pathway of TGFβ1 (an inhibitor of iNOS mRNA expression), silencing of RNA for TAK-1 upregulates membrane-bound fractalkine tripartite motif 28 (TRIM28)/transcriptional intermediary factor 1β (TIF1β) functions as an E3 ubiquitin ligase and specificity protein 1 negatively regulate TGFβ1 levels to upregulate the generation of peroxynitrite, leading to increased shedding of membrane-bound fractalkine via SP/NK1R signaling. (scientificarchives.com)
  • In addition, we found that TBS enhanced the expression of the adenosine monophosphate-activated protein kinase (AMPK) and inhibited the expression of transcription factors, such as CCAAT/enhancer-binding proteins (C/EBPs), sterol regulatory element-binding protein 1 (SREBP1), and peroxisome proliferator-activated receptor γ (PPARγ) in the liver and epididymal WAT as measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). (biomedcentral.com)
  • Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
  • Longer-term (24 and 48 h) treatment reduced the expression of lipogenic markers (FA synthase and sterol regulatory element-binding protein-1) and increased the expression of lipolytic [hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL)] and mitochondrial (peroxisome proliferator-activated receptor γ coactivator-1α and carnitine palmitoyltransferase 1) markers. (academic-accelerator.com)
  • The expression of regulatory molecules, TGF-β1/2, phospho-Akt (Ser473), PPARα, sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), hormone-sensitive lipase (HSL), and acyl dehydrogenases was analyzed in virus-infected hepatocytes. (academic-accelerator.com)
  • Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
  • OBJECTIVE: We identified lipocalin 2 (Lcn2) as a gene induced by dexamethasone and tumor necrosis factor-alpha in cultured adipocytes. (evanrosenlab.com)
  • Down-regulation of collagen and connective tissue growth factor expression with hepatocyte growth factor in lung fibroblasts from white scleroderma patients via two signaling pathways. (musc.edu)
  • Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis. (musc.edu)
  • D1398G Variant of MET Is Associated with Impaired Signaling of Hepatocyte Growth Factor in Alveolar Epithelial Cells and Lung Fibroblasts. (musc.edu)
  • M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. (musc.edu)
  • In vivo, the increase in CYP3A6 by hypoxia is associated with the increased expression and nuclear translocation of hypoxia-inducible factor-1 (HIF-1), activator protein 1 (AP-1), and constitutive androstane receptor ( Fradette and du Souich, 2003 ). (aspetjournals.org)
  • Description: A sandwich ELISA kit for detection of Hepatocyte Nuclear Factor 1 Alpha from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (wildpalm.net)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Hepatocyte Nuclear Factor 1 Alpha (HNF1a) in Tissue homogenates, cell lysates and other biological fluids. (wildpalm.net)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Hepatocyte Nuclear Factor 1 Alpha (HNF1a) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (wildpalm.net)
  • Description: Quantitativesandwich ELISA kit for measuring Rat Hepatocyte nuclear factor 1-alpha (HNF1A) in samples from serum, plasma, cell culture supernates, tissue homogenates. (wildpalm.net)
  • Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)
  • Description: A sandwich ELISA kit for detection of High Density Lipoprotein Binding Protein from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosistest.net)
  • Description: A sandwich ELISA kit for detection of Sialic Acid Binding Ig Like Lectin 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (therabio.org)
  • Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
  • The expression levels of LPL (lipoprotein lipase), HSL (Hormone-sensitive lipase), FAS (fatty acid synthase), and PPARα/PPARγ (peroxisome proliferator-activated receptor alpha/gamma) were significantly changed in the sheep preadipocytes during differentiation for 7 days. (academic-accelerator.com)
  • The Role of Membraneembedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling. (scientificarchives.com)
  • The adenosine monophosphate-activated protein kinase (AMPK) is a principal energy sensor, defined as a protein kinase activated by an increase in the AMP/ATP energy ratio [ 14 ]. (biomedcentral.com)
  • Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)
  • We have identified a 30-kDa isoform (p30) of C/EBP alpha that is expressed by 3T3-L1 adipocytes, mouse adipose tissue, and rat liver. (duke.edu)
  • ACADL is not only a key protein in the liver metabolism, but also an important regulator in lipid metabolism [ 8 , 9 ]. (animbiosci.org)
  • Tbx3 regulates liver organ friend development by curbing cholangiocyte along with favoring hepatocyte distinction within the hard working liver marijuana. (kinasepathway.com)
  • Although transfection of 3T3-L1 preadipocytes with a strong p30C/EBP alpha expression vector is insufficient to induce differentiation, this vector advances the differentiation program. (duke.edu)
  • During differentiation of 3T3-L1 preadipocytes and during hepatocyte development, the cellular p42C/EBP alpha/p30C/EBP alpha ratio changes, raising the possibility of a regulatory role. (duke.edu)
  • UDP-GlcNAc is then used for N-linked and O-linked glycosylation in the ER and Golgi and for O-GlcNAc modification of nuclear and cytoplasmic proteins by OGT (O-GlcNAc transferase). (biomedcentral.com)
  • Here, we discuss how transcription factors, and their unique position as the gatekeepers of cellular identity, are exploited in cell reprogramming protocols by exploring work focusing on one reprogramming paradigm - the transdifferentiation of hepatocytes to pancreatic beta cells (β-cell). (silverchair.com)
  • Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
  • Your protein identified and also related to regrowth were found to get right allied with various molecular, organic, as well as cellular functions. (kinasepathway.com)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • p30C/EBP alpha binds to the C/EBP sites within and activates reporter gene expression driven by the 422(aP2) and C/EBP alpha gene promoters. (duke.edu)
  • Compared with rabbits breathing room air, hypoxia in rabbits reduced the amount of CYP1A1, 1A2, 2B4, 2C5, and 2C16 proteins and increased the expression of CYP3A6. (aspetjournals.org)
  • In vivo, in rats, hypoxia increased the mRNA and protein expression of P-glycoprotein but did not affect the mRNA of breast cancer resistance protein and organic anion-transporting polypeptide 2. (aspetjournals.org)
  • Thirty five protein had been indicated for its expression in any five regenerating time items from the manage trials. (kinasepathway.com)
  • Beef has high nutritional value from children to seniors, is a rich source of protein (essential amino acids), iron, zinc, B vitamins and essential polyunsaturated fatty acids such as linoleic and linolenic acid [ 2 ]. (biomedcentral.com)
  • Here, we explore the evolution of reprogramming and directed differentiation approaches within the context of hepatocyte to β-cell transdifferentiation focussing on how the introduction of new techniques has improved our ability to generate β-cells. (silverchair.com)
  • Protease-activated receptors (PARs) and the neurokinin 1 receptor (NK1R) belong to the G protein-coupled receptor (GPCR) family. (scientificarchives.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human High Density Lipoprotein Binding Protein (HDLBP) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (tuberculosistest.net)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat High Density Lipoprotein Binding Protein (HDLBP) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (tuberculosistest.net)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) in samples from serum, plasma, tissue homogenates or other biological fluids. (therabio.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) in serum, plasma, tissue homogenates and other biological fluids. (therabio.org)
  • The particular obtained differential proteome and the immediate affiliation of the various healthy proteins could trigger a whole new knowledge of the regeneration mechanism. (kinasepathway.com)
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
  • Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
  • The key healthy proteins which were located differentially regulated through zebrafish caudal very b rejuvination involves keratin and its particular 10 isoforms, cofilin 2, annexin a3, bone alpha dog 1 actin, and also architectural meats. (kinasepathway.com)
  • AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
  • In vitro translation of wild-type C/EBP alpha mRNA or transient transfection with a wild-type C/EBP alpha vector gave rise to similar levels of p42 and p30. (duke.edu)
  • One well-established example of transdifferentiation is the conversion of hepatocytes to pancreatic β-cells. (silverchair.com)
  • Substance P (SP)/NK1R signals enhance shedding of membrane-bound fractalkine, whereas small interfering RNA for DUOX2 further increases membrane-bound fractalkine but decreases soluble fractalkine compared with cells treated with SP alone. (scientificarchives.com)
  • These nutrient-driven post-translational modifications are highly altered in cancer and regulate protein functions in various cancer-associated processes. (biomedcentral.com)
  • The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
  • Further, the GR gene expresses a splicing variant GRbeta, which does not bind glucocorticoids but functions as a dominant negative isoform for GRalpha. (brainimmune.com)
  • Inside Tbx3-deficient embryos, growth inside the hepatic epithelium can be seriously diminished, hepatoblasts neglect to delaminate, along with cholangiocyte as an alternative to hepatocyte distinction comes about. (kinasepathway.com)
  • Contractile activity and smooth muscle alpha-actin organization in thrombin-induced human lung myofibroblasts. (musc.edu)
  • The human GR protein is produced from 9 exons of the GR gene and is composed of 3 major subdomains, each of which has specific structural and functional properties. (brainimmune.com)
  • Overlap of 2 suggestive SNPs with likely TF binding sites suggests possible roles in disruption of gene regulation. (cdc.gov)
  • Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF. (umassmed.edu)
  • Mutational analysis revealed that p30 is an alternative translation product initiated at the third in-frame methionine codon of the C/EBP alpha message. (duke.edu)
  • and 3) describing the functions of cholesteryl ester transfer protein (CETP) in regulating the LDL:HDL ratio in humans, including therapeutic strategies targeting CETP. (biomedcentral.com)
  • Forkhead box I1 is a protein that in humans is encoded by the FOXI1 gene. (wikipedia.org)
  • This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or minor topic of these publications. (umassmed.edu)
  • This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID). (biomedcentral.com)
  • Cholesteryl Ester Transfer Protein in Alzheimer's Disease. (biomedcentral.com)
  • Molecular looks at claim that the main aim of Tbx3 is to preserve phrase regarding hepatocyte transcription components, including hepatic fischer aspect 4a (Hnf4a) along with CCAAT/enhancer holding health proteins (C/EBP), alpha (Cebpa), and to repress appearance associated with cholangiocyte transcription elements like Onecut1 (Hnf6) along with Hnf1b. (kinasepathway.com)