Hepatocellular liver transplantation. Medical search. Frequent questions

Application and success of orthotopic liver transplantation (OLT) has continued to grow, and liver transplantation has become accepted therapy for several causes of irreversible liver disease. (medscape.com)
Background: Orthotopic liver transplantation (OLT) is the most effective treatment for hepatocellular carcinoma (HCC) in patients with underlying cirrhosis and portal hypertension. (elsevierpure.com)
Spectral Doppler ultrasonographic waveform of the right hepatic artery in a 60-year-old man, 8 years after orthotopic liver transplantation. (medscape.com)
Pre-operative hepatic artery chemoembolization followed by orthotopic liver transplantation for HCC. (aetna.com)
Pre-operative use as a bridge to orthotopic liver transplantation for HCC. (aetna.com)
Patients with non-cirrhotic portal hypertension receiving EBL, other than EBL endoscopic treatment, previous transjugular intrahepatic portosystemic shunt (TIPS) implantation or orthotopic liver transplantation, occlusive portal vein thrombosis, patients with fundal varices only, patients with acute and/or uncontrolled variceal bleeding at baseline and insufficient medical/endoscopic records were excluded from this study. (springer.com)

Organ transplantation in Japan is regulated by the 1997 Organ Transplant Law which legalized organ procurement from "brain dead" donors. (wikipedia.org)
After an early involvement in organ transplantation that was on a par with developments in the rest of the world, attitudes in Japan altered after a transplant by Dr. Wada in 1968 failed, and a subsequent ban on cadaveric organ donation lasted 30 years. (wikipedia.org)
Liver transplantation is the 2nd most common type of solid organ transplantation. (msdmanuals.com)
He is an editorial board member of World Journal of Hepatology, Organ Transplantation. (wjgnet.com)

Nivolumab ( Opdivo , Bristol-Myers Squibb) has been approved by the US Food and Drug Administration (FDA) for use in the treatment of hepatocellular carcinoma (HCC) in patients who have previously been treated with sorafenib ( Nexavar , Bayer). (medscape.com)
Aetna considers percutaneous ethanol injection (PEI) medically necessary for the treatment of hepatocellular cancers (HCC) without extra-hepatic spread. (aetna.com)
Immunotherapy with dendritic cells and/or cytokine-induced killer cells for the treatment of hepatocellular carcinoma. (aetna.com)
In their article "Liver Transplantation for the Treatment of Hepatocellular Carcinoma,' Drs. Hanish and Knechtle provide a cogent review of many of the issues surrounding the management of hepatocellular carcinoma (HCC) in patients with cirrhosis. (cancernetwork.com)

We report a cluster of donor-derived cryptococcosis after liver and kidney transplantation in China. (cdc.gov)
Patients awaiting or had received liver or combined liver-kidney transplantation for hepatitis B including hepatitis B cirrhosis, hepatitis B liver cancer and fulminant hepatitis B. (knowcancer.com)
Chapters in this book present current challenges in the use of bone allografts in complex orthopedic procedures, in addition to dealing in depth with the use of hepatic and renal allografts in liver and kidney transplantation. (novapublishers.com)
Disadvantages to the donor include mortality risk of 1/600 to 700 (compared with 1/3300 in living-donor kidney transplantation) and complications (eg, bile leakage, bleeding) in up to one fourth. (msdmanuals.com)

As of May 2022, 194,777 liver transplants had been reported to the United Organ Sharing (UNOS) network since it created a national database in 1988. (medscape.com)

Dr. Wang holds memberships in the International Liver Transplantation Society (ILTS), European Association for the Study of the Liver (EASL), American Society of Transplantation (AST), and International Society for Infectious Diseases (ISID). (wjgnet.com)

Liver resection and liver transplantation (LT) remain the most effective treatments for HCC [ 2 ]. (ijbs.com)
In few patients who are diagnosed at an early stage, receipt of curative treatment (i.e., liver transplantation, resection, or ablation) and long-term survival may be possible. (thieme-connect.com)
[ 12 ] In his review of liver tumors and tumorlike liver lesions, Edmondson included a report of a 14-year-old girl with an unusually long survival following hepatic resection for liver cancer. (medscape.com)
Cost-Effectiveness Analysis of Liver Resection Versus Transplantation for Early Hepatocellular Carcinoma Within the Milan Criteria. (sgh.com.sg)
Systematic Review of Outcomes of Liver Resection for Early Hepatocellular Carcinoma Within the Milan Criteria. (sgh.com.sg)
Treatment with curative intent is possible in only 20% to 25% of cases and consists of resection or liver transplantation. (cancernetwork.com)
Common therapeutic approaches in the early stage of disease are surgical resection, ablation, and liver transplantation. (stanford.edu)
In addition, surgical resection and liver transplantation are restricted, and are suitable only for patients diagnosed with early stage disease ( 6 ). (spandidos-publications.com)
Potentially curative treatments, such as liver transplantation, hepatic resection, or local ablative therapies, having a 5-year survival of 40-70%, can only be offered to patients with early stage HCC. (medscape.com)
Survival and prognostic factors after transplantation, resection and ablation in a national cohort of early hepatocellular carcinoma. (cancercentrum.se)
Impact of patient, primary tumor and metastatic pattern including tumor location on survival in patients undergoing ablation or resection for colorectal liver metastases: A population-based national cohort study. (cancercentrum.se)
Microwave ablation versus resection for colorectal cancer liver metastases - A propensity score analysis from a population-based nationwide registry. (cancercentrum.se)

For a lack of more precise risk-stratification tools, current approaches to defining a target population in noncirrhotic NAFLD are limited to noninvasive tests for liver fibrosis, as a proxy for liver-related morbidity and mortality. (thieme-connect.com)
Hepatitis C virus (HCV) infection is the leading cause of liver transplantation in theUnited States and almost 80% of patients suffer a persistent chronic infection thatresults in fibrosis, cirrhosis and hepatocellular carcinoma. (nature.com)
Hepatic fibrosis is a pathological response to chronic liver injuries such as chronic alcohol consumption, non-alcoholic fatty liver disease (NAFLD) or chronic viral infections. (lu.se)
No antifibrotic compound has been approved for liver fibrosis and if the cause of the chronic injury is not solved, fibrosis can progress to cirrhosis. (lu.se)
NV556 decreased liver fibrosis in two animal models of Non-alcoholic steatohepatitis (NASH), STAM and methionine-choline-deficient (MCD) mice. (lu.se)
In summary, cyclophilin inhibition in liver fibrosis and HCC could be used as a potential therapeutic strategy, individually or in combination. (lu.se)

These criteria plus the absence of extrahepatic and major vessel involvement satisfy the Milan criteria, used to assess suitability of liver transplantation for patients who have cirrhosis and hepatocellular carcinoma. (msdmanuals.com)

1 The Hepato-Oncology Group, Gastro-Intestinal Surgery, Liver Transplantation and Hepatology, Fondazione IRCCS Istituto Nazionale Tumori (National Cancer Institute), Milan, Italy. (nih.gov)
Unfortunately, the majority of HCC patients are diagnosed with advanced-stage disease and are not candidates for potentially curative surgical interventions," said Adrian M. Di Bisceglie, MD, co-director, Saint Louis University Liver Center, and chief of hepatology, Saint Louis University School of Medicine, Missouri. (medscape.com)

This study aimed to assess whether there was a need to provide curative treatments for sub-centimeter hepatocellular carcinomas (HCCs) to patients at risk for high false positives. (medscimonit.com)
Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. (google.it)
In the United States, 80%-90% of primary hepatic tumors are hepatocellular carcinomas and 10%-15% are cholangiocarcinomas (CCA), both with high mortality rate, particularly CCA, which portends a worse prognosis. (wjgnet.com)

His principal research interests are in the transplant-related immune tolerance and genes associated with progression and recurrence of hepatocellular carcinoma in patients undergoing liver transplantation. (wjgnet.com)
Acquired hepatitis C from blood product transfusions is an important risk factor because the risk of hepatocellular carcinoma in patients with chronic hepatitis C and cirrhosis is highest (2-8% per year). (medscape.com)

The purpose of this study was to assess the diagnostic performance of multidetector computed tomography (MDCT) in the detection of hepatocellular carcinoma (HCC) in cirrhotic patients who are recommended for liver transplantation according to the Milan criteria. (eg.net)

The aim of this study was to evaluate the efficacy of sorafenib, compared to best supportive care (BSC), in two cohorts of patients which presented with hepatocellular carcinoma (HCC) recurrence after LT. (nih.gov)

Our results showed that up-regulation of circulating miR-148a, miR-1246 or miR-1290 at early-phase was significantly associated with HCC recurrence after liver transplantation. (oncotarget.com)

Post-liver transplantation tumor recurrence is a major challenge for hepatocellular carcinoma (HCC) recipients. (oncotarget.com)
We aimed to identify early-phase circulating microRNAs after liver transplantation for predicting tumor recurrence and survival of HCC recipients. (oncotarget.com)
Circulating microRNA profiles at early-phase (2-hour after portal vein reperfusion) after liver transplantation were compared between HCC recipients with (n=4) and without tumor recurrence (n=8) by microarray analyses. (oncotarget.com)
The level of early-phase circulating miR-1246 was positively correlated with serum AST and ALT levels in HCC recipients after liver transplantation. (oncotarget.com)
In conclusion, early-phase circulating miR-1246 is an indicator of hepatic injury and a novel prognostic biomarker for tumor recurrence and survival of HCC recipients after liver transplantation. (oncotarget.com)
20 reports of HBV infection among recipients of livers from were defined as unexpected, new,¶ reproducible laboratory donors who had no evidence of past or current HBV infection. (cdc.gov)
Investigation included review of laboratory data and medical in liver recipients after transplantation that were reported to records. (cdc.gov)
Recipients of a the Advisory Committee on Immunization liver from a donor with isolated total anti-HBc positive results can develop reactivation of hepatitis B after transplantation. (cdc.gov)
We report a cluster of donor-derived cryptococcosis infection in liver and kidney transplant recipients from the same donor in China. (cdc.gov)
A few livers come from deceased, non-heart-beating donors (called donation-after-cardiac-death [DCD] donors), but in such cases, bile duct complications develop in up to one third of recipients because the liver had been damaged by ischemia before donation. (msdmanuals.com)

ABSTRACT Serum levels of glutathione reductase (GR), glutathione S-transferase- (GST-) and malondialdehyde (MDA) were determined to evaluate their use in diagnosing hepatocellular damage in 75 children with liver disease. (who.int)

The Consensus Conference will be a shared effort between ILTS and the International Liver Cancer Association, both leading the management and guidelines in Transplant Oncology for primary liver cancer. (ilts.org)
Submit your clinical case on the topic of Transplant Oncology - Liver Transplantation for Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma for your chance to present at the Case Discussion Session at ILTS-ILCA 2024 Consensus Conference. (ilts.org)
Methods We investigated patients registered in the European Liver Transplant Registry (ELTR) database using multivariate Cox regression survival analysis. (unipi.it)
However, standard regimens often change during the course of a liver transplant recipient's life. (medscape.com)
Contact a transplant gastroenterologist or the liver transplant service for admission or prior to discharge. (medscape.com)
In the same year, a liver transplant was performed at Chiba University by Professor Komei Nakayama. (wikipedia.org)
In 2018, 8,250 patients received a liver transplant and 12,975 patients were on the waiting list for a liver transplant. (medscape.com)
As of June 30, 2017, nearly 83,925 liver transplant recepients were living with a functioning liver graft. (medscape.com)
Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: analysis of the us multicenter hcc transplant consortium. (cdc.gov)

Multivariate analysis revealed that ZIP4 was an independent predictor of overall survival ( P = 0.037) after liver transplantation. (ijbs.com)
Conclusion: Hypothyroidism is associated with poorer overall and recurrence-free survival of HCC patients receiving liver transplantation. (elsevierpure.com)
Aim: To investigate the levels of leptin and adiponectin in prediction of hepatocellular carcinoma (HCC) survival among patients without liver transplantation. (tmu.edu.tw)
Results: Gender, hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, high body mass index (BMI), diabetes mellitus (DM) history and Child-Pugh (CP) class were associated with leptin and adiponectin levels, while fetoprotein (AFP) and presence of metastasis, being outside the Milan criteria and Barcelona clinic liver cancer (BCLC) stage, were significantly associated with liver transplantation and HCC survival. (tmu.edu.tw)
In subgroup analyses among those without liver transplantation, we found significant associations between metastasis, Milan criteria, BCLC stage, hepatitis B surface antigen (HBsAg) and HCC survival. (tmu.edu.tw)
When separately determining the Cox proportional hazard models and Kaplan-Meier survival curves by liver transplantation status, higher adiponectin was significantly associated with an increased hazard ratio (HR) of death of 1.72 (95% confidence interval (CI)=1.12-2.64), i.e. poor survival among patients without liver transplantation. (tmu.edu.tw)
No significant impact was observed for leptin on HCC survival regardless of liver transplantation status. (tmu.edu.tw)
Conclusion: Higher levels of plasma adiponectin may predict poor HCC survival among patients without liver transplantation. (tmu.edu.tw)
Introduction Locoregional treatment while on the waiting list for liver transplantation (Ltx) for hepatocellular carcinoma (HCC) has shown to improve survival. (unipi.it)
[ 3 ] Survival of the allograft and the patient is made possible by immunosuppression following transplantation. (medscape.com)
Age, gender, tumour characteristics, BCLC classification, Child-Pugh stage, pre-existing liver disease, treatment, survival, frequency of HCC surveillance and reasons for surveillance failures were retrospectively determined in 616 patients diagnosed with HCC at Karolinska University Hospital 2005-2012. (medscape.com)
Treatment patterns and survival in patients with hepatocellular carcinoma in the Swedish national registry SweLiv. (cancercentrum.se)

We investigated the impact of hypothyroidism on outcomes after liver transplantation for HCC. (elsevierpure.com)
Ten-year outcomes after liver transplantation were "excellent" for hepatocellular carcinoma patients whose disease was successfully downstaged to within Milan criteria, validating national downstaging policies . (medpagetoday.com)

Until recently, the leading indication for liver transplantation in the United States was HCV, which accounted for approximately 30% of new waitlist registrations. (medscape.com)
Biliary atresia remains a common indication for liver transplantation in pediatric patients. (medscape.com)

The efficacy of sorafenib in the post-liver transplantation (LT) setting has been scarcely studied. (nih.gov)
Sorafenib in advanced hepatocellular carcinoma. (medscape.com)

Results: A total of 343 HCC patients who underwent liver transplantation were included in the analysis. (elsevierpure.com)
The first recipient was a 64-year-old man who had hepatocellular carcinoma and underwent liver transplantation. (cdc.gov)

18 years and diagnosis of liver cirrhosis. (springer.com)
The aim of this project is to develop AI-based algorithms for (i) diagnosis of Hepatocellular carcinoma (HCC) and (ii) prediction of driver genomic events underlying HCC. (sgh.com.sg)
Imaging Techniques for the Diagnosis of Hepatocellular Carcinoma: A Systematic Review and Meta-analysis. (medscape.com)
in the diagnosis and management of liver diseases. (who.int)
Diagnosis of NAFLD or alcoholic liver disease increased the risk of not receiving surveillance more than two-fold. (medscape.com)

Hepatocellular carcinoma in children: results of the first prospective study of the International Society of Pediatric Oncology group. (medscape.com)

For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
A variant of FLC, known as mixed fibrolamellar hepatocellular carcinoma (mFL-HCC) and characterized by the presence of both FLC and conventional HCC components within the same tumors, has also been reported. (medscape.com)
I was the US National PI for the International Hepatoblastoma therapeutic trials, SIOPEL 4 and SIOPEL 6.I am currently the senior sub-PI for the Hepatocellular Carcinoma treatment arm of the Pediatric Hepatic tumors International Therapeutic Trial (PHITT). (ucsf.edu)
For patients with liver metastases, transplantation is indicated only for neuroendocrine tumors without extrahepatic growth after removal of the primary tumor. (msdmanuals.com)

The aim of this retrospective multicenter study was to assess potential risk factors for procedure-related bleeding (PRB) within 30 days after first elective/prophylactic EBL in patients with liver cirrhosis and portal hypertension. (springer.com)
This retrospective study was conducted in two tertiary clinical centers (Vienna General Hospital of the Medical University of Vienna and Klinik Landstrasse in Vienna) including patients with liver cirrhosis and portal hypertension. (springer.com)

The Optimal Management for Sub-Centimeter Hepatocellular Carcinoma: Curative Treatments or Follow-Up? (medscimonit.com)
This is a narrative review of various treatment modalities for advanced hepatocellular carcinoma (HCC), with a focus on recent updates in radiological treatments, as well as novel treatment concepts related. (koreamed.org)

Liver biopsy on POD 7 showed no evidence of rejection, biliary complications or drug-induced liver injury. (cdc.gov)
See the images below of transplantation complications. (medscape.com)
Lee et al retrospectively enrolled 75 patients who had undergone liver transpalantation and found that although MDCT in the late period should be interpreted with caution in patients with suspected biliary complication, MDCT is a reliable diagnostic technique for the identification of early and late abdominal complications after liver transplantation. (medscape.com)
The role of potential risk factors (e.g. liver function, platelets count, number of rubber bands placed, etc.) for PRB has not yet been entirely clarified, but a better understanding of these factors could help to avoid such complications. (springer.com)

Immunotherapy in liver transplantation for hepatocellular carcinoma: Pros and cons. (wjgnet.com)

Hepatocellular carcinoma (HCC) is a major health problem and one of the most prevalent neoplasms worldwide, especially in China. (ijbs.com)
This Clinical Policy Bulletin addresses treatment approaches for liver and other neoplasms. (aetna.com)
Percutaneous ethanol injection (PEI) for liver neoplasms when criteria above are not met. (aetna.com)

Because injection drug or HBV DNA) in an organ recipient without evidence for HBV infection (anti-HBc, HBsAg, or HBV DNA) preceding transplantation. (cdc.gov)
unexpected, donor-derived HBV infection among liver recipi- ents. (cdc.gov)
Cryptococcosis infection after transplantation is easily overlooked or misdiagnosed. (cdc.gov)
The recipient showed good liver function for 30 months without active infection ( Table ). (cdc.gov)
Complex issues, such as the role of the immune system trying to deal with allograft acceptance or rejection on the one hand, and the presence of hepatitis B or C infection on the other hand, with the addition of the possibility of coexisting hepatocellular malignancy, are at the core of this book. (novapublishers.com)
The more typical form of hepatocellular carcinoma is often associated with active hepatic inflammation, hepatitis B or C viral infection, alcohol-related liver disease, nonalcoholic fatty liver disease (NAFLD), cirrhosis from any other cause, or dietary aflatoxin B1. (medscape.com)
Living with children has been associated with greater risks of SARS-CoV-2 infection, COVID-19 hospitalisation, and COVID-19 death. (imperial.ac.uk)
HR=1.50, 95% CI:1.49-1.51, for SARS-CoV-2 infection in the 'Omicron dominant' period, when schools were open, in adults living with children aged 0-11 years only). (imperial.ac.uk)
Vaccinated adults living with children had greater risks of SARS-CoV-2 infection, but lower risks of COVID-19 hospitalisation and death, than unvaccinated adults not living with children. (imperial.ac.uk)
Hepatitis C virus (HCV) infection is the leading cause of chronic liver disease thatcurrently affects at least 170 million people worldwide. (nature.com)
Of those with chronic HCV infection 15%-30% carry the risk of developing liver cirrhosis within 20 years. (who.int)
Co-infection with human immunodeficiency virus (HIV) may further enhance a patient's risk for developing hepatocellular carcinoma (HCC). (medscape.com)
GR was more sensitive in hepatitis C infection, while MDA re ected changes in liver ultrasound and GST- was the best indicator for histopathological changes. (who.int)

The best indications for liver transplantation according to the Milan criteria are as follows: patients with a single tumor of 5 cm, or patients with fewer than three nodules not exceeding 3 cm in diameter and no macroscopic vascular invasion or extrahepatic metastases [3] . (eg.net)
Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)

Liver transplantation has been considered to be the only causal treatment for patients with liver cirrhosis and HCC because of its theoretical advantage of eliminating both the tumor and liver disease. (eg.net)
Liver transplantation, in recent times, has become the ultimate solution for decompensating liver diseases, and it has been considered to be the only causal treatment for liver cirrhosis in patients with HCC because of its theoretical advantage of eliminating both the tumor and liver disease. (eg.net)
I facilitate an International Hepatobiliary Multicenter Tumor Board, where we consider therapeutic strategies for children with relapsed and refractory liver cancers from around the world, with expert participants from North America, Europe, and Asia. (ucsf.edu)
In patients with a history of chronic liver disease, a change in routine symptoms may indicate the presence of a liver tumor. (medscape.com)
In advanced cases, or when the primary tumor is large, the liver may be palpable below the right costal margin. (medscape.com)

The burden for hepatocellular carcinoma (HCC) attributed to nonalcoholic fatty liver disease (NAFLD) continues to grow in parallel with rising global trends in obesity. (thieme-connect.com)
The quality of current evidence for HCC surveillance in all patients with chronic liver disease is poor, and even lower in those with NAFLD. (thieme-connect.com)
Beyond etiology and severity of liver disease, traditional and metabolic risk factors, such as diabetes mellitus, older age, male gender and tobacco smoking, are not enough for HCC risk stratification for surveillance efficacy and effectiveness in NAFLD. (thieme-connect.com)
2 ] [ 5 ] [ 6 ] In parallel with the rising prevalence of obesity and metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of HCC and is anticipated to result in up to 135,000 HCC cases in the United States between 2015 and 2030. (thieme-connect.com)
Calls for a shift to redefine non-alcoholic fatty liver disease (NAFLD) as metabolic associated fatty liver disease could result in the exclusion of lean patients with NAFLD, a meta-analysis suggested. (medpagetoday.com)
Hepatitis C, alcoholic liver disease and non-alcoholic fatty liver disease (NAFLD) were the most common diagnoses. (medscape.com)
Undiagnosed liver disease was most common in NAFLD patients. (medscape.com)
NAFLD and alcoholic liver disease were associated with deficient surveillance. (medscape.com)

MDCT has reasonable sensitivity and high diagnostic accuracy in the detection of HCC in cirrhotic patients indicated for liver transplantation according to the Milan criteria. (eg.net)

Cite this: Nivolumab Approved for Liver Cancer - Medscape - Sep 25, 2017. (medscape.com)

Morbidity and Mortality Weekly Report archived donor serum, plasma, or liver biopsy samples were of nonliver organs** from the 20 donors developed a new tested for HBV DNA. (cdc.gov)
Nearly all donated livers come from size- and ABO-matched brain-dead (deceased), heart-beating donors. (msdmanuals.com)
Annually, more than 500 transplants in the US come from living donors, who can live without their right lobe (in adult-to-adult transplantation) or the lateral segment of their left lobe (in adult-to-child transplantation). (msdmanuals.com)

infections were detected a median of 38 from the same donor as the liver recipient were evaluated for (range = 5-116) weeks after transplantation. (cdc.gov)
Transplanted liver tissue biopsy specimen on postoperative day 30 from donor in cluster of donor-derived cryptococcosis, China. (cdc.gov)
However, because of the shortage of donor organs, it is strongly recommended that liver transplantations be performed on cirrhotic patients with HCCs only when the patients meet the predetermined criteria. (eg.net)
[ 3 ] . An increasing number of orthotopic and living-donor liver transplantations are being performed to salvage patients with otherwise incurable end-stage liver disease (ESLD). (medscape.com)
Clinical analysis of patients with hepatocellular carcinoma recurrence after living-donor liver transplantation. (wjgnet.com)

Most HCCs develop in the setting of cirrhosis from chronic liver disease, with hepatitis B virus (HBV) and hepatitis C virus (HCV) as the predominant risk factors worldwide. (thieme-connect.com)
Hepatocellular carcinoma (HCC) remains a formidable challenge in the United States due to its increasing incidence, its advanced-stage presentation, and its association with chronic liver disease. (cancernetwork.com)
Elements to ascertain include a prior history of hepatitis B or hepatitis C , chronic cirrhosis, or other diseases that tend to induce liver dysfunction. (medscape.com)
Although no cause has been clearly elucidated, the risk factors for children and adolescents include a history of hepatitis B or C, alpha-1 antitrypsin deficiency, hereditary tyrosinemia, Gaucher disease , congenital biliary atresia, urea cycle defects, severe iron overload (as occurs with thalassemia or sickle cell disease requiring chronic blood transfusion), or other forms of chronic cirrhosis or liver dysfunction. (medscape.com)

Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
Electro-coagulation for the treatment of liver metastases. (aetna.com)
One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
Metastases in Sweden - A Nationwide Study with Special Reference to Major Liver Resections. (cancercentrum.se)

Fibrolamellar carcinoma (FLC) is a primary liver cancer that occurs in adolescents and young adults without underlying liver disease. (medscape.com)
Fibrolamellar carcinoma is a rare primary hepatic malignancy that was first described as a pathological variant of hepatocellular carcinoma by Edmondson in 1956. (medscape.com)
[ 14 ] both of which again highlighted the young age of onset and the relatively good prognosis that continue to distinguish fibrolamellar carcinoma from conventional hepatocellular carcinoma. (medscape.com)

In building a HCC prediction model, deaths and liver transplantations should be considered as competing events because many ALD patients experience hepatic decompensations and deaths before HCC is detected. (nature.com)

Multidetector computed tomography (MDCT) is currently considered one of the most reliable techniques for evaluating hepatic cancer in the presence of cirrhotic liver disease, and it is primarily involved in patient treatment strategies [4] . (eg.net)
Hepatocellular carcinoma (HCC) is a major contributor to the global cancer burden, with rising global frequency of cases, and in some regions of the United States and several parts of the Western world also rising incidence and mortality rates over the past decade shown in [ Fig. 1 ] (2010-2019). (thieme-connect.com)
Fig. 1 Age-standardized death rates of liver cancer by World Health Organization region from 2010 to 2019. (thieme-connect.com)
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer. (thieme-connect.com)
A nomogram was developed to calculate the Alcohol-associated Liver Cancer Estimation (ALICE) score. (nature.com)
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer in ALD, is responsible for one-third of ALD-related mortality, and one-third of all HCC-related deaths are attributed to alcohol use globally 2 . (nature.com)
Primary liver cancer or hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the second leading cause of cancer mortality. (sgh.com.sg)
Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. (spandidos-publications.com)
Cirrhosis is associated with increased risk in the development of hepatocellular carcinoma (HCC), the most common primary liver cancer. (lu.se)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, and shows an increasing incidence in many Western countries. (medscape.com)

Rare cases of acute liver failure and death have been attributed to simvastatin. (nih.gov)

The notion of allografts is explored in specialty areas ranging from orthopedics and thoracic surgery to kidney and liver transplantation, in an effort to identify certain common themes having to do with the immunological response to the allograft and the various methods to avoid rejection. (novapublishers.com)

The purpose of the technology assessment is to provide information to assist HCFA in determining whether there is sufficient evidence to conclude whether liver transplantation for malignant diseases other than HCC meets the criteria of being reasonable and necessary under the Medicare law. (cms.gov)
He completed Masters in Comprehensive care of patient in the Intensive Care Unit and Emergency Department in 2009 and completed Masters in Research in Liver Diseases in 2011, both at the University of Barcelona. (plymouthhospitals.nhs.uk)
Liver diseases that cause cirrhosis increase risk for developing hepatocellular carcinoma (eg, alpha-1 antitrypsin deficiency). (medscape.com)

However, our search of the literature did not produce a significant volume of literature, or literature of sufficiently sound methodology, to permit our staff to make a determination regarding liver transplantation for other malignant diagnoses, such as metastatic disease, bile duct carcinoma and epithelioid hemangioendothelioma. (cms.gov)

The pattern of injury is variable, hepatocellular, cholestatic or mixed patterns have been described. (nih.gov)

Prophylactic endoscopic band ligation (EBL) is used to prevent variceal bleeding in patients with liver cirrhosis. (springer.com)

Success of BT was assessed by radiologic response compared to histopathological examination of explanted livers. (elsevierpure.com)
After liver transplantation, the imaging findings were correlated with histopathological findings in the explanted livers on a patient-by-patient and a lesion-by-lesion basis. (eg.net)

The role of hepatocellular carcinoma (HCC) surveillance is being questioned in alcoholic cirrhosis because of the relative low HCC risk. (nature.com)

Anatomy20

Organisms9

Diseases75

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment98

Phenomena and Processes17

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Named Groups2

Health Care33

Geographicals1

Orthotopic liver transplantation6

Organ Transplantation4

Treatment of hepatocellular4

Kidney Transplantation4

20221

International Liver Transplantation Society1

Resection12

Fibrosis6

Cirrhosis and hepatocellular carcinoma1

Hepatology2

Carcinomas3

Carcinoma in Patients2

Detection of hepatocellular carcinoma1

Presented with hepatocellular carcinoma1

Recurrence after liver1

Recipients10

ABSTRACT1

Transplant9

Survival12

Outcomes after liver transplantation2

Indication for liver transplantation2

Sorafenib2

Underwent2

Diagnosis5

Oncology1

Tumors4

Portal hypertension2

Treatments2

Complications4

Immunotherapy1

Neoplasms3

Infection13

Indications4

Tumor5

NAFLD8

Milan Criteria1

20171

Donors3

Donor5

Chronic4

Metastases5

Fibrolamellar carcinoma3

Prediction1

Cancer10

Acute Liver F1

Surgery1

Diseases3

Metastatic1

Cholestatic1

Patients with liver1

Histopathological2

Alcoholic1