miR-223 is commonly repressed in hepatocellular carcinoma and leukemia. (wikipedia.org)
MicroRNA-223 is commonly repressed in hepatocellular carcinoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, acute myeloid leukemia, gastric MALT lymphoma, and recurrent ovarian cancer. (wikipedia.org)
Integrative analysis in hepatocellular carcinoma implicates Stathmin 1 (STMN1) as a downstream target of miR-223. (wikipedia.org)
The reduced expressions of miR-223 may predispose to the development of hepatocellular carcinoma via the widespread induction of chromosomal instability by STMN1. (wikipedia.org)
Binge drinking leads to many disorders, including alcoholic hepatosteatosis, which is characterized by intrahepatic neutrophil infiltration and which increases the risk of hepatocellular carcinoma (HCC). (researchsquare.com)
The most common disease associated with alcohol is hepatosteatosis, which in the long term increases incidence of hepatocellular carcinoma (HCC) 2 . (researchsquare.com)
Post-liver transplantation tumor recurrence is a major challenge for hepatocellular carcinoma (HCC) recipients. (oncotarget.com)
Hypervascular Hepatocellular Carcinoma: Correlation between Biologic Features and Signal Intensity on Gadoxetic Acid-enhanced MR Images. (kanazawa-u.ac.jp)
Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma. (kanazawa-u.ac.jp)
NAFLD/NASH is responsible for many cases of cryptogenic cirrhosis and hepatocellular carcinoma in adults and is rapidly becoming the leading indication for liver transplantation in the United States. (medscape.com)
The aim of this review is to describe the mechanisms and pathways through which the nervous system affects the development and progression of the most common liver diseases, such as alcoholic liver damage, non-alcoholic fatty liver disease, cholestatic liver diseases, hepatitis, cirrhosis, and hepatocellular carcinoma. (csgh.info)
However, the efficacy of 18F-FDG PET-CT in hepatocellular carcinoma(HCC) is still controversy. (cetp-signal.com)
Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). (hindawi.com)
Bosentan, a novel endothelin receptor antagonist, was infused directly into the portal vein prior to cold ischemia and immediately on reperfusion, in five porcine livers. (duke.edu)
Hepatology1
2014). "T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury" Hepatology 60(6): 2052-2064. (bioxcell.com)
Injury32
Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
Numerous preclinical models have depicted the impact of I/R injury and hepatic parenchymal quality (steatosis, age) on increased cancer growth in the injured liver. (123dok.net)
Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
Tao Q, Tianyu W, Jiangqiao Z, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z. Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. (ijbs.com)
However, the function of Trim8 in hepatic ischaemia/reperfusion (I/R) injury remains largely unknown. (ijbs.com)
The aim of this study is to explore the role of Trim8 in hepatic I/R injury. (ijbs.com)
The effect of Trim8 on hepatic I/R injury was analysed via pathological and molecular analyses. (ijbs.com)
The results indicated that Trim8 was significantly upregulated in liver of mice subjected to hepatic I/R injury. (ijbs.com)
Trim8 knockout relieved hepatocyte injury triggered by I/R. Silencing of Trim8 expression alleviated hepatic inflammation responses and inhibited apoptosis in vitro and in vivo . (ijbs.com)
TAK1 was required for Trim8 function in hepatic I/R injury as TAK1 activation abolished Trim8 function in vitro . (ijbs.com)
In conclusion, our study demonstrates that Trim8 deficiency plays a protective role in hepatic I/R injury by inhibiting the activation of TAK1-dependent signalling pathways. (ijbs.com)
Hepatic I/R injury can result in loss of viability of a liver graft, which is directly correlated with the recipient's survival [ 2 ]. (ijbs.com)
Unfortunately, there are no good treatments to improve hepatic I/R injury. (ijbs.com)
Hepatic I/R injury is characterized by endothelial and Kupffer cell swelling, vasoconstriction, leukocyte infiltration, and platelet aggregation in sinusoids [ 3 ]. (ijbs.com)
Scholars@Duke publication: Bosentan, an endothelin antagonist, augments hepatic graft function by reducing graft circulatory impairment following ischemia/reperfusion injury. (duke.edu)
We evaluated the role of an endothelin antagonist in hepatic ischemia/reperfusion injury. (duke.edu)
13 Furthermore, octreotide can reduce ischemia-reperfusion injury by decreasing portal pressure. (ectrx.org)
In animal models of hepatic ischemia-reperfusion injury, use of octreotide resulted in a possible protective effect. (ectrx.org)
Simulated in vitro ischemia-reperfusion injury models were employed to characterize the possible mechanism of up-regulation of circulating microRNAs. (oncotarget.com)
In conclusion, early-phase circulating miR-1246 is an indicator of hepatic injury and a novel prognostic biomarker for tumor recurrence and survival of HCC recipients after liver transplantation. (oncotarget.com)
It has also been reported that triiodothyronine (T3) alleviates oxidative stress, inflammation and apoptosis caused by hepatic ischemia-reperfusion injury, and its mechanism of action is associated with negative regulation of the NLRP3 signaling pathway ( 10 ). (spandidos-publications.com)
Hepatic ischemia-reperfusion injury (IRI), an innate immunity-driven inflammation response, occurs in multiple clinical settings including liver resection, transplantation, trauma, and shock. (bioxcell.com)
Many studies (9-10) indicate that oxygen free-radical formation after reoxygenation of liver may initiate the cascade of hepatocellular injury. (lomr.org)
Also, ozone therapy applied in an experimental model of liver ischemia-reperfusion, protected the organ against the injury caused by this surgical procedure, decreasing transaminases and lactate figures, preserving the hepatocellular integrity and reducing the ROS by the stimulation and/or preservation of the endogenous antioxidant systems (19). (lomr.org)
To date, there is no specific treatment available to prevent or reduce hepatic I/R injury, and the current treatment is based merely on supportive care. (dub-signal.com)
Thus, extensive SB203580 in vivo research efforts to better understand the mechanisms of hepatic I/R injury after LT are warranted. (dub-signal.com)
Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
Inflammation2
Finally, in a newly established model of liver IRI, adoptive transfer of WT but not TIM-4-deficient BMM readily recreated local inflammation response/hepatocellular damage in the CD11b-DTR mouse system. (bioxcell.com)
Autophagy prevents NAFLD and AFLD progression through enhanced lipid catabolism and decreasing hepatic steatosis, which is characterized by the accumulation of triglycerides and increased inflammation. (hindawi.com)
Livers1
To determine the relative importance of hepatic CD4+ T cell versus iNKT cell deficiencies in protection from IRI, iNKT KO and CD4-depleted WT livers were transplanted into WT recipients. (cetp-signal.com)
In addition, ozone was able to induce an adaptation to oxidative stress with a preservation of the antioxidant endogenous systems in an animal model of renal ischemia-reperfusion (20). (lomr.org)
14. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract ( Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. (ac.ir)
Acute2
Microscopic studies of tissues exposed to ischemia/reperfusion (I/R) have revealed an acute inflammatory response. (lomr.org)
Acute ischemia apparently produces minor tissue damage, the major damage is apparently secondary to reperfusion (11). (lomr.org)
Circulating microRNA profiles at early-phase (2-hour after portal vein reperfusion) after liver transplantation were compared between HCC recipients with (n=4) and without tumor recurrence (n=8) by microarray analyses. (oncotarget.com)
Geha JA, Geha JD, O'Mahony CA, Cotton RT, Galván TN, Rana A, Goss JA " Reconstruction of the Replaced Right Hepatic Artery Using Donor Iliac Arterial Y-Graft in Orthotopic Liver Transplantation . (bcm.edu)
This suggests that the Oxymatrine resident hepatic CD4+ T cells (but not iNKT cells) are predominant mediators of early IRI following prolonged cold preservation and liver transplantation. (cetp-signal.com)
A-1: Magnetic resonance angiogram in a transplantation patient with hepatic artery thrombosis. (medscape.com)
Mechanism3
In conclusion, this study highlights the importance of cross talk between HO-1 and TLR system in the mechanism of hepatic IRI. (houstonmethodist.org)
CONCLUSION: These findings document the importance of macrophage-specific TIM-4 activation in the mechanism of hepatic IRI. (bioxcell.com)
Additionally, considering that FASN and ACLY contribute to hepatic lipogenesis, our results suggest a potential mechanism for the dyslipidemia in adult male mice that is associated with TFA diets. (biomedcentral.com)
Endothelial3
These results indicate that administration of bosentan before and after ischemia/reperfusion reduces hepatic circulatory disturbances, diminishes endothelial cell damage, and augments hepatic graft function. (duke.edu)
However, hepatic EVs elevated endothelial ICAM-1 levels per se independent of the miR-224-5p. (biomedcentral.com)
This indicated a role of hepatic EVs identified by the miR-224-5p in endothelial dysfunction in patients with Low CFR. (biomedcentral.com)
TLR44
Using a 90-min lobar warm ischemia model, wild type (WT), TLR4 KO/mutant and TLR2 KO mice were first assessed for the severity of hepatocellular damage at 6 h postreperfusion. (houstonmethodist.org)
In contrast, tin protoporphyrin-mediated HO-1 inhibition restored hepatic damage in otherwise IRI-resistant TLR4 mutant/KO mice. (houstonmethodist.org)
CoPP-induced HO-1 overexpression ameliorated hepatic damage in IRI-susceptible TLR2 KO mice, comparable with WT controls, and concomitantly diminished TLR4 levels. (houstonmethodist.org)
Hepatic IRI represents a case for innate immunity in which HO-1 modulates proinflammatory responses that are triggered via TLR4 signaling, a putative HO-1 repressor. (houstonmethodist.org)
Fibrosis1
[ 8 ] In adolescents with NAFLD, a direct relationship between the degree of hypoxemia and severity of hepatic fibrosis was noted. (medscape.com)
Vitro1
Hepatic EVs with and without the miR-224-5p were introduced to ECs in-vitro, but with no difference in effect on ICAM-1 or eNOS expression. (biomedcentral.com)
Occlusion2
Subsequent angiography confirmed occlusion at the hepatic arterial anastomosis. (medscape.com)
Magnetic resonance angiogram of the recipient celiac axis depicts complete occlusion of the hepatic artery. (medscape.com)
Therapeutic1
Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
Damage4
Hepatic I/R is an important cause of liver damage and is also the underlying cause of graft dysfunction in marginal organs. (ijbs.com)
Hepatocellular damage was assessed through hepatic venous levels of sorbitol dehydrogenase and lactate dehydrogenase. (duke.edu)
No difference was observed in hepatocellular damage. (duke.edu)
The ischemia insult triggered TIM-4 expression by stressed hepatocellular phosphatidylserine (PS) presentation, peaking at 6 hours of reperfusion, and coinciding with the maximal hepatocellular damage. (bioxcell.com)
Vascular1
Hepatic vascular resistance and liver tissue blood flow, as measured by thermistor flow probes, were determined following reperfusion. (duke.edu)
Nervous2
2. Jensen KJ, Alpini G, Glaser S. Hepatic nervous system and neurobiology of the liver. (csgh.info)
Role of circadian rhythm and autonomic nervous system in liver function: a hypothetical basis for improving the management of hepatic encephalopathy. (csgh.info)
Knockout1
Trim8 gene knockout mice and primary hepatocytes were used to construct hepatic I/R models. (ijbs.com)
Expression2
The expression of hepatic miR-1246 was positively correlated with TNF α mRNA. (oncotarget.com)
A q-PCR panel of the conventional cell type-EVs along with hepatic EVs showed that EVs from liver cells showed higher expression of the miR-224-5p. (biomedcentral.com)
Mice2
TIM-4-deficient or wild-type WT mice treated with antagonistic TIM-4 monoclonal antibody (mAb) were resistant against liver IRI, evidenced by diminished serum alanine aminotransferase (sALT) levels and well-preserved hepatic architecture. (bioxcell.com)
A recent study examined the effects of a short-term (9-week) high-fat diet in C57BL/6 J mice aged 8, 16, and 52 weeks, and demonstrated that this diet increased the production of superoxide from hepatic mitochondria in each age group [ 6 ]. (biomedcentral.com)
Surgery1
Bile duct strictures can also occur as unexpected complications after other surgeries, such as gastrectomy, pancreatic surgery, or hepatic and portal vein surgery. (medscape.com)
Most strictures after a laparoscopic procedure are short and occur more commonly in the common hepatic duct (ie, distal to the confluence of the right and left hepatic ducts). (medscape.com)
Evaluate1
Ultrasonography (US), CT, MRI, cholangiography, angiography and scintigraphy are the most common radiological modalities used to evaluate the hepatic graft. (medscape.com)
Protective1
Mechanistically, our study suggests that Trim8 deficiency may elicit hepatic protective effects by inhibiting the activation of transforming growth factor β-activated kinase 1 (TAK1)-p38/JNK signalling pathways. (ijbs.com)
Subsequent1
Ischemic preconditioning, short periods of ischemia with intermittent reperfusion, has been shown to protect the myocardium from a subsequent longer ischemic insult (21-23). (lomr.org)
Treatment1
Five other pigs underwent routine liver harvest and reperfusion without bosentan treatment. (duke.edu)