Hepatocellular carcinoma hepg2 cell arrest cells cell cycle. Medical search. Frequent questions

12 The activation of cyclin/CDK complex accelerates cell cycle progression, which are regulated by phosphorylation. (jcpjournal.org)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
In addition, we found that HBX introduction downregulated miR-18a, upregulated CTGF, elevated the viability, and promoted cell cycle progression. (medscimonit.com)
Helix-distorting CPDs and 6-4PPs strongly block the progression of DNA polymerases, which causes prolonged replication fork stalling and formation of DNA strand breaks, eventually leading to cell death (7). (colinsbraincancer.com)
The transformation of a normal cell into a cancerous phenotype requires stages of initiation, progression, and promotion by altering specific genes. (fapesp.br)
It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
EIF5B (Eukaryotic Translation Initiation Factor 5B) is a conserved eukaryotic translation factor that mediates association of the 40S and 60S ribosomal subunits during eukaryotic translation initiation, and modulates the cell cycle progression by regulating the translation of upstream open reading frames (uORF)-containing mRNAs such as p27 and p21 [ 3 ]. (techscience.com)
These data suggest that EIF5B functions as an oncogene that promotes cancer cell growth, survival, and progression. (techscience.com)
PP4IP interacts with PP4 complex, which is affected by DNA damage and cell cycle progression and decreases the dephosphorylational activity of PP4. (molcells.org)
Additionally, miR-146a silencing or restoration of FLAP led to a reduction of HepG2 cell proliferation, cell cycle progression, migration, and invasion. (biomedcentral.com)
The cellular model system for hepatocellular carcinoma (HCC)/cirrhosis development and progression may be used in the screening of compounds useful in the treatment and/or prevention of cirrhosis and/or HCC as well as in the identification biomarkers for the prediction of liver disease (especially cirrhosis) progression and HCC. (sumobrain.com)
Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). (biomedcentral.com)

Though ECH has inhibitory activity against aggressive colorectal cancer (CRC) cells, its anti-metastasis effect in vivo and the action mechanism is undetermined. (bvsalud.org)
The epithelial-to-mesenchymal changes in cell phenotype has been defined as the epithelial-mesenchymal transition (EMT), which plays a critical role in cancer metastasis [ 2 , 3 ]. (biomedcentral.com)
Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)
Epithelial-mesenchymal transition (EMT) is a dynamic process involved in cancer metastasis wherein cancer cells with epithelial characteristics acquire mesenchymal characteristics such as increased motility, invasion, and survival [ 6 ]. (techscience.com)
Hsieh SL, Hsieh S, Kuo YH, Wang JJ, Wang JC, Wu CC*. Effects of Panax notoginseng on the metastasis of human colorectal cancer cells. (nutr-metab-pu.org)
Chen C, Song G, Xiang J, Zhang H, Zhao S, Zhan Y. AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma. (cellmolbiol.org)
The miR-367-3p increases sorafenib chemotherapy efficacy to suppress hepatocellular carcinoma metastasis through altering the androgen receptor signals. (cellmolbiol.org)

The gene modulates p21-mediated epithelial cell proliferation by activating the p38 MAPK pathway during the development of teeth. (wikipedia.org)
Increased sub-G1 population and annexin-V binding, activation of caspases 9 and 3, cleavage of poly(ADPribose) polymerase (PARP), and a decrease of mitochondrial membrane potential (MMP) indicated involvement of the mitochondrial apoptotic pathway in terpinen-4-ol-treated A549 and CL1-0 cells. (hindawi.com)
Our results indicated that terpinen-4-ol induced apoptosis through a mitochondria-mediated pathway in NSCLC cells and that the apoptosis elicited by terpinen-4-ol was p53 dependent. (hindawi.com)
Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. (nature.com)
The Cdk5-AMT signal pathway involved in regulation of DDR by TIGAR defines a new role of TIGAR in cancer cell survival and it suggests that TIGAR may be a therapeutic target for cancers. (nature.com)
In breast cancer, ATF-3 enhances cancer cell-initiating features [ 22 ] and is associated with activation of the canonical Wnt/ β -catenin pathway [ 23 ]. (hindawi.com)
Western blotting revealed that silibinin downregulated SOD1 and SOD2 and triggered the JNK/c-Jun pathway in oral cancer cells. (jcancer.org)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
In the HCC cells, activation of the NF-kappa B signaling pathway and IkB phosphorylation was significantly reduced by EIF5B silencing. (techscience.com)
PI3K-PKC pathway is a key monitor of mammalian cells regulated by its different isoenzymes, which may exert similar or opposite cellular effects by differential coupling of signaling pathways. (pi3k-inhibitors.com)
Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)
Furthermore, our findings also demonstrated that RASSF7 promoted HCC cell proliferation through activating MEK1/2-ERK1/2 signaling pathway. (cellmolbiol.org)
RASSF7 Hepatocellular carcinoma Proliferation Cell cycle MEK1/2-ERK1/2 pathway. (cellmolbiol.org)
TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway. (cellmolbiol.org)
The inhibition of cell proliferation and apoptosis on MDA-MB231 and MCF-7 cell lines occurred via the mitochondrial pathway and induction of oxidative damage to DNA through Bax/Bcl-2 modulation, decreased levels of procaspase-8, -9, -3, increased levels of cleaved caspase-3 and ROS, and also cell cycle arrest at S-phase (Jamali et al. (dieselok.md)
We have generated model systems to explore drug resistance in ovarian cancer, which have revealed a key pathway related to the spindle assembly checkpoint underlying paclitaxel resistance in ovarian cell lines. (biomedcentral.com)
Lastly, through gene expression profiling we have demonstrated disruption of the spindle assembly checkpoint in the paclitaxel resistant cell lines, indicating a potential therapeutic pathway. (biomedcentral.com)
LncARSR activated the IRS2/AKT pathway by reducing YAP1 phosphorylation, and further increased lipid accumulation, cell proliferation, invasion and cell cycle. (biomedcentral.com)
Silencing lncARSR suppressed the IRS2/AKT pathway, consequently reducing HCC cell proliferation and invasion and inhibiting lipid accumulation in NAFLD mice by downregulating YAP1, which suggests a clinical application in treating NAFLD. (biomedcentral.com)
Yes-associated protein (YAP) is an effective transcriptional co-activator in the Hippo pathway, which is associated with the regulation of organ size through mediating cell proliferation, cell cycle and apoptosis. (biomedcentral.com)

Hsieh SL, Li JH, Dong CD, Chen CW, Wu CC*. Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy, and reducing angiogenesis. (nutr-metab-pu.org)
Suppression of carnosine on adhesion and extravasation of human colorectal cancer cells. (nutr-metab-pu.org)
Hsieh SL, Hsieh S, Lai PY, Wang JJ, Li CC, Wu CC*. Carnosine suppresses human colorectal cell migration and intravasation by regulating EMT and MMP expression. (nutr-metab-pu.org)

Sorafenib (Sor) can block receptor tyrosine kinases, which are involved in the development of new blood vessels, as well as cell proliferation as a result [ 22 ]. (biomedcentral.com)
The mainstay of treatment for advanced hepatocellular carcinoma (HCC) was the tyrosine kinase inhibitor (TKI) sorafenib [ 5 ]. (biomedcentral.com)

GADD45G interacts with several other proteins that are involved in DNA repair, cell cycle control, apoptosis, and senescence. (wikipedia.org)
ATR/Mec1 phosphorylates a variety of proteins substrates after that, a lot of which promote DNA replication conclusion and therefore cell success (11, 12). (colinsbraincancer.com)
GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)
In the glioma cells, EIF5B promotes cell survival by enhancing the translation of several IRES-containing mRNAs including those encoding anti-apoptotic proteins such as XIAP and Bcl-xL [ 4 ]. (techscience.com)

When permanent scar tissue replaces healthy liver cells and your liver loses the ability to function, its called cirrhosis . (hepatitisprohelp.com)

Human gastric cancer cell lines BGC-823 and SGC-7901, oesophageal cancer cell line CaEs-17, hepatocellular carcinoma cell lines SMMC-7721, QGY-7701 and HepG2, pancreatic cancer cell line Panc-1 and colon cancer cell lines LoVo and Ls174T were obtained from the Shanghai Institute of Cell Biology (Shanghai, China). (iiarjournals.org)

The present study established a docetaxel-resistant gastric cancer cell line and evaluated the alteration of mRNA expression levels globally by microarray, in an attempt to obtain novel predictive biomarkers for docetaxel chemotherapy. (iiarjournals.org)
Furthermore, the high refractoriness of liver cancer to treatments has been associated with the interaction of very complex and diverse mechanisms of chemoresistance, which can act synergistically to protect tumor cells from the chemotherapy agents [ 3 ] . (encyclopedia.pub)
2013). Same combination in polymeric micelles reduced the doxorubicin-induced cardiotoxicity in SKOV-3 and H9C2 cells as well as in mice, suggesting to limit the adverse effects of chemotherapy (Cote et al. (pi3k-inhibitors.com)
Finally, we showed that decreasing NSMCE2 gene expression increases breast cancer cells' sensitivity to chemotherapy treatment. (biomedcentral.com)

This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)
Lower DRI values may protect normal cells while selectively destroying tumor cells (Chou 2010). (pi3k-inhibitors.com)
It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
Abnormal expression of 5-Lipoxygenase Activating Protein (FLAP) has been detected in many tumor cells. (biomedcentral.com)

Targeting the mitochondrial VDAC in hepatocellular carcinoma using a polyclonal antibody-conjugated to a nitrosyl ruthenium complex. (harvard.edu)

First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
Functional experiments demonstrated that knockdown of PTTG3P inhibited cell proliferation, migration and invasion, and promoted cell apoptosis, acting as an oncogene. (biomedcentral.com)

GADD45G is involved with dental epithelial cell proliferation. (wikipedia.org)
Here, we evaluated the efficacy of ST on three different human cancer cell lines including skin epidermoid carcinoma A431 cells, lung epithelial carcinoma A549 cells and breast adenocarcinoma MDA-MB-231. (biomedcentral.com)
This study aims to evaluate the potential anti-metastatic activities of OFE on human ovarian cancer cells, and investigate its inhibitory effect on epithelial-to-mesenchymal transition (EMT). (biomedcentral.com)
EMT converts polarized and immotile epithelial cells to motile mesenchymal cells, accompanied by loss of cell-cell adhesion, planar and apical-basal polarity, and acquired mesenchymal features, including motility, invasiveness and enhanced resistance to apoptosis [ 4 ]. (biomedcentral.com)
Furthermore, EIF5B knockdown suppressed epithelial-mesenchymal transition (EMT) and the cancer stem cell (CSC) phenotype. (techscience.com)
Human ovarian cancer cell lines TOV21G (representing clear cell ovarian carcinoma) and TOV112D (representing endometrioid adenocarcinoma) were purchased from American Type Culture Collection (Manassas, VA). The human ovarian epithelial-serous cell line COV504 was purchased from Sigma Aldrich (St. Louis, MO). (biomedcentral.com)

We transfected HepG2.2.15 with miR-18a mimics and CTGF siRNA, finding that upregulated miR-18a and downregulated CTGF suppress the viability and cause cell cycle arrest. (medscimonit.com)
This suggests that BI-78D3 has the potential to modify ERK for a minimum of 8?h in cells to suppress its activation. (cell-signaling-pathways.com)

To investigate the mechanism of EESR-mediated cytotoxicity, HT29 cells were treated with various concentrations of EESR and the induction of cell cycle arrest and apoptosis was analyzed by flow cytometry, 4,6-diamidino-2-phenylindole staining, and Western blot analysis. (jcpjournal.org)
After being stained with 25 μg/ml propidium iodide solution, cells were analysed using a flow cytometry (Becton Dickinson, CA, USA). (iiarjournals.org)
Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
a , b Effect of TRIM3 overexpression on the cell cycle was determined using flow cytometry. (biomedcentral.com)
Cell proliferation was monitored by MTT and soft-agar colony formation assays, cell cycle was analyzed by flow cytometry, and cell invasion was examined by transwell assay. (biomedcentral.com)
Annexin V-PE/PI and PI staining were used to analyze cell apoptosis and cell cycle distribution by flow cytometry, respectively. (biomedcentral.com)

Furthermore, the expression of CTGF evaluated in HepG2 was transfected with HBX, while the HepG2.2.15 was transfected with miR-18a and CTGF siRNA. (medscimonit.com)
To define a role of TIGAR in DNA damage, TIGAR expression was knocked down with siRNA in HepG2 cells. (nature.com)

MATERIAL AND METHODS: CRPC prostate cancer cell models and xenograft mice models were established for research. (bvsalud.org)
Materials and Methods: Microarray analysis was performed to explore various gene expression levels between parental and docetaxel-resistant cells. (iiarjournals.org)

It also interacts with CRIF, which causes the inhibition of Cdc2-cyclin B1 and Cdk-cyclin E. GADD45 also works with the cyclin-dependent kinase inhibitor p21, which can cause growth arrest as well. (wikipedia.org)
6 , 7 Therefore, the inhibition of cancer cell proliferation by inducing cell cycle arrest and apoptosis is being an important preventive strategy against cancer. (jcpjournal.org)
We previously showed that decreased ATR function engenders deep inhibition of NER particularly during S stage in a number of individual cell types (13, 14). (colinsbraincancer.com)
This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)
In MDA-MB-231 cells, ST caused a significant dose-dependent cell growth inhibition by 31- 63% (p ≤ 0.0001) in 48 h and 40-50% (p ≤ 0.0001) in 72 h. (biomedcentral.com)
Both overexpression and depletion of PP4IP impairs DSB repairs and sensitizes cells to genotoxic stress, suggesting timely inhibition of PP4 to be indispensable for cells in responding to DNA damage. (molcells.org)
Properly designed drug delivery systems like liposomes and nanoparticles have been reported as efficient emodin carriers and to enhance emodin activity in cancer cell inhibition. (longdom.org)
According to the reports and findings, saffron plays a key role to cure different digestive system disorders via chemopreventive, inhibition of cell proliferation, induction of apoptosis, antioxidant effects and radical scavenging, genoprotective property, prevention of lipid peroxidation and anti-inflammatory processes. (ac.ir)

Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)
Our previous findings suggest the extensive mechanism of quercetin (QUE) mediated regression of cell survival, cell proliferation, oxidative stress, inflammation, and angiogenesis via modulating PI3K and PKC signaling in lym- phoma as well as hepatocellular carcinoma. (pi3k-inhibitors.com)
2015). Our previous finding entails the QUE-mediated regression of cell survival, cell proliferation, oxidative stress, inflammation, and angiogenesis in lympho- ma as well as hepatocellular carcinoma via modulating PI3K and PKC signaling (Maurya and Vinayak 2015a, b, c, 2016a, 2017a). (pi3k-inhibitors.com)
Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
Through the genome-wide regulation of gene expression, MYC is involved in diverse cellular processes including cell growth, cell cycle, apoptosis, angiogenesis, cell differentiation and genomic instability [ 4 ]. (oncotarget.com)

In this study, the antitumor effects of terpinen-4-ol and the cellular and molecular mechanisms responsible for it were evaluated and studied, respectively on human nonsmall cell lung cancer (NSCLC) cells. (hindawi.com)
It is noteworthy that several essential NER factors (RPA1C3, proliferating cell nuclear antigen, and DNA ligase) also play independent functions in other crucial cellular processes, such as DNA replication and homologous recombination. (colinsbraincancer.com)
2015). Therefore, effective che- motherapeutic drugs require multiple molecular/cellular tar- gets/pathways to control cancer cell survival/proliferation. (pi3k-inhibitors.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Sia D, Villanueva A, Friedman S and Llovet J: Liver cancer cell of origin, molecular class, and effects on patient prognosis. (spandidos-publications.com)
Hepatocellular carcinoma (HCC) is the most frequent primary malignancy of the liver and accounts for as many as 1 million deaths annually worldwide [ 1 - 4 ]. (hindawi.com)
The most frequent types of primary liver cancer in adults are hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), constituting HCC the 70-85% of cases and CCA the 30-15%, depending on the country [ 2 ] . (encyclopedia.pub)
These drawbacks may be explained, at least in part, by the various phenotypes and histological characteristics of tumor liver cells and its microenvironment [ 5 ] . (encyclopedia.pub)
Role of ADAM17 in invasion and migration of CD133-expressing liver cancer stem cells after irradiation. (cellmolbiol.org)
Herein, we aimed to demonstrate the expression of miR-146a and FLAP in human HCC tissues and liver cancer cell lines. (biomedcentral.com)
Nonalcoholic fatty liver disease (NAFLD) is the main cause for hepatocellular carcinoma (HCC). (biomedcentral.com)
The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)

Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)
Antimelanogenic, antioxidant and antiproliferative effects of antrodia camphorata fruiting bodies on B16-F0 melanoma cells. (nutr-metab-pu.org)

Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
DNA damage in HepG2 cells after TIGAR knockdown with or without treatment of epirubicin or CoCl 2 was detected by Comet assay. (nature.com)
Knockdown of RASSF7 suppressed cell growth, induced G1-S phase cell cycle arrest and cell apoptosis. (cellmolbiol.org)
Knockdown of miR-146a also resulted in increased FLAP expression of cancer cells. (biomedcentral.com)

In the present study, we investigated the expression profile and prognostic potential of EIF5B in HCC tissues and cell lines. (techscience.com)
RASSF7 was significantly up-regulated in HCC tissues and cell lines, and correlated with AFP, poor tumor histology and T stage. (cellmolbiol.org)
We demonstrated that miR-146a expression is overexpressed, while FLAP protein and mRNA are suppressed in hepatocellular carcinoma tissues and HepG2 cells compared to para-carcinoma tissues and HL-7702 cells. (biomedcentral.com)
In this study, we found that PTTG3P was up-regulated in HCC tissues and cells. (biomedcentral.com)

In this study, we examined the antitumor effects of GS-002 in human hepatoma Hep3B and HepG2 cells in vitro . (hindawi.com)

Finally, the Normal-like classified tumors show high expression levels of many genes expressed by adipose tissue and other nonepithelial cell types and are characterized by gene expression patterns that are similar to those of normal breast tissue. (biomedcentral.com)

Craig A, von Felden J, Garcia-Lezana T, Sarcognato S and Villanueva A: Tumour evolution in hepatocellular carcinoma. (spandidos-publications.com)
It results in the arrested growth of tumour cells at G 2 -M phase in a variety of tumours, including non-small cell lung cancer (NSCLC), hormone-refractory prostate cancer, advanced gastric cancer and breast cancer ( 2 ). (iiarjournals.org)

PI3k belongs to a family of lipid kinases, involved in extracellular signals transduction and cell growth promotion (Wullschleger et al. (dieselok.md)
After gain- and loss-of-function approaches in high fatty acid-treated HepG2 cells and NAFLD mice, lipid accumulation in livers from NAFLD mice and high fatty acid-treated cells was determined by H&E staining, Oil Red-O staining or Nile Red staining respectively. (biomedcentral.com)

BI-78D3 forms a covalent adduct with ERK in mammalian cells We next evaluated the ability of BI-78D3 to covalently modify C159 of ERK in intact cells. (cell-signaling-pathways.com)

Potassium (K + ) channels have an important role in HCC, including regulating the proliferation, migration, invasion and drug resistance of HCC cells. (spandidos-publications.com)
The abnormal cell growth is one of the critical characteristics of cancer for invasion or spreading out to other parts of the body. (jcpjournal.org)
The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)
Cytotoxicity, cell death by apoptosis and autophagy, migration and cell invasion, genotoxicity and gene expression will be performed. (fapesp.br)
This study showed that miR-146a has a stimulatory role in HepG2 cells and promotes HepG2 cell migration and invasion by targeting FLAP mRNA. (biomedcentral.com)
This study was intended to identify the function of long non-coding RNA (lncRNA) lncARSR in NAFLD and its role in human HCC cells (HepG2) proliferation and invasion. (biomedcentral.com)
Transwell migration and invasion assays were used to examine cell migration and invasion abilities. (biomedcentral.com)

Therefore, we hypothesized the improved anticancer efficacy of QUE in combination with isoenzyme inhibitors-rottlerin (ROT-PKCδ inhibitor), G0 6983 (PKCα inhibitor), and PI-103 (p110α-class I PI3K inhibitor) in MCF-7 and RAW 264.7 cells. (pi3k-inhibitors.com)

These results suggest prominent in vitro anti-proliferative and pro-apoptotic effects of ST in MDA-MB-231 cells. (biomedcentral.com)
The aim of this study will be on mechanistic pathways that can be regulate in vitro by nutraceuticals sulforaphane, diallyl disulfide and vitamin D in human cancer cell lines (HepG2, PC-3 and DU-145) and non-cancer cells (GAS, HUVEC and PNT2). (fapesp.br)

GADD45G is expressed in enamel knots, where it regulates gene expression and cell growth. (wikipedia.org)

Llovet J, Montal R, Sia D and Finn R: Molecular therapies and precision medicine for hepatocellular carcinoma. (spandidos-publications.com)
Collectively, these data provide insight into the molecular mechanisms underlying terpinen-4-ol-induced apoptosis in NSCLC cells, rendering this compound a potential anticancer drug for NSCLC. (hindawi.com)
The objective of this study is to evaluate the antioxidant and anticancer effects of ethanol extract of S. rufopilosa (EESR) and to determine the molecular mechanism of its anticancer activity in human colon carcinoma HT29 cells. (jcpjournal.org)
While exploring the molecular changes associated with strong ST efficacy in breast cancer cells, we observed that ST induced cell cycle arrest as well as cell death. (biomedcentral.com)
This study provides valuable insight into the chemopreventive efficacy and associated molecular alterations of ST in breast cancer cells whereas it had only moderate efficacy on lung cancer cells and did not show any considerable effect on skin cancer cells. (biomedcentral.com)
To explore the role of RASSF7 in hepatocellular carcinoma (HCC) cells proliferation and molecular mechanism. (cellmolbiol.org)
Los cromatogramas fueron elaborados en: Instituto de InvestigaciÃ³n en BioquÃ-mica y BiologÃ-a Molecular de la UNALM, 2014. (dieselok.md)

Panobinostat therapy significantly repressed mRNA for DNMT1 and DNMT3a in the two cell lines while no modifications had been observed in DNMT3b levels. (thrombininhibitors.com)
Down-regulation of EIF5B significantly decreased proliferation and invasiveness of the HCC cells. (techscience.com)
QUE significantly improves the cytotoxicity of ROT + G0 6983 ranged 30-55% and PI-103 ranged 24-63% after 24-48 h against MCF-7 cells. (pi3k-inhibitors.com)
Apoptosis rates are not significantly different between HepG2 ( c ) and Bel-7402 ( d ) cells infected with LV-TRIM3 and those infected with LV-NC. (biomedcentral.com)

In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)
Additionally in the presence of QUE, the improved cytotoxicity of ROT + G0 6983 is observed to range 69-75% and PI-103 ranged 45-88% after 24-48 h in RAW 264.7 cells. (pi3k-inhibitors.com)
These pre-clinical models were used to observe cytotoxicity, cell cycle modulation and changes in gene expression to examine the mechanisms driving drug resistance. (biomedcentral.com)

Therefore, in this study, the anticancer effects of terpinen-4-ol were evaluated on two NSCLC cell lines, namely, A549 and CL1-0 human lung adenocarcinoma cells. (hindawi.com)
The A549 human lung adenocarcinoma and CL1-0 lung adenocarcinoma cell lines were cultured in Dulbecco′s modified eagle medium supplemented with 10% fetal bovine serum (FBS) and 1% antibiotic antimycotic. (hindawi.com)
In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. (frontiersin.org)

Octyl gallate reduces ATP levels and Ki67 expression leading HepG2 cells to cell cycle arrest and mitochondria-mediated apoptosis. (harvard.edu)

TG 003 signaling dynamics and to induce cell cycle arrest and apoptosis in ERK-dependent cancers. (cell-signaling-pathways.com)
Aloe emodin is also reported to induce cell cycle arrest and apoptosis [ 11 ]. (longdom.org)

We have generated paclitaxel resistant ovarian cell lines from their corresponding native cell lines to determine driver mechanisms of drug resistance using gene expression arrays. (biomedcentral.com)
These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)
We have generated isogenic paclitaxel resistant cell lines from their corresponding native cell lines which reflect the 3 most common ovarian histologic subtypes, these include serous, clear cell and endometrioid subtypes [ 2 ]. (biomedcentral.com)

We first investigated the expression of several candidate microRNAs (miRNAs) reported to have been aberrantly expressed between HepG2 and HepG2.2.15, which is characterized by stable HBV infection, while the CTGF is identified as a target of miR-18a. (medscimonit.com)

Cell growth assay, cell cycle analysis, FACS, JC-1 staining, annexin V staining and immunoblotting were used to study the efficacy of ST on cancer cells. (biomedcentral.com)
Overall results of the current study suggested that QUE improves the synergistic anticancer efficacy in combination with PI-103, ROT, and G0 6983 in MCF-7 and RAW 264.7 cells. (pi3k-inhibitors.com)

doi:10.7287/peerj.9626v0.1/reviews/1, Soković, M., Glamoclija, J., and Ciric, A. Thymol also caused a decrease in cell viability of prostate cancer (PC-3 cell line), and provoked cytotoxic effects (Pathania et al. (dieselok.md)

Overexpression of RASSF7 promoted HCC cell proliferation, drived G1-S phase cell cycle transition and inhibited apoptosis. (cellmolbiol.org)

BACKGROUND Regorafenib (RGF) is the drug of choice for treating hepatic carcinoma (HCC), but the drug has drawbacks due to resistance and associated adverse effects. (cancerindex.org)

Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene on chromosome 9. (wikipedia.org)
This gene plays a role in cell cycle regulation. (wikipedia.org)
Deletion of an enhancer close to the GADD45G gene is correlated to increased proliferation of neuronal cells, which could account for part of the difference in neural development between humans and other species. (wikipedia.org)
ATF-3 induces DNA synthesis and expression of cyclin D1 in hepatocytes [ 21 ] and is involved in serum-induced cell proliferation as a target gene of c-myc [ 10 ]. (hindawi.com)
By screening cell cycle-related genes regulated by MYC and the MYC-repressed MYCLos, we identified the MYC-repressed gene GADD45A as a target gene of the MYC-repressed MYCLos such as MYCLo-4 and MYCLo-6. (oncotarget.com)
Our computational findings were experimentally confirmed in breast cancer cells by pharmacological SE disruption and gene silencing techniques. (biomedcentral.com)

Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
Inhibitory effect of EESR on cancer cell growth and proliferation was determined by water-soluble tetrazolium salt assay. (jcpjournal.org)
Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. (spandidos-publications.com)
A panel of 11 genes selected according to microarray analysis were validated and tested further in 11 cancer cell lines, resulting in 4 genes, CXCR4, CDK6, USP15 and CDH1. (iiarjournals.org)
Human gastric cancer cell lines MKN-45, Kato III and AGS were preserved in our laboratory. (iiarjournals.org)
Doc-resistant cancer cell line BGC-823/Doc was developed as described previously ( 13 ). (iiarjournals.org)
The effects on cancer cell migration and motility were evaluated by wound-healing and transwell assays. (biomedcentral.com)
Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)

Among lung cancers, nonsmall cell lung carcinomas (NSCLC) account for approximately 80% of lung cancer cases [ 1 ]. (hindawi.com)
In addition, there is no report on the antitumor effects of terpinen-4-ol against human nonsmall cell lung cancer cells. (hindawi.com)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)

EESR induced cell cycle arrest at G2/M phase in a dose-dependent manner by modulating cyclin B, cyclin-dependent kinase 1 (CDK1), and CDK inhibitor p21 expression. (jcpjournal.org)
The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated cells. (hindawi.com)
Ping TN, Hsieh SL, Wang JJ, Chen JB, Wu CC*. Panax notoginseng suppresses bone morphogenetic protein-2 expression in EA.hy926 endothelial cells by inhibiting the noncanonical NF-κB and Wnt/β-catenin signaling pathways. (nutr-metab-pu.org)
LncARSR expression was detected both in high fatty acid-treated HepG2 cells and NAFLD mouse model. (biomedcentral.com)

Cell culture and in vivo studies suggest that ingestion of these nutraceuticals may inhibit certain types of cancers. (fapesp.br)

GADD45G is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. (wikipedia.org)

Normal cells, advanced prostate malignancy and multitumor TMA The normal cells TMA was composed of 8 samples each of 76 different normal cells types (608 samples on one glide). (cancercurehere.com)

Eukaryotic cells have thus developed the extremely conserved DNA harm response (DDR), a significant branch which (the S stage checkpoint) works to decelerate DNA synthesis, thus providing more possibility to mitigate the genotoxic implications of replicative tension. (colinsbraincancer.com)
In this study, we investigated the functional role of eukaryotic initiation factor 5B (EIF5B) in hepatocellular carcinoma (HCC) and the underlying mechanisms. (techscience.com)
To prevent these detrimental consequences, eukaryotic cells have evolved an elaborate and complex system, so called DNA damage response (DDR) comprising of DNA DSB repair, cell cycle arrest, apoptosis, and transcriptional regulation ( Jackson and Bartek, 2009 ). (molcells.org)

Cancer is the uncontrolled growth of cells in the body, which is caused by the stepwise accumulation of mutations that affect cell growth control, differentiation and survival. (nutraculture.com)

A subset of cancer cells undergoing EMT acquire characteristics of stem cells and are designated as cancer stem cells (CSCs) [ 8 ]. (techscience.com)

Kelly and SH-SY5Y neuroblastoma cells also exhibited a reduced proliferation rate after exposure to carvacrol (Kocal and Pakdemirli, 2020). (dieselok.md)

Cells were exposed to an incremental dose escalation of paclitaxel (2 nM) for approximately 2 passages, up to a final concentration of 25 nM, once paclitaxel resistance was achieved. (biomedcentral.com)

Down-regulation of EIF5B also increased the sensitivity of HCC cells to 5-fluorouracil (5-FU). (techscience.com)
The functional importance of PP4 in cells is evident by the need of tight regulation of its activity required to maintain cell health. (molcells.org)
The MYC-repressed MYCLos are implicated in MYC-modulated cell proliferation through cell cycle regulation. (oncotarget.com)

Anatomy11

Organisms5

Diseases45

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes36

Disciplines and Occupations1

Information Science5

Health Care12

Geographicals1

Progression12

Metastasis7

Pathway20

Colorectal3

Sorafenib2

Proteins5

Cirrhosis1

Pancreatic1

Chemotherapy4

Tumor cells4

Mitochondrial1

Inhibited cell proliferation2

Epithelial6

Suppress2

Flow cytometry6

SiRNA2

Methods2

Inhibition8

Angiogenesis5

Cellular4

Liver8

Melanoma cells2

Knockdown4

Tissues4

Hepatoma1

Tumors1

Tumour2

Lipid2

Mammalian cells1

Invasion7

PI3K1

Vitro2

Regulates1

Molecular7

Significantly4

Cytotoxicity3

Adenocarcinoma3

Mitochondria-mediated1

Induce2

Ovarian3

MiRNAs1

Efficacy2

Cytotoxic1

Promoted HCC cell proliferation1

Hepatic1

Gene6

Cancer cell9

Lung3

Expression4

Cancers1

Genes1

Prostate1

Eukaryotic3

Differentiation1

Stem Cells1

20201

Paclitaxel1

Regulation3