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  • squamous cell carc
  • But little is known about the dysregulation of miR-195 in tongue squamous cell carcinoma (TSCC). (plos.org)
  • Jia L-f, Wei S-b, Gong K, Gan Y-h, Yu G-y (2013) Prognostic Implications of MicoRNA miR-195 Expression in Human Tongue Squamous Cell Carcinoma. (plos.org)
  • Head and neck squamous cell carcinoma, including cancers of oral cavity, oropharynx, larynx, and hypopharynx, represents the sixth most frequent solid cancer around the world . (plos.org)
  • Tumor associated macrophages induce epithelial to mesenchymal transition via the EGFR/ERK1/2 pathway in head and neck squamous cell carcinoma. (medworm.com)
  • Authors: Gao L, Zhang W, Zhong WQ, Liu ZJ, Li HM, Yu ZL, Zhao YF Abstract The development of head and neck squamous cell carcinoma (HNSCC) is closely associated with inflammation. (medworm.com)
  • MicroRNA-27b inhibits the migration and invasion of oral squamous cell carcinoma cells via direct suppression of vascular endothelial growth factor-C. Int J Clin Exp Pathol 2017;10(2):950-956. (ijcep.com)
  • Daily rhythmic variations of VEGF in esophageal squamous cell carcinoma patients: a correlation study of clock gene PER1, PER2 and VEGF expression. (ijcep.com)
  • invasion
  • We proved that, by modulating cyclin G1, miR-122 influences p53 protein stability and transcriptional activity and reduces invasion capability of HCC-derived cell lines. (aacrjournals.org)
  • Functionally, GAS5 suppresses while miR-135b promotes HCC cell invasion capacities in vitro . (hindawi.com)
  • Furthermore, GAS5 positively regulates expression of RECK, also a target of miR-135b, which further inhibits MMP-2 expression and contributes to invasion repression. (hindawi.com)
  • Leite KRM, Reis ST, Viana N, Morais DR, Moura CM, Silva IA, Pontes J Jr, Katz B, Srougi M. Controlling RECK miR21 Promotes Tumor Cell Invasion and Is Related to Biochemical Recurrence in Prostate Cancer. (jcancer.org)
  • Invasion assay with Matrigel showed increase in tumor cell invasion after miR-21 transfection. (jcancer.org)
  • And the negative control of RECK results in overexpression of MMP9 promotes increasing tumor cell invasion supporting miR-21 as an oncomiR related to aggressiveness in prostate cancer. (jcancer.org)
  • RT-PCR and Western blotting were used to evaluate the effects of miR-21 overexpression on the expression of various LCSC markers, a Transwell assay was used to assess the effects on cell migration and invasion, and a spheroid formation assay was used to examine the effects on clonogenesis. (biomedcentral.com)
  • Overexpression of miR-21 was associated with greater cell migration and invasion. (biomedcentral.com)
  • Cancer stem cells (CSCs), also referred to as "side populations" because they are low-abundance subpopulations in tumors, can initiate and sustain cell migration, invasion, and treatment resistance. (biomedcentral.com)
  • Restoration of miR-101 significantly inhibited cell migration and invasion in Caki-1 and 786-O cells. (oncotarget.com)
  • ROCK2 are responsible for many key cellular processes including cell migration and invasion (Croft et al. (atlasgeneticsoncology.org)
  • Overexpression of FOXQ1 rescued the inhibitory effects of miR-342-3p on NPC cell growth and invasion. (biomedcentral.com)
  • Overexpression
  • Reduced expression of VEGFR2 and FGFR1 by miR-16 or miR-424 overexpression regulated VEGF and bFGF signaling through these receptors, thereby affecting the activity of downstream components of the pathways. (ahajournals.org)
  • Overexpression of the putative tumor suppressor miR-125b, which is underexpressed in DCIS, repressed the expression of MEMO1 , which is required for ErbB2-driven cell motility (also a target of miR-125b), and NRIP1/RIP140 , which modulates the transcriptional activity of the estrogen receptor. (beds.ac.uk)
  • It was reported that overexpression of a dominant-active form of RhoA re-localized ROCK2 to the membranous actin filaments in a cervical cancer cell line, HeLa (Leung et al. (atlasgeneticsoncology.org)
  • Overexpression of miR-155 in NK cells from IA patients led to a decrease in SOCS1 expression and an increase of IFN-γ production. (frontiersin.org)
  • cancer
  • The aims of the current study were to evaluate effects of propofol on the behavior of human epithelial ovarian cancer (EOC) cells and role of miR-let-7i in these effects. (cancerindex.org)
  • The inhibitory role of miR-214 in cervical cancer cells through directly targeting mitochondrial transcription factor A (TFAM). (cancerindex.org)
  • Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and the ninth most common cancer in women. (frontiersin.org)
  • Surprisingly, recent progress on noncoding RNAs refreshes our understanding of cancer development [ 6 ]. (hindawi.com)
  • Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. (mdpi.com)
  • Isolation and biological characteristics of human cervical cancer side population cells. (ijcep.com)
  • MicroRNA-301a promotes growth and migration by repressing TGFBR2 in non-small cell lung cancer. (ijcep.com)
  • Dr Michaela Frye, a Cancer Research UK scientist at the University of Cambridge, said: "This is an important and solid piece of research that highlights our growing understanding of micro-RNAs in cancer development. (cancerresearchuk.org)
  • In the present study, a high-throughput quantitative proteomics approach was applied to identify differentially expressed proteins of HCT116 colorectal cancer cell line with artesunate (ART) treatment. (mdpi.com)
  • These proteomic findings will contribute to improving our understanding of the underlying molecular mechanisms of ART for its therapeutic cytotoxic effect towards cancer cells. (mdpi.com)
  • This review focuses on miRNA regulations of cancer cell metabolism,including glucose uptake, glycolysis, tricarboxylic acid cycle and insulin production, lipid metabolism and amino acid biogenesis, as well as several oncogenic signaling pathways. (biomedcentral.com)
  • Title: MicroRNA-411 inhibits malignant biological behaviours of colorectal cancer cells by directly targeting PIK3R3. (nih.gov)
  • CDC25 phosphatases in cancer cells: key players? (wikipathways.org)
  • Our study first indicates that miR-1271 functions as a suppressor in regulating of pancreatic cancer EMT by targeting ZEB1 and TWIST1, and it promise as a therapeutic target and prognostic marker for metastatic pancreatic cancer. (cancerindex.org)
  • inhibit
  • We found that the knockdown of MEKK3 could inhibit the activation of microglia by regulating NF-κB expression. (biomedcentral.com)
  • Taken together, our data suggest that miR-124 can inhibit neuroinflammation in the development of PD by regulating the MEKK3/NF-κB signalling pathways and implicate miR-124 as a potential therapeutic target for regulating the inflammatory response in PD. (biomedcentral.com)
  • pathogenesis
  • The potential role of these microRNAs in the pathogenesis of HCC is worth of further study. (frontiersin.org)
  • Our group recently identified a panel of 16 microRNAs aberrantly expressed in plasma of children with CHB and suggested a potential role of these microRNAs in the pathogenesis of childhood CHB [ 4 ]. (hindawi.com)
  • Our data provide an important resource for future investigations aiming at deciphering the role of specific microRNAs in the pathogenesis of childhood CHB. (hindawi.com)
  • biological
  • Through Ingenuity Pathway Analysis, we discovered that the top-ranked ART-regulated biological pathways are abrogation of fatty acid biosynthetic pathway and mitochondrial dysfunction. (mdpi.com)
  • In the present study, we aimed to explore the expression, prognostic significance, and biological relevance of miR-342-3p in nasopharyngeal carcinoma (NPC). (biomedcentral.com)
  • significantly
  • however, miR-338-3p was only significantly down-regulated in HBx-positive tumors, indicating that HBx inversely correlated with miR-338-3p. (mdpi.com)
  • Brain-specific microRNA-124 (miR-124) expression is significantly downregulated in lipopolysaccharide (LPS)-treated BV2 cells and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD. (biomedcentral.com)
  • Tumors of overexpressing cells in nude mice had a significantly larger mean volume after 34 days of growth (773.62 ± 163.46 mm 3 ) than tumors of negative control cells (502.79 ± 33.94 mm 3 , p = 0.048), as well as greater mean weight (0.422 ± 0.019 vs. 0.346 ± 0.006 g, p = 0.003). (biomedcentral.com)
  • Particularly, miR-155 expression in natural killer (NK) cells was significantly downregulated in IA patients compared with HC. (frontiersin.org)
  • transfection
  • Supplementary Fig. 1 (a-b) Western blot analysis of SRC-3 expression in HepG2 cells with or without transfection of miR-195 mimics (a), antisense (b) or negative control (NC). (springer.com)
  • Co-transfection of uc.158− inhibitor and anti-miR-193b rescued the effect of uc.158− inhibition on cell viability. (bmj.com)
  • Transfection of miR-21 using lipid based assay in DU145 cell line, showed decrease in expression of RECK resulting in increase in expression of MMP9. (jcancer.org)
  • Finally, transfection experiments combined with drug treatments performed in the UACC-62 and SK-MEL-5 melanoma cells corroborated miR-195 as potential anti-proliferative agent, with potential impact in sensitization of melanoma cell death. (biomedcentral.com)
  • Serum
  • MiR-186-5p was upregulated in serum from PCa patients and metastatic PCa cell lines (i.e. (biomedcentral.com)
  • PC-3, MDA-PCa-2b, LNCaP) compared to serum from disease-free individuals or a normal prostate epithelial cell line (RWPE1), respectively. (biomedcentral.com)